Detailed information for compound 1129303

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 868.668 | Formula: C42H50I2N2O2
  • H donors: 0 H acceptors: 0 LogP: 9.94 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[N+]12CCc3c(C2c2c(CC1)cccc2)ccc(c3)OCCCCCCOc1ccc2c(c1)CC[N+]1(C2c2ccccc2CC1)C.[I-].[I-]
  • InChi: 1S/C42H50N2O2.2HI/c1-43-23-19-31-11-5-7-13-37(31)41(43)39-17-15-35(29-33(39)21-25-43)45-27-9-3-4-10-28-46-36-16-18-40-34(30-36)22-26-44(2)24-20-32-12-6-8-14-38(32)42(40)44;;/h5-8,11-18,29-30,41-42H,3-4,9-10,19-28H2,1-2H3;2*1H/q+2;;/p-2
  • InChiKey: WZZGLMGDYJASRO-UHFFFAOYSA-L  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Electrophorus electricus Acetylcholinesterase Starlite/ChEMBL References
Equus caballus Cholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein Cholinesterase   574 aa 538 aa 31.4 %
Onchocerca volvulus Putative nuclear protein Cholinesterase   574 aa 572 aa 40.9 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 576 aa 23.4 %
Echinococcus granulosus neuroligin Cholinesterase   574 aa 492 aa 24.4 %
Schistosoma japonicum ko:K01050 cholinesterase [EC3.1.1.8], putative Cholinesterase   574 aa 577 aa 36.9 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   633 aa 690 aa 32.3 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   633 aa 690 aa 31.7 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   633 aa 622 aa 24.9 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Cholinesterase   574 aa 554 aa 36.1 %
Schistosoma mansoni gliotactin Cholinesterase   574 aa 587 aa 27.9 %
Onchocerca volvulus Cholinesterase   574 aa 578 aa 25.3 %
Onchocerca volvulus Cholinesterase   574 aa 551 aa 29.9 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   633 aa 597 aa 25.1 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   633 aa 576 aa 28.8 %
Onchocerca volvulus Galectin homolog Cholinesterase   574 aa 531 aa 39.7 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   633 aa 549 aa 30.4 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   633 aa 507 aa 23.9 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 517 aa 25.1 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   633 aa 620 aa 28.4 %
Onchocerca volvulus Acetylcholinesterase   633 aa 648 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0238 0.0074
Brugia malayi Carboxylesterase family protein 0.0028 0.0395 0.0449
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0238 1
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.519 0.6683
Mycobacterium ulcerans DNA polymerase IV 0.002 0.018 0.0643
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0395 1
Schistosoma mansoni DNA polymerase eta 0.002 0.018 0.0015
Echinococcus multilocularis importin subunit beta 1 0.003 0.0467 0.0307
Schistosoma mansoni hypothetical protein 0.0362 1 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.018 0.002
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0028 0.0395 0.0306
Brugia malayi Carboxylesterase family protein 0.0028 0.0395 0.0449
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.018 0.0167
Echinococcus multilocularis BC026374 protein (S09 family) 0.0028 0.0395 0.0234
Trichomonas vaginalis ran, putative 0.0022 0.0238 0.0097
Schistosoma mansoni gliotactin 0.0028 0.0395 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.018 0.0643
Loa Loa (eye worm) carboxylesterase 0.0164 0.4309 0.4767
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.018 0.1075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2305 0.2175
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0238 0.5097
Brugia malayi RNA, U transporter 1 0.0086 0.2065 0.2637
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0238 0.0243
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.018 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0301 0.4508
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.519 0.6683
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0028 0.0395 0.0234
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.7685 0.8652
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.7685 1
Echinococcus multilocularis acetylcholinesterase 0.0164 0.4309 0.4213
Echinococcus granulosus para nitrobenzyl esterase 0.0028 0.0395 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.018 0.0017
Plasmodium falciparum importin beta, putative 0.003 0.0467 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0301 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0238 0.2408
Brugia malayi hypothetical protein 0.0024 0.0301 0.0326
Loa Loa (eye worm) carboxylesterase 0.0028 0.0395 0.0265
Schistosoma mansoni hypothetical protein 0.0362 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0301 0.9883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2305 0.2175
Leishmania major importin beta-1 subunit, putative 0.0024 0.0303 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0028 0.0395 0.0306
Echinococcus granulosus dna polymerase eta 0.002 0.018 0.0015
Echinococcus multilocularis geminin 0.0362 1 1
Brugia malayi Carboxylesterase family protein 0.0164 0.4309 0.5577
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.018 0.3858
Echinococcus multilocularis para nitrobenzyl esterase 0.0028 0.0395 0.0234
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.018 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.018 0.1075
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0164 0.4309 0.4213
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0467 1
Schistosoma mansoni ran 0.0022 0.0238 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0165 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0431 0.8795
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2305 0.2175
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Leishmania major hypothetical protein, conserved 0.0024 0.0301 0.9883
Loa Loa (eye worm) hypothetical protein 0.0163 0.4276 0.473
Brugia malayi hypothetical protein 0.0028 0.0395 0.0449
Echinococcus granulosus snurportin 1 0.0322 0.8856 0.8837
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.018 0.0167
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.04 0.0239
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0165 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0431 0.027
Onchocerca volvulus 0.0229 0.6192 1
Echinococcus granulosus acetylcholinesterase 0.0164 0.4309 0.4213
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0431 0.027
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0395 0.0234
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0467 1
Brugia malayi Muscleblind-like protein 0.0163 0.4276 0.5534
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.018 0.1075
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0301 0.4508
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0431 0.027
Schistosoma mansoni neuroligin 3 (S09 family) 0.0028 0.0395 0.0234
Schistosoma mansoni acetylcholinesterase 0.0028 0.0395 0.0234
Onchocerca volvulus 0.0029 0.0431 0.0061
Schistosoma mansoni importin beta-1 0.003 0.0467 0.0307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0431 0.027
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.018 0.3858
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0165 0.0148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.5392 0.6014
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0165 0.3541
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0238 0.2408
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.018 0.1075
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Echinococcus granulosus importin subunit beta 1 0.003 0.0467 0.0307
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0395 0.0234
Echinococcus granulosus acetylcholinesterase 0.0164 0.4309 0.4213
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0303 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0431 0.027
Giardia lamblia DINP protein human, muc B family 0.002 0.018 0.2037
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2305 0.2175
Loa Loa (eye worm) acetylcholinesterase 1 0.0164 0.4309 0.4767
Echinococcus multilocularis snurportin 1 0.0322 0.8856 0.8837
Entamoeba histolytica hypothetical protein 0.0024 0.0303 1
Echinococcus granulosus BC026374 protein S09 family 0.0028 0.0395 0.0234
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.018 0.3858
Trichomonas vaginalis set domain proteins, putative 0.0229 0.6192 0.8015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0303 0.0183
Echinococcus granulosus carboxylesterase 5A 0.0164 0.4309 0.4213
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0238 0.2408
Brugia malayi Carboxylesterase family protein 0.0028 0.0395 0.0449
Brugia malayi Pre-SET motif family protein 0.0201 0.5392 0.6996
Schistosoma mansoni ran 0.0022 0.0238 0.0074
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2305 0.2175
Echinococcus granulosus dna polymerase kappa 0.002 0.018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0431 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Loa Loa (eye worm) hypothetical protein 0.0164 0.4309 0.4767
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0301 0.9883
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.018 0.1075
Echinococcus multilocularis muscleblind protein 1 0.0163 0.4276 0.418
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Mycobacterium ulcerans carboxylesterase, LipT 0.0028 0.0395 1
Leishmania major GTP-binding protein, putative 0.0022 0.0238 0.5279
Schistosoma mansoni BC026374 protein (S09 family) 0.0028 0.0395 0.0234
Echinococcus multilocularis muscleblind protein 0.0163 0.4276 0.418
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0303 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0028 0.0395 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.018 0.0015
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0028 0.0395 0.0234
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.8856 1
Entamoeba histolytica Ran family GTPase 0.0022 0.0238 0.5279
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Echinococcus multilocularis neuroligin 0.0028 0.0395 0.0234
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.2305 0.2951
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0238 0.5279
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0238 0.0074
Echinococcus granulosus neuroligin 0.0028 0.0395 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.4904 0.7779
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2305 0.2175
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.018 0.0015
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0028 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0467 0.0347
Loa Loa (eye worm) hypothetical protein 0.0164 0.4309 0.4767
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Loa Loa (eye worm) hypothetical protein 0.0163 0.4276 0.473
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0301 0.4508
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0238 0.0084
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0265
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0301 0.6453
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0028 0.0395 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Echinococcus multilocularis dna polymerase eta 0.002 0.018 0.0015
Brugia malayi Importin beta-1 subunit 0.003 0.0467 0.0543
Brugia malayi Carboxylesterase family protein 0.0028 0.0395 0.0449
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.2305 0.2462
Plasmodium vivax importin-beta 2, putative 0.003 0.0467 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Echinococcus granulosus muscleblind protein 0.0163 0.4276 0.418
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0303 0.0183
Loa Loa (eye worm) carboxylesterase 0.0028 0.0395 0.0265
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.018 0.1075
Echinococcus multilocularis acetylcholinesterase 0.0164 0.4309 0.4213
Mycobacterium ulcerans DNA polymerase IV 0.002 0.018 0.0643
Leishmania major DNA polymerase kappa, putative 0.002 0.018 0.1075
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0238 0.5279
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0467 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2305 0.2175
Echinococcus multilocularis carboxylesterase 5A 0.0164 0.4309 0.4213
Plasmodium vivax SET domain protein, putative 0.0029 0.0431 0.8795
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.018 0.0017
Brugia malayi Pre-SET motif family protein 0.0029 0.0431 0.0495
Brugia malayi Carboxylesterase family protein 0.0164 0.4309 0.5577
Leishmania major DNA polymerase eta, putative 0.002 0.018 0.1075
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.4904 0.6303
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0301 0.4508
Schistosoma mansoni hypothetical protein 0.0322 0.8856 0.8837
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0431 0.027
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0431 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.018 0.3858
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.018 0.1075
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.018 0.3858
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.7685 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.018 0.0015
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.018 0.0643
Trypanosoma brucei unspecified product 0.002 0.018 0.3858

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.822 Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay ChEMBL. 20350808
IC50 (binding) = 7.57 Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay ChEMBL. 20350808
IC50 (binding) = 0.027 uM Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay ChEMBL. 20350808
IC50 (binding) = 0.15 uM Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay ChEMBL. 20350808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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