Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0039 | 0.2085 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.1101 | 0.1101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2687 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.0924 | 0.4398 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.0924 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0017 | 0.0621 | 0.2941 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0012 | 0.0056 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.1216 | 0.5834 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.2687 | 0.2486 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0026 | 0.1216 | 0.1216 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.1216 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0027 | 0.1326 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0026 | 0.1216 | 0.581 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2687 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0039 | 0.2085 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0017 | 0.0621 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2411 | 0.2202 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.1216 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0015 | 0.0459 | 0.2199 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.1193 | 0.0951 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.0873 | 0.4155 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.0873 | 0.4188 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.0924 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0064 | 0.0306 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0021 | 0.0896 | 0.4299 |
Onchocerca volvulus | 0.0045 | 0.2517 | 0.9285 | |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0027 | 0.1326 | 0.6357 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0027 | 0.1326 | 0.6337 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.0924 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0025 | 0.1163 | 0.5576 |
Echinococcus granulosus | muscleblind protein | 0.0155 | 1 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.1326 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0017 | 0.0621 | 0.2981 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0024 | 0.1101 | 0.0856 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.1216 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.017 | 0.0817 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0039 | 0.2085 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.2687 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0024 | 0.1101 | 0.528 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.1216 | 0.5834 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0018 | 0.071 | 0.3708 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0155 | 1 | 1 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0049 | 0.2789 | 0.2789 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0012 | 0.0056 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0027 | 0.1326 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0027 | 0.1326 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0026 | 0.1216 | 0.581 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.2687 | 0.2687 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.0873 | 0.4188 |
Mycobacterium ulcerans | polyketide synthase | 0.0027 | 0.1326 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.1216 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0027 | 0.1326 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0444 | 0.0181 |
Echinococcus multilocularis | muscleblind protein | 0.0155 | 1 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0039 | 0.2085 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0027 | 0.1326 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.1216 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0026 | 0.1216 | 0.5834 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.2626 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0025 | 0.1163 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.0722 | 0.3461 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.0599 | 0.2574 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0027 | 0.1326 | 0.6337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antimicrobial activity against Candida albicans ATCC 2091 by disk diffusion method | ChEMBL. | 19939516 | |
DIZ (functional) | Antimicrobial activity against Escherichia coli ATCC 10536 by disk diffusion method | ChEMBL. | 19939516 | |
MIC (functional) | Antimicrobial activity against Escherichia coli ATCC 10536 after 24 hrs by microplate assay | ChEMBL. | 19939516 | |
MIC (functional) | Antimicrobial activity against Candida albicans ATCC 2091 after 48 hrs by microplate assay | ChEMBL. | 19939516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.