Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2877 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2877 | 0.3295 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0822 | 0.2858 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2877 | 0.3295 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2877 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.8732 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0871 | 0.3026 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0871 | 0.3026 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2877 | 1 |
Onchocerca volvulus | 0.003 | 0.0871 | 0.0871 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.3026 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.3026 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0871 | 0.0997 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2877 | 0.3295 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.3026 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0871 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0871 | 0.3026 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2877 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2877 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2877 | 0.3295 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.8732 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0871 | 0.0997 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0871 | 0.3026 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2877 | 0.3295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2877 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2877 | 0.3295 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0871 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2877 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.