Detailed information for compound 112981

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.557 | Formula: C26H32N4O3
  • H donors: 3 H acceptors: 5 LogP: 3.55 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)[C@@H](C[C@@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1ccccc1)O)CC(C)C
  • InChi: 1S/C26H32N4O3/c1-17(2)13-19(25(32)27-3)15-24(31)22(14-18-9-5-4-6-10-18)30-26(33)23-16-28-20-11-7-8-12-21(20)29-23/h4-12,16-17,19,22,24,31H,13-15H2,1-3H3,(H,27,32)(H,30,33)/t19-,22+,24+/m1/s1
  • InChiKey: BZGNSHZZBYWLGG-UCFCWBNQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein chemokine (C-C motif) receptor 1 355 aa 289 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0016 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0007 0.0114
Schistosoma mansoni organic anion transporter 0.0121 0.0094 0.1496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0007 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0059 0.0107
Treponema pallidum cysteinyl-tRNA synthetase 0.0088 0.0065 1
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0016 0.0004 0.0055
Loa Loa (eye worm) cytochrome P450 0.0031 0.0016 0.0278
Echinococcus multilocularis neuropeptide FF receptor 2 0.0182 0.0146 0.0146
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0007 0.0114
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0016 0.0004 0.0236
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.0061 0.5014
Echinococcus granulosus snurportin 1 0.035 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0042 0.0026 0.044
Onchocerca volvulus 0.0182 0.0146 1
Brugia malayi Cytochrome P450 family protein 0.0031 0.0016 0.0276
Schistosoma mansoni organic anion transporter 0.0121 0.0094 0.1496
Loa Loa (eye worm) RNA binding protein 0.0064 0.0045 0.0772
Schistosoma mansoni amine GPCR 0.0182 0.0146 0.2331
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Schistosoma mansoni 60S ribosomal protein L21 0.0019 0.0006 0.0097
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0081 0.1398
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.001 0.0164
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5373
Schistosoma mansoni growth hormone secretagogue receptor 0.0182 0.0146 0.2331
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0055 0.4553
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0033 0.0569
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0012 0.0998
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0055 0.0055
Echinococcus multilocularis orexin receptor type 2 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) cytochrome P450 family protein 0.0107 0.0081 0.1398
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0012 0.0734
Schistosoma mansoni biogenic amine (5HT) receptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0012 0.0998
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Echinococcus multilocularis transcription factor btf3 0.0153 0.0121 0.0121
Brugia malayi Cytochrome P450 family protein 0.0107 0.0081 0.1396
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0012 0.1857
Echinococcus granulosus biogenic amine 5HT receptor 0.0182 0.0146 0.0146
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0182 0.0146 0.0146
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0007 0.0114
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0006 0.0501
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0059 0.1008
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0016 0.0004 0.0284
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0016 0.0004 0.0007
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0055 0.4393
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0055 0.088
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0007 0.0114
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.0054 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0081 0.6607
Echinococcus granulosus tm gpcr rhodopsin 0.0182 0.0146 0.0146
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0055 0.4393
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0182 0.0146 0.2512
Echinococcus multilocularis fmrfamide receptor 0.0182 0.0146 0.0146
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0016 0.0024
Brugia malayi Thioredoxin reductase 0.0075 0.0054 0.0933
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0016 0.0004 0.0055
Leishmania major protein kinase, putative 0.0017 0.0004 0.0321
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.0094 0.1612
Echinococcus granulosus transcription factor btf3 0.0153 0.0121 0.0121
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0003 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0012 0.0208
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Schistosoma mansoni neuropeptide F-like receptor 0.0182 0.0146 0.2331
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0026 0.0012 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.0054 0.4318
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0182 0.0146 0.0146
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5238
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0007 0.0114
Brugia malayi glutathione reductase 0.0075 0.0054 0.0933
Schistosoma mansoni retinoic acid receptor RXR 0.012 0.0093 0.1474
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0016 0.0004 0.0284
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0018 0.1223
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0016 0.0024
Echinococcus granulosus g protein coupled receptor 0.0182 0.0146 0.0146
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0011 0.113
Echinococcus granulosus FTZ F1 alpha 0.002 0.0007 0.0007
Brugia malayi cytochrome P450 0.0031 0.0016 0.0276
Schistosoma mansoni hypothetical protein 0.0031 0.0016 0.0256
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0083 0.0061 0.1046
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0016 0.107
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0061
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0016 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0182 0.0146 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0121 1
Brugia malayi neuropeptide F receptor 0.0182 0.0146 0.2512
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0182 0.0146 0.0146
Leishmania major importin beta-1 subunit, putative 0.0027 0.0013 0.1033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0006 0.0426
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0012
Echinococcus granulosus G protein coupled receptor 139 0.0182 0.0146 0.0146
Brugia malayi follicle stimulating hormone receptor 0.0689 0.0582 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.001 0.001
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0016 0.0031
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0011 0.086
Schistosoma mansoni transcription factor btf3 0.0153 0.0121 0.1933
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0007 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0045 0.0715
Brugia malayi Dopamine receptor protein 2 0.0182 0.0146 0.2512
Schistosoma mansoni amine GPCR 0.0182 0.0146 0.2331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0016 0.0004 0.0055
Leishmania major cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5373
Plasmodium falciparum thioredoxin reductase 0.0026 0.0012 0.0998
Echinococcus multilocularis lamin dm0 0.009 0.0067 0.0067
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.001 0.0164
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0007 0.0106
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.0054 0.0935
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) hypothetical protein 0.0105 0.008 0.1376
Loa Loa (eye worm) melatonin receptor type 1A 0.0182 0.0146 0.2513
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.001 0.0164
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Trypanosoma brucei trypanothione reductase 0.0075 0.0054 0.4318
Schistosoma mansoni alpha-1 adrenergic receptor 0.0182 0.0146 0.2331
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0004 0.0001
Echinococcus granulosus somatostatin receptor 0.0182 0.0146 0.0146
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.0061 0.1044
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0016 0.0031
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0016 0.0024
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0012 0.0017
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.004 0.3055
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0097
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0007 0.0007
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0016 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0007 0.0106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0689 0.0582 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0003 0.005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0055 0.0055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0006 0.0006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Onchocerca volvulus 0.0182 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Onchocerca volvulus 0.0182 0.0146 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0016 0.0024
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0012 0.1019
Schistosoma mansoni hypothetical protein 0.0742 0.0627 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0007 0.0106
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0059 0.0059
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0016 0.107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0182 0.0146 0.0146
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0004 0.0284
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0016 0.0004 0.0529
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0004 0.0062
Echinococcus granulosus 7tm_1 domain containing protein 0.0182 0.0146 0.0146
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.002 0.0316
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0007 0.0007
Onchocerca volvulus 0.0182 0.0146 1
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0055
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.001 0.0177
Schistosoma mansoni coup transcription factor 0.002 0.0007 0.0106
Echinococcus multilocularis musashi 0.009 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.004 0.0629
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0055 0.0055
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0007 0.0114
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0026 0.0012 0.0023
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0045 0.077
Echinococcus multilocularis agrin 0.0083 0.0061 0.0061
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0182 0.0146 0.2331
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0088 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0016 0.0024
Brugia malayi Dopamine receptor protein 1 0.0182 0.0146 0.2512
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0103 0.1647
Schistosoma mansoni hypothetical protein 0.0035 0.0019 0.0309
Echinococcus multilocularis dro:myosuppressin receptor 0.0182 0.0146 0.0146
Brugia malayi Cytochrome P450 family protein 0.0031 0.0016 0.0276
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0016 0.0024
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.004 0.3253
Schistosoma mansoni ran 0.0024 0.0011 0.0166
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0094 0.161
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.004 0.3253
Echinococcus multilocularis 0.0031 0.0016 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0016 0.0016
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.1046
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0067 0.1148
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0011 0.0592
Echinococcus granulosus intermediate filament protein 0.009 0.0067 0.0067
Leishmania major hypothetical protein, conserved 0.008 0.0059 0.484
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0182 0.0146 0.2331
Brugia malayi prostaglandin transporter 0.0121 0.0094 0.1612
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0004 0.0004
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.004 0.3055
Brugia malayi nuclear hormone receptor 0.002 0.0007 0.0114
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0088 0.0065 0.5373
Loa Loa (eye worm) hypothetical protein 0.0042 0.0026 0.044
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.001 0.001
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.008 0.0059 0.0114
Entamoeba histolytica hypothetical protein 0.0027 0.0013 0.1033
Schistosoma mansoni hypothetical protein 0.0742 0.0627 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0055
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0055 0.088
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0182 0.0146 0.2331
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0182 0.0146 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0007 0.0116
Echinococcus multilocularis snurportin 1 0.035 0.029 0.029
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0016 0.0031
Onchocerca volvulus 0.0182 0.0146 1
Echinococcus granulosus g protein coupled receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) beta-lactamase 0.008 0.0059 0.101
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0055 0.0055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0055 0.4553
Echinococcus granulosus orexin receptor type 2 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0076 0.0055 0.0945
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0007 0.0456
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0107 0.0081 0.0151
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0011 0.0011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Trypanosoma brucei protein kinase, putative 0.0058 0.004 0.3055
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0016 0.0004 0.0004
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.004 0.3055
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0113 0.0087 0.7167
Plasmodium falciparum glutathione reductase 0.0075 0.0054 0.448
Schistosoma mansoni intermediate filament proteins 0.009 0.0067 0.1064
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0011 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.035 0.029 0.4626
Brugia malayi larval opioid receptor 0.0182 0.0146 0.2512
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0052
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0182 0.0146 0.2331
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0004 0.0004
Echinococcus granulosus lamin 0.009 0.0067 0.0067
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0004
Brugia malayi GnHR receptor homolog 0.0182 0.0146 0.2512
Brugia malayi AKH receptor 0.0182 0.0146 0.2512
Echinococcus granulosus geminin 0.0742 0.0627 0.0627
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0055 0.8387
Echinococcus multilocularis expressed conserved protein 0.0017 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Plasmodium falciparum importin beta, putative 0.0033 0.0018 0.1472
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.001 0.0164
Brugia malayi beta-NAC-like protein 0.0153 0.0121 0.2083
Leishmania major cytochrome p450-like protein 0.0031 0.0016 0.1324
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0182 0.0146 0.2513
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0059 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0335
Schistosoma mansoni cytochrome P450 0.0031 0.0016 0.0256
Leishmania major protein kinase A regulatory subunit, putative 0.0016 0.0004 0.0284
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.004 0.3253
Schistosoma mansoni hypothetical protein 0.0182 0.0146 0.2331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Brugia malayi Dopamine receptor 0.0182 0.0146 0.2512
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0007 0.0114
Echinococcus granulosus voltage gated potassium channel 0.0035 0.002 0.002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0182 0.0146 0.2513
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0011 0.0181
Onchocerca volvulus 0.0182 0.0146 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0007 0.0007
Toxoplasma gondii ABC1 family protein 0.008 0.0059 0.484
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0182 0.0146 0.2331
Onchocerca volvulus 0.0182 0.0146 1
Onchocerca volvulus 0.0016 0.0004 0.0236
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0109 0.0084 0.0084
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0007 0.0007
Leishmania major GTP-binding protein, putative 0.0024 0.0011 0.086
Toxoplasma gondii transporter, major facilitator family protein 0.0121 0.0094 0.7738
Echinococcus granulosus neuropeptide Y receptor 0.0182 0.0146 0.0146
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi steroid hormone receptor 0.002 0.0007 0.0114
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0182 0.0146 0.0146
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0094 0.1612
Brugia malayi neuropeptide F receptor 0.0182 0.0146 0.2512
Brugia malayi secreted modular calcium-binding protein 1 0.0083 0.0061 0.1044
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Onchocerca volvulus 0.009 0.0067 0.4565
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0016 0.0004 0.0059
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.004 0.3253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0007 0.0007
Brugia malayi Melatonin receptor type 1A 0.0182 0.0146 0.2512
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0007 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0045 0.0715
Trichomonas vaginalis esterase, putative 0.008 0.0059 0.484
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0113 0.0087 0.7167
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0734
Toxoplasma gondii exonuclease III APE 0.0019 0.0006 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Entamoeba histolytica Ran family GTPase 0.0024 0.0011 0.086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0094 0.0094
Mycobacterium leprae putative cytochrome p450 0.0031 0.0016 0.0024
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5238
Brugia malayi Serotonin receptor 0.0182 0.0146 0.2512
Echinococcus granulosus fmrfamide receptor 0.0182 0.0146 0.0146
Schistosoma mansoni lamin 0.009 0.0067 0.1064
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0016 0.0024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0004 0.0007
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0006 0.0501
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0007 0.0106
Onchocerca volvulus Putative organic anion transporter 0.0121 0.0094 0.6417
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0016 0.0024
Echinococcus granulosus dro:myosuppressin receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0004 0.0061
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0012 0.1402
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0088 0.0065 0.1119
Echinococcus multilocularis g protein coupled receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.0061 0.1044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0088 0.0065 0.1121
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0018 0.0018
Giardia lamblia Cysteinyl-tRNA synthetase 0.0088 0.0065 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0012 0.0734
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0011 0.0592
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0045 0.0772
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.1046
Brugia malayi intermediate filament protein 0.009 0.0067 0.1147
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0006 0.0501
Echinococcus multilocularis allatostatin A receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.001 0.0179
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0284
Brugia malayi hypothetical protein 0.0121 0.0094 0.1612
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Echinococcus multilocularis neuropeptide s receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0016 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Echinococcus multilocularis serotonin receptor 0.0182 0.0146 0.0146
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.0061 0.1044
Mycobacterium tuberculosis Conserved protein 0.0016 0.0004 0.0007
Brugia malayi sulfakinin receptor protein 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni nuclear hormone receptor 0.002 0.0007 0.0106
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0016 0.0004 0.0055
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0016 0.0024
Onchocerca volvulus 0.0182 0.0146 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0998
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0182 0.0146 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0004 0.0285
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0016 0.107
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.004 0.3055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0016 0.0031
Onchocerca volvulus 0.0182 0.0146 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0004 0.0284
Plasmodium falciparum cysteine--tRNA ligase 0.0088 0.0065 0.5373
Schistosoma mansoni histamine h1 receptor 0.0182 0.0146 0.2331
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0006 0.0097
Brugia malayi Egg laying defective protein 4 0.0017 0.0004 0.0067
Trypanosoma cruzi MFS transporter, putative 0.0121 0.0094 0.7672
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.1046
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.001 0.001
Echinococcus granulosus g-protein coupled receptor 0.0182 0.0146 0.0146
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0001
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.004 0.5833
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0013 0.1033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0012 0.0998
Loa Loa (eye worm) intermediate filament protein 0.009 0.0067 0.1148
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.001 0.0164
Schistosoma mansoni netrin receptor unc5 0.0015 0.0003 0.0045
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0016 0.0024
Schistosoma mansoni opsin-like receptor 0.0182 0.0146 0.2331
Trypanosoma brucei transcription factor BTF3, putative 0.0153 0.0121 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.002 0.002
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0003 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0016 0.0278
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0013 0.0771
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.001 0.0849
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0016 0.0004 0.0055
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0016 0.1324
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0045 0.0045
Leishmania major trypanothione reductase 0.0075 0.0054 0.448
Onchocerca volvulus 0.0121 0.0094 0.6417
Echinococcus granulosus cGMP dependent protein kinase 0.0017 0.0004 0.0004
Brugia malayi G-protein coupled receptor 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0006 0.0012
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0182 0.0146 0.0146
Trypanosoma brucei cytochrome P450, putative 0.0107 0.0081 0.6607
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0309
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus multilocularis neuropeptide receptor 0.0182 0.0146 0.0146
Onchocerca volvulus 0.0083 0.0061 0.4158
Entamoeba histolytica hypothetical protein 0.0153 0.0121 1
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0016 0.0004 0.0059
Echinococcus multilocularis somatostatin receptor 0.0182 0.0146 0.0146
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0059 0.0059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0059 0.0936
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0016 0.0024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 1.1656 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0007 0.0116
Loa Loa (eye worm) ICD-1 protein 0.0153 0.0121 0.2084
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Echinococcus multilocularis voltage gated potassium channel 0.0035 0.002 0.002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0017 0.0004 0.0321
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0059 0.0114
Plasmodium vivax hypothetical protein, conserved 0.008 0.0059 0.484
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0003 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0033 0.057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0006 0.0426
Plasmodium falciparum thioredoxin reductase 0.0075 0.0054 0.448
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0004 0.0285
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0012 0.0998
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0012 0.0998
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0182 0.0146 0.0146
Onchocerca volvulus 0.0182 0.0146 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0121 0.0094 0.1613
Echinococcus multilocularis neuropeptide receptor 0.0182 0.0146 0.0146
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Conserved protein 0.008 0.0059 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0182 0.0146 0.0146
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0004 0.0284
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0006 0.0501
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0182 0.0146 0.2513
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.004 0.004
Echinococcus granulosus cysteinyl tRNA synthetase 0.0088 0.0065 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0088 0.0065 0.1124
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0016 0.0004 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0067 0.1147
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0055 0.4553
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0016 0.0031
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0016 0.1324
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0182 0.0146 0.0146
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0035 0.002 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0059 0.484
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0057 0.0057
Echinococcus granulosus peptide allatostatin:somatostatin 0.0182 0.0146 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0007 0.0114
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0006 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0045 0.0715
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0004 0.0284
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0007 0.0007
Brugia malayi RNA binding protein 0.0064 0.0045 0.077
Echinococcus multilocularis lamin 0.009 0.0067 0.0067
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0012 0.0998
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0006 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0007 0.0007
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0007 0.0116
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0088 0.0065 0.1039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0182 0.0146 0.0146
Echinococcus multilocularis neuropeptide receptor A26 0.0182 0.0146 0.0146
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0059 0.0107
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0055 0.4393
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0004 0.0062
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0012 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0006 0.0104
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0016 0.0004 0.0055
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0016 0.0004 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0035 0.002 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0007 0.0116
Mycobacterium ulcerans lipase LipD 0.008 0.0059 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0016 0.0004 0.0284
Brugia malayi Serotonin receptor 0.0182 0.0146 0.2512
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0006 0.0223
Schistosoma mansoni myosin xvIII 0.0182 0.0146 0.2331
Onchocerca volvulus 0.008 0.0059 0.4014
Schistosoma mansoni biogenic amine receptor 0.0182 0.0146 0.2331
Brugia malayi beta-lactamase family protein 0.008 0.0059 0.1008
Schistosoma mansoni amine GPCR 0.0182 0.0146 0.2331
Echinococcus multilocularis fmrfamide receptor 0.0182 0.0146 0.0146
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0284
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0016 0.0031
Onchocerca volvulus 0.0182 0.0146 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.0061 0.5014
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0016 0.0031
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.005
Schistosoma mansoni hypothetical protein 0.0062 0.0043 0.0681
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0016 0.0004 0.0284
Brugia malayi ecdysteroid receptor 0.002 0.0007 0.0114
Echinococcus multilocularis neuropeptide Y receptor 0.0182 0.0146 0.0146
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0059
Echinococcus granulosus agrin 0.0083 0.0061 0.0061
Echinococcus multilocularis neuropeptides capa receptor 0.0182 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0055
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0121 0.0094 0.0094
Echinococcus multilocularis Ankyrin 0.0015 0.0003 0.0003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0011 0.0179
Echinococcus granulosus patatin phospholipase domain containing protein 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0016 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0998
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0016 0.0004 0.0055
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0059 0.0114
Brugia malayi Uncoordinated protein 44 0.0015 0.0003 0.0048
Echinococcus granulosus leucyl tRNA synthetase 0.0088 0.0065 0.0065
Mycobacterium ulcerans hypothetical protein 0.008 0.0059 0.0107
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0013 0.1033
Brugia malayi RNA, U transporter 1 0.0093 0.007 0.1198
Brugia malayi SPARC precursor 0.0083 0.0061 0.1044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0182 0.0146 0.2331
Schistosoma mansoni importin beta-1 0.0033 0.0018 0.0285
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0285
Brugia malayi hypothetical protein 0.0121 0.0094 0.1612
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0061
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0013 0.1033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.004 0.0679
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0182 0.0146 0.2331
Schistosoma mansoni agrin 0.0083 0.0061 0.0969
Echinococcus granulosus follistatin 0.0083 0.0061 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0006 0.0223
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Leishmania major regulatory subunit of protein kinase a-like protein 0.0016 0.0004 0.0284
Echinococcus granulosus Ankyrin 0.0015 0.0003 0.0003
Onchocerca volvulus Putative organic anion transporter 0.0121 0.0094 0.6417
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0007 0.0007
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0012 0.0998
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0016 0.0031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0182 0.0146 0.2512
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0016 0.0024
Onchocerca volvulus 0.0182 0.0146 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0182 0.0146 0.0146
Echinococcus multilocularis neuropeptides capa receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.001 0.0179
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0061
Schistosoma mansoni lamin 0.009 0.0067 0.1064
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0182 0.0146 1
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5238
Echinococcus granulosus hypothetical protein 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.001 0.0849
Echinococcus granulosus neuropeptide FF receptor 2 0.0182 0.0146 0.0146
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0016 0.0004 0.0284
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0027 0.0027
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0016 0.0004 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0007 0.0456
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0026 0.0012 0.0017
Wolbachia endosymbiont of Brugia malayi cysteinyl-tRNA synthetase 0.0088 0.0065 1
Mycobacterium leprae conserved hypothetical protein 0.008 0.0059 0.0107
Onchocerca volvulus 0.009 0.0067 0.4565
Loa Loa (eye worm) neuropeptide F receptor 0.0182 0.0146 0.2513
Echinococcus granulosus lamin dm0 0.009 0.0067 0.0067
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0007 0.0007
Brugia malayi putative neuropeptide receptor NPR1 0.0182 0.0146 0.2512
Echinococcus multilocularis expressed protein 0.0083 0.0061 0.0061
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0006 0.0106
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Leishmania major cytochrome p450-like protein 0.0031 0.0016 0.1324
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0182 0.0146 0.2512
Schistosoma mansoni amine GPCR 0.0182 0.0146 0.2331
Schistosoma mansoni neuropeptide receptor 0.0182 0.0146 0.2331
Entamoeba histolytica transcription factor BTF3, putative 0.0153 0.0121 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0012 0.0734
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0019 0.0333
Echinococcus granulosus tar DNA binding protein 0.0064 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0004 0.0062
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.035 0.029 0.4985
Echinococcus multilocularis thioredoxin glutathione reductase 0.0075 0.0054 0.0054
Chlamydia trachomatis cysteine--tRNA ligase 0.0088 0.0065 1
Leishmania major basic transcription factor 3a, putative 0.0153 0.0121 1
Echinococcus multilocularis geminin 0.0742 0.0627 0.0627
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0016 0.0004 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0004 0.0004
Schistosoma mansoni ran 0.0024 0.0011 0.0166
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0012 0.0998
Loa Loa (eye worm) hypothetical protein 0.005 0.0033 0.057
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus multilocularis neuropeptide Y receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) multidrug resistance protein 3 0.0012 0 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0103 0.1647
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0004 0.0285
Toxoplasma gondii protease inhibitor PI2 0.0083 0.0061 0.5014
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.002 0.002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.004 0.3055
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0016 0.0024
Brugia malayi N-terminal motif family protein 0.0016 0.0004 0.0059
Echinococcus multilocularis g-protein coupled receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0059 0.0114
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0007 0.0114
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.001 0.001
Brugia malayi isocitrate dehydrogenase 0.0016 0.0004 0.0059
Onchocerca volvulus 0.008 0.0059 0.4014
Brugia malayi G protein-coupled receptor 0.0182 0.0146 0.2512
Leishmania major protein kinase, putative 0.0017 0.0004 0.0321
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni opsin-like receptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0045 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0007 0.0114
Brugia malayi Death domain containing protein 0.0015 0.0003 0.0048
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0182 0.0146 0.2513
Leishmania major cytochrome p450-like protein 0.0107 0.0081 0.6703
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0006 0.0106
Brugia malayi RE15519p 0.0182 0.0146 0.2512
Echinococcus granulosus alpha 1A adrenergic receptor 0.0182 0.0146 0.0146
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0088 0.0065 0.1039
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Echinococcus granulosus sex peptide receptor 0.0182 0.0146 0.0146
Brugia malayi beta-lactamase 0.008 0.0059 0.1008
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0004 0.0284
Loa Loa (eye worm) hypothetical protein 0.0076 0.0055 0.095
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0059 0.4689
Echinococcus granulosus tachykinin peptides receptor 99D 0.0182 0.0146 0.0146
Loa Loa (eye worm) CYP4Cod1 0.0107 0.0081 0.1398
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.001 0.001
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Trypanosoma cruzi transcription factor btf3, putative 0.0153 0.0121 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0075 0.0054 0.0054
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0012 0.0998
Onchocerca volvulus 0.0182 0.0146 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.004 0.3253
Onchocerca volvulus 0.0121 0.0094 0.6417
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0182 0.0146 0.2331
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Plasmodium vivax basic transcription factor 3b, putative 0.0153 0.0121 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0007 0.0114
Plasmodium falciparum cysteine--tRNA ligase 0.0088 0.0065 0.5373
Echinococcus granulosus rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0016 0.0024
Schistosoma mansoni neuropeptide receptor 0.0182 0.0146 0.2331
Schistosoma mansoni biogenic amine (5HT) receptor 0.0182 0.0146 0.2331
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0003 0.0047
Schistosoma mansoni ap endonuclease 0.0019 0.0006 0.0097
Brugia malayi beta-lactamase family protein 0.008 0.0059 0.1008
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.602 0.516 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.002 0.0343
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0012 0.1019
Echinococcus granulosus g protein coupled receptor 0.0182 0.0146 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0059 0.484
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0006 0.0106
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0007 0.0114
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0018 0.1223
Schistosoma mansoni neuropeptide F-like receptor 0.0182 0.0146 0.2331
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.0094 0.1612
Brugia malayi Protein kinase domain containing protein 0.0016 0.0003 0.0056
Schistosoma mansoni biogenic amine receptor 0.0182 0.0146 0.2331
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0059 0.0114
Onchocerca volvulus Putative organic anion transporter 0.0121 0.0094 0.6417
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0016 0.0024
Brugia malayi Cytochrome P450 family protein 0.0107 0.0081 0.1396
Treponema pallidum NADH oxidase 0.0026 0.0012 0.1402
Toxoplasma gondii thioredoxin reductase 0.0075 0.0054 0.448
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.004 0.3253
Mycobacterium leprae Probable lipase LipE 0.008 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.009 0.0067 0.1148
Onchocerca volvulus 0.0121 0.0094 0.6417
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0055 0.4553
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi sodium-independent organic anion transporter family protein 0.0121 0.0094 0.1612
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus granulosus serotonin receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0059 0.0114
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0031 0.0532
Echinococcus multilocularis sex peptide receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) G-protein coupled receptor 0.0182 0.0146 0.2513
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0088 0.0065 0.012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0007 0.0106
Trypanosoma cruzi transcription factor btf3, putative 0.0153 0.0121 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0016 0.0031
Echinococcus granulosus Solute carrier organic anion transporter family 0.0121 0.0094 0.0094
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0003 0.0003
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.004 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0007 0.0106
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0012
Schistosoma mansoni opsin-like receptor 0.0182 0.0146 0.2331
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0055 0.0948
Onchocerca volvulus 0.008 0.0059 0.4014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0182 0.0146 0.2331
Echinococcus multilocularis follistatin 0.0083 0.0061 0.0061
Schistosoma mansoni thyroid hormone receptor 0.002 0.0007 0.0106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0012 0.0734
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0016 0.0004 0.0055
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0004 0.0004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Brugia malayi ORL1-like opioid receptor 0.0182 0.0146 0.2512
Onchocerca volvulus 0.0121 0.0094 0.6417
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.001 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0107 0.0081 0.6607
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0016 0.0031
Echinococcus granulosus death domain containing protein 0.0015 0.0003 0.0003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0182 0.0146 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0059 0.4689
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0016 0.0004 0.0284
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.001 0.0164
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Brugia malayi MAP kinase sur-1 0.0058 0.004 0.0677
Echinococcus granulosus retinoic acid receptor rxr beta a 0.012 0.0093 0.0093
Loa Loa (eye worm) AGC/PKG protein kinase 0.0017 0.0004 0.0069
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0016 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0007 0.0116
Toxoplasma gondii NAC domain-containing protein 0.0153 0.0121 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0045 0.0715
Plasmodium vivax glutathione reductase, putative 0.0075 0.0054 0.448
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0016 0.0004 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0182 0.0146 0.2331
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0004 0.0059
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0083 0.0061 0.1044
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0182 0.0146 0.2331
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0007 0.0106
Onchocerca volvulus 0.0016 0.0004 0.0236
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0182 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0182 0.0146 0.2331
Onchocerca volvulus 0.0182 0.0146 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.001 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0182 0.0146 0.0146
Schistosoma mansoni biogenic amine receptor 0.0182 0.0146 0.2331
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0016 0.0031
Echinococcus granulosus allatostatin A receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0179
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0182 0.0146 0.0146
Onchocerca volvulus 0.0182 0.0146 1
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0059 0.484
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0016 0.0004 0.0055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0007 0.0007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0012 0.0998
Brugia malayi G protein-coupled receptor F59B2.13 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Brugia malayi TAR-binding protein 0.0064 0.0045 0.077
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.004 0.3253
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0033 0.0569
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0012 0 0.0002
Echinococcus granulosus importin subunit beta 1 0.0033 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0016 0.0024
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.004 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0059 0.484
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0088 0.0065 0.1121
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0182 0.0146 0.0146
Plasmodium vivax importin-beta 2, putative 0.0033 0.0018 0.1472
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0094 0.0094
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0016 0.0004 0.0059
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.008 0.0059 0.101
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Loa Loa (eye worm) glutathione reductase 0.0075 0.0054 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0027 0.0464
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0016 0.0004 0.0007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0004 0.0007
Mycobacterium ulcerans beta-lactamase 0.008 0.0059 0.0107
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0004 0.0007
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0284
Brugia malayi hypothetical protein 0.0182 0.0146 0.2512
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0 0.0002
Mycobacterium tuberculosis Probable oxidoreductase 0.0026 0.0012 0.0023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0017
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0016 0.0004 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0007 0.0116
Schistosoma mansoni neuropeptide receptor 0.0182 0.0146 0.2331
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0017 0.0004 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0059 0.0936
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0004 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0007 0.0114
Plasmodium falciparum glutathione reductase 0.0026 0.0012 0.0998
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0193
Echinococcus granulosus neuropeptides capa receptor 0.0182 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0007 0.0116
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus granulosus neuropeptide receptor 0.0182 0.0146 0.0146
Echinococcus multilocularis G protein coupled receptor 139 0.0182 0.0146 0.0146
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0016 0.0004 0.0061
Echinococcus granulosus neuropeptide s receptor 0.0182 0.0146 0.0146
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0513 0.043 0.0834
Plasmodium falciparum basic transcription factor 3b, putative 0.0153 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.004 0.004
Onchocerca volvulus 0.0182 0.0146 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0007 0.0007
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0016 0.0004 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0059 0.484
Loa Loa (eye worm) agrin synaptic family protein 0.0083 0.0061 0.1046
Brugia malayi G-protein coupled receptor 0.0182 0.0146 0.2512
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0121 0.0094 0.0094
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0004 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0004 0.0004
Echinococcus multilocularis G-protein coupled receptor, putative 0.0182 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0182 0.0146 0.2331
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0045
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0059 0.101
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0012 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0182 0.0146 0.2513
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0012 0.0734
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0182 0.0146 0.0146
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0121 0.0094 0.0094
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0007 0.0114
Echinococcus granulosus neuropeptide Y receptor 0.0182 0.0146 0.0146
Schistosoma mansoni amine GPCR 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.0083 0.0061 0.1046
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0016 0.0004 0.0055
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0011 0.086
Onchocerca volvulus 0.0121 0.0094 0.6417
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0027 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0059 0.4689
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0004 0.0001
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0003 0.0003
Leishmania major hypothetical protein, unknown function 0.0016 0.0004 0.0284
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.0061 0.5014
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0031 0.0534
Mycobacterium tuberculosis Conserved protein 0.008 0.0059 0.0114
Onchocerca volvulus 0.0088 0.0065 0.4456
Plasmodium vivax cysteine--tRNA ligase, putative 0.0088 0.0065 0.5373
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0016 0.0024
Schistosoma mansoni follistatin 0.0083 0.0061 0.0969
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni neuropeptide receptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0045 0.0772
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0016 0.0024
Echinococcus granulosus neuropeptide receptor 0.0182 0.0146 0.0146
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0004 0.0055
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0016 0.107
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0007 0.0106
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0016 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0012 0.0734
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0018 0.1472
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0083 0.0061 0.5014
Echinococcus granulosus neuropeptide receptor A26 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Brugia malayi putative neuropeptide receptor 0.0182 0.0146 0.2512
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0016 0.0004 0.0284
Schistosoma mansoni neuropeptide f receptor 76f 0.0182 0.0146 0.2331
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.602 0.516 1
Echinococcus multilocularis g protein coupled receptor 0.0182 0.0146 0.0146
Plasmodium falciparum cGMP-dependent protein kinase 0.0017 0.0004 0.0321
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0016 0.0004 0.0007
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.602 0.516 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0011 0.0592
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0088 0.0065 0.5373
Trichomonas vaginalis ran, putative 0.0024 0.0011 0.086
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0057 0.0057
Loa Loa (eye worm) G-protein coupled receptor 0.0182 0.0146 0.2513
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0011 0.086
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0016 0.0004 0.0055
Schistosoma mansoni hypothetical protein 0.0182 0.0146 0.2331
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0055 0.4553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0182 0.0146 0.2331
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Loa Loa (eye worm) hypothetical protein 0.0182 0.0146 0.2513
Echinococcus granulosus neuropeptides capa receptor 0.0182 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0007 0.0007
Brugia malayi Importin beta-1 subunit 0.0033 0.0018 0.0307
Leishmania major cyclic nucleotide-binding protein-like protein 0.0016 0.0004 0.0284
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0059 0.0114
Echinococcus multilocularis serotonin receptor 0.0182 0.0146 0.0146
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.0054 0.448
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.001 0.001
Echinococcus granulosus cGMP dependent protein kinase 1 0.0017 0.0004 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0182 0.0146 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0012 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0007 0.0114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0006 0.0501
Onchocerca volvulus 0.002 0.0007 0.0456
Schistosoma mansoni adenoreceptor 0.0182 0.0146 0.2331
Loa Loa (eye worm) neuropeptide F receptor 0.0182 0.0146 0.2513
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0116
Loa Loa (eye worm) hypothetical protein 0.0121 0.0094 0.1613
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0003 0.0192
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0016 0.0031

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.064 uM Inhibition of CCL3 binding to C-C chemokine receptor type 1 ChEMBL. 15081002
IC50 (functional) = 0.064 uM Inhibition of CCL3 induced chemotaxis in THP-1 cells ChEMBL. 15081002
IC50 (binding) = 0.064 uM Inhibition of CCL3 binding to C-C chemokine receptor type 1 ChEMBL. 15081002
IC50 (functional) = 0.064 uM Inhibition of CCL3 induced chemotaxis in THP-1 cells ChEMBL. 15081002

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15081002

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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