Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0221 | 0.9322 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.5107 | 0.5069 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0563 | 0.0489 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0221 | 0.9322 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.1248 | 0.1179 |
Brugia malayi | MAP kinase sur-1 | 0.0221 | 0.9322 | 0.9317 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0221 | 0.9322 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0383 | 0.0411 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.2949 | 0.5 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.3027 | 0.3247 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1248 | 0.1339 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.1248 | 0.1179 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.1248 | 0.1179 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1248 | 0.1339 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0221 | 0.9322 | 0.9317 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0221 | 0.9322 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.9322 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0221 | 0.9322 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0092 | 0.2644 | 0.2586 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.2949 | 0.2894 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2949 | 0.2894 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0383 | 0.0307 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1248 | 0.1339 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0383 | 0.0308 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0221 | 0.9322 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.1248 | 0.1179 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0221 | 0.9322 | 0.9317 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0383 | 0.0411 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.1248 | 0.1179 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0221 | 0.9322 | 1 |
Onchocerca volvulus | 0.0048 | 0.0383 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1248 | 0.1339 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0221 | 0.9322 | 0.9317 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0221 | 0.9322 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.9322 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0221 | 0.9322 | 0.9317 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0221 | 0.9322 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.1248 | 0.1179 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.5107 | 0.5069 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0221 | 0.9322 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.9322 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.2949 | 0.2894 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0221 | 0.9322 | 0.5 |
Brugia malayi | RNA binding protein | 0.0064 | 0.1248 | 0.1179 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0078 | 0.0083 |
Echinococcus granulosus | expressed conserved protein | 0.0092 | 0.2644 | 0.2586 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.1248 | 0.1339 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0221 | 0.9322 | 1 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.1248 | 0.1179 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.2949 | 0.2894 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0221 | 0.9322 | 0.9317 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0.02 nmol | Photocytotoxicity against human HeLa cells assessed as survival-fraction per unit uptake measured as concentration in incubation medium necessary to produce cell uptake of 0.3 nmol per mg of protein at which survival fraction was determined after 24 hrs in presence of 10 J/cm2 light | ChEMBL. | 20441223 |
Drug uptake (ADMET) | = 15 nmol | Cellular uptake in human HeLa cells measured per mg of protein at 20.5 uM after 24 hrs by fluorescence measurements | ChEMBL. | 20441223 |
LD50 (functional) | = 60 nM | Photocytotoxicity against human HeLa cells after 24 hrs by MTT assay in presence of 10 J/cm2 laser | ChEMBL. | 20441223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.