Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0577 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2285 | 0.224 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.009 | 0.0039 |
Onchocerca volvulus | 0.0046 | 0.0915 | 0.0437 | |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0915 | 0.099 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1392 | 0.1619 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.1116 | 0.1064 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0915 | 0.104 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.1116 | 0.1543 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0105 | 0.2778 | 0.3302 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.1392 | 0.1341 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2285 | 0.2943 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.1116 | 0.1277 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1392 | 0.1619 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2285 | 0.224 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.1116 | 0.1064 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0577 | 0.0629 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1004 | 0.1388 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.2778 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1617 | 0.2234 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.4112 | 0.4078 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2285 | 0.2703 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1392 | 0.1619 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.0536 | 0.048 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1281 | 0.123 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0915 | 0.104 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0105 | 0.2778 | 0.2736 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1281 | 0.123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1392 | 0.1619 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1096 | 0.126 |
Brugia malayi | Pre-SET motif family protein | 0.0246 | 0.7236 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0629 | 0.0582 |
Onchocerca volvulus | 0.0049 | 0.1004 | 0.0553 | |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.139 | 0.1616 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1096 | 0.1515 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.1116 | 0.1284 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.009 | 0.0125 |
Onchocerca volvulus | 0.0281 | 0.831 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1116 | 0.1543 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.1392 | 0.1923 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2285 | 0.2703 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4112 | 0.5683 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0915 | 0.104 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.4112 | 0.4078 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.2778 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0915 | 0.1265 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0915 | 0.1265 |
Brugia malayi | Bromodomain containing protein | 0.0072 | 0.1747 | 0.2175 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.1096 | 0.1044 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.1392 | 0.1669 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.1392 | 0.1669 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0035 | 0.0577 | 0.0522 |
Trichomonas vaginalis | set domain proteins, putative | 0.0281 | 0.831 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2285 | 0.224 |
Brugia malayi | Pre-SET motif family protein | 0.0035 | 0.0577 | 0.0508 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.4112 | 0.5548 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.1116 | 0.1064 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.2778 | 0.5 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0915 | 0.0862 |
Entamoeba histolytica | hypothetical protein | 0.0105 | 0.2778 | 0.5 |
Brugia malayi | hypothetical protein | 0.0105 | 0.2778 | 0.3646 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.1004 | 0.1148 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.1392 | 0.1341 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0105 | 0.2778 | 0.2736 |
Brugia malayi | RNA binding protein | 0.0061 | 0.1392 | 0.1669 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.1392 | 0.1923 |
Echinococcus multilocularis | tumor protein p63 | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0631 | 0.0872 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0915 | 0.0862 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2285 | 0.2703 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2285 | 0.224 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0915 | 0.099 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0149 | 0.011 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0149 | 0.0091 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0557 | 0.0501 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0703 | 0.0971 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.1392 | 0.1923 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.2778 | 0.3302 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0915 | 0.0437 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0149 | 0.0091 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.1116 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4112 | 0.5683 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.8297 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0182 | 0.5189 | 0.5161 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0182 | 0.5189 | 0.5161 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0246 | 0.7236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0761 | 0.1052 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0035 | 0.0577 | 0.0629 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2285 | 0.3158 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0557 | 0.0501 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1096 | 0.126 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.1096 | 0.1044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.1392 | 0.1619 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.4112 | 0.4078 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0577 | 0.5 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0915 | 0.0862 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0915 | 0.0862 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Analgesic efficacy (functional) | = 97 % | Analagesic activity as percentage analgesic efficacy on male albino swiss-webster mice with the hot-plate test | ChEMBL. | 8201605 |
ED50 (functional) | = 32 mg kg-1 | Analagesic activity after subcutaneous administration in male albino swiss-webster mice with the hot-plate test | ChEMBL. | 8201605 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.