Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA, U transporter 1 | 0.0094 | 0.1876 | 0.4155 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0158 | 0.0299 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0178 | 0.448 | 0.4466 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0035 | 0.001 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.3019 | 0.3002 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.2099 | 0.2099 |
Schistosoma mansoni | inositol monophosphatase | 0.0076 | 0.1312 | 0.1291 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0.0158 | 0.1036 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0067 | 0.1025 | 0.1002 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.1041 | 0.1041 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.1312 | 1 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0101 | 0.2099 | 0.208 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.3706 | 0.3691 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.5947 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0101 | 0.2099 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0919 | 0.0919 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0158 | 0.1036 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.257 | 0.5713 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.2431 | 0.5402 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0035 | 0.0035 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0068 | 0.1041 | 0.1019 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.1322 | 0.1301 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.1312 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0067 | 0.1025 | 0.1002 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.0158 | 0.0421 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0068 | 0.1041 | 0.1019 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0035 | 0.001 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0158 | 0.1036 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.1312 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0067 | 0.1025 | 0.1002 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0035 | 0.001 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0137 | 0.3196 | 0.3179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0101 | 0.2099 | 0.208 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.1312 | 0.406 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Schistosoma mansoni | jumonji domain containing protein | 0.0068 | 0.1041 | 0.1019 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0137 | 0.3196 | 0.3179 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0137 | 0.3196 | 0.5354 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0178 | 0.448 | 0.4466 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0076 | 0.1312 | 0.1291 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0158 | 0.1036 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0098 | 0.1993 | 0.1974 |
Schistosoma mansoni | hypothetical protein | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0076 | 0.1312 | 0.1312 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0137 | 0.3196 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0035 | 0.001 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3019 | 0.3002 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0025 | 0.0025 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0067 | 0.1025 | 0.1002 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0158 | 0.0134 |
Brugia malayi | jmjC domain containing protein | 0.0068 | 0.1041 | 0.2282 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0178 | 0.448 | 0.4466 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.2431 | 0.2431 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0076 | 0.1312 | 1 |
Brugia malayi | Inositol-1 | 0.0076 | 0.1312 | 0.289 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.3019 | 0.3019 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.3019 | 0.3019 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0035 | 0.001 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.0101 | 0.2099 | 0.208 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.1322 | 0.2912 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0035 | 0.001 |
Echinococcus granulosus | TRP transient receptor potential channel | 0.0038 | 0.0106 | 0.0081 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0076 | 0.1312 | 0.406 |
Schistosoma mansoni | inositol monophosphatase | 0.0076 | 0.1312 | 0.1291 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0068 | 0.1062 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0035 | 0.001 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0.0158 | 0.1036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3019 | 0.3002 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 0.1041 | 0.1019 |
Schistosoma mansoni | transient receptor potential channel | 0.0067 | 0.1025 | 0.1002 |
Brugia malayi | RNA binding protein | 0.0131 | 0.3019 | 0.6721 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Echinococcus multilocularis | TRP (transient receptor potential) channel | 0.0038 | 0.0106 | 0.0081 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0098 | 0.1993 | 0.1974 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.0158 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0025 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0137 | 0.3196 | 0.3179 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.257 | 0.257 |
Echinococcus multilocularis | snurportin 1 | 0.0354 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0035 | 0.001 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0035 | 0.001 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0137 | 0.3196 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.3019 | 0.3002 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0035 | 0.0023 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.2431 | 0.2431 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0158 | 0.0421 |
Brugia malayi | Transient-receptor-potential like protein | 0.0038 | 0.0106 | 0.0182 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.3019 | 0.6721 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0158 | 0.1036 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0068 | 0.1041 | 0.1019 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.3019 | 0.3019 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.3706 | 0.3691 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3019 | 0.3002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3019 | 0.3002 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0067 | 0.1025 | 0.1002 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0178 | 0.448 | 0.448 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0068 | 0.1041 | 0.1019 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1322 | 0.1322 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0076 | 0.1312 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0137 | 0.3196 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0137 | 0.3196 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.2431 | 0.5402 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0076 | 0.1312 | 0.1291 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0076 | 0.1312 | 0.5 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0158 | 0.1036 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.0158 | 0.0134 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0076 | 0.1312 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0068 | 0.1041 | 0.2282 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0137 | 0.3196 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0178 | 0.448 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.257 | 0.257 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.3019 | 0.6721 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0025 | 0.0025 |
Onchocerca volvulus | 0.0103 | 0.2138 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0137 | 0.3196 | 0.3179 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0106 | 0.0106 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.3019 | 0.3002 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0025 | 0.0025 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0035 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0035 | 0.0035 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0035 | 0.0023 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0076 | 0.1312 | 0.406 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0068 | 0.1041 | 0.1019 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0076 | 0.1312 | 1 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0068 | 0.1062 | 0.1752 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.