Detailed information for compound 113072

Basic information

Technical information
  • TDR Targets ID: 113072
  • Name: [(9R,10R)-9-acetyloxy-8,8-dimethyl-2-oxo-9,10 -dihydropyrano[2,3-h]chromen-10-yl] 3-methylb utanoate
  • MW: 388.411 | Formula: C21H24O7
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)O[C@@H]1c2c(ccc3c2oc(=O)cc3)OC([C@@H]1OC(=O)C)(C)C)C
  • InChi: 1S/C21H24O7/c1-11(2)10-16(24)27-19-17-14(28-21(4,5)20(19)25-12(3)22)8-6-13-7-9-15(23)26-18(13)17/h6-9,11,19-20H,10H2,1-5H3/t19-,20-/m1/s1
  • InChiKey: KLUTZDJBVDPOFE-WOJBJXKFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-h]chromen-10-yl] 3-methylbutanoate
  • 3-methylbutanoic acid [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-h][1]benzopyran-10-yl] ester
  • 3-methylbutyric acid [(9R,10R)-9-acetoxy-2-keto-8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-10-yl] ester
  • suksdorfin
  • [(9R,10R)-9-acetyloxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] 3-methylbutanoate
  • [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] 3-methylbutanoate
  • 3-methylbutanoic acid [(9R,10R)-9-acetoxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[6,5-h]chromen-10-yl] ester
  • 3-methylbutyric acid [(9R,10R)-9-acetoxy-2-keto-8,8-dimethyl-9,10-dihydropyrano[6,5-h]chromen-10-yl] ester
  • 53023-17-9
  • 3'-O-Acetyl-4'-O-isopentanoyl-(+)-cis-khellactone
  • AIDS-005880
  • AIDS005880
  • Pyranocoumarin iBuCOO deriv.
  • (9R-cis)-9-(Acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b')dipyran-10-yl 3-methylbutanoate
  • 3'-O-Acetyl-4'-O-isovaleryl-cis-khellactone
  • Butanoic acid, 3-methyl-, 9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo(1,2-b:3,4-b')dipyran-10-yl ester, (9R-cis)-
  • Saxdorphin
  • STOCK1N-52768
  • MLS000574879
  • NSC666862
  • SMR000156247

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0016
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0109 0.0762 0.3263
Giardia lamblia Kinase, NEK 0.0104 0.0719 0.3072
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0058 0.0336 0.1386
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Peptidase family M1 containing protein 0.0256 0.198 0.198
Onchocerca volvulus 0.009 0.0602 0.3039
Onchocerca volvulus Neuropeptide F receptor homolog 0.009 0.0602 0.3039
Loa Loa (eye worm) NEK/NEK6 protein kinase 0.0206 0.1566 0.1944
Echinococcus granulosus G protein coupled receptor 139 0.009 0.0602 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Loa Loa (eye worm) plexin A 0.002 0.0026 0.0032
Echinococcus granulosus carbonic anhydrase II 0.0349 0.2754 0.3412
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0293 0.2289 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Echinococcus granulosus leukotriene A 4 hydrolase 0.0026 0.0078 0.0088
Schistosoma mansoni tyrosine kinase 0.0259 0.2008 0.2493
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0216 0.071
Echinococcus granulosus plexin a4 0.002 0.0026 0.0023
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.008 0.0518 0.1815
Brugia malayi putative neuropeptide receptor 0.009 0.0602 0.0602
Loa Loa (eye worm) thyroid receptor interactor 0.0074 0.0473 0.0588
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0649 0.0797
Schistosoma mansoni hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.009 0.0602 0.0738
Leishmania major protein kinase, putative 0.0058 0.0336 0.115
Brugia malayi serine/threonine kinase 12 0.0058 0.0336 0.0336
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0167 0.1244 0.1536
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0293 0.2289 0.2289
Schistosoma mansoni neuropeptide receptor 0.009 0.0602 0.0747
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.009 0.0602 0.0738
Echinococcus multilocularis chromobox protein 1 0.0078 0.0504 0.0617
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0221 0.0875
Echinococcus multilocularis insulin receptor 0.0264 0.2051 0.2539
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0109 0.0762 0.2708
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1219 0.1504
Echinococcus multilocularis protein tyrosine kinase 0.0259 0.2008 0.2485
Loa Loa (eye worm) peptidase family M1 containing protein 0.0207 0.1575 0.1955
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0097
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0109 0.0762 0.3268
Schistosoma mansoni biogenic amine receptor 0.009 0.0602 0.0747
Brugia malayi serine/threonine protein kinase 6 0.0058 0.0336 0.0336
Leishmania major carbonic anhydrase-like protein 0.0349 0.2754 1
Plasmodium falciparum carbonic anhydrase 0.0164 0.1219 0.5281
Schistosoma mansoni carbonic anhydrase 0.0164 0.1219 0.1513
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0602 0.0738
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.3263
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0248 0.1252
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Loa Loa (eye worm) acetylcholinesterase 1 0.0989 0.8057 1
Echinococcus granulosus neuropeptide receptor A26 0.009 0.0602 0.0738
Echinococcus granulosus dna polymerase kappa 0.002 0.0022 0.0018
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0058 0.0336 0.0408
Loa Loa (eye worm) hypothetical protein 0.0055 0.0315 0.0391
Schistosoma mansoni myosin xvIII 0.009 0.0602 0.0747
Echinococcus granulosus aminopeptidase N 0.0256 0.198 0.2451
Onchocerca volvulus 0.009 0.0602 0.3039
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0602 0.0738
Giardia lamblia Rab geranylgeranyltransferase 0.0109 0.0762 0.3263
Onchocerca volvulus 0.009 0.0602 0.3039
Chlamydia trachomatis serine/threonine protein kinase 0.0206 0.1566 0.5
Echinococcus granulosus hypothetical protein 0.0883 0.7181 0.8913
Schistosoma mansoni kinase 0.0049 0.0269 0.0334
Echinococcus multilocularis MAM 0.0055 0.0315 0.0382
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0167 0.1244 0.488
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0602 0.0747
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0602 0.0738
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0602 0.0738
Onchocerca volvulus 0.0167 0.1244 0.628
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0349 0.2754 0.2754
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0762 0.2708
Echinococcus granulosus g-protein coupled receptor 0.009 0.0602 0.0738
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0109 0.0762 0.0937
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0075 0.0483 0.2033
Loa Loa (eye worm) hypothetical protein 0.0405 0.3212 0.3987
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0012 0.0012
Brugia malayi protein-tyrosine kinase 0.0043 0.0216 0.0216
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus tyrosine kinase 0.0043 0.0216 0.0259
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0125 0.0895 0.1102
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0504 0.2127
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0274 0.2129 0.2635
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0518 0.1815
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Entamoeba histolytica protein kinase, putative 0.0058 0.0336 0.1386
Schistosoma mansoni tyrosine kinase 0.0018 0.0008 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0762 0.2708
Onchocerca volvulus 0.0075 0.0483 0.2439
Echinococcus granulosus carbonic anhydrase 0.0164 0.1219 0.1504
Brugia malayi Protein kinase domain containing protein 0.0262 0.2033 0.2033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0315 0.0391
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus g protein coupled receptor 0.009 0.0602 0.0738
Echinococcus granulosus geminin 0.0371 0.2932 0.3633
Brugia malayi Hr1 repeat family protein 0.014 0.102 0.102
Echinococcus granulosus chromobox protein 1 0.0078 0.0504 0.0617
Brugia malayi SRC-1 0.0047 0.0247 0.0246
Brugia malayi Carboxylesterase family protein 0.0167 0.1244 0.1244
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0078 0.0205
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.0915 0.1127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.009 0.0602 0.0738
Echinococcus granulosus sex peptide receptor 0.009 0.0602 0.0738
Schistosoma mansoni amine GPCR 0.0393 0.312 0.3873
Echinococcus multilocularis neuropeptide FF receptor 2 0.009 0.0602 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0109 0.0762 0.3268
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0602 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.009 0.0602 0.0747
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0293 0.2289 0.2835
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0047 0.0247 0.0297
Trichomonas vaginalis spcc417.12 protein, putative 0.0167 0.1244 0.5388
Brugia malayi neuropeptide F receptor 0.009 0.0602 0.0602
Echinococcus granulosus BC026374 protein S09 family 0.0167 0.1244 0.1536
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0419 0.052
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0055 0.0315 0.0391
Giardia lamblia Kinase, NEK 0.0104 0.0719 0.3072
Schistosoma mansoni hypothetical protein 0.009 0.0602 0.0747
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0049 0.0264 0.0883
Mycobacterium ulcerans carboxylesterase, LipT 0.0167 0.1244 0.8712
Echinococcus granulosus MAM 0.0055 0.0315 0.0382
Onchocerca volvulus 0.002 0.002 0.0103
Loa Loa (eye worm) carboxylesterase 0.0167 0.1244 0.1544
Echinococcus multilocularis serotonin receptor 0.039 0.3091 0.383
Brugia malayi G-protein coupled receptor 0.009 0.0602 0.0602
Schistosoma mansoni biogenic amine (5HT) receptor 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0015
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0075 0.0483 0.0591
Echinococcus granulosus roundabout 2 0.0024 0.0057 0.0061
Giardia lamblia Kinase, PLK 0.0095 0.0649 0.2766
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trypanosoma brucei Aminopeptidase M1, putative 0.0075 0.0483 0.1687
Trypanosoma brucei polo-like protein kinase 0.0095 0.0649 0.2295
Echinococcus multilocularis neuropeptide Y receptor 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.0109 0.0762 0.0946
Mycobacterium tuberculosis Carboxylesterase LipT 0.0167 0.1244 0.488
Loa Loa (eye worm) hypothetical protein 0.0989 0.8057 1
Schistosoma mansoni amine GPCR 0.009 0.0602 0.0747
Echinococcus granulosus neuroligin 0.0167 0.1244 0.1536
Echinococcus multilocularis allatostatin A receptor 0.009 0.0602 0.0738
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0649 0.0797
Echinococcus granulosus tyrosine protein kinase Src42A 0.0033 0.0128 0.015
Echinococcus multilocularis alpha 1A adrenergic receptor 0.009 0.0602 0.0738
Schistosoma mansoni tyrosine kinase 0.0125 0.0895 0.111
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.009 0.0602 0.0738
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0111 0.0324
Echinococcus multilocularis carboxylesterase 5A 0.0989 0.8057 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0022 0.0018
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0293 0.2289 0.8299
Onchocerca volvulus 0.002 0.002 0.0103
Schistosoma mansoni lipoxygenase 0.0117 0.0826 0.1026
Schistosoma mansoni hypothetical protein 0.002 0.002 0.0025
Trypanosoma brucei lanosterol synthase 0.0322 0.2525 0.9164
Leishmania major hypothetical protein, conserved 0.003 0.0111 0.0324
Loa Loa (eye worm) hypothetical protein 0.0964 0.785 0.9744
Echinococcus multilocularis epidermal growth factor receptor 0.0125 0.0895 0.1102
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1219 0.1219
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0111 0.0324
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0274 0.2129 0.2635
Onchocerca volvulus 0.009 0.0602 0.3039
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0216 0.0259
Brugia malayi Carboxylesterase family protein 0.0989 0.8057 0.8057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0015
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1219 0.1219
Echinococcus granulosus g protein coupled receptor 0.009 0.0602 0.0738
Loa Loa (eye worm) TK/ALK protein kinase 0.047 0.3757 0.4663
Echinococcus granulosus neuropeptide receptor 0.009 0.0602 0.0738
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0026 0.0078 0.0097
Brugia malayi Dopamine receptor 0.009 0.0602 0.0602
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1219 0.1504
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0049 0.0264 0.0318
Onchocerca volvulus 0.009 0.0602 0.3039
Onchocerca volvulus 0.0034 0.0142 0.0719
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0022 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0206 0.1566 0.1944
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.0327
Loa Loa (eye worm) TK protein kinase 0.0043 0.0216 0.0269
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0167 0.1244 0.5388
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0293 0.2289 0.2841
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) TK/INSR protein kinase 0.0264 0.2051 0.2546
Loa Loa (eye worm) TK/FAK protein kinase 0.0262 0.2033 0.2523
Trypanosoma cruzi aurora B kinase, putative 0.0058 0.0336 0.115
Echinococcus multilocularis chromobox protein 1 0.0078 0.0504 0.0617
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0109 0.0762 0.3268
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.009 0.0602 0.3039
Echinococcus granulosus 7tm_1 domain containing protein 0.009 0.0602 0.0738
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0018
Onchocerca volvulus Tyrosine kinase homolog 0.0149 0.1097 0.5538
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0602 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus acetylcholinesterase 0.0989 0.8057 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.014 0.102 0.1258
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0058 0.0336 0.1386
Schistosoma mansoni amine GPCR 0.009 0.0602 0.0747
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0214 0.163 0.7094
Echinococcus granulosus serine:threonine protein kinase N2 0.0127 0.0915 0.1127
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.009 0.0602 0.0738
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.008 0.0518 0.1815
Schistosoma mansoni peptide (allatostatin)-like receptor 0.009 0.0602 0.0747
Brugia malayi Heterochromatin protein 1 0.0078 0.0504 0.0504
Echinococcus granulosus carboxylesterase 5A 0.0989 0.8057 1
Echinococcus multilocularis orexin receptor type 2 0.009 0.0602 0.0738
Echinococcus multilocularis plexin a4 0.002 0.0026 0.0023
Brugia malayi hypothetical protein 0.002 0.0021 0.0021
Brugia malayi Melatonin receptor type 1A 0.009 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0025
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0075 0.0483 0.1687
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0293 0.2289 0.2835
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trypanosoma brucei aminopeptidase, putative 0.0026 0.0078 0.0205
Echinococcus multilocularis epidermal growth factor receptor 0.0125 0.0895 0.1102
Echinococcus granulosus neuropeptide receptor 0.009 0.0602 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0115 0.0408
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0047 0.0247 0.0297
Brugia malayi neuropeptide F receptor 0.009 0.0602 0.0602
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.3263
Onchocerca volvulus 0.009 0.0602 0.3039
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0259 0.1042
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Onchocerca volvulus 0.009 0.0602 0.3039
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0216 0.0268
Loa Loa (eye worm) hypothetical protein 0.0259 0.2002 0.2485
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0026 0.0078 0.0205
Loa Loa (eye worm) hypothetical protein 0.0043 0.0216 0.0268
Schistosoma mansoni gliotactin 0.0167 0.1244 0.1544
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0419 0.052
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0109 0.0762 0.0762
Loa Loa (eye worm) carboxylesterase 0.0167 0.1244 0.1544
Loa Loa (eye worm) AUR protein kinase 0.0058 0.0336 0.0418
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.2708
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0176 0.1314 0.5161
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0075 0.0483 0.06
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0047 0.0247 0.0297
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0322 0.2525 1
Echinococcus granulosus serine:threonine protein kinase N2 0.014 0.102 0.1258
Schistosoma mansoni loxhd1 0.002 0.002 0.0025
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.008 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Schistosoma mansoni tyrosine kinase 0.0264 0.2051 0.2546
Schistosoma mansoni lipoxygenase 0.0082 0.0535 0.0664
Echinococcus granulosus orexin receptor type 2 0.009 0.0602 0.0738
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Onchocerca volvulus 0.0256 0.198 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.2708
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.009 0.0602 0.0747
Brugia malayi Carboxylesterase family protein 0.0989 0.8057 0.8057
Onchocerca volvulus 0.009 0.0602 0.3039
Onchocerca volvulus 0.009 0.0602 0.3039
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0111 0.0399
Brugia malayi sulfakinin receptor protein 0.009 0.0602 0.0602
Echinococcus granulosus peptide allatostatin:somatostatin 0.009 0.0602 0.0738
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.008 0.0518 0.2193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.008 0.0518 0.0634
Plasmodium falciparum serine/threonine protein kinase, putative 0.0058 0.0336 0.1393
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0047 0.0247 0.0297
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0602 0.0747
Brugia malayi Protein kinase domain containing protein 0.0264 0.2051 0.2051
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.5533 0.6865
Brugia malayi Dopamine receptor protein 1 0.009 0.0602 0.0602
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0075 0.0483 0.2033
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0349 0.2754 0.3418
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.009 0.0602 0.0747
Giardia lamblia Prenyltransferase 0.0293 0.2289 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0419 0.0511
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0008 0.0009
Schistosoma mansoni alpha-1 adrenergic receptor 0.009 0.0602 0.0747
Echinococcus multilocularis RUN 0.002 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0000036651 0.0000045492
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0109 0.0762 0.0946
Entamoeba histolytica protein kinase, putative 0.0039 0.0186 0.0721
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.008 0.0518 0.0643
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0221 0.1114
Schistosoma mansoni biogenic amine receptor 0.009 0.0602 0.0747
Echinococcus multilocularis biogenic amine (5HT) receptor 0.009 0.0602 0.0738
Brugia malayi hypothetical protein 0.003 0.0111 0.0111
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0075 0.0483 0.1687
Schistosoma mansoni biogenic amine receptor 0.009 0.0602 0.0747
Brugia malayi Peptidase family M1 containing protein 0.0026 0.0078 0.0078
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.008 0.0518 0.0643
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0026 0.0078 0.0255
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.0504 0.0626
Loa Loa (eye worm) follicle stimulating hormone receptor 0.009 0.0602 0.0747
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0602 0.0747
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0293 0.2289 0.2841
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0109 0.0762 0.3263
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0016
Brugia malayi hypothetical protein 0.0019 0.0012 0.0012
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0483 0.3862 0.4794
Echinococcus multilocularis tyrosine protein kinase Blk 0.0043 0.0216 0.0259
Echinococcus multilocularis neuroligin 0.0167 0.1244 0.1536
Echinococcus granulosus tyrosine protein kinase Blk 0.0043 0.0216 0.0259
Leishmania major geranylgeranyltransferase, putative 0.008 0.0518 0.1815
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0216 0.0259
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Leishmania major farnesyltransferase beta subunit 0.0293 0.2289 0.8299
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.008 0.0518 0.2186
Echinococcus multilocularis aminopeptidase N 0.0256 0.198 0.2451
Giardia lamblia Rab geranylgeranyltransferase 0.0109 0.0762 0.3263
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0248 0.0996
Trichomonas vaginalis chromobox protein, putative 0.0078 0.0504 0.2127
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0293 0.2289 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0649 0.3278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0028
Brugia malayi gonadotropin-releasing hormone receptor 2 0.009 0.0602 0.0602
Schistosoma mansoni tyrosine kinase 0.0114 0.0806 0.1001
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Brugia malayi TATA binding protein associated factor 0.0026 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0164 0.1219 0.1513
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.008 0.0518 0.2186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0602 0.0747
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Loa Loa (eye worm) AUR protein kinase 0.0058 0.0336 0.0418
Brugia malayi hypothetical protein 0.002 0.002 0.002
Echinococcus multilocularis dna polymerase eta 0.002 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0109 0.0762 0.0937
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0419 0.1451
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0349 0.2754 0.3418
Brugia malayi Furin-like cysteine rich region family protein 0.0125 0.0895 0.0895
Echinococcus multilocularis fmrfamide receptor 0.009 0.0602 0.0738
Schistosoma mansoni opsin-like receptor 0.009 0.0602 0.0747
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Echinococcus multilocularis geminin 0.0371 0.2932 0.3633
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.009 0.0602 0.0747
Loa Loa (eye worm) doublecortin family protein 0.002 0.002 0.0025
Brugia malayi putative neuropeptide receptor NPR1 0.009 0.0602 0.0602
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0075 0.0483 0.1687
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0183 0.0217
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0649 0.0649
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0602 0.0747
Echinococcus granulosus protein tyrosine kinase 0.0259 0.2008 0.2485
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.0055 0.0315 0.0391
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0216 0.0259
Onchocerca volvulus 0.0026 0.0078 0.0394
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0078 0.0205
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0104 0.0719 0.2896
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi chromobox protein homolog 3 0.0044 0.0221 0.0221
Brugia malayi hypothetical protein 0.0075 0.0483 0.0483
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.008 0.0518 0.0518
Echinococcus granulosus alpha 1A adrenergic receptor 0.009 0.0602 0.0738
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0216 0.0259
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0049 0.0264 0.0327
Loa Loa (eye worm) hypothetical protein 0.0164 0.1219 0.1513
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0111 0.0399
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Onchocerca volvulus 0.009 0.0602 0.3039
Echinococcus granulosus chromobox protein 1 0.0078 0.0504 0.0617
Echinococcus granulosus microtubule associated protein 2 0.0685 0.5533 0.6865
Echinococcus multilocularis acetylcholinesterase 0.0989 0.8057 1
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0109 0.0762 0.0937
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1219 0.1513
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Toxoplasma gondii aurora kinase 0.0058 0.0336 0.1168
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0293 0.2289 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.009 0.0602 0.0738
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0047 0.0247 0.0297
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1244 0.1544
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0336 0.0417
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0049 0.0264 0.0327
Echinococcus multilocularis conserved hypothetical protein 0.0794 0.6438 0.7989
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0078 0.0255
Brugia malayi Protein kinase domain containing protein 0.015 0.1103 0.1103
Loa Loa (eye worm) aminopeptidase N 0.0075 0.0483 0.06
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.009 0.0602 0.0747
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0349 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0989 0.8057 1
Plasmodium vivax geranylgeranyltransferase, putative 0.008 0.0518 0.2193
Schistosoma mansoni opsin-like receptor 0.009 0.0602 0.0747
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0058 0.0336 0.1393
Loa Loa (eye worm) TK protein kinase 0.0039 0.0186 0.023
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.009 0.0602 0.0738
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0058 0.0336 0.1386
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.008 0.0518 0.2193
Schistosoma mansoni tyrosine kinase 0.0047 0.0247 0.0306
Brugia malayi hypothetical protein 0.0055 0.0315 0.0315
Echinococcus multilocularis G protein coupled receptor 139 0.009 0.0602 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0115 0.0408
Echinococcus multilocularis tyrosine protein kinase Srms 0.0043 0.0216 0.0259
Echinococcus multilocularis neuropeptide receptor 0.009 0.0602 0.0738
Trypanosoma cruzi lanosterol synthase, putative 0.0322 0.2525 0.9164
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.009 0.0602 0.0747
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0026 0.0078 0.0205
Echinococcus multilocularis serotonin receptor 0.039 0.3091 0.383
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0111 0.0399
Schistosoma mansoni adenoreceptor 0.009 0.0602 0.0747
Brugia malayi RE15519p 0.009 0.0602 0.0602
Loa Loa (eye worm) AGC/PKN protein kinase 0.014 0.102 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0221 0.0875
Brugia malayi AKH receptor 0.009 0.0602 0.0602
Echinococcus granulosus tachykinin peptides receptor 99D 0.009 0.0602 0.0738
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0047 0.0247 0.0297
Echinococcus granulosus carbonic anhydrase 0.0164 0.1219 0.1504
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0649 0.2766
Toxoplasma gondii hypothetical protein 0.0164 0.1219 0.5158
Echinococcus granulosus serotonin receptor 0.009 0.0602 0.0738
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0026 0.0078 0.0255
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.0139 0.1015 0.126
Onchocerca volvulus 0.009 0.0602 0.3039
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0649 0.0806
Echinococcus multilocularis roundabout 2 0.0024 0.0057 0.0061
Schistosoma mansoni histamine h1 receptor 0.009 0.0602 0.0747
Brugia malayi G-protein coupled receptor 0.009 0.0602 0.0602
Echinococcus multilocularis g protein coupled receptor 0.009 0.0602 0.0738
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.0181 0.1356 0.1683
Schistosoma mansoni hypothetical protein 0.0371 0.2932 0.3639
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0349 0.2754 1
Schistosoma mansoni acetylcholinesterase 0.0167 0.1244 0.1544
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0649 0.2295
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.0518 0.4152 0.5154
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0602 0.0738
Schistosoma mansoni amine GPCR 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.008 0.0518 0.0643
Echinococcus multilocularis g-protein coupled receptor 0.009 0.0602 0.0738
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0293 0.2289 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.009 0.0602 0.0738
Echinococcus multilocularis sex peptide receptor 0.009 0.0602 0.0738
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.008 0.0518 0.0643
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.008 0.0518 0.1989
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.009 0.0602 0.0747
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0159 0.1178 0.1463
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0026 0.0078 0.0088
Loa Loa (eye worm) TK/EGFR protein kinase 0.0125 0.0895 0.1111
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0336 0.1386
Schistosoma mansoni tyrosine kinase 0.0047 0.0247 0.0306
Schistosoma mansoni polycystin 1-related 0.002 0.002 0.0025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0216 0.071
Entamoeba histolytica protein kinase , putative 0.0058 0.0336 0.1386
Schistosoma mansoni hypothetical protein 0.0164 0.1219 0.1513
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0104 0.0719 0.3077
Schistosoma mansoni neuropeptide receptor 0.009 0.0602 0.0747
Loa Loa (eye worm) G-protein coupled receptor 0.009 0.0602 0.0747
Entamoeba histolytica aminopeptidase, putative 0.0075 0.0483 0.2033
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0183 0.0217
Trypanosoma cruzi lanosterol synthase, putative 0.0322 0.2525 0.9164
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0026 0.0078 0.0205
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0419 0.0511
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0602 0.0738
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0602 0.0747
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.009 0.0602 0.0602
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0216 0.0259
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.008 0.0518 0.2186
Plasmodium falciparum geranylgeranyltransferase, putative 0.008 0.0518 0.2193
Loa Loa (eye worm) hypothetical protein 0.0164 0.1219 0.1513
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0216 0.0259
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0989 0.8057 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0293 0.2289 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.009 0.0602 0.0602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Echinococcus granulosus neuropeptide s receptor 0.009 0.0602 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0216 0.0855
Trypanosoma cruzi aminopeptidase, putative 0.0026 0.0078 0.0205
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Echinococcus granulosus RUN 0.002 0.002 0.0016
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Schistosoma mansoni tyrosine kinase 0.0125 0.0895 0.111
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.009 0.0602 0.0747
Echinococcus multilocularis tachykinin peptides receptor 99D 0.009 0.0602 0.0738
Echinococcus granulosus thyrotropin releasing hormone receptor 0.009 0.0602 0.0738
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0293 0.2289 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0026 0.0078 0.0246
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0216 0.0855
Schistosoma mansoni hypothetical protein 0.009 0.0602 0.0747
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0043 0.0216 0.0259
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.008 0.0518 0.2186
Brugia malayi Tachykinin-like peptides receptor 99D 0.009 0.0602 0.0602
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.002 0.0016
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.008 0.0518 0.0634
Schistosoma mansoni serine/threonine protein kinase 0.014 0.102 0.1266
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi hypothetical protein 0.0026 0.0078 0.0078
Brugia malayi Dopamine receptor protein 2 0.009 0.0602 0.0602
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0649 0.2295
Echinococcus multilocularis fmrfamide receptor 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0025
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.2708
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0026 0.0078 0.0255
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0336 0.1386
Brugia malayi GnHR receptor homolog 0.009 0.0602 0.0602
Echinococcus multilocularis g protein coupled receptor 0.009 0.0602 0.0738
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Schistosoma mansoni neuropeptide receptor 0.009 0.0602 0.0747
Schistosoma mansoni protein kinase 0.0058 0.0336 0.0417
Loa Loa (eye worm) hypothetical protein 0.0044 0.0221 0.0274
Schistosoma mansoni tyrosine kinase 0.0114 0.0806 0.1001
Brugia malayi Serotonin receptor 0.0619 0.4988 0.4988
Mycobacterium ulcerans aminopeptidase N PepN 0.0026 0.0078 0.0398
Schistosoma mansoni chromobox protein 0.0078 0.0504 0.0626
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0186 0.0221
Echinococcus granulosus 7TM GPCR rhodopsin 0.009 0.0602 0.0738
Trypanosoma brucei Aminopeptidase M1, putative 0.0075 0.0483 0.1687
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.5533 0.6868
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0216 0.0268
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0336 0.1386
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Echinococcus granulosus dna polymerase eta 0.002 0.0022 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.009 0.0602 0.0747
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.009 0.0602 0.0738
Onchocerca volvulus 0.009 0.0602 0.3039
Onchocerca volvulus 0.0167 0.1244 0.628
Brugia malayi Serotonin/octopamine receptor family protein 7 0.009 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Toxoplasma gondii hypothetical protein 0.0109 0.0762 0.3092
Brugia malayi Carboxylesterase family protein 0.0167 0.1244 0.1244
Loa Loa (eye worm) TATA binding protein associated factor 0.0026 0.0078 0.0097
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0109 0.0762 0.0937
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0419 0.1748
Echinococcus multilocularis somatostatin receptor 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni neuropeptide receptor 0.009 0.0602 0.0747
Schistosoma mansoni tyrosine kinase 0.0114 0.0806 0.1001
Echinococcus granulosus biogenic amine 5HT receptor 0.039 0.3091 0.383
Onchocerca volvulus 0.0064 0.0393 0.1982
Brugia malayi serine/threonine-protein kinase 6 0.0058 0.0336 0.0336
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0109 0.0762 0.0937
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.009 0.0602 0.0602
Brugia malayi Doublecortin family protein 0.002 0.002 0.002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.009 0.0602 0.0747
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0111 0.0148
Schistosoma mansoni DNA polymerase eta 0.002 0.0022 0.0028
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0164 0.1219 0.1513
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0026 0.0078 0.0205
Brugia malayi follicle stimulating hormone receptor 0.009 0.0602 0.0602
Loa Loa (eye worm) AUR protein kinase 0.0058 0.0336 0.0418
Onchocerca volvulus 0.009 0.0602 0.3039
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.009 0.0602 0.0747
Leishmania major lanosterol synthase, putative 0.0242 0.1866 0.675
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Schistosoma mansoni nephrin 0.0021 0.0032 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni biogenic amine (5HT) receptor 0.039 0.3091 0.3836
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0078 0.0088
Echinococcus multilocularis neuropeptides capa receptor 0.009 0.0602 0.0738
Onchocerca volvulus 0.0167 0.1244 0.628
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0075 0.0483 0.06
Loa Loa (eye worm) SRC-1 0.0047 0.0247 0.0306
Echinococcus multilocularis BC026374 protein (S09 family) 0.0167 0.1244 0.1536
Echinococcus granulosus tm gpcr rhodopsin 0.009 0.0602 0.0738
Echinococcus multilocularis g protein coupled receptor 0.009 0.0602 0.0738
Schistosoma mansoni tyrosine kinase 0.0264 0.2051 0.2546
Echinococcus granulosus allatostatin A receptor 0.009 0.0602 0.0738
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0602 0.0738
Schistosoma mansoni hypothetical protein 0.0371 0.2932 0.3639
Brugia malayi Carboxylesterase family protein 0.0167 0.1244 0.1244
Loa Loa (eye worm) hypothetical protein 0.039 0.3091 0.3836
Onchocerca volvulus 0.0167 0.1244 0.628
Plasmodium falciparum NIMA related kinase 1 0.0104 0.0719 0.3077
Trypanosoma cruzi protein farnesyltransferase, putative 0.0293 0.2289 0.8299
Onchocerca volvulus 0.0136 0.0989 0.4994
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0138
Schistosoma mansoni growth hormone secretagogue receptor 0.009 0.0602 0.0747
Echinococcus granulosus para nitrobenzyl esterase 0.0167 0.1244 0.1536
Brugia malayi G protein-coupled receptor F59B2.13 0.009 0.0602 0.0602
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0216 0.0259
Brugia malayi larval opioid receptor 0.009 0.0602 0.0602
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1219 0.1513
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0129 0.0926 0.1149
Echinococcus granulosus epidermal growth factor receptor 0.0125 0.0895 0.1102
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0349 0.2754 0.2754
Echinococcus granulosus g protein coupled receptor 0.009 0.0602 0.0738
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.009 0.0602 0.0738
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0649 0.0806
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0109 0.0762 0.0762
Brugia malayi Serine/threonine-protein kinase Nek7 0.0206 0.1566 0.1566
Echinococcus granulosus insulin receptor 0.0264 0.2051 0.2539
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0109 0.0762 0.0937
Echinococcus multilocularis carbonic anhydrase II 0.0349 0.2754 0.3412
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi hypothetical protein 0.002 0.002 0.002
Schistosoma mansoni neuroligin 3 (S09 family) 0.0167 0.1244 0.1544
Echinococcus granulosus epidermal growth factor receptor 0.0125 0.0895 0.1102
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Onchocerca volvulus 0.009 0.0602 0.3039
Schistosoma mansoni cell adhesion molecule 0.0022 0.0037 0.0046
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.008 0.0518 0.0634
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.002 0.0016
Echinococcus granulosus fmrfamide receptor 0.009 0.0602 0.0738
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.0229 0.1761 0.2186
Echinococcus granulosus acetylcholinesterase 0.0989 0.8057 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.009 0.0602 0.0738
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0518 0.1815
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0164 0.1219 0.1219
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0164 0.1219 0.1219
Echinococcus multilocularis neuropeptide receptor 0.009 0.0602 0.0738
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0336 0.1386
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0649 0.2766
Onchocerca volvulus 0.009 0.0602 0.3039
Schistosoma mansoni hypothetical protein 0.0055 0.0315 0.0391
Onchocerca volvulus 0.0167 0.1244 0.628
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0189 0.1424 1
Trypanosoma cruzi aminopeptidase, putative 0.0075 0.0483 0.1687
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0022 0.0022
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0293 0.2289 1
Brugia malayi ORL1-like opioid receptor 0.009 0.0602 0.0602
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.008 0.0518 0.2186
Schistosoma mansoni tyrosine kinase 0.0018 0.0008 0.0009
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.008 0.0518 0.1989
Schistosoma mansoni amine GPCR 0.009 0.0602 0.0747
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0216 0.071
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0109 0.0762 0.0946
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0293 0.2289 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.009 0.0602 0.0738
Schistosoma mansoni neuropeptide F-like receptor 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni aminopeptidase A (M01 family) 0.0026 0.0078 0.0097
Trichomonas vaginalis STE family protein kinase 0.0104 0.0719 0.3072
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0097
Schistosoma mansoni neuropeptide f receptor 76f 0.009 0.0602 0.0747
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0216 0.0855
Schistosoma mansoni tyrosine kinase 0.0125 0.0895 0.111
Mycobacterium ulcerans aminopeptidase N PepN 0.0075 0.0483 0.3287
Brugia malayi hypothetical protein 0.0167 0.1244 0.1244
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.3263
Schistosoma mansoni opsin-like receptor 0.009 0.0602 0.0747
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0109 0.0762 0.0946
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.002 0.0016
Echinococcus granulosus neuropeptide Y receptor 0.009 0.0602 0.0738
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0649 0.2295
Echinococcus multilocularis carbonic anhydrase 0.0164 0.1219 0.1504
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.2708
Brugia malayi Protein kinase domain containing protein 0.047 0.3758 0.3758
Schistosoma mansoni hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) TYRA-2 protein 0.009 0.0602 0.0747
Echinococcus multilocularis neuropeptide receptor A26 0.009 0.0602 0.0738
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0419 0.1451
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0026 0.0078 0.0088
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.009 0.0602 0.0747
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0216 0.0855
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.009 0.0602 0.0738
Loa Loa (eye worm) carbonic anhydrase 3 0.0349 0.2754 0.3418
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0247 0.0297
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis acetylcholinesterase 0.0989 0.8057 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1244 0.1544
Onchocerca volvulus 0.009 0.0602 0.3039
Echinococcus granulosus tyrosine protein kinase Src64B 0.0047 0.0247 0.0297
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.009 0.0602 0.0747
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Echinococcus granulosus dro:myosuppressin receptor 0.009 0.0602 0.0738
Echinococcus multilocularis aurora kinase A 0.0058 0.0336 0.0408
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Loa Loa (eye worm) hypothetical protein 0.0167 0.1244 0.1544
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0189 0.1424 1
Trichomonas vaginalis AGC family protein kinase 0.0104 0.0719 0.3072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.0177
Echinococcus granulosus biogenic amine 5HT receptor 0.009 0.0602 0.0738
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0266 0.0321
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0167 0.1244 0.1536
Echinococcus multilocularis para nitrobenzyl esterase 0.0167 0.1244 0.1536
Brugia malayi hypothetical protein 0.009 0.0602 0.0602
Echinococcus granulosus aurora kinase A 0.0058 0.0336 0.0408
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0248 0.0996
Brugia malayi Fes/CIP4 homology domain containing protein 0.0074 0.0473 0.0473
Echinococcus multilocularis dro:myosuppressin receptor 0.009 0.0602 0.0738
Schistosoma mansoni ephrin receptor 0.002 0.0024 0.003
Loa Loa (eye worm) neuropeptide F receptor 0.009 0.0602 0.0747
Brugia malayi G protein-coupled receptor 0.009 0.0602 0.0602
Giardia lamblia Kinase, NEK 0.0104 0.0719 0.3072
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.008 0.0518 0.0643
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0026 0.0078 0.0097
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0419 0.1451
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0419 0.1451
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0164 0.1219 0.1219
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0058 0.0336 0.0408
Echinococcus multilocularis 0.0033 0.0136 0.0159
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0186 0.0221
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109 0.0762 0.2708
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0022 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0022 0.0028
Brugia malayi Tyrosine-protein kinase abl-1 0.0018 0.0008 0.0008
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0167 0.1244 0.488
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.009 0.0602 0.0738
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0167 0.1244 0.1544
Trypanosoma brucei carbonic anhydrase-like protein 0.0349 0.2754 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0109 0.0762 0.3268
Trypanosoma brucei aurora B kinase 0.0058 0.0336 0.115
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Loa Loa (eye worm) hypothetical protein 0.008 0.0518 0.0643
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0109 0.0762 0.2708
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0216 0.071
Trypanosoma cruzi protein farnesyltransferase, putative 0.0293 0.2289 0.8299
Echinococcus granulosus carbonic anhydrase 0.0164 0.1219 0.1504
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0047 0.0247 0.0297
Brugia malayi Carboxylesterase family protein 0.0167 0.1244 0.1244
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Schistosoma mansoni chromobox protein 0.0078 0.0504 0.0626
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0446 0.3557 0.4414
Onchocerca volvulus 0.0109 0.0762 0.3847
Onchocerca volvulus 0.009 0.0602 0.3039
Giardia lamblia Aurora kinase 0.0058 0.0336 0.1386
Loa Loa (eye worm) hypothetical protein 0.039 0.3091 0.3836
Onchocerca volvulus 0.0055 0.0315 0.159
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0826 0.1017
Schistosoma mansoni rab6-interacting 0.002 0.002 0.0025
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0826 0.1017
Echinococcus granulosus rhodopsin orphan GPCR 0.009 0.0602 0.0738
Brugia malayi Immunoglobulin I-set domain containing protein 0.0159 0.1178 0.1178
Echinococcus multilocularis rhodopsin orphan GPCR 0.009 0.0602 0.0738
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0419 0.0419
Echinococcus granulosus neuropeptides capa receptor 0.009 0.0602 0.0738
Brugia malayi plexin A 0.002 0.0026 0.0026
Schistosoma mansoni BC026374 protein (S09 family) 0.0167 0.1244 0.1544
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0293 0.2289 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0033 0.0128 0.015
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Trypanosoma cruzi Aminopeptidase M1, putative 0.0075 0.0483 0.1687
Brugia malayi Serotonin receptor 0.009 0.0602 0.0602
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0109 0.0762 0.3263
Loa Loa (eye worm) carboxylesterase 0.0989 0.8057 1
Schistosoma mansoni carbonic anhydrase-related 0.0164 0.1219 0.1513
Entamoeba histolytica protein kinase, putative 0.0058 0.0336 0.1386
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0349 0.2754 0.3418
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0762 0.2708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.009 0.0602 0.0747
Echinococcus granulosus neuropeptide FF receptor 2 0.009 0.0602 0.0738
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0259 0.1042
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0026 0.0078 0.0097
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0216 0.0216
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0111 0.0324
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0293 0.2289 1
Brugia malayi Peptidase family M1 containing protein 0.0075 0.0483 0.0483
Giardia lamblia Rab geranylgeranyltransferase 0.008 0.0518 0.2186
Echinococcus granulosus somatostatin receptor 0.009 0.0602 0.0738
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0075 0.0483 0.1687
Trichomonas vaginalis AGC family protein kinase 0.0058 0.0336 0.1386
Loa Loa (eye worm) hypothetical protein 0.009 0.0602 0.0747
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0483 0.0591
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0216 0.0855

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.3 uM Effective concentration of the compound against HIV-1 replication in H9 lymphocyte cells was determined ChEMBL. No reference
EC50 (functional) = 1.3 uM Effective concentration of the compound against HIV-1 replication in H9 lymphocyte cells was determined ChEMBL. No reference
EC50 (functional) = 2.6 uM Anti-HIV activity in acutely infected H9 lymphocytes. ChEMBL. 7525962
IC50 (functional) = 11 uM Inhibitory activity against LPS-induced NO production in mouse peritoneal macrophages was evaluated ChEMBL. 9873511
IC50 (functional) = 11 uM Inhibitory activity against LPS-induced NO production in mouse peritoneal macrophages was evaluated ChEMBL. 9873511
IC50 (functional) > 52 uM Compound was tested for inhibitory activity against HIV-1 replication in H9 lymphocyte cells ChEMBL. No reference
IC50 (functional) > 52 uM Compound was tested for inhibitory activity against HIV-1 replication in H9 lymphocyte cells ChEMBL. No reference
IC50 (functional) > 100 uM Inhibitory activity against D-GalN-induced cytotoxicity in rat hepatocytes ChEMBL. 9873511
Inhibition (functional) = -3.4 % Inhibitory activity against D-GalN-induced cytotoxicity in rat hepatocytes at 100 microM ChEMBL. 9873511
Potency (functional) 7.9433 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
TI (ADMET) = 30.6 Tested for in vitro therapeutic index as the ratio of IC50 to EC50 in acutely infected H9 Lymphocytes ChEMBL. 7525962
TI (functional) > 40 Therapeutic index of the compound was determined ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Mus musculus ChEMBL23 9873511
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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