Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0118 | 0.0118 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0118 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0034 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0034 | 1 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0118 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0118 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0034 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0034 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0034 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0034 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0034 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0034 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0034 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0118 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0118 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0118 | 0.0118 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0118 | 0.0118 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0118 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0118 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0118 | 0.0118 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0034 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0118 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0034 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0034 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0118 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0034 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0034 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0118 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0034 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0118 | 0.0118 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0034 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0118 | 0.0118 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0034 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0034 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0118 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0034 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0034 | 1 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0118 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0034 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0118 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0034 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0034 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0034 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0034 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0034 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0118 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0034 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0034 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0034 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0034 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0034 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0034 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0118 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 42 % | Antiinflammatory activity against carrageenan-induced pleurisy in po dosed mouse assessed as inhibition of leukocyte infiltration administered 1 hr before carrageenan challenge measured after 6 hrs by hemocytometry relative to untreated control | ChEMBL. | 20471839 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.