TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.367 | Formula: C19H23BrN2O3S
H donors: 1 H acceptors: 1 LogP: 3.24 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C(Oc1ccc(cc1)Br)C)NCC(c1cccs1)N1CCOCC1
InChi: 1S/C19H23BrN2O3S/c1-14(25-16-6-4-15(20)5-7-16)19(23)21-13-17(18-3-2-12-26-18)22-8-10-24-11-9-22/h2-7,12,14,17H,8-11,13H2,1H3,(H,21,23)
InChiKey: FAIUZZMCPNCUFZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.003	0.1781	0.2409
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0177	0.0177
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0177	0.024
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.003	0.1781	0.2409
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1349	0.1349
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0962	0.2399
Schistosoma mansoni	hypothetical protein	0.0017	0.0687	0.0929
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.2426	0.3281
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0177	0.0177
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0962	0.0356
Onchocerca volvulus		0.0025	0.1349	1
Entamoeba histolytica	hypothetical protein	0.0037	0.2426	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0687	0.0929
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1349	0.1028
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0177	0.024
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.003	0.1781	0.1781
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0962	0.2831
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0177	0.0177
Mycobacterium ulcerans	hypothetical protein	0.0025	0.1349	0.1347
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0962	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0823	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0687	0.0687
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0177	0.0177
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0962	0.0962
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0962	0.1302
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0177	0.0177
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0687	0.0687
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0177	0.024
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0177	0.024
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.003	0.1781	0.2409
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0177	0.0177
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Schistosoma mansoni	hypothetical protein	0.0017	0.0687	0.0929
Schistosoma mansoni	blooms syndrome DNA helicase	0.0015	0.0549	0.0743
Echinococcus granulosus	bloom syndrome protein	0.0043	0.2881	0.3896
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0962	0.2831
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.7394	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1349	0.1349
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.7394	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0177	0.0177
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.7394	0.7394
Trichomonas vaginalis	DNA helicase recq, putative	0.0032	0.2008	0.5453
Loa Loa (eye worm)	hypothetical protein	0.0036	0.2332	0.2332
Schistosoma mansoni	blooms syndrome DNA helicase	0.0028	0.16	0.2164
Echinococcus multilocularis	dna polymerase eta	0.002	0.0962	0.1302
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0025	0.1421	1
Schistosoma mansoni	hypothetical protein	0.0036	0.2332	0.3154
Echinococcus granulosus	dna polymerase eta	0.002	0.0962	0.1302
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1349	0.1347
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.1349	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1349	0.1347
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.7394	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0177	0.024
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0025	0.1373	0.1971
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Entamoeba histolytica	hypothetical protein	0.0037	0.2426	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.003	0.1781	0.5234
Entamoeba histolytica	recQ family DNA helicase	0.0015	0.0549	0.0253
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.4727	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0177	0.024
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0823	0.0823
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0962	0.3344
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.375	0.375
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1349	0.1349
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0177	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0177	0.0177
Schistosoma mansoni	DNA polymerase eta	0.002	0.0962	0.1302
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0032	0.2008	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0549	0.0549
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.003	0.1781	0.2409
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0177	0.0177
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.375	0.375
Trichomonas vaginalis	DNA helicase recq, putative	0.0043	0.2881	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.1349	0.1347
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1349	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0177	0.0177
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.4727	0.6392
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0823	0.0823
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.4727	0.6392
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0962	0.1302
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0177	0.024
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0177	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0177	0.0177
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0687	0.0687
Entamoeba histolytica	recQ family helicase, putative	0.0032	0.2008	0.7831
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0687	0.0929
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.1349	0.4408
Brugia malayi	nuclear hormone receptor	0.0011	0.0177	0.0177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0177	0.0177
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.1349	0.5
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0032	0.2008	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0687	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	1	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.003	0.1781	0.1781
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.4727	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.7394	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.003	0.1781	0.2948
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.2426	0.3281
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.4727	0.6392
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0177	0.0177
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0962	0.2831
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0962	0.2831
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0687	0.0687
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0823	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0032	0.2008	0.2779
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0177	0.024
Brugia malayi	steroid hormone receptor	0.0011	0.0177	0.0177
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.4727	0.6392
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0177	0.024
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0177	0.024
Trichomonas vaginalis	DNA helicase recq1, putative	0.0043	0.2881	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0823	0.3506
Brugia malayi	hypothetical protein	0.0037	0.2426	0.2426
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0177	0.024
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0962	0.3344
Echinococcus granulosus	dna polymerase kappa	0.002	0.0962	0.1302
Giardia lamblia	Sgs1 DNA helicase, putative	0.003	0.1781	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.1349	0.1347
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0028	0.1649	0.1649
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0823	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0823	0.0823
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0823	0.0213
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0177	0.024
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0687	0.0929
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0177	0.024
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0962	0.2831
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.2426	0.3281
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0177	0.0177
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0177	0.024
Brugia malayi	Bloom's syndrome protein homolog	0.0043	0.2881	0.2881
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0962	0.1302
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0177	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0177	0.0177
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1349	0.1347
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.1349	0.1532
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.1349	0.4408
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.7394	0.7394
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0962	0.0561
Brugia malayi	ecdysteroid receptor	0.0011	0.0177	0.0177
Treponema pallidum	ATP-dependent DNA helicase	0.0015	0.0549	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0177	0.024
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.1349	0.4408
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0177	0.024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0962	0.0962
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0962	0.1302
Schistosoma mansoni	DNA helicase recq1	0.003	0.1781	0.2409
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.4727	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0177	0.024
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0177	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0177	0.0177
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0177	0.024
Schistosoma mansoni	hypothetical protein	0.0037	0.2426	0.3281
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0177	0.024
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0962	0.1302
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0687	0.0929
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0962	0.3344
Echinococcus multilocularis	bloom syndrome protein	0.0043	0.2881	0.3896
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1349	0.1028
Loa Loa (eye worm)	hypothetical protein	0.003	0.1781	0.1781
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.1349	0.1532
Schistosoma mansoni	DNA helicase recq5	0.003	0.1781	0.2409
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0962	0.0962
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1349	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0177	0.0177
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0962	0.3344
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0177	0.0177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.7394	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.4727	1
Entamoeba histolytica	hypothetical protein	0.0037	0.2426	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0177	0.024
Entamoeba histolytica	hypothetical protein	0.0037	0.2426	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.4727	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.2332	0.2332
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0962	0.0962
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0177	0.024
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.004	0.2653	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0177	0.024
Schistosoma mansoni	hypothetical protein	0.0017	0.0687	0.0929
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0177	0.024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0177	0.024
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0177	0.0177
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0962	0.0561
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1349	0.1349
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0962	0.3344
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.003	0.1781	0.1781
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0177	0.0177
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.003	0.1781	0.2948
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0177	0.0177
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.1349	0.1347
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0177	0.0177
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1349	0.1349
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.7394	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0687	0.0929
Schistosoma mansoni	coup transcription factor	0.0011	0.0177	0.024
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0177	0.024
Echinococcus granulosus	GPCR family 2	0.0017	0.0687	0.0929
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.4727	1
Loa Loa (eye worm)	RecQ helicase	0.0043	0.2881	0.2881
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.7394	1
Trypanosoma brucei	unspecified product	0.002	0.0962	0.3344
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0177	0.0177
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.1349	0.1347
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0177	0.024
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.375	0.375
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0177	0.024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0177	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0053	0.375	0.375

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1872638

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1130917