Detailed information for compound 1131060

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.468 | Formula: C26H23F3N2O3
  • H donors: 0 H acceptors: 2 LogP: 5.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(c2c(N1C(=O)c1ccc(cc1)OC(F)(F)F)cccc2)N(c1ccccc1)C(=O)C
  • InChi: 1S/C26H23F3N2O3/c1-17-16-24(31(18(2)32)20-8-4-3-5-9-20)22-10-6-7-11-23(22)30(17)25(33)19-12-14-21(15-13-19)34-26(27,28)29/h3-15,17,24H,16H2,1-2H3
  • InChiKey: UNMNTCJQSOPSJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Brugia malayi topoisomerase 0.001 0.0044 0.0064
Onchocerca volvulus 0.001 0.0044 0.01
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0193 0.028
Brugia malayi Latrophilin receptor protein 2 0.0065 0.1357 0.1971
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0128 0.1304
Loa Loa (eye worm) hypothetical protein 0.0205 0.473 0.6869
Schistosoma mansoni tar DNA-binding protein 0.0196 0.4503 0.4503
Entamoeba histolytica hypothetical protein 0.0038 0.0703 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0688 1
Echinococcus granulosus GPCR family 2 0.0065 0.1357 0.1357
Onchocerca volvulus 0.0097 0.2122 0.4769
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Onchocerca volvulus 0.0031 0.0536 0.1206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0153 0.0153
Schistosoma mansoni lipoxygenase 0.002 0.0283 0.0283
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.1357 0.1357
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0688 0.5806
Schistosoma mansoni hypothetical protein 0.0065 0.1357 0.1357
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0688 0.0999
Schistosoma mansoni hypothetical protein 0.0065 0.1357 0.1357
Schistosoma mansoni alpha-glucosidase 0.0144 0.3257 0.3257
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.473 0.6869
Brugia malayi hypothetical protein 0.002 0.0283 0.041
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.026 0.0378
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0283 0.0283
Echinococcus granulosus lamin dm0 0.0031 0.0536 0.0536
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0044 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0128 0.0186
Schistosoma mansoni tar DNA-binding protein 0.0196 0.4503 0.4503
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0688 0.0999
Schistosoma mansoni polycystin 1-related 0.002 0.0283 0.0283
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.026 0.026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0128 0.0186
Echinococcus granulosus replication factor c subunit 1 0.001 0.0044 0.0044
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0283 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.026 1
Brugia malayi RNA binding protein 0.0196 0.4503 0.6539
Schistosoma mansoni alpha-glucosidase 0.0144 0.3257 0.3257
Schistosoma mansoni topbp1 0.001 0.0044 0.0044
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0536 0.0779
Schistosoma mansoni hypothetical protein 0.0065 0.1357 0.1357
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Echinococcus granulosus nibrin 0.001 0.0044 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Schistosoma mansoni lipoxygenase 0.0057 0.1158 0.1158
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0044 0.0044
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0182 0.4173 0.606
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0536 0.0779
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0044 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0688 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0044 0.0064
Schistosoma mansoni hypothetical protein 0.0367 0.863 0.863
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.026 0.2354
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0688 0.9784
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.026 0.0378
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0128 0.0186
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.3817 0.3817
Entamoeba histolytica hypothetical protein 0.001 0.0044 0.0631
Onchocerca volvulus 0.002 0.0283 0.0635
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0128 0.0186
Echinococcus multilocularis musashi 0.0031 0.0536 0.0536
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0128 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.4699 0.6823
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0688 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.473 0.6869
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Schistosoma mansoni tar DNA-binding protein 0.0196 0.4503 0.4503
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0703 0.0703
Brugia malayi Doublecortin family protein 0.002 0.0283 0.041
Schistosoma mansoni hypothetical protein 0.014 0.3169 0.3169
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1153 1
Schistosoma mansoni cpg binding protein 0.0031 0.0553 0.0553
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0044 0.0631
Loa Loa (eye worm) hypothetical protein 0.0014 0.0128 0.0186
Brugia malayi CXXC zinc finger family protein 0.003 0.0513 0.0744
Echinococcus multilocularis cpg binding protein 0.0031 0.0553 0.0553
Schistosoma mansoni DNA ligase IV 0.001 0.0044 0.0044
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0128 0.0186
Entamoeba histolytica hypothetical protein 0.0038 0.0703 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0779
Echinococcus multilocularis geminin 0.0367 0.863 0.863
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.3817 0.5542
Schistosoma mansoni cpg binding protein 0.0031 0.0553 0.0553
Schistosoma mansoni topbp1 0.001 0.0044 0.0044
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0688 0.0999
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.026 0.5
Echinococcus multilocularis dnaJ subfamily B 0.0424 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0688 0.9784
Brugia malayi DKFZp564C0469 protein 0.001 0.0044 0.0064
Onchocerca volvulus 0.002 0.0283 0.0635
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.4544 0.6598
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0044 0.0064
Onchocerca volvulus 0.0031 0.0536 0.1206
Schistosoma mansoni hypothetical protein 0.002 0.0283 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0044 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0688 0.0999
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.026 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.014 0.3169 0.4602
Schistosoma mansoni hypothetical protein 0.0424 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0128 0.0186
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0703 0.0703
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0688 0.0999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.4544 0.4544
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.3352
Echinococcus multilocularis RUN 0.002 0.0283 0.0283
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.1158 0.1158
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0128 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0688 0.0999
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0128 0.1304
Loa Loa (eye worm) TAR-binding protein 0.0196 0.4503 0.6539
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0283 0.0283
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.9058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.4544 0.6598
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.4544 0.4544
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.026 1
Brugia malayi hypothetical protein 0.001 0.0044 0.0064
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.3817 0.3817
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.041
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0128 0.1825
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0128 0.0186
Schistosoma mansoni hypothetical protein 0.0065 0.1357 0.1357
Schistosoma mansoni rab6-interacting 0.002 0.0283 0.0283
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Echinococcus multilocularis nibrin 0.001 0.0044 0.0044
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0536 0.0779
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0688 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0283 0.0283
Loa Loa (eye worm) RNA binding protein 0.0196 0.4503 0.6539
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0283 0.0283
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0128 0.1304
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0283 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.2742 0.3982
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.3817 0.5542
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.4503 0.6539
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.1357 0.1357
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.026 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.1357 0.1971
Schistosoma mansoni tar DNA-binding protein 0.0196 0.4503 0.4503
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.026 0.9058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.4544 0.4544
Echinococcus multilocularis lamin 0.0031 0.0536 0.0536
Schistosoma mansoni hypothetical protein 0.0367 0.863 0.863
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.1357 0.1357
Echinococcus multilocularis GPCR, family 2 0.0065 0.1357 0.1357
Brugia malayi hypothetical protein 0.002 0.0283 0.041
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0193 0.028
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.6887 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.026 0.0378
Echinococcus granulosus RUN 0.002 0.0283 0.0283
Schistosoma mansoni rab6-interacting 0.002 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Loa Loa (eye worm) hypothetical protein 0.0015 0.0153 0.0223
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.6887 1
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0018 0.0026
Schistosoma mansoni alpha glucosidase 0.0037 0.0688 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Loa Loa (eye worm) doublecortin family protein 0.002 0.0283 0.041
Loa Loa (eye worm) hypothetical protein 0.0014 0.014 0.0203
Loa Loa (eye worm) hypothetical protein 0.003 0.0523 0.0759
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0044 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0688 0.0999
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.4544 0.4544
Toxoplasma gondii exonuclease III APE 0.0019 0.026 0.1946
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.026 0.3352
Trichomonas vaginalis conserved hypothetical protein 0.0177 0.4054 0.5886
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0688 0.0999
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.3169 0.4602
Onchocerca volvulus Glucosylceramidase homolog 0.0193 0.4448 1
Echinococcus granulosus intermediate filament protein 0.0031 0.0536 0.0536
Echinococcus multilocularis tar DNA binding protein 0.0196 0.4503 0.4503
Brugia malayi hypothetical protein 0.001 0.0044 0.0064
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.1158 0.1158
Echinococcus granulosus cpg binding protein 0.0031 0.0553 0.0553
Brugia malayi hypothetical protein 0.0038 0.0703 0.1021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.4544 0.4544
Brugia malayi intermediate filament protein 0.0031 0.0536 0.0779
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0688 0.0999
Brugia malayi MH2 domain containing protein 0.0122 0.2742 0.3982
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0065 0.1357 0.1971
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.026 0.0378
Echinococcus granulosus tar DNA binding protein 0.0196 0.4503 0.4503
Echinococcus multilocularis lamin dm0 0.0031 0.0536 0.0536
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.026 0.026
Chlamydia trachomatis DNA ligase 0.001 0.0044 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Schistosoma mansoni hypothetical protein 0.0038 0.0703 0.0703
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0128 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0044 0.0064
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0044 0.0064
Schistosoma mansoni cpg binding protein 0.003 0.0513 0.0513
Entamoeba histolytica hypothetical protein 0.0038 0.0703 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0688 0.0688
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.4448 0.6459
Echinococcus granulosus lamin 0.0031 0.0536 0.0536
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0688 0.0999
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0015 0.0022
Schistosoma mansoni loxhd1 0.002 0.0283 0.0283
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0703 0.0703
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0044 0.0064
Echinococcus granulosus geminin 0.0367 0.863 0.863
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0044 0.0064
Onchocerca volvulus 0.003 0.0513 0.1152
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0044 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.4544 0.4544
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.2742 0.3982
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0688 0.0999
Schistosoma mansoni tar DNA-binding protein 0.0196 0.4503 0.4503
Schistosoma mansoni lamin 0.0031 0.0536 0.0536
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.026 0.3699
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.1357 0.1971
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0044 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.4544 0.4544
Loa Loa (eye worm) hypothetical protein 0.0182 0.4173 0.606
Schistosoma mansoni lamin 0.0031 0.0536 0.0536
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.4503 0.6539
Entamoeba histolytica hypothetical protein 0.0038 0.0703 1
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.6887 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0044 0.0064
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0153 0.0153
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.473 0.6869
Schistosoma mansoni intermediate filament proteins 0.0031 0.0536 0.0536
Brugia malayi TAR-binding protein 0.0196 0.4503 0.6539
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.002 0.0283 0.041
Trypanosoma brucei glucosidase, putative 0.0037 0.0688 1
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.4699 0.6823
Loa Loa (eye worm) hypothetical protein 0.001 0.0044 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0513 0.0744
Schistosoma mansoni ap endonuclease 0.0019 0.026 0.026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1316 0.1316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.026 0.3352
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.3817 0.3817
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0018 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.1357 0.1357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.026 uM Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 0.5% BSA ChEMBL. 19896843
IC50 (binding) > 10 uM Displacement of [3H]PGD2 from human CRTH2 receptor expressed in 293 cells by scintillation counting in presence of 50% human plasma ChEMBL. 19896843

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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