Detailed information for compound 1131247

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.331 | Formula: C14H19N5O6
  • H donors: 4 H acceptors: 8 LogP: -1.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@]([C@@H]1O)(C)O)n1cnc2c1ncnc2N(C(=O)CC)O
  • InChi: 1S/C14H19N5O6/c1-3-8(21)19(24)12-9-11(15-5-16-12)18(6-17-9)13-14(2,23)10(22)7(4-20)25-13/h5-7,10,13,20,22-24H,3-4H2,1-2H3/t7-,10-,13?,14-/m1/s1
  • InChiKey: OCIHBUXSXFCWOR-RPNCAOPKSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0178 0.1754 0.5159
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Giardia lamblia Cathepsin L-like protease 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.1303 0.4942
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Schistosoma mansoni rab6-interacting 0.0023 0.0084 0.0101
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0057 0.0446 0.1548
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0454 0.097
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Brugia malayi Cathepsin L-like precursor 0.0174 0.1703 0.3638
Brugia malayi RNA binding protein 0.0067 0.0561 0.1193
Schistosoma mansoni loxhd1 0.0023 0.0084 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0168 0.0168
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Brugia malayi Inositol-1 0.0043 0.03 0.0634
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0075 0.0075
Brugia malayi Pre-SET motif family protein 0.0215 0.2147 0.4588
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Echinococcus multilocularis protein dispatched 1 0.0056 0.0441 0.0441
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0634
Onchocerca volvulus Cathepsin L homolog 0.0253 0.256 1
Onchocerca volvulus 0.0253 0.256 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0168 0.0644
Brugia malayi TAR-binding protein 0.0067 0.0561 0.1193
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0057 0.0446 0.1548
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0107 0.0221
Onchocerca volvulus 0.0031 0.0175 0.0367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0084 0.01
Echinococcus multilocularis cathepsin L cysteine protease 0.0253 0.256 0.256
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Onchocerca volvulus 0.0057 0.0446 0.1462
Loa Loa (eye worm) cytochrome P450 0.0016 0.0004 0.0008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0905
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1522 0.4474
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.1086 0.2318
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0059 0.0135
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1712 0.4165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Brugia malayi Cytochrome P450 family protein 0.0057 0.0454 0.0963
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0173 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.108 0.2623
Echinococcus multilocularis musashi 0.0031 0.0175 0.0175
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0691 0.1471
Schistosoma mansoni hypothetical protein 0.0079 0.0691 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0057 0.0446 0.1494
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.008 0.0694 0.1477
Plasmodium vivax unspecified product 0.0136 0.1303 0.4974
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0057 0.0446 0.0954
Plasmodium falciparum cysteine proteinase falcipain 1 0.0136 0.1303 0.4974
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Brugia malayi intermediate filament protein 0.0031 0.0175 0.0366
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0366 0.046
Schistosoma mansoni cathepsin C 0.0057 0.0446 0.0555
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.1071 0.2284
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0168 0.0207
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0446 0.0947
Onchocerca volvulus 0.0253 0.256 1
Loa Loa (eye worm) ctsf protein 0.0253 0.256 0.5476
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Onchocerca volvulus 0.0253 0.256 1
Plasmodium falciparum serine repeat antigen 3 0.0057 0.0446 0.1548
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Echinococcus granulosus neuropeptide receptor A26 0.0541 0.5653 0.7092
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0251 0.2301
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0138 0.1321 0.3882
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0084 0.0084
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0337 0.0983
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0446 0.0947
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0075 0.021
Brugia malayi Doublecortin family protein 0.0023 0.0084 0.0172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.3397 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0134 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0134 0.0238
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0253 0.256 0.256
Plasmodium vivax vivapain-1 0.0136 0.1303 0.4974
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.1703 0.6552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0057 0.0446 0.0555
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Echinococcus granulosus expressed conserved protein 0.0108 0.0996 0.125
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0873
Loa Loa (eye worm) cathepsin B 0.0178 0.1754 0.3752
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.108 0.2303
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0175 0.0374
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus multilocularis neuropeptide receptor A26 0.0541 0.5653 0.5653
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.108 1
Leishmania major cysteine peptidase A (CPA) 0.0253 0.256 0.7535
Plasmodium falciparum serine repeat antigen 6 0.0057 0.0446 0.1548
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0075 0.0152
Echinococcus multilocularis neuropeptide s receptor 0.0541 0.5653 0.5653
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0057 0.0446 0.0555
Brugia malayi hypothetical protein 0.0023 0.0084 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0884 0.0884
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0173 0.0455
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0134 0.0318
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.045 0.4675 0.5864
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0057 0.0446 0.2211
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0075 0.021
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0337 0.0714
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0446 0.0954
Entamoeba histolytica cysteine protease, putative 0.0253 0.256 1
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.1071 0.1343
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0446 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0253 0.256 1
Giardia lamblia Encystation-specific protease 0.0057 0.0446 0.2211
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0251 0.0604
Plasmodium vivax unspecified product 0.0057 0.0446 0.1548
Brugia malayi cathepsin L-like cysteine proteinase 0.0057 0.0446 0.0947
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0446 0.1494
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.1086 0.2318
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0366 0.0784
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.108 0.108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Plasmodium vivax vivapain-2 0.0253 0.256 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0057 0.0446 0.1548
Onchocerca volvulus 0.0028 0.0134 0.0202
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0253 0.256 0.256
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0134 0.0318
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus multilocularis cathepsin L cysteine protease 0.0253 0.256 0.256
Echinococcus granulosus lamin dm0 0.0031 0.0175 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0634
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.16 0.2008
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Echinococcus granulosus cathepsin L cysteine proteinase 0.0253 0.256 0.3212
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0134 0.1211
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Entamoeba histolytica cysteine proteinase, putative 0.0174 0.1703 0.6552
Brugia malayi Cathepsin L-like precursor 0.0174 0.1703 0.3638
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0057 0.0446 0.1494
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1202 0.2571
Mycobacterium ulcerans epoxide hydrolase EphA 0.0397 0.4105 1
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Onchocerca volvulus 0.0253 0.256 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1202 0.2571
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Loa Loa (eye worm) hypothetical protein 0.0253 0.256 0.5476
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0084 0.01
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0173 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Onchocerca volvulus 0.0244 0.2466 0.9621
Schistosoma mansoni cathepsin S (C01 family) 0.0057 0.0446 0.0555
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.1321 0.1653
Loa Loa (eye worm) papain family cysteine protease containing protein 0.008 0.0694 0.1484
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0446 0.1548
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0337 0.0714
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0253 0.256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0173 0.0661
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0057 0.0446 0.173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0884 0.1109
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0084 0.0105
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.0374
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0134 0.0318
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0446 0.0947
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0057 0.0446 0.1548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0884 0.189
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0075 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Schistosoma mansoni patched 1 0.0049 0.0366 0.0455
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0253 0.256 0.5476
Echinococcus granulosus cathepsin b 0.045 0.4675 0.5866
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0178 0.1754 0.3747
Plasmodium vivax vivapain-3 0.0136 0.1303 0.4974
Onchocerca volvulus 0.0253 0.256 1
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.3397 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0173 0.0582
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.1303 0.2782
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Schistosoma mansoni hypothetical protein 0.0042 0.0288 0.0357
Entamoeba histolytica cysteine proteinase 1, putative 0.0136 0.1303 0.4942
Schistosoma mansoni lipoxygenase 0.0137 0.1315 0.1646
Brugia malayi cathepsin F-like cysteine proteinase 0.008 0.0694 0.1477
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Plasmodium vivax SET domain protein, putative 0.0031 0.0168 0.0437
Echinococcus granulosus cathepsin L cysteine protease 0.0136 0.1303 0.1635
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Brugia malayi phosphofructokinase 0.0116 0.108 0.2303
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.1703 0.3638
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.256 1
Plasmodium falciparum serine repeat antigen 8 0.0057 0.0446 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0905
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0057 0.0446 0.1494
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.108 0.3171
Brugia malayi CHE-14 protein 0.0049 0.0366 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0178 0.1754 0.6757
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.108 0.3171
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0075 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3397 0.7262
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Echinococcus multilocularis lamin 0.0031 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Plasmodium vivax unspecified product 0.008 0.0694 0.2539
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.1315 0.1315
Schistosoma mansoni rab6-interacting 0.0023 0.0084 0.0101
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.1303 0.2782
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.045 0.4675 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0138 0.1321 0.1321
Echinococcus granulosus cathepsin l1 0.0253 0.256 0.3212
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0173 0.0973
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0084 0.018
Brugia malayi Cathepsin L-like cysteine proteinase 0.0174 0.1703 0.3638
Toxoplasma gondii cathepsin B 0.0178 0.1754 0.6847
Toxoplasma gondii aldehyde dehydrogenase 0.0138 0.1321 0.5152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0175 0.0374
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0173 0.0455
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0089
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.03 0.0722
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Schistosoma mansoni cathepsin F (C01 family) 0.0174 0.1703 0.2133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0134 0.1211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Onchocerca volvulus 0.0174 0.1703 0.6539
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0075 0.016
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0173 0.0455
Entamoeba histolytica cysteine proteinase 2 0.0136 0.1303 0.4942
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0057 0.0446 0.1548
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0057 0.0446 0.1548
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Onchocerca volvulus 0.0031 0.0175 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0446 0.1494
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0075 0.0173
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0372
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.03 0.0905
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.108 0.1351
Echinococcus granulosus cathepsin l1 0.0174 0.1703 0.2137
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0232 0.0232
Loa Loa (eye worm) cysteine protease 0.0253 0.256 0.5476
Toxoplasma gondii cathepsin CPL 0.0253 0.256 1
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0561 0.12
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0288 0.0361
Brugia malayi hypothetical protein 0.0042 0.0288 0.0608
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0107 0.0252
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.108 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0156 0.0196
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0446 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.1703 0.6552
Brugia malayi Cytochrome P450 family protein 0.0025 0.0107 0.0221
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.256 1
Onchocerca volvulus 0.0253 0.256 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.2797 0.5983
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus granulosus cysteine protease 0.0136 0.1303 0.1635
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0446 0.1548
Loa Loa (eye worm) hypothetical protein 0.0115 0.1071 0.229
Echinococcus multilocularis cathepsin L 0.0136 0.1303 0.1303
Brugia malayi Cytochrome P450 family protein 0.0025 0.0107 0.0221
Toxoplasma gondii exonuclease III APE 0.0022 0.0075 0.0278
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0059 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0884 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.1315 0.165
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0134 0.0238
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.256 0.5472
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0075 0.0152
Mycobacterium ulcerans hypothetical protein 0.0174 0.1712 0.4165
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Echinococcus multilocularis protein patched 0.0049 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Brugia malayi MH2 domain containing protein 0.0127 0.1202 0.2565
Schistosoma mansoni polycystin 1-related 0.0023 0.0084 0.0101
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0884 0.1884
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Echinococcus multilocularis cysteine protease 0.0253 0.256 0.256
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0447 0.0949
Entamoeba histolytica hypothetical protein 0.0057 0.0446 0.1494
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0075 0.0152
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0057 0.0446 0.1548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0232 0.0291
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0107 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0057 0.0446 0.1494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0178 0.1754 0.2197
Loa Loa (eye worm) inositol-1 0.0043 0.03 0.0641
Brugia malayi cathepsin B-like cysteine proteinase 0.045 0.4675 1
Echinococcus granulosus cathepsin L 0.0136 0.1303 0.1635
Loa Loa (eye worm) hypothetical protein 0.0037 0.0232 0.0497
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0397 0.4105 1
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.7971 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0075 0.0173
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0173 0.0455
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.108 0.1351
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0253 0.256 0.5476
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0232 0.0489
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Brugia malayi 6-phosphofructokinase 0.0116 0.108 0.2303
Plasmodium falciparum serine repeat antigen 2 0.0057 0.0446 0.1548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.109 0.1363
Schistosoma mansoni lamin 0.0031 0.0175 0.0215
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.1303 0.4942
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.018
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Brugia malayi cathepsin F-like cysteine proteinase 0.0057 0.0446 0.0947
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0561 0.12
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0134 0.0318
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.03 0.0905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Trypanosoma cruzi cruzipain precursor, putative 0.008 0.0694 0.1477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0057 0.0446 0.1548
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0561 0.1193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Plasmodium falciparum serine repeat antigen 9 0.0057 0.0446 0.1548
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0253 0.256 1
Loa Loa (eye worm) phosphofructokinase 0.0116 0.108 0.2309
Plasmodium falciparum serine repeat antigen 7 0.0057 0.0446 0.1548
Echinococcus granulosus cathepsin l cysteine peptidase 0.0253 0.256 0.3212
Echinococcus multilocularis cysteine protease 0.0253 0.256 0.256
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0018 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0694 0.1477
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0366 0.046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.018
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.1303 0.2782
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0446 0.1494
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3397 0.7262
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.1071 0.4007
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Loa Loa (eye worm) RNA binding protein 0.0067 0.0561 0.12
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Onchocerca volvulus Cathepsin L homolog 0.0253 0.256 1
Giardia lamblia Hypothetical protein 0.0057 0.0446 0.2211
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0288 0.0357
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.108 0.1355
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Echinococcus multilocularis cathepsin b 0.045 0.4675 0.4675
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Onchocerca volvulus 0.0253 0.256 1
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.1321 0.1653
Brugia malayi cathepsin L precursor 0.0057 0.0446 0.0947
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1522 0.3249
Schistosoma mansoni intermediate filament proteins 0.0031 0.0175 0.0215
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.108 0.2309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.1303 0.2782
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.108 0.2309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Giardia lamblia Hypothetical protein 0.0057 0.0446 0.2211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Schistosoma mansoni cathepsin F (C01 family) 0.0253 0.256 0.3209
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0446 0.1462
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0884 0.0884
Echinococcus granulosus cathepsin L 0.0057 0.0446 0.056
Brugia malayi Pre-SET motif family protein 0.0031 0.0168 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0253 0.256 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0057 0.0446 0.1548
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0173 0.0661
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0173 0.0661
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0446 0.1494
Loa Loa (eye worm) hypothetical protein 0.045 0.4675 1
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0372
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2147 0.4593
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.03 0.03
Schistosoma mansoni lipoxygenase 0.0096 0.087 0.1088
Echinococcus granulosus microtubule associated protein 2 0.0756 0.7971 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0561 0.0561
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0446 0.0954
Plasmodium falciparum cysteine proteinase falcipain 3 0.0253 0.256 1
Echinococcus granulosus neuropeptide s receptor 0.0541 0.5653 0.7092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Brugia malayi Cathepsin L-like precursor 0.008 0.0694 0.1477
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Mycobacterium ulcerans hypothetical protein 0.0028 0.0134 0.0318
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0337 0.0714
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Trypanosoma brucei cysteine peptidase C (CPC) 0.0178 0.1754 0.5159
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0232 0.0497
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0004 0.0005
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Brugia malayi 6-phosphofructokinase 0.0116 0.108 0.2303
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Toxoplasma gondii cathepsin CPC2 0.0057 0.0446 0.173
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0446 0.0947
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Brugia malayi hypothetical protein 0.0023 0.0084 0.0172
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Schistosoma mansoni cathepsin B (C01 family) 0.0057 0.0446 0.0555
Plasmodium falciparum serine repeat antigen 4 0.0057 0.0446 0.1548
Echinococcus multilocularis lamin dm0 0.0031 0.0175 0.0175
Plasmodium vivax vivapain-2 0.0253 0.256 1
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Schistosoma mansoni hypothetical protein 0.0023 0.0084 0.0101
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0084 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0366 0.0366
Onchocerca volvulus Cathepsin F homolog 0.0253 0.256 1
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trypanosoma cruzi cysteine protease, putative 0.0136 0.1303 0.2782
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus multilocularis expressed conserved protein 0.0108 0.0996 0.0996
Plasmodium falciparum serine repeat antigen 5 0.0057 0.0446 0.1548
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0107 0.0304
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0084 0.0105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0138 0.1321 0.3212
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0232 0.0489
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0107 0.0229
Brugia malayi cathepsin L-like precursor 0.0174 0.1703 0.3638
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0446 0.1548
Echinococcus granulosus cathepsin b 0.045 0.4675 0.5866
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0232 0.0291
Echinococcus granulosus RUN 0.0023 0.0084 0.0105
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.16 0.16
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0107 0.0229
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0075 0.0094
Brugia malayi follicle stimulating hormone receptor 0.0275 0.2797 0.598
Echinococcus granulosus GPCR family 2 0.0037 0.0232 0.0291
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0232 0.0232
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0018 0.0038
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.1071 0.1071
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0168 0.0211
Echinococcus multilocularis RUN 0.0023 0.0084 0.0084
Echinococcus multilocularis cathepsin L 0.0057 0.0446 0.0446
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0873
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Echinococcus granulosus intermediate filament protein 0.0031 0.0175 0.0219
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0446 0.1548
Echinococcus granulosus tar DNA binding protein 0.0067 0.0561 0.0704
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Echinococcus granulosus lamin 0.0031 0.0175 0.0219
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.1303 0.2782
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.03 0.1158
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0107 0.0229
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0173 0.0393
Schistosoma mansoni lamin 0.0031 0.0175 0.0215
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0134 0.0318
Plasmodium falciparum serine repeat antigen 1 0.0057 0.0446 0.1548
Brugia malayi fibroinase precursor 0.0057 0.0446 0.0947
Leishmania major cytochrome p450-like protein 0.0025 0.0107 0.0304
Toxoplasma gondii cathepsin CPC1 0.0057 0.0446 0.173
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0366 0.1173
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0136 0.1303 0.2782
Onchocerca volvulus 0.0031 0.0168 0.034
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Schistosoma mansoni cathepsin s 0.008 0.0694 0.0866
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.1039
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.7971 0.7971
Loa Loa (eye worm) hypothetical protein 0.0079 0.0691 0.1478
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0057 0.0446 0.1548
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0361
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.108 0.2623
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0134 0.0238
Giardia lamblia Cathepsin L-like protease 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus multilocularis 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0116 0.1086 0.2324
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Loa Loa (eye worm) fibroinase 0.0253 0.256 0.5476
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.03 0.0376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0366 0.0784
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.1086 0.2324
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0173 0.0393
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0138 0.1321 0.1657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.1303 0.383
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2466 0.9623
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0057 0.0446 0.1548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.1303 0.383
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0175 0.0366
Schistosoma mansoni cathepsin F (C01 family) 0.0253 0.256 0.3209
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0084 0.0084
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0168 0.0168
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1522 0.4474
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Toxoplasma gondii hypothetical protein 0.0053 0.0411 0.1593
Echinococcus multilocularis GPCR, family 2 0.0037 0.0232 0.0232
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0057 0.0446 0.0947
Trypanosoma cruzi cruzipain precursor, putative 0.0253 0.256 0.5472
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus multilocularis cathepsin b 0.045 0.4675 0.4675

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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