Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1851 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.1851 | 0.45 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3824 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.7466 | 0.7466 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.1851 | 0.45 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1851 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3824 | 0.3824 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.3231 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.3231 | 0.8346 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3231 | 1 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0236 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.1851 | 0.45 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0236 | 0.0236 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3231 | 0.8346 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.1626 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3824 | 1 |
Brugia malayi | Inositol-1 | 0.004 | 0.1851 | 0.1851 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3824 | 0.3824 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.1851 | 0.45 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 1 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.1851 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.7466 | 0.7466 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3824 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3231 | 1 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0236 | 0.0236 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.3231 | 0.8346 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.3231 | 1 |
Brugia malayi | Smad1 | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3231 | 0.8346 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.3231 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3824 | 0.3824 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3231 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3824 | 0.3824 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3824 | 0.3824 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0186 | 0.9718 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.1851 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3824 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3824 | 1 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0236 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.7466 | 0.7466 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1851 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0236 | 0.0236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3824 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3824 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3824 | 0.3824 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.1851 | 0.1851 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.