Detailed information for compound 1132618

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.491 | Formula: C24H29NO5
  • H donors: 0 H acceptors: 2 LogP: 3.88 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1(CCCN(C1)C(=O)COc1ccccc1OC)Cc1ccccc1
  • InChi: 1S/C24H29NO5/c1-3-29-23(27)24(16-19-10-5-4-6-11-19)14-9-15-25(18-24)22(26)17-30-21-13-8-7-12-20(21)28-2/h4-8,10-13H,3,9,14-18H2,1-2H3
  • InChiKey: KMBUJJLISJBNSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0016 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0057 0.0566 0.0567
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Mycobacterium tuberculosis Conserved protein 0.0119 0.1402 0.1392
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0016 0.0016 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1402 0.2221
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0016 0.0056
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0465 0.326
Trypanosoma brucei trypanothione reductase 0.0044 0.04 0.2791
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0103 0.0103
Echinococcus multilocularis synaptojanin 1 0.0016 0.0016 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0336 0.4294 0.6843
Onchocerca volvulus 0.0022 0.0103 0.0463
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0408 0.0397
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0021 0.0084 0.0115
Schistosoma mansoni pyruvate kinase 0.0034 0.0254 0.0387
Onchocerca volvulus Huntingtin homolog 0.0122 0.143 0.7591
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0848 0.6017
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0016 0.0033
Brugia malayi glutathione reductase 0.0044 0.04 0.0401
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 0.9632
Schistosoma mansoni GTP-binding protein alpha subunit 0.0021 0.0084 0.0115
Mycobacterium tuberculosis Probable lipase LipE 0.0119 0.1402 0.1392
Brugia malayi TAR-binding protein 0.0336 0.4294 0.4306
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0103 0.0091
Leishmania major hypothetical protein, conserved 0.0016 0.0016 0.0033
Mycobacterium ulcerans lipase LipD 0.0119 0.1402 0.978
Echinococcus multilocularis expressed protein 0.0021 0.0084 0.0072
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0084 0.0518
Leishmania major pyruvate kinase 0.0034 0.0254 0.1705
Loa Loa (eye worm) glutathione reductase 0.0044 0.04 0.0401
Brugia malayi hypothetical protein 0.0021 0.0084 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0484 0.6269 0.6284
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0254 0.1743
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0566 0.6626
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0254 0.1743
Loa Loa (eye worm) hypothetical protein 0.0122 0.143 0.1435
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0817 0.0809
Onchocerca volvulus 0.0046 0.042 0.2169
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0016 0.0033
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0021 0.0084 0.0115
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.04 0.0401
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0016 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1402 1
Trichomonas vaginalis cation chloride cotransporter, putative 0.0027 0.0166 0.111
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0015 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0465 0.326
Mycobacterium tuberculosis Probable esterase LipL 0.0119 0.1402 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0781 0.5532
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0119 0.1402 0.1392
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0103 0.0145
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0016 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0154 0.1706
Mycobacterium leprae conserved hypothetical protein 0.0119 0.1402 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1276
Schistosoma mansoni hypothetical protein 0.0026 0.0147 0.0216
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0084 0.0084
Brugia malayi exodeoxyribonuclease III family protein 0.0078 0.0848 0.085
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0016 0.0033
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0015 0.0015
Echinococcus multilocularis pyruvate kinase 0.0026 0.016 0.0149
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0103 0.0103
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0021 0.0084 0.0115
Plasmodium falciparum pyruvate kinase 0.0034 0.0254 0.2898
Brugia malayi CCR4 0.0016 0.0016 0.0016
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0103 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1433 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0119 0.1402 0.978
Mycobacterium tuberculosis Probable lipase LipD 0.0119 0.1402 0.1392
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0254 0.0255
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0254 0.1743
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0119 0.1402 0.1392
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.033 0.2291
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0166 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1402 1
Plasmodium falciparum thioredoxin reductase 0.0044 0.04 0.4639
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0084 0.0115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0084
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0103 0.0145
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0179
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0465 0.3189
Leishmania major endonuclease/exonuclease protein-like protein 0.0016 0.0016 0.0033
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0016 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0118 0.0119
Brugia malayi hypothetical protein 0.0761 0.9971 1
Loa Loa (eye worm) solute carrier family 12 member 1 0.0054 0.0528 0.053
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0016 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0538 0.054
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0016 0.0033
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0103 0.0145
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0004
Toxoplasma gondii thioredoxin reductase 0.0044 0.04 0.273
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0021 0.0084 0.0115
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0016 0.0016
Mycobacterium ulcerans esterase/lipase LipP 0.0119 0.1402 0.978
Leishmania major pyruvate kinase 0.0034 0.0254 0.1705
Trypanosoma brucei hypothetical protein, conserved 0.0119 0.1402 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0119 0.1402 0.1396
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0078 0.0848 0.6017
Loa Loa (eye worm) G protein alpha subunit 3 0.0021 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Brugia malayi hypothetical protein 0.0057 0.0566 0.0567
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0021 0.0084 0.0518
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0484 0.6269 0.6284
Onchocerca volvulus 0.0021 0.0084 0.0361
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0566 0.3899
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Schistosoma mansoni pyruvate kinase 0.0017 0.0036 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0566 0.3987
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0336 0.4294 0.4306
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1433 0.1423
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0119 0.1402 0.1392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0484 0.6269 1
Brugia malayi MAP kinase sur-1 0.0049 0.0465 0.0466
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0465 0.0455
Schistosoma mansoni tar DNA-binding protein 0.0336 0.4294 0.6843
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0166 0.111
Brugia malayi hypothetical protein 0.0037 0.0297 0.0297
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0817 0.5668
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0179
Echinococcus multilocularis lamin dm0 0.0027 0.0168 0.0157
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0465 0.0455
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0318 0.2154
Echinococcus granulosus cation chloride cotransporter 0.0027 0.0166 0.0155
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0016 0.0033
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0021 0.0084 0.0115
Schistosoma mansoni cript-related 0.0016 0.0016 0.0007
Toxoplasma gondii hypothetical protein 0.0026 0.0154 0.1004
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0318 0.2202
Treponema pallidum exodeoxyribonuclease (exoA) 0.0078 0.0848 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0465 0.326
Loa Loa (eye worm) hypothetical protein 0.0761 0.9971 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0168 0.0169
Schistosoma mansoni survival motor neuron protein 0.0155 0.1879 0.2984
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0084 0.0084
Echinococcus granulosus pyruvate kinase 0.0017 0.0036 0.0024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0078 0.0848 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.116 0.115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0318 0.2154
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0021 0.0084 0.0518
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.116 0.115
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0103 0.0145
Mycobacterium tuberculosis Probable hydrolase 0.0119 0.1402 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0103 0.0103
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0817 0.5668
Echinococcus multilocularis pyruvate kinase 0.0017 0.0036 0.0024
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0016 0.0033
Brugia malayi nuclear receptor NHR-88 0.0022 0.0103 0.0103
Chlamydia trachomatis pyruvate kinase 0.0034 0.0254 0.3009
Echinococcus granulosus geminin 0.02 0.2484 0.2482
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0465 0.0455
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0374 0.0364
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1276
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0155 0.1879 0.1885
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0058 0.0333
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0469 0.0459
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0016 0.0016 0.0033
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0078 0.0848 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0465 0.0466
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0016 0.0016 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0336 0.4294 0.6843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0078 0.0848 0.5884
Brugia malayi G-protein alpha subunit 0.0021 0.0084 0.0084
Echinococcus multilocularis lamin 0.0027 0.0168 0.0157
Toxoplasma gondii ABC1 family protein 0.0119 0.1402 0.978
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0103 0.0103
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0004
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0015 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0103 0.0103
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0166 0.111
Brugia malayi isocitrate dehydrogenase 0.0016 0.0015 0.0015
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0103 0.0145
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0084 0.0115
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.4307
Echinococcus granulosus synaptojanin 1 0.0016 0.0016 0.0005
Onchocerca volvulus Huntingtin homolog 0.0122 0.143 0.7591
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0103 0.0091
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0103 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1402 1
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0103 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.0336 0.4294 0.4306
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0021 0.0084 0.0072
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0021 0.0084 0.0072
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0016 0.0016 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0015 0.0015
Brugia malayi steroid hormone receptor 0.0022 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0103 0.0103
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0021 0.0084 0.0072
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Onchocerca volvulus 0.0119 0.1402 0.7436
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0431
Echinococcus multilocularis pyruvate kinase 0.0017 0.0036 0.0024
Echinococcus multilocularis survival motor neuron protein 1 0.0761 0.9971 1
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0016 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0179
Loa Loa (eye worm) beta-lactamase 0.0119 0.1402 0.1406
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0021 0.0084 0.0072
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0078 0.0848 0.6017
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0469 0.0458
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.04 0.2791
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0016 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.04 0.0388
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0113 0.1311 0.1301
Treponema pallidum hypothetical protein 0.0016 0.0016 0.0056
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0848 0.6017
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Mycobacterium tuberculosis Conserved protein 0.0119 0.1402 0.1392
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0021 0.0084 0.0084
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0255
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0078 0.0848 0.085
Onchocerca volvulus 0.0021 0.0084 0.0361
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0466 0.0467
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1276
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0465 0.326
Schistosoma mansoni cation chloride cotransporter 0.0027 0.0166 0.0247
Entamoeba histolytica G protein alpha subunit, putative 0.0021 0.0084 0.0809
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0103 0.0145
Mycobacterium ulcerans beta-lactamase 0.0119 0.1402 0.978
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0103 0.0103
Echinococcus granulosus GPCR family 2 0.0016 0.0015 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0484 0.6269 0.6284
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Schistosoma mansoni GTP-binding protein alpha subunit 0.0021 0.0084 0.0115
Loa Loa (eye worm) TAR-binding protein 0.0336 0.4294 0.4306
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0055 0.0538 0.0841
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1433 1
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0016 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0103 0.0103
Trypanosoma cruzi hypothetical protein, conserved 0.0119 0.1402 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0566 0.3987
Trichomonas vaginalis rotamase, putative 0.0038 0.0318 0.2202
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0113 0.1311 0.1301
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0021 0.0084 0.0084
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0016 0.0016
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0016 0.0016 0.0033
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0021 0.0084 0.0072
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0103 0.0463
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0431
Schistosoma mansoni synaptojanin 0.0016 0.0016 0.0007
Echinococcus granulosus tar DNA binding protein 0.0336 0.4294 0.43
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0484 0.6269 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0817 0.5795
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0084 0.0518
Echinococcus granulosus pyruvate kinase 0.0034 0.0254 0.0243
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0007
Giardia lamblia Pyruvate kinase 0.0034 0.0254 0.2898
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0016 0.0016 0.0033
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0016 0.0016 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0103 0.0091
Schistosoma mansoni rotamase 0.0039 0.033 0.0509
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0154 0.1706
Loa Loa (eye worm) amino acid permease 0.0036 0.0286 0.0287
Leishmania major hypothetical protein, conserved 0.0119 0.1402 0.978
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0166 0.111
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0103 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0103 0.0103
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0103 0.0463
Trichomonas vaginalis ap endonuclease, putative 0.0078 0.0848 0.6017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Brugia malayi MH2 domain containing protein 0.0125 0.1482 0.1486
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0103 0.0145
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Echinococcus multilocularis cation chloride cotransporter 0.0027 0.0166 0.0155
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0465 0.326
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1433 0.1427
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0374 0.0364
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Echinococcus granulosus pyruvate kinase 0.0017 0.0036 0.0024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0015 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0168 0.0169
Schistosoma mansoni ap endonuclease 0.0078 0.0848 0.1336
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0466 0.0467
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0016 0.0005
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0016 0.0007
Brugia malayi beta-lactamase family protein 0.0119 0.1402 0.1406
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0016 0.0016 0.0033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0408 0.0397
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0021 0.0084 0.0115
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0318 0.2202
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0103 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0016 0.0033
Leishmania major hypothetical protein, conserved 0.0016 0.0016 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0119 0.1402 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0119 0.1402 0.2221
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0103 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0058 0.0333
Brugia malayi intermediate filament protein 0.0027 0.0168 0.0169
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0103 0.0145
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0287
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0484 0.6269 0.6288
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0021 0.0084 0.0084
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0119 0.1402 0.1406
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0254 0.1743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Leishmania major hypothetical protein, conserved 0.0016 0.0016 0.0033
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0015 0.0025
Brugia malayi Amino acid permease family protein 0.0055 0.0538 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0103 0.0103
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0016 0.0007
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0103 0.0091
Brugia malayi hypothetical protein 0.0122 0.143 0.1435
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Plasmodium vivax exodeoxyribonuclease III, putative 0.0016 0.0016 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0466 0.0467
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0103 0.0091
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0318 0.2202
Brugia malayi Probable ClpP-like protease 0.0076 0.0817 0.082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0016 0.0033
Leishmania major RNA-editing complex protein MP100, putative 0.0016 0.0016 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0103 0.0091
Loa Loa (eye worm) hypothetical protein 0.0055 0.0538 0.054
Trichomonas vaginalis Phospholipase C precursor, putative 0.0016 0.0016 0.0033
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0103 0.0103
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0016 0.0033
Brugia malayi RNA binding protein 0.0336 0.4294 0.4306
Giardia lamblia Pyruvate kinase 0.0017 0.0036 0.029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0119 0.1402 0.1396
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0016 0.0005
Trypanosoma brucei RNA editing exonuclease 2 0.0016 0.0016 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0015 0.0004
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0036 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0103 0.0103
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1482 0.1486
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0103 0.0091
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0817 0.1287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0287
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1433 0.1427
Echinococcus multilocularis GPCR, family 2 0.0016 0.0015 0.0003
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0021 0.0084 0.0084
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0255
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0118 0.1228
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0113 0.1311 0.9275
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0021 0.0084 0.0072
Mycobacterium tuberculosis Probable exported protein 0.0016 0.0016 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 0.9632
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0469 0.2521
Echinococcus granulosus expressed protein 0.0021 0.0084 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0058 0.0333
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0055 0.0538 0.054
Schistosoma mansoni hypothetical protein 0.0034 0.0257 0.0392
Leishmania major hypothetical protein, conserved 0.0057 0.0566 0.3899
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0036 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1433 0.2271
Echinococcus multilocularis pyruvate kinase 0.0034 0.0254 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.02 0.2484 0.395
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0015 0.0003
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0016 0.0016 0.0033
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0015 0.0025
Schistosoma mansoni coup transcription factor 0.0022 0.0103 0.0145
Echinococcus granulosus survival motor neuron protein 1 0.0761 0.9971 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0469 0.0459
Echinococcus multilocularis solute carrier family 12 0.0055 0.0538 0.0529
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0465 0.3189
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0078 0.0848 1
Brugia malayi beta-lactamase 0.0119 0.1402 0.1406
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0469 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0103 0.0103
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0021 0.0084 0.0072
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0021 0.0084 0.0084
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0254 0.1705
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0103 0.0463
Trichomonas vaginalis esterase, putative 0.0119 0.1402 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.116 0.115
Echinococcus granulosus expressed protein 0.0039 0.033 0.032
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1482 0.1486
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0078 0.0848 0.0837
Schistosoma mansoni hypothetical protein 0.0155 0.1879 0.2984
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0078 0.0848 0.084
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0015 0.0003
Toxoplasma gondii exonuclease III APE 0.0078 0.0848 0.5884
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0103 0.0103
Schistosoma mansoni lamin 0.0027 0.0168 0.025
Schistosoma mansoni hypothetical protein 0.02 0.2484 0.395
Loa Loa (eye worm) hypothetical protein 0.0034 0.0254 0.0255
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0021 0.0084 0.0084
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0254 0.0799
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0016 0.0016
Onchocerca volvulus 0.0021 0.0084 0.0361
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0154 0.1026
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.116 0.115
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1402 1
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0781 0.5532
Echinococcus granulosus pyruvate kinase 0.0034 0.0254 0.0243
Echinococcus multilocularis geminin 0.02 0.2484 0.2482
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0015 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0016 0.0016 0.0033
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0465 0.326
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0103 0.0091
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.4307
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0021 0.0084 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0466 0.0467
Brugia malayi hypothetical protein 0.0043 0.0374 0.0376
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 0.9632
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0166 0.111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0103 0.0103
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0168 0.0169
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0021 0.0084 0.0072
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0015 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0078 0.0848 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.116 0.8064
Schistosoma mansoni tar DNA-binding protein 0.0336 0.4294 0.6843
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0103 0.0091
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0287
Loa Loa (eye worm) RNA binding protein 0.0336 0.4294 0.4306
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0465 0.0455
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0004
Brugia malayi nuclear hormone receptor 0.0022 0.0103 0.0103
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0084 0.0518
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0021 0.0084 0.0115
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0036 0.0171
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0016 0.0016 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0078 0.0848 0.5884
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0015 0.0006
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0016 0.0056
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0254 0.1743
Leishmania major trypanothione reductase 0.0044 0.04 0.273
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0025
Echinococcus granulosus solute carrier family 12 0.0055 0.0538 0.0529
Loa Loa (eye worm) hypothetical protein 0.0027 0.0162 0.0162
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0021 0.0084 0.0518
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0021 0.0084 0.0518
Echinococcus multilocularis pyruvate kinase 0.0034 0.0254 0.0243
Echinococcus granulosus lamin dm0 0.0027 0.0168 0.0157
Mycobacterium leprae Probable lipase LipE 0.0119 0.1402 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0465 0.326
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0021 0.0084 0.0518
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0016 0.0005
Onchocerca volvulus 0.0027 0.0168 0.0815
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0484 0.6269 0.6284
Loa Loa (eye worm) hypothetical protein 0.0076 0.0817 0.082
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0021 0.0084 0.0084
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.116 0.115
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0021 0.0084 0.0072
Echinococcus multilocularis pyruvate kinase 0.0017 0.0036 0.0024
Giardia lamblia hypothetical protein 0.0016 0.0016 0.0056
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0168 0.0169
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Echinococcus granulosus lamin 0.0027 0.0168 0.0157
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0147 0.0136
Brugia malayi hypothetical protein 0.0019 0.0058 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1433 1
Schistosoma mansoni tar DNA-binding protein 0.0336 0.4294 0.6843
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0016 0.0033
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.033 0.0331
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0103 0.0145
Plasmodium falciparum glutathione reductase 0.0044 0.04 0.4639
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0673 0.4755
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0254 0.0255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0103 0.0103
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0465 0.5419
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.043 0.0431
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0016 0.0056
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0021 0.0084 0.0115
Echinococcus granulosus intermediate filament protein 0.0027 0.0168 0.0157
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.033 0.0331
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0103 0.0091
Brugia malayi GH09271p 0.0019 0.0058 0.0058
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0016 0.0016 0.0033
Loa Loa (eye worm) hypothetical protein 0.0119 0.1402 0.1406
Brugia malayi Thioredoxin reductase 0.0044 0.04 0.0401
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0021 0.0084 0.0072
Mycobacterium ulcerans hypothetical protein 0.0119 0.1402 0.978
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0021 0.0084 0.0084
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Echinococcus granulosus pyruvate kinase 0.0017 0.0036 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0015 0.0004
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0147 0.0136
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0113 0.1311 0.1301
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0817 0.5314
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0016 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0103 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0103 0.0091
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0286 0.0287
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0084
Echinococcus multilocularis musashi 0.0027 0.0168 0.0157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0015 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0566 0.6626
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0781 0.5532
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0118 0.0119
Trichomonas vaginalis D-aminoacylase, putative 0.0119 0.1402 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0484 0.6269 0.6288
Trypanosoma cruzi mitochondrial protein 99, putative 0.0016 0.0016 0.0033
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0103 0.0091
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0817 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0465 0.0724
Onchocerca volvulus 0.0027 0.0168 0.0815
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0021 0.0084 0.0084
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.4307
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0318 0.3625
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1433 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0374 0.058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0103 0.0103
Onchocerca volvulus 0.0119 0.1402 0.7436
Onchocerca volvulus 0.0119 0.1402 0.7436
Loa Loa (eye worm) hypothetical protein 0.0122 0.143 0.1435
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0254 0.0243
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0257 0.0258
Schistosoma mansoni synaptojanin 0.0016 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0257 0.0258
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0015 0.0025
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0016 0.0016 0.0033
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0016 0.0016 0.0033
Schistosoma mansoni pyruvate kinase 0.0034 0.0254 0.0387
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0015 0.0003
Brugia malayi Amino acid permease family protein 0.0027 0.0166 0.0167
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0103 0.0145
Brugia malayi beta-lactamase family protein 0.0119 0.1402 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0103 0.0103
Plasmodium vivax glutathione reductase, putative 0.0044 0.04 0.2791
Schistosoma mansoni lamin 0.0027 0.0168 0.025
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0005
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0016 0.0016 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0484 0.6269 1
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0566 0.3987
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0465 0.326
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0012 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1433 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0078 0.0848 0.6017
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0016 0.0056
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0016 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0119 0.1402 0.1406
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0254 0.1743
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0254 0.1705
Loa Loa (eye worm) hypothetical protein 0.0019 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0055 0.0538 0.054
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0103 0.0091
Onchocerca volvulus 0.0155 0.1879 1
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0016 0.0033
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0465 0.326
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0465 0.3189
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Schistosoma mansoni nocturnin 0.0016 0.0016 0.0007
Mycobacterium tuberculosis Probable reductase 0.0101 0.116 0.115
Trypanosoma brucei protein kinase, putative 0.0049 0.0465 0.326
Echinococcus multilocularis tar DNA binding protein 0.0336 0.4294 0.43
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0084
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.04 0.2791
Giardia lamblia Inositol 5-phosphatase 4 0.0016 0.0016 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0119 0.1402 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0103 0.0091
Brugia malayi solute carrier family 12 member 1 0.0073 0.0781 0.0783
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0078 0.0848 0.084
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0021 0.0084 0.0115
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0016 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1433 0.2271
Schistosoma mansoni hypothetical protein 0.0043 0.0374 0.058
Entamoeba histolytica hypothetical protein 0.0043 0.0374 0.4307
Schistosoma mansoni ap endonuclease 0.0078 0.0848 0.1336
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0015 0.0025
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0566 0.3987
Trichomonas vaginalis cation chloride cotransporter, putative 0.0027 0.0166 0.111
Schistosoma mansoni hypothetical protein 0.0016 0.0015 0.0005
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0254 0.1743
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0103 0.0103
Brugia malayi ecdysteroid receptor 0.0022 0.0103 0.0103
Echinococcus multilocularis expressed protein 0.0039 0.033 0.032
Schistosoma mansoni intermediate filament proteins 0.0027 0.0168 0.025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0015 0.0015
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 0.5668
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0021 0.0084 0.0084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0817 0.5668
Loa Loa (eye worm) hypothetical protein 0.0028 0.0178 0.0179
Mycobacterium tuberculosis Conserved protein 0.0119 0.1402 0.1392
Trichomonas vaginalis rotamase, putative 0.0039 0.033 0.2291
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0166 0.111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0103 0.0103

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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