Detailed information for compound 1132781

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 324.417 | Formula: C20H24N2O2
  • H donors: 2 H acceptors: 2 LogP: 3.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1/C=N/CCCCCC/N=C/c1ccccc1O
  • InChi: 1S/C20H24N2O2/c23-19-11-5-3-9-17(19)15-21-13-7-1-2-8-14-22-16-18-10-4-6-12-20(18)24/h3-6,9-12,15-16,23-24H,1-2,7-8,13-14H2/b21-15+,22-16+
  • InChiKey: DXVHKINVBJRBGQ-YHARCJFQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Escherichia coli 3-oxoacyl-[acyl-carrier-protein] synthase III Starlite/ChEMBL References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens carbonic anhydrase XII Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Plasmodium berghei apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Plasmodium knowlesi beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans beta-ketoacyl synthase-like protein Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) Get druggable targets OG5_129509 All targets in OG5_129509
Neospora caninum 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative Get druggable targets OG5_129509 All targets in OG5_129509
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Chlamydia trachomatis oxoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium falciparum beta-ketoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase XII 354 aa 295 aa 23.1 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Mycobacterium tuberculosis Conserved hypothetical protein 3-oxoacyl-[acyl-carrier-protein] synthase III 317 aa 265 aa 26.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0499 0.3105
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.002 0.0036 0.0209
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0061 0.037 0.0412
Schistosoma mansoni importin beta-1 0.0028 0.0107 0.0112
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0036 0.051
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.002 0.0036 0.0209
Brugia malayi MH2 domain containing protein 0.0025 0.0078 0.0086
Echinococcus granulosus endonuclease exonuclease phosphatase 0.002 0.0036 0.004
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0687 0.0781
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0687 0.0781
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0687 0.0759
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Echinococcus granulosus histone acetyltransferase KAT2B 0.0152 0.1102 0.1228
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0211 0.0235
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1108 0.8772 1
Brugia malayi Ets-domain containing protein 0.0083 0.0542 0.0615
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0298 0.1851
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.1471 0.1638
Brugia malayi hypothetical protein 0.005 0.0279 0.0315
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0056 0.0334
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 0.2955 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0298 0.0976
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.002 0.0036 0.004
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0056 0.0334
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.037 0.0405
Onchocerca volvulus 0.0149 0.1075 0.1043
Leishmania major oligopeptidase b 0.0052 0.0298 0.1851
Schistosoma mansoni ets-related 0.0251 0.1893 0.2103
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.002 0.0036 0.0209
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.2955 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0309 0.2363 0.2633
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0423 0.0471
Brugia malayi hypothetical protein 0.0041 0.0211 0.0238
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0011 0.0005
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0293 0.0335
Brugia malayi acetyltransferase, GNAT family protein 0.0159 0.1157 0.1317
Brugia malayi calpain family protein 1 0.0058 0.0349 0.0394
Echinococcus multilocularis traf and tnf receptor associated protein 0.002 0.0036 0.004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.032
Echinococcus granulosus geminin 0.1133 0.8977 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0658 0.0733
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0036 0.0086
Schistosoma mansoni synaptojanin 0.002 0.0036 0.0033
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0687 0.0781
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0293 0.0327
Schistosoma mansoni smad 0.0025 0.0078 0.008
Echinococcus multilocularis calpain A 0.0061 0.037 0.0412
Plasmodium vivax hypothetical protein, conserved 0.002 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0295 0.0337
Echinococcus granulosus GPCR family 2 0.0052 0.0293 0.0327
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0276
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0028
Loa Loa (eye worm) fli-1 protein 0.0251 0.1893 0.2158
Schistosoma mansoni ap endonuclease 0.0097 0.0658 0.0726
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0658 0.4104
Brugia malayi MH2 domain containing protein 0.0025 0.0078 0.0086
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0658 0.1355
Echinococcus multilocularis zinc finger protein 0.0026 0.0087 0.0097
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0159 0.1157 0.1289
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.0934 0.5829
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.0934 0.1062
Echinococcus granulosus calpain A 0.0022 0.0056 0.0062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0934 0.1033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0078 0.0087
Schistosoma mansoni ran 0.0021 0.0047 0.0045
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.16 1
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0658 0.0747
Leishmania major carbonic anhydrase-like protein 0.0214 0.16 1
Entamoeba histolytica hypothetical protein 0.0041 0.0211 0.3178
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0687 0.0759
Schistosoma mansoni rotamase 0.0034 0.0151 0.016
Echinococcus granulosus synaptojanin 1 0.002 0.0036 0.004
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0078 0.0087
Schistosoma mansoni hypothetical protein 0.002 0.0036 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0159 0.1159 0.1291
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.002 0.0036 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0153 0.1107 0.1233
Brugia malayi Bromodomain containing protein 0.0084 0.055 0.0625
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.0041
Schistosoma mansoni synaptojanin 0.002 0.0036 0.0033
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0298 0.1851
Leishmania major importin beta-1 subunit, putative 0.0023 0.0064 0.0383
Echinococcus granulosus carbonic anhydrase 0.0101 0.0687 0.0765
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0144 0.0886
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0041
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0011 0.0012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0214 0.16 0.1821
Loa Loa (eye worm) hypothetical protein 0.0052 0.0293 0.0335
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0658 0.4104
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.002 0.0036 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0293 0.0327
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0011 0.0012
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0025
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0298 0.0976
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Schistosoma mansoni cpg binding protein 0.003 0.0119 0.0125
Schistosoma mansoni hypothetical protein 0.0303 0.2315 0.2574
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0056 0.0334
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0211 0.0228
Brugia malayi Importin beta-1 subunit 0.0028 0.0107 0.0119
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.2807 0.32
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0056 0.0062
Echinococcus granulosus cpg binding protein 0.0034 0.0149 0.0166
Echinococcus granulosus calpain 5 0.0022 0.0056 0.0062
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0151 0.0169
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0144 0.0886
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0658 0.0733
Trichomonas vaginalis set domain proteins, putative 0.126 1 1
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0278 0.4204
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.002 0.0036 0.0086
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.0542 0.0618
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0081 0.009
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0151 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0041
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0056 0.0334
Echinococcus granulosus carbonic anhydrase 0.0101 0.0687 0.0765
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0293 0.0332
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0658 0.4104
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0078 0.0089
Schistosoma mansoni neutral sphingomyelinase 0.002 0.0036 0.0033
Loa Loa (eye worm) Smad1 0.0025 0.0078 0.0089
Brugia malayi calpain 7 0.0022 0.0056 0.0061
Schistosoma mansoni cpg binding protein 0.0034 0.0149 0.0158
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0225 0.0256
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0011 0.0051
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0036 0.0209
Echinococcus multilocularis Smad4 0.0025 0.0078 0.0087
Brugia malayi MH2 domain containing protein 0.0365 0.2807 0.3198
Trypanosoma cruzi oligopeptidase b 0.0052 0.0298 0.1851
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0658 1
Schistosoma mansoni carbonic anhydrase 0.0101 0.0687 0.0759
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0658 0.2199
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0214 0.16 0.1821
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0025
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.002 0.0036 0.051
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0775 0.088
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0078 0.0087
Trypanosoma brucei RNA editing exonuclease 2 0.002 0.0036 0.0209
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0269 0.0299
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0058 0.0349 0.0381
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.032
Leishmania major hypothetical protein, conserved 0.002 0.0036 0.0209
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 0.2955 1
Plasmodium falciparum carbonic anhydrase 0.0101 0.0687 0.2297
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.0542 0.0604
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0011 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0499 0.3105
Echinococcus multilocularis expressed protein 0.0034 0.0151 0.0168
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.1471 0.1638
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0499 0.1657
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0061 0.037 0.0412
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0078 0.0089
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0269 0.2246
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.2807 0.32
Brugia malayi Pre-SET motif family protein 0.1108 0.8772 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0011 0.0012
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Echinococcus granulosus zinc finger protein 0.0026 0.0087 0.0097
Loa Loa (eye worm) calpain 5 0.0015 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0177 0.1301 0.1443
Trypanosoma brucei ISWI complex protein 0.0016 0.0007 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0293 0.0327
Loa Loa (eye worm) hypothetical protein 0.0149 0.1075 0.1225
Schistosoma mansoni hypothetical protein 0.0426 0.3299 0.367
Loa Loa (eye worm) hypothetical protein 0.0163 0.1189 0.1356
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Leishmania major pantothenate kinase subunit, putative 0.002 0.0036 0.0209
Loa Loa (eye worm) hypothetical protein 0.0046 0.025 0.0285
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.002 0.0036 0.0086
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0431 0.3662
Toxoplasma gondii prolyl endopeptidase 0.0131 0.0934 0.8038
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0056 0.0055
Trichomonas vaginalis rotamase, putative 0.0033 0.0144 0.0108
Loa Loa (eye worm) hypothetical protein 0.0028 0.0107 0.0122
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0051 0.0059
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0658 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.1471 0.1632
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0269 0.2246
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.0177 0.1301 0.145
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0218 0.0704
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0047 0.0313
Schistosoma mansoni Smad4 0.0025 0.0078 0.008
Echinococcus multilocularis snurportin 1 0.0303 0.2315 0.2579
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0047 0.0122
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Loa Loa (eye worm) calpain family protein 1 0.0058 0.0349 0.0397
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Onchocerca volvulus 0.003 0.0119 0.0083
Echinococcus multilocularis smad 0.0025 0.0078 0.0087
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0036 0.004
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0021 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0198 0.1471 0.1677
Trypanosoma brucei antigen, putative 0.0022 0.0056 0.0334
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.0041
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0658 0.4104
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Brugia malayi Fli-1 protein 0.0251 0.1893 0.2156
Echinococcus multilocularis calpain family protein 1, d 0.0043 0.0225 0.025
Schistosoma mansoni hypothetical protein 0.1133 0.8977 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0157 0.0175
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Schistosoma mansoni hypothetical protein 0.0112 0.0775 0.0856
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Leishmania major endonuclease/exonuclease protein-like protein 0.002 0.0036 0.0209
Echinococcus granulosus traf and tnf receptor associated protein 0.002 0.0036 0.004
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0101 0.0687 0.0781
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0107 0.0119
Schistosoma mansoni nocturnin 0.002 0.0036 0.0033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0198 0.1471 0.1674
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0159 0.1157 0.1283
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0107 0.0837
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.0934 0.5829
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0278 0.4204
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0144 0.0886
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0499 0.1657
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Loa Loa (eye worm) hypothetical protein 0.0101 0.0687 0.0783
Loa Loa (eye worm) hypothetical protein 0.0131 0.0934 0.1064
Schistosoma mansoni hypothetical protein 0.0101 0.0687 0.0759
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.008
Loa Loa (eye worm) carbonic anhydrase 3 0.0214 0.16 0.1824
Schistosoma mansoni hypothetical protein 0.0041 0.0211 0.0228
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0036 0.0209
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0144 0.0886
Brugia malayi RNA, U transporter 1 0.0081 0.0528 0.0599
Trypanosoma brucei carbonic anhydrase-like protein 0.0214 0.16 1
Brugia malayi CCR4 0.002 0.0036 0.0038
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0056 0.0055
Plasmodium vivax SET domain protein, putative 0.0159 0.1159 0.3899
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.002 0.0036 0.0209
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0051
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.032
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.002 0.0036 0.0209
Echinococcus granulosus calpain A 0.0061 0.037 0.0412
Brugia malayi MH1 domain containing protein 0.0025 0.0078 0.0086
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0011 0.0009
Brugia malayi CXXC zinc finger family protein 0.003 0.0119 0.0133
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.002 0.0036 0.0209
Brugia malayi hypothetical protein 0.0077 0.0499 0.0565
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.0934 0.0901
Trypanosoma brucei oligopeptidase b 0.0052 0.0298 0.1851
Echinococcus granulosus carbonic anhydrase II 0.0214 0.16 0.1782
Trypanosoma cruzi oligopeptidase b 0.0052 0.0298 0.1851
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0171
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0298 0.5
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0021 0.0024
Loa Loa (eye worm) hypothetical protein 0.0058 0.0349 0.0397
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0107 0.0653
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0107 0.0653
Brugia malayi PHD-finger family protein 0.0031 0.0132 0.0147
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.005
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0122
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0144 0.1161
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.0934 0.104
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0218 0.3286
Loa Loa (eye worm) hypothetical protein 0.0177 0.1301 0.1484
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0276
Leishmania major hypothetical protein, conserved 0.0077 0.0499 0.3105
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Echinococcus granulosus carbonic anhydrase 0.0101 0.0687 0.0765
Schistosoma mansoni cpg binding protein 0.0034 0.0149 0.0158
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Entamoeba histolytica Ran family GTPase 0.0021 0.0047 0.0672
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.2315 0.264
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0293 0.0327
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0435 0.0478
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0081 0.009
Trichomonas vaginalis rotamase, putative 0.0034 0.0151 0.0115
Brugia malayi Pre-SET motif family protein 0.0159 0.1159 0.1318
Loa Loa (eye worm) hypothetical protein 0.0101 0.0687 0.0783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0177 0.1301 0.1443
Echinococcus multilocularis deoxyribonuclease 1 2 0.002 0.0036 0.004
Leishmania major hypothetical protein, conserved 0.002 0.0036 0.0209
Echinococcus granulosus smad 0.0025 0.0078 0.0087
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.2955 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0078 0.0087
Brugia malayi calpain family protein 1 0.0058 0.0349 0.0394
Schistosoma mansoni cript-related 0.002 0.0036 0.0033
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.16 0.1776
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.0041
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0658 0.2199
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0499 0.3105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0163 0.1189 0.1353
Echinococcus granulosus importin subunit beta 1 0.0028 0.0107 0.0119
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0064 0.0028
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0276
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.002 0.0036 0.0209
Entamoeba histolytica sphingomyelinase C precursor, putative 0.002 0.0036 0.051
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0218 0.2925
Echinococcus multilocularis geminin 0.1133 0.8977 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 0.2955 1
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 0.2955 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0061 0.037 0.0405
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0278 0.4204
Echinococcus multilocularis carbonic anhydrase II 0.0214 0.16 0.1782
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0269 0.0233
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0269 0.0876
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0159 0.1159 1
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.0542 0.0604
Toxoplasma gondii exonuclease III APE 0.0097 0.0658 0.5638
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0151 0.0115
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0036 0.051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.002 0.0036 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0293 0.0332
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0658 0.075
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0499 0.4248
Echinococcus multilocularis hypothetical protein 0.0022 0.0056 0.0062
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0047 0.0052
Schistosoma mansoni hypothetical protein 0.0035 0.0157 0.0167
Plasmodium falciparum DNase I-like protein, putative 0.002 0.0036 0.0086
Entamoeba histolytica hypothetical protein 0.0023 0.0064 0.0933
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0056 0.0055
Leishmania major GTP-binding protein, putative 0.0021 0.0047 0.0276
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0015 0.0014
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0687 0.0765
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0157 0.0175
Brugia malayi Smad1 0.0025 0.0078 0.0086
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0056 0.0062
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Onchocerca volvulus 0.0159 0.1159 0.1127
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0118 0.0823 0.2758
Onchocerca volvulus 0.0036 0.0171 0.0136
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.002 0.0036 0.0209
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0053
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0214 0.16 0.1824
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0658 0.0624
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0057 0.0065
Schistosoma mansoni calpain (C02 family) 0.0022 0.0056 0.0055
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.002 0.0036 0.0209
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0036 0.0086
Schistosoma mansoni carbonic anhydrase-related 0.0101 0.0687 0.0759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0198 0.1471 0.1638
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0179 0.02
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0658 1
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0025
Plasmodium falciparum importin beta, putative 0.0028 0.0107 0.0327
Echinococcus multilocularis calpain 5 0.0022 0.0056 0.0062
Entamoeba histolytica hypothetical protein 0.0041 0.0211 0.3178
Echinococcus multilocularis calpain 0.0022 0.0056 0.0062
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0423 0.0471
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0298 0.1851
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0214 0.16 0.1776
Plasmodium vivax calpain, putative 0.0022 0.0056 0.0153
Schistosoma mansoni ran 0.0021 0.0047 0.0045
Trypanosoma brucei prolyl endopeptidase 0.0131 0.0934 0.5829
Echinococcus granulosus expressed protein 0.0034 0.0151 0.0168
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0383 0.2955 0.5
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.1471 0.1632
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.002 0.0036 0.0086
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0159 0.1159 0.1284
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0298 0.1851
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0278 0.4204
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0499 0.1657
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0269 0.0233
Loa Loa (eye worm) hypothetical protein 0.0112 0.0775 0.0883
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0012
Entamoeba histolytica hypothetical protein 0.0041 0.0211 0.3178
Schistosoma mansoni hypothetical protein 0.1133 0.8977 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0163 0.1189 0.1356
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.051
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0041
Brugia malayi isocitrate dehydrogenase 0.0016 0.0011 0.0009
Echinococcus multilocularis synaptojanin 1 0.002 0.0036 0.004
Trypanosoma cruzi pantothenate kinase subunit, putative 0.002 0.0036 0.0209
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0064 0.0383
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.002 0.0036 0.0209
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0064 0.0028
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0214 0.16 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0021 0.0016
Loa Loa (eye worm) acetyltransferase 0.0159 0.1157 0.1319
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 0.2955 1
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0278 0.4204
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.002 0.0036 0.004
Brugia malayi Ets-domain containing protein 0.0083 0.0542 0.0615
Echinococcus granulosus tachykinin peptides receptor 99D 0.0309 0.2363 0.2633
Leishmania major RNA-editing complex protein MP100, putative 0.002 0.0036 0.0209
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0012
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.008
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0658 0.0624
Loa Loa (eye worm) hypothetical protein 0.0101 0.0687 0.0783
Brugia malayi Bromodomain containing protein 0.0044 0.023 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Schistosoma mansoni zinc finger protein 0.0026 0.0087 0.009
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0119 0.0136
Schistosoma mansoni bromodomain containing protein 0.0071 0.0452 0.0497
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.002 0.0036 0.0033
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.004 0.02 0.0228
Echinococcus multilocularis neutral sphingomyelinase 0.002 0.0036 0.004
Schistosoma mansoni hypothetical protein 0.0021 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0171 0.0195
Echinococcus granulosus snurportin 1 0.0303 0.2315 0.2579
Plasmodium vivax exodeoxyribonuclease III, putative 0.002 0.0036 0.0086
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0056 0.0334
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.002 0.0036 0.022
Loa Loa (eye worm) hypothetical protein 0.0077 0.0499 0.0568
Brugia malayi MH1 domain containing protein 0.0025 0.0078 0.0086
Echinococcus multilocularis GPCR, family 2 0.0052 0.0293 0.0327
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0056 0.0334
Schistosoma mansoni hypothetical protein 0.0052 0.0293 0.032
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.002 0.0036 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0041
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0081 0.0083
Loa Loa (eye worm) hypothetical protein 0.005 0.028 0.0319
Loa Loa (eye worm) calpain 0.0022 0.0056 0.0064
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0011 0.0051
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Toxoplasma gondii hypothetical protein 0.0101 0.0687 0.5891
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0047 0.0052
Echinococcus granulosus dnaJ subfamily B 0.0426 0.3299 0.3675
Loa Loa (eye worm) hypothetical protein 0.0071 0.0446 0.0509
Loa Loa (eye worm) hypothetical protein 0.0074 0.047 0.0536
Echinococcus granulosus calpain 0.0022 0.0056 0.0062
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.3299 0.3675
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0198 0.1471 0.1638
Mycobacterium tuberculosis Probable exported protein 0.002 0.0036 0.0086
Plasmodium vivax importin-beta 2, putative 0.0028 0.0107 0.0327
Schistosoma mansoni smad1 5 8 and 0.0025 0.0078 0.008
Echinococcus multilocularis cpg binding protein 0.0034 0.0149 0.0166
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0179 0.02
Schistosoma mansoni carbon catabolite repressor protein 0.002 0.0036 0.0033
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0101 0.0687 0.0781
Brugia malayi hypothetical protein 0.0149 0.1075 0.1223
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0159 0.1159 0.1284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0198 0.1471 0.1632
Entamoeba histolytica hypothetical protein 0.0041 0.0211 0.3178
Plasmodium falciparum exodeoxyribonuclease III, putative 0.002 0.0036 0.0086
Trypanosoma cruzi mitochondrial protein 99, putative 0.002 0.0036 0.0209
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0177 0.1301 0.145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0163 0.1189 0.1353
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0298 0.1851
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0036 0.0209
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0011 0.0012
Schistosoma mansoni ap endonuclease 0.0097 0.0658 0.0726
Leishmania major hypothetical protein, conserved 0.002 0.0036 0.0209
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0078 0.008
Echinococcus granulosus prolyl endopeptidase 0.0131 0.0934 0.104
Echinococcus granulosus neutral sphingomyelinase 0.002 0.0036 0.004
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.002 0.0036 0.051
Echinococcus granulosus Smad4 0.0025 0.0078 0.0087
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0934 0.1033
Trichomonas vaginalis ran, putative 0.0021 0.0047 0.0011
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0687 0.0765
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0144 0.2158
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.002 0.0036 0.0209
Schistosoma mansoni gabp alpha 0.0083 0.0542 0.0597
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0056 0.0334
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0211 0.0235
Echinococcus multilocularis carbonic anhydrase 0.0101 0.0687 0.0765
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0658 0.2199
Loa Loa (eye worm) hypothetical protein 0.0043 0.0225 0.0256
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.002 0.0036 0.0038
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0101 0.0687 0.0783

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 14.47 ug ml-1 Inhibition of Escherichia coli Beta-ketoacyl-ACP synthase III expressed in Escherichia coli BL21 (DE3) by liquid scintillation counting ChEMBL. 19884012
Ki (binding) = 0.43 uM Inhibition of human recombinant carbonic anhydrase 12-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 3.6 uM Inhibition of human recombinant carbonic anhydrase 2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) = 4.35 uM Inhibition of human recombinant carbonic anhydrase 9-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Ki (binding) > 100 uM Inhibition of human recombinant carbonic anhydrase 1-mediated CO2 hydration preincubated for 15 mins by stopped-flow assay ChEMBL. 24189056
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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