Detailed information for compound 1132812

Basic information

Technical information
  • TDR Targets ID: 1132812
  • Name: N4-(4-bromo-2-methylphenyl)-5-nitrosopyrimidi ne-2,4,6-triamine
  • MW: 323.149 | Formula: C11H11BrN6O
  • H donors: 3 H acceptors: 3 LogP: 2.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Nc1c(nc(nc1N)N)Nc1ccc(cc1C)Br
  • InChi: 1S/C11H11BrN6O/c1-5-4-6(12)2-3-7(5)15-10-8(18-19)9(13)16-11(14)17-10/h2-4H,1H3,(H5,13,14,15,16,17)
  • InChiKey: FOQHVFBOCWDLSX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N4-(4-bromo-2-methyl-phenyl)-5-nitroso-pyrimidine-2,4,6-triamine
  • (4-bromo-2-methyl-phenyl)-(2,6-diamino-5-nitroso-pyrimidin-4-yl)amine
  • 6971-59-1
  • NCIOpen2_008341
  • NSC 66578
  • NSC66578
  • 2,4,6-Pyrimidinetriamine, N4-(4-bromo-2-methylphenyl)-5-nitroso-
  • AIDS-028999
  • AIDS028999

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0054 0.3431 0.3377
Echinococcus granulosus GPCR family 2 0.0019 0.0926 0.1636
Echinococcus granulosus bloom syndrome protein 0.0029 0.1637 0.3934
Trypanosoma brucei unspecified product 0.0016 0.0713 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.1231 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.1231 0.579
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0894
Echinococcus granulosus dna polymerase eta 0.0054 0.3431 0.9729
Schistosoma mansoni DNA helicase recq1 0.0012 0.042 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.3869 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.3431 0.9762
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.1231 0.3034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0926 0.1636
Schistosoma mansoni hypothetical protein 0.0019 0.0926 0.2635
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.1231 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.2281 0.6568
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Loa Loa (eye worm) hypothetical protein 0.0041 0.2507 0.2446
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1637 0.4107
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0926 0.1636
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.3514 0.9063
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.3431 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.042 0.0341
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.1231 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.3869 0.3819
Loa Loa (eye worm) hypothetical protein 0.0019 0.0926 0.0852
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.042 0.0341
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.1231 0.3432
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0926 0.2231
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.2507 0.6404
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.3431 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0926 0.1636
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0949 0.416
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Leishmania major DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1637 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.1231 0.579
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0081 0.0231
Echinococcus granulosus dna polymerase kappa 0.0023 0.1231 0.262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.3514 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.1637 0.1569
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.3514 1
Leishmania major DNA polymerase eta, putative 0.0054 0.3431 1
Schistosoma mansoni hypothetical protein 0.0041 0.2507 0.7134
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0926 0.2231
Leishmania major DNA polymerase eta, putative 0.0038 0.2281 0.6568
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0966 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.1201 0.3417
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1637 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.3514 0.3461
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Echinococcus multilocularis dna polymerase kappa 0.0023 0.1231 0.262
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0713 0.1887
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.1385 1
Loa Loa (eye worm) hypothetical protein 0.006 0.3869 0.3819
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.3514 1
Trypanosoma brucei unspecified product 0.0016 0.0713 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Trypanosoma brucei unspecified product 0.0023 0.1231 0.3432
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.1231 0.3501
Schistosoma mansoni hypothetical protein 0.0019 0.0926 0.2635
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0926 0.0852
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.042 0.2596
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.2281 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.1231 0.1159
Schistosoma mansoni DNA helicase recq5 0.0012 0.042 0.1194
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0671 0.1762
Schistosoma mansoni hypothetical protein 0.0019 0.0926 0.2635
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.3869 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.1231 0.3432
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.1231 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.3431 0.8842
Echinococcus multilocularis GPCR, family 2 0.0019 0.0926 0.1636
Giardia lamblia DINP protein human, muc B family 0.0023 0.1231 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.262
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0007 0.0081 0.0355
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.1231 0.262
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0671 0.5456
Schistosoma mansoni hypothetical protein 0.0019 0.0926 0.2635
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.1231 0.3432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.1231 0.3501
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.042 0.2945
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1637 0.3934
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0081 0.0355
Echinococcus multilocularis dna polymerase eta 0.0054 0.3431 0.9729
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.042 0.184
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0926 0.1636

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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