Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.2366 | 0.1922 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0377 | 0.0233 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0377 | 0.0233 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.58 | 0.5556 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.54 | 0.5219 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.2772 | 0.2489 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.1809 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4368 | 0.5807 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.2144 | 0.257 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.0548 | 0.0249 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.0548 | 0.5 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0435 | 0.006 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.2164 | 0.2599 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1113 | 0.0597 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.7251 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.0548 | 0.0249 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0613 | 0.0344 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.2535 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.0548 | 0.0477 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.4368 | 0.5807 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0377 | 0.0233 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.0548 | 0.0249 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.7251 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.9714 | 0.9702 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.9714 | 0.9697 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.2144 | 0.257 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.2164 | 0.2772 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0891 | 0.0748 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0019 | 0.0377 | 0.0233 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.2164 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0891 | 0.0963 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2594 | 0.2303 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0891 | 0.0748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.2372 | 0.2073 |
Trypanosoma brucei | ISWI complex protein | 0.0017 | 0.0213 | 0.0984 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.0548 | 0.0249 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0548 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0548 | 0.0178 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0712 | 0.0709 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.4703 | 0.638 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.2164 | 0.2599 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.7251 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.7251 | 0.7143 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.2535 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.7251 | 0.7091 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.2164 | 0.2772 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.172 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.0548 | 0.172 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.7251 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.0548 | 0.0249 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.2164 | 0.1856 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.0548 | 0.0178 |
Brugia malayi | Inositol-1 | 0.004 | 0.2164 | 0.1709 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.2164 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.7251 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.2164 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.0548 | 0.0477 |
Onchocerca volvulus | Huntingtin homolog | 0.0132 | 1 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0712 | 0.0348 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.2164 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.0548 | 0.172 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.0548 | 0.0477 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.9714 | 0.9702 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0613 | 0.0344 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.1809 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.0548 | 0.2535 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.2164 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0613 | 0.0569 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 4000 uM | Activation of chloride ion uptake into mouse brain synaptoneurosomes, no net uptake at 4 nM | ChEMBL. | 12113824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.