Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0617 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0947 | 0.1287 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0617 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0947 | 0.1188 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.4951 | 0.6727 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0617 | 0.0838 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.3258 | 0.4427 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4951 | 0.6206 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1407 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1407 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1407 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0106 | 0.0114 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1407 | 0.0842 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0617 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0617 | 0.0773 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0617 | 0.0838 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0617 | 0.0773 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1407 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3667 | 0.325 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0618 | 0.0667 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4951 | 0.6206 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9262 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0617 | 0.0666 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.4951 | 0.4619 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.736 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0617 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.3258 | 0.4427 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1407 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0617 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1407 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1407 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.4951 | 0.5346 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0617 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1407 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.4951 | 0.6727 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1407 | 0.1519 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.7978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4417 | 0.4769 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0435 | 0.0592 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0617 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0617 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.736 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.4951 | 0.6206 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.4951 | 0.6727 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0435 | 0.0592 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.1356 | 0.0788 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.4951 | 0.6727 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0618 | 0.0774 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0435 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4087 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3679 | 0.3972 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0947 | 0.1287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0282 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.