Detailed information for compound 1133520

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.294 | Formula: C14H10F3NO4S
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C/1\SC(=O)N(C1=O)CC(=O)C(F)(F)F
  • InChi: 1S/C14H10F3NO4S/c1-22-9-4-2-8(3-5-9)6-10-12(20)18(13(21)23-10)7-11(19)14(15,16)17/h2-6H,7H2,1H3/b10-6-
  • InChiKey: GLTPTVQBEPWMEX-POHAHGRESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Onchocerca volvulus 0.0038 0.344 0.5
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.344 0.4503
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Trypanosoma cruzi aldo-keto reductase 0.0038 0.344 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0717 0.0575
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0294 0.0366
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.344 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.5099 0.6345
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.7638 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.344 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.7437 0.9727
Echinococcus granulosus aldehyde reductase 0.0027 0.1701 0.1916
Loa Loa (eye worm) hypothetical protein 0.0041 0.3864 0.3972
Leishmania major prostaglandin f synthase, putative 0.0038 0.344 0.4503
Loa Loa (eye worm) hypothetical protein 0.0043 0.4261 0.4413
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.344 0.5
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.3456 0.4306
Schistosoma mansoni pol-related 0.0038 0.344 0.428
Echinococcus granulosus aldo keto reductase 0.0038 0.344 0.4283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Loa Loa (eye worm) oxidoreductase 0.0038 0.344 0.3499
Toxoplasma gondii aldose reductase, putative 0.0038 0.344 0.5
Trypanosoma brucei prostaglandin f synthase 0.0038 0.344 1
Schistosoma mansoni aldo-keto reductase 0.0038 0.344 0.428
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.7638 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.7638 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.5099 0.4159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0294 0.0366
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.344 1
Loa Loa (eye worm) oxidoreductase 0.0038 0.344 0.3499
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.6951 0.7405
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.5099 0.6543
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.5099 0.6543
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Schistosoma mansoni bromodomain containing protein 0.0068 0.8037 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.344 0.5
Echinococcus granulosus hypothetical protein 0.0038 0.344 0.4283
Onchocerca volvulus 0.0038 0.344 0.5
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.344 0.2181
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.7638 1
Onchocerca volvulus 0.0038 0.344 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Loa Loa (eye worm) hypothetical protein 0.0046 0.4581 0.4769
Brugia malayi Bromodomain containing protein 0.0041 0.3853 0.2673
Echinococcus multilocularis aldo keto reductase 0.0038 0.344 0.4283
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.5099 0.6543
Giardia lamblia Aldose reductase 0.0038 0.344 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.7638 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.7437 0.9727
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.5099 0.6543
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Leishmania major aldo-keto reductase-like protein 0.0038 0.344 0.4503
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Entamoeba histolytica aldose reductase, putative 0.0038 0.344 0.5
Onchocerca volvulus 0.0038 0.344 0.5
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.1214 0.151
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus granulosus aldo keto reductase 0.0038 0.344 0.4283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.5099 0.5346
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.1214 0.1252
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0397 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0294 0.0366
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.344 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.344 0.2181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.5099 0.6345
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.344 0.5
Loa Loa (eye worm) hypothetical protein 0.0076 0.9283 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0294 0.0366
Schistosoma mansoni zinc finger protein 0.0021 0.0717 0.0891
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.344 0.2181
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.5099 0.6345
Onchocerca volvulus 0.0038 0.344 0.5
Echinococcus multilocularis aldo keto reductase 0.0038 0.344 0.4283
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Loa Loa (eye worm) oxidoreductase 0.0038 0.344 0.3499
Echinococcus granulosus zinc finger protein 0.0021 0.0717 0.0575
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.344 0.2181
Entamoeba histolytica aldose reductase, putative 0.0038 0.344 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.344 0.3499
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.1214 0.1252
Schistosoma mansoni hypothetical protein 0.0022 0.0894 0.1112
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.7638 0.7184
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.7638 0.9503
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Giardia lamblia Aldose reductase 0.0038 0.344 0.5
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.344 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.344 1
Schistosoma mansoni aldo-keto reductase 0.0038 0.344 0.428
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.344 0.4503
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.3456 0.4306
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Entamoeba histolytica aldose reductase, putative 0.0038 0.344 0.5
Loa Loa (eye worm) oxidoreductase 0.0038 0.344 0.3499
Loa Loa (eye worm) hypothetical protein 0.0038 0.344 0.3499
Echinococcus multilocularis aldo keto reductase 0.0038 0.344 0.4283
Echinococcus multilocularis aldo keto reductase 0.0038 0.344 0.4283
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.344 0.4283
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.344 0.4283
Echinococcus granulosus aldo keto reductase 0.0038 0.344 0.4283
Echinococcus multilocularis aldehyde reductase 0.0027 0.1701 0.1916
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.7638 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.344 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0894 0.0667
Onchocerca volvulus 0.0038 0.344 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17.4 uM Inhibition of bovine lens aldose reductase ChEMBL. 20452228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.