Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.1632 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.1632 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.2997 | 0.3898 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0102 | 0.0133 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.1632 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.1632 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1632 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.1632 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7689 | 0.7239 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.1632 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.2997 | 0.2925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7689 | 0.7239 |
Schistosoma mansoni | lamin | 0.0026 | 0.2997 | 0.1632 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7689 | 0.7665 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2895 | 0.3765 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.7689 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7689 | 0.7665 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.2997 | 0.3564 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.1632 | 0.169 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.1632 | 0.5 |
Onchocerca volvulus | 0.0026 | 0.2997 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.2997 | 0.2925 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.1632 | 0.1545 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.1632 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.7689 | 0.7665 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.1632 | 0.2122 |
Onchocerca volvulus | 0.0026 | 0.2997 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.7689 | 0.7665 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.2997 | 0.3564 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.2997 | 0.2925 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.7689 | 0.7239 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.2997 | 0.1632 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.2997 | 0.3898 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0399 | 0.052 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.1632 | 0.1545 |
Echinococcus multilocularis | lamin | 0.0026 | 0.2997 | 0.2925 |
Schistosoma mansoni | lamin | 0.0026 | 0.2997 | 0.1632 |
Echinococcus granulosus | lamin | 0.0026 | 0.2997 | 0.2925 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.7689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2997 | 0.3898 |
Echinococcus multilocularis | musashi | 0.0026 | 0.2997 | 0.2925 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1632 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.1632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1350 nM | Functional activity against adenosine A2a receptor from rat aorta. | ChEMBL. | 7739005 |
EC50 (functional) | > 10 uM | Functional activity against adenosine A1 receptor from rat atria. | ChEMBL. | 7739005 |
Ki (binding) | = 743 nM | Binding affinity against adenosine A2a receptor from rat striatum using [3H]-CGS- 21680 as a radioligand. | ChEMBL. | 7739005 |
Ki (binding) | > 10 uM | Binding affinity against adenosine A1 receptor from rat brain using [3H]-CHA as a radioligand. | ChEMBL. | 7739005 |
Potency ratio (functional) | = 0.009 | Anti-aggregatory activity against adenosine A2A receptor from rabbit platelets. Potency ratio was reported with reference to the NECA IC50 of 0.2 uM. | ChEMBL. | 7739005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.