Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.0058 | 0.6005 | 0.8295 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3818 | 0.4014 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.6005 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.5463 | 0.4979 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.6005 | 0.6434 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.7886 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.0058 | 0.6005 | 0.6434 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.724 | 1 |
Echinococcus granulosus | protein kinase shaggy | 0.0058 | 0.6005 | 0.8295 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.6005 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.3378 | 0.2673 |
Trypanosoma brucei | protein kinase, putative | 0.0058 | 0.6005 | 0.5 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.0058 | 0.6005 | 0.7615 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0058 | 0.6005 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.0058 | 0.6005 | 0.5 |
Giardia lamblia | Kinase, CMGC GSK | 0.0058 | 0.6005 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.5463 | 0.4979 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5463 | 0.5833 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0191 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.9228 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.2617 | 0.183 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.0058 | 0.6005 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.724 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.6005 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.2617 | 0.2684 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0535 | 0.0739 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.0058 | 0.6005 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0535 | 0.0679 |
Onchocerca volvulus | 0.0058 | 0.6005 | 0.5 | |
Echinococcus multilocularis | protein kinase shaggy | 0.0058 | 0.6005 | 0.8295 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.2951 | 0.4076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.5463 | 0.5833 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0535 | 0.0739 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6005 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.3391 | 0.3541 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.2951 | 0.4076 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.0058 | 0.6005 | 0.8295 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.0058 | 0.6005 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.2617 | 0.3318 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4163 | 0.4395 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.0058 | 0.6005 | 0.5 |
Brugia malayi | intracellular kinase | 0.0058 | 0.6005 | 0.558 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0058 | 0.6005 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of PKCalpha | ChEMBL. | 20138512 | |
IC50 (binding) | = 730 nM | Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting | ChEMBL. | 20138512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.