TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 629.109 | Formula: C30H32ClN3O8S
H donors: 1 H acceptors: 5 LogP: 3.35 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(O[11CH3])ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl
InChi: 1S/C30H32ClN3O8S/c1-32(2)28(36)24-15-19(35)17-33(24)30(21-8-6-7-9-25(21)41-4)22-14-18(31)10-12-23(22)34(29(30)37)43(38,39)27-13-11-20(40-3)16-26(27)42-5/h6-14,16,19,24,35H,15,17H2,1-5H3/t19-,24+,30+/m1/s1/i3-1
InChiKey: NJXZWIIMWNEOGJ-BHWIVFNJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	heat shock protein, putative	0.0132	0.0224	0.4321
Loa Loa (eye worm)	endoplasmin	0.0141	0.0242	0.024
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0053	0.0051
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0077	0.0116	0.0114
Plasmodium falciparum	heat shock protein 90, putative	0.0533	0.1024	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Brugia malayi	TATA binding protein associated factor	0.0267	0.0495	0.1081
Echinococcus granulosus	thioredoxin glutathione reductase	0.0077	0.0116	0.0114
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0026	0.0014	1
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0267	0.0495	0.0493
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.0267	0.0495	0.4821
Toxoplasma gondii	NADPH-glutathione reductase	0.0026	0.0014	0.012
Echinococcus granulosus	microtubule associated protein 2	0.068	0.1319	0.1317
Plasmodium falciparum	heat shock protein 90, putative	0.0082	0.0124	0.1198
Brugia malayi	Endoplasmin precursor	0.0141	0.0242	0.0528
Loa Loa (eye worm)	glutathione reductase	0.0076	0.0114	0.0112
Brugia malayi	Peptidase family M1 containing protein	0.0267	0.0495	0.1081
Trichomonas vaginalis	heat shock protein, putative	0.0082	0.0124	0.2377
Echinococcus multilocularis	heat shock protein	0.0141	0.0242	0.024
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0026	0.0014	0.025
Plasmodium falciparum	heat shock protein 90	0.0141	0.0242	0.2347
Echinococcus granulosus	geminin	0.016	0.0281	0.0279
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0093	0.0148	0.2958
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0267	0.0495	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0267	0.0495	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0026	0.0014	0.012
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.025
Trypanosoma brucei	trypanothione reductase	0.0076	0.0114	0.227
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0267	0.0495	1
Toxoplasma gondii	aminopeptidase N, putative	0.0267	0.0495	0.4821
Echinococcus multilocularis	microtubule associated protein 2	0.068	0.1319	0.1317
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0346	0.6672
Entamoeba histolytica	aminopeptidase, putative	0.0267	0.0495	1
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.503	1	1
Schistosoma mansoni	endoplasmin	0.0141	0.0242	0.024
Trypanosoma cruzi	heat shock protein 90, putative	0.012	0.0201	0.4046
Echinococcus granulosus	heat shock protein 90	0.0141	0.0242	0.024
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Loa Loa (eye worm)	TAR-binding protein	0.0194	0.0349	0.0347
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Echinococcus granulosus	aminopeptidase N	0.0267	0.0495	0.0493
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0026	0.0014	0.025
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0026	0.0014	0.012
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0267	0.0495	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.0012
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0053	0.0115
Trypanosoma brucei	heat shock protein 90, putative	0.0141	0.0242	0.4868
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0053	0.0051
Trichomonas vaginalis	heat shock protein, putative	0.0141	0.0242	0.4655
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0279	0.0517	0.113
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.503	1	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0267	0.0495	1
Plasmodium vivax	heat shock protein 90, putative	0.0093	0.0148	0.1426
Schistosoma mansoni	hypothetical protein	0.016	0.0281	0.0279
Onchocerca volvulus	Glucosylceramidase homolog	0.0183	0.0326	0.6579
Brugia malayi	RNA recognition motif domain containing protein	0.0194	0.0349	0.0762
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0026	0.0014	0.025
Brugia malayi	kinase, mitochondrial precursor	0.002	0.0002	0.0004
Echinococcus granulosus	tar DNA binding protein	0.0194	0.0349	0.0347
Trichomonas vaginalis	endoplasmin, putative	0.0102	0.0165	0.3163
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.0349	0.0347
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0267	0.0495	0.0493
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0093	0.0148	0.0146
Plasmodium vivax	heat shock protein 86, putative	0.0141	0.0242	0.2347
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0053	0.0051
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Leishmania major	trypanothione reductase	0.0076	0.0114	0.227
Toxoplasma gondii	heat shock protein 75, putative	0.0093	0.0148	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0495	0.0493
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Giardia lamblia	Heat shock protein HSP 90-alpha	0.012	0.0201	0.8311
Schistosoma mansoni	heat shock protein	0.0141	0.0242	0.024
Trypanosoma cruzi	Heat shock protein 83, putative	0.0141	0.0242	0.4868
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.0012
Schistosoma mansoni	endoplasmin	0.0141	0.0242	0.024
Onchocerca volvulus		0.0267	0.0495	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.0267	0.0495	0.0493
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0029	0.0064
Trichomonas vaginalis	heat shock protein, putative	0.0132	0.0224	0.4321
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0089	0.0139	0.0137
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0026	0.0014	0.025
Plasmodium vivax	thioredoxin reductase, putative	0.0076	0.0114	0.1094
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0279	0.0517	0.0515
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0267	0.0495	1
Schistosoma mansoni	hypothetical protein	0.016	0.0281	0.0279
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0174	0.0309	0.8879
Loa Loa (eye worm)	RNA binding protein	0.0194	0.0349	0.0347
Brugia malayi	TAR-binding protein	0.0194	0.0349	0.0762
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0053	0.0051
Brugia malayi	RNA binding protein	0.0194	0.0349	0.0762
Echinococcus granulosus	heat shock protein 90	0.012	0.0201	0.0199
Loa Loa (eye worm)	hypothetical protein	0.005	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0028
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trypanosoma cruzi	heat shock protein 90, putative	0.0059	0.0079	0.156
Schistosoma mansoni	hypothetical protein	0.0034	0.0029	0.0028
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Toxoplasma gondii	heat shock protein HSP90	0.0141	0.0242	0.2347
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0076	0.0114	0.3234
Mycobacterium tuberculosis	Probable oxidoreductase	0.0194	0.0348	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0267	0.0495	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0174	0.0309	0.8879
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0053	0.0051
Trypanosoma brucei	Aminopeptidase M1, putative	0.0267	0.0495	1
Brugia malayi	Hsp90 protein	0.0093	0.0148	0.0322
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0495	0.0493
Brugia malayi	Peptidase family M1 containing protein	0.0267	0.0495	0.1081
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Loa Loa (eye worm)	hypothetical protein	0.0267	0.0495	0.0493
Trypanosoma cruzi	aminopeptidase, putative	0.0267	0.0495	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0174	0.0309	0.8879
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0026	0.0014	0.0513
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0267	0.0495	0.0493
Loa Loa (eye worm)	heat shock protein 75	0.0093	0.0148	0.0146
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Trypanosoma cruzi	heat shock protein 85, putative	0.0141	0.0242	0.4868
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.002	0.0002	0.0004
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Trypanosoma cruzi	heat shock protein 85, putative	0.0141	0.0242	0.4868
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0267	0.0495	0.0493
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0053	0.0051
Plasmodium vivax	heat shock protein, putative	0.0533	0.1024	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0061	0.0059
Brugia malayi	heat shock protein 90	0.0141	0.0242	0.0528
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0132	0.0224	1
Toxoplasma gondii	heat shock protein 90, putative	0.0141	0.0242	0.2347
Schistosoma mansoni	heat shock protein	0.0141	0.0242	0.024
Plasmodium vivax	glutathione reductase, putative	0.0076	0.0114	0.1094
Brugia malayi	hypothetical protein	0.0267	0.0495	0.1081
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0026	0.0014	0.012
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0194	0.0348	1
Plasmodium vivax	endoplasmin, putative	0.0141	0.0242	0.2347
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0267	0.0495	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Trichomonas vaginalis	heat shock protein, putative	0.012	0.0201	0.3869
Echinococcus granulosus	endoplasmin	0.0132	0.0224	0.0223
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Trypanosoma cruzi	heat shock protein 85, putative	0.012	0.0201	0.4046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Mycobacterium ulcerans	aminopeptidase N PepN	0.0267	0.0495	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0026	0.0014	0.012
Schistosoma mansoni	heat shock protein	0.0093	0.0148	0.0146
Trypanosoma brucei	Aminopeptidase M1, putative	0.0267	0.0495	1
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0093	0.0148	0.0146
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.0349	0.0347
Trypanosoma brucei	aminopeptidase, putative	0.0267	0.0495	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0089	0.0139	0.0137
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0026	0.0014	0.0356
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Echinococcus granulosus	heat shock protein	0.0141	0.0242	0.024
Trypanosoma brucei	heat shock protein 90, putative	0.0141	0.0242	0.4868
Echinococcus multilocularis	tar DNA binding protein	0.0194	0.0349	0.0347
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0132	0.0224	0.6438
Brugia malayi	hypothetical protein	0.0267	0.0495	0.1081
Brugia malayi	hypothetical protein	0.2313	0.4577	1
Mycobacterium ulcerans	heat shock protein 90	0.0132	0.0224	0.4519
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0267	0.0495	0.4821
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Plasmodium falciparum	glutathione reductase	0.0076	0.0114	0.1094
Giardia lamblia	Grp94/Hsp90	0.0132	0.0224	0.9282
Echinococcus multilocularis	aminopeptidase N	0.0267	0.0495	0.0493
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0132	0.0224	0.6438
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0026	0.0014	0.025
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.025
Trypanosoma cruzi	heat shock protein, putative	0.0093	0.0148	0.2958
Mycobacterium tuberculosis	Probable dehydrogenase	0.0174	0.0309	0.8879
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Echinococcus multilocularis	endoplasmin	0.0132	0.0224	0.0223
Leishmania major	heat shock protein, putative	0.0093	0.0148	0.2958
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0026	0.0014	0.0031
Plasmodium falciparum	thioredoxin reductase	0.0076	0.0114	0.1094
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0026	0.0014	0.025
Trichomonas vaginalis	glucosylceramidase, putative	0.0193	0.0346	0.6672
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0267	0.0495	0.0493
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0061	0.0133
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0141	0.0242	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Toxoplasma gondii	aminopeptidase N protein	0.0267	0.0495	0.4821
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0267	0.0495	0.9562
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0026	0.0014	0.025
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Echinococcus multilocularis	geminin	0.016	0.0281	0.0279
Trichomonas vaginalis	mercuric reductase, putative	0.0026	0.0014	0.0239
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0267	0.0495	0.9562
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0267	0.0495	0.0493
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0267	0.0495	1
Mycobacterium tuberculosis	Probable reductase	0.0174	0.0309	0.8879
Toxoplasma gondii	aminopeptidase n, putative	0.0267	0.0495	0.4821
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0194	0.0348	1
Entamoeba histolytica	heat shock protein 90, putative	0.0141	0.0242	0.4868
Trypanosoma cruzi	trypanothione reductase, putative	0.0026	0.0014	0.025
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Treponema pallidum	NADH oxidase	0.0026	0.0014	0.0552
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0267	0.0495	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0533	0.1024	1
Loa Loa (eye worm)	thioredoxin reductase	0.0076	0.0114	0.0112
Treponema pallidum	heat shock protein 90	0.0132	0.0224	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0053	0.0051
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0061	0.0133
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0132	0.0224	0.4519
Trichomonas vaginalis	heat shock protein, putative	0.0102	0.0165	0.3163
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0026	0.0014	0.0552
Trypanosoma cruzi	aminopeptidase, putative	0.0267	0.0495	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0194	0.0349	0.0347
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0026	0.0014	0.0552
Brugia malayi	glutathione reductase	0.0076	0.0114	0.0248
Schistosoma mansoni	microtubule-associated protein tau	0.068	0.1319	0.1317
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0194	0.0348	1
Onchocerca volvulus		0.0267	0.0495	1
Plasmodium falciparum	endoplasmin, putative	0.0102	0.0165	0.1595
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.025
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.503	1	1
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0267	0.0495	1
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.0267	0.0495	0.4821
Brugia malayi	Thioredoxin reductase	0.0076	0.0114	0.0248
Echinococcus multilocularis	heat shock protein 90	0.0141	0.0242	0.024
Trypanosoma brucei	Heat shock protein 83, putative	0.0141	0.0242	0.4868
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0174	0.0309	0.8879
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0014	0.025
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0174	0.0309	0.8879
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0026	0.0014	0.012
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.0267	0.0495	0.4821
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.0349	0.0347
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Loa Loa (eye worm)	heat shock protein 90	0.0141	0.0242	0.024
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Loa Loa (eye worm)	aminopeptidase N	0.0267	0.0495	0.0493
Trichomonas vaginalis	glucosylceramidase, putative	0.0279	0.0517	1
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0093	0.0148	0.2958
Trypanosoma brucei	heat shock protein, putative	0.0141	0.0242	0.4868
Toxoplasma gondii	thioredoxin reductase	0.0076	0.0114	0.1094
Leishmania major	heat shock protein 83-1	0.0141	0.0242	0.4868
Trichomonas vaginalis	glutathione reductase, putative	0.0026	0.0014	0.0239
Plasmodium falciparum	thioredoxin reductase	0.0026	0.0014	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0053	0.0051
Brugia malayi	Probable DNA topoisomerase II	0.002	0.0002	0.0004
Plasmodium falciparum	glutathione reductase	0.0026	0.0014	0.012
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0026	0.0014	0.025
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.012	0.0201	0.0199
Echinococcus multilocularis	heat shock protein 90	0.012	0.0201	0.0199
Brugia malayi	Peptidase family M1 containing protein	0.0267	0.0495	0.1081
Trypanosoma cruzi	heat shock protein 85, putative	0.0141	0.0242	0.4868
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0026	0.0014	0.0012
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0267	0.0495	0.9562
Trypanosoma cruzi	heat shock protein 90, putative	0.0141	0.0242	0.4868
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.0267	0.0495	1
Entamoeba histolytica	heat shock protein 90, putative	0.0141	0.0242	0.4868
Trichomonas vaginalis	glucosylceramidase, putative	0.0183	0.0326	0.6291
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.002	0.0002	0.0004
Trypanosoma brucei	heat shock protein 84, putative	0.0093	0.0148	0.2958
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0267	0.0495	0.0493
Onchocerca volvulus		0.0267	0.0495	1
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.0349	0.0347
Trypanosoma cruzi	trypanothione reductase, putative	0.0076	0.0114	0.227
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.0349	0.0347

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1098000

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1133767