Detailed information for compound 1133887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.557 | Formula: C24H26FN5O5S
  • H donors: 1 H acceptors: 3 LogP: 1.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)NC[C@@H]1OC(=O)N(C1)c1ccc(c(c1)F)N1CCN(CC1)C(=O)C1ON=C(C1)c1cccs1
  • InChi: 1S/C24H26FN5O5S/c1-15(31)26-13-17-14-30(24(33)34-17)16-4-5-20(18(25)11-16)28-6-8-29(9-7-28)23(32)21-12-19(27-35-21)22-3-2-10-36-22/h2-5,10-11,17,21H,6-9,12-14H2,1H3,(H,26,31)/t17-,21?/m0/s1
  • InChiKey: DWFQBENTUSYNLQ-PBVYKCSPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0215 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0215 0.0497
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.014 0.1272
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0708
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0103 0.0208
Brugia malayi Pre-SET motif family protein 0.0214 0.2388 0.6078
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1102 0.2773
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0103 0.0208
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0916 0.8313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131 0.1343 0.3392
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1102 0.1166
Schistosoma mansoni coup transcription factor 0.0042 0.0215 0.0163
Onchocerca volvulus 0.0106 0.1019 0.3524
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1011 0.2539
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.03 0.1666
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0334 0.3916 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1102 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0621 0.5633
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0144 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0708
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.03 0.1666
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0036
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0196 0.0708
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0312 0.0746
Entamoeba histolytica hypothetical protein 0.0037 0.0151 0.1366
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0215 0.0497
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0708
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.1102 0.1166
Echinococcus granulosus lysosomal alpha glucosidase 0.0182 0.1993 0.2187
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0708
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0506 0.1244
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1011 0.2539
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0074 0.0483
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0621 0.1538
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0144 0.0093
Echinococcus multilocularis FTZ F1 alpha 0.0131 0.1343 0.1281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0334 0.3916 0.4348
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0621 0.0947
Echinococcus granulosus importin subunit beta 1 0.0031 0.0074 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0621 0.0947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0215 0.0497
Echinococcus multilocularis GPCR, family 2 0.0033 0.0103 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.014 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0215 0.0497
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.1775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0215 0.0497
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0215 0.0497
Schistosoma mansoni importin beta-1 0.0031 0.0074 0.0003
Echinococcus multilocularis protein patched 0.0042 0.0217 0.0147
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0196 0.0157
Toxoplasma gondii ABC1 family protein 0.0074 0.0621 1
Brugia malayi AMP-binding enzyme family protein 0.0049 0.03 0.0715
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0621 0.2247
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.03 0.1666
Entamoeba histolytica hypothetical protein 0.0037 0.0151 0.1366
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0119 0.0048
Echinococcus multilocularis tumor protein p63 0.0333 0.39 0.3856
Loa Loa (eye worm) inositol-1 0.0036 0.014 0.0304
Schistosoma mansoni hypothetical protein 0.0041 0.0197 0.0143
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0217 0.0181
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1993 0.1936
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0927 0.2324
Loa Loa (eye worm) hypothetical protein 0.0072 0.059 0.146
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.03 0.1666
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0215 0.0163
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0074 0.0871
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0708
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0144 0.2044
Mycobacterium ulcerans hypothetical protein 0.0074 0.0621 0.4997
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0196 0.0446
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.014 0.0507
Brugia malayi 6-phosphofructokinase 0.0112 0.1102 0.2773
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Onchocerca volvulus 0.0074 0.0621 0.2042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0215 0.0497
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0196 0.1775
Schistosoma mansoni hypothetical protein 0.0729 0.8914 1
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0215 0.0163
Trypanosoma brucei polo-like protein kinase 0.0097 0.0916 0.8279
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0151 0.009
Echinococcus granulosus tumor protein p63 0.0333 0.39 0.4339
Brugia malayi RNA binding protein 0.0065 0.0506 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0215 0.0497
Schistosoma mansoni survival motor neuron protein 0.005 0.0312 0.0273
Onchocerca volvulus 0.0042 0.0215 0.0536
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.03 0.2726
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.1102 0.118
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0215 0.0163
Loa Loa (eye worm) hypothetical protein 0.0098 0.0927 0.2324
Mycobacterium leprae Probable lipase LipE 0.0074 0.0621 0.5234
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0196 0.0708
Echinococcus multilocularis expressed conserved protein 0.0092 0.0851 0.0786
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.03 0.2726
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0715
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Schistosoma mansoni alpha-glucosidase 0.0157 0.1672 0.181
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0196 0.2901
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Loa Loa (eye worm) hypothetical protein 0.0244 0.2769 0.7056
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.014 0.1272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0215 0.0497
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0506 0.0439
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.1102 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0119 0.0048
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0215 0.0497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0151 0.0106
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0074 0.0483
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0196 0.1775
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0215 0.0145
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.146 0.1585
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0215 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0506 0.0492
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.0916 0.3139
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0215 0.0179
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.1102 0.2773
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Entamoeba histolytica hypothetical protein 0.0037 0.0151 0.1366
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0715
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0036
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.1102 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.2388 0.6078
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0506 0.0492
Brugia malayi phosphofructokinase 0.0112 0.1102 0.2773
Brugia malayi Inositol-1 0.0036 0.014 0.0304
Echinococcus granulosus snurportin 1 0.033 0.3858 0.4292
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.1102 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.014 0.007
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.0126
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.5566 0.5535
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0621 0.5633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0334 0.3916 0.4348
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0052
Loa Loa (eye worm) hypothetical protein 0.0131 0.1343 0.3392
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0621 0.0554
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0215 0.0497
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Trypanosoma brucei glucosidase, putative 0.004 0.0196 0.1609
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0217 0.05
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0215 0.0179
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0916 0.0955
Brugia malayi nuclear receptor NHR-88 0.0042 0.0215 0.0497
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0215 0.0179
Loa Loa (eye worm) hypothetical protein 0.0049 0.03 0.0715
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Schistosoma mansoni hypothetical protein 0.005 0.0312 0.0273
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.1102 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0071 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0208
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0215 0.0163
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0621 0.5545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0215 0.0179
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.1102 0.1038
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0215 0.0536
Loa Loa (eye worm) hypothetical protein 0.0105 0.1011 0.2539
Loa Loa (eye worm) beta-lactamase 0.0074 0.0621 0.1538
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.2769 0.2718
Brugia malayi hypothetical protein 0.0162 0.1733 0.4394
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0196 0.1775
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0621 0.2247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.03 0.0373
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0621 0.5234
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Schistosoma mansoni hypothetical protein 0.0041 0.0197 0.0143
Schistosoma mansoni alpha-glucosidase 0.0157 0.1672 0.181
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0215 0.0163
Schistosoma mansoni hypothetical protein 0.0041 0.0197 0.0143
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0215 0.0145
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0215 0.0145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0119 0.0048
Mycobacterium ulcerans beta-lactamase 0.0074 0.0621 0.4997
Echinococcus granulosus neuropeptide s receptor 0.0465 0.5566 0.6221
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0215 0.0497
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0293 0.1061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0144 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0215 0.0497
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.0916 0.097
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1102 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0314
Trichomonas vaginalis set domain proteins, putative 0.0243 0.2762 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0066 0.074
Brugia malayi CHE-14 protein 0.0042 0.0217 0.05
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.5566 0.6221
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.0916 0.8313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0215 0.0497
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0334 0.3916 0.4357
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.1993 0.5063
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0215 0.0497
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.014 0.1976
Plasmodium vivax importin-beta 2, putative 0.0031 0.0074 0.0871
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0506 0.0492
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0946 0.099
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0215 0.0163
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0215 0.0536
Schistosoma mansoni alpha glucosidase 0.004 0.0196 0.0141
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0215 0.0163
Onchocerca volvulus 0.005 0.0312 0.0897
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0052
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.1102 1
Plasmodium falciparum importin beta, putative 0.0031 0.0074 0.4262
Brugia malayi hypothetical protein 0.0037 0.0151 0.0331
Echinococcus granulosus FTZ F1 alpha 0.0461 0.5524 0.6173
Schistosoma mansoni patched 1 0.0042 0.0217 0.0165
Brugia malayi nuclear hormone receptor 0.0042 0.0215 0.0497
Brugia malayi steroid hormone receptor 0.0042 0.0215 0.0497
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0066 0.074
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1102 0.3988
Brugia malayi AMP-binding enzyme family protein 0.0049 0.03 0.0715
Onchocerca volvulus 0.0049 0.03 0.0851
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0334 0.3916 0.4357
Schistosoma mansoni inositol monophosphatase 0.0036 0.014 0.0078
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0621 0.0947
Schistosoma mansoni hypothetical protein 0.0072 0.059 0.0588
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.03 0.1666
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0621 0.0947
Schistosoma mansoni hypothetical protein 0.0089 0.081 0.0836
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0103 0.0032
Onchocerca volvulus 0.0074 0.0621 0.2042
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.059 0.146
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1102 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0621 0.4997
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0215 0.0163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0151 0.008
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0066 0.074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0314
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0066 0.0239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0215 0.0145
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0066 0.3621
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0621 0.4997
Onchocerca volvulus 0.0243 0.2762 1
Giardia lamblia Kinase, PLK 0.0097 0.0916 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Schistosoma mansoni hypothetical protein 0.0041 0.0197 0.0143
Schistosoma mansoni kinase 0.0049 0.0309 0.027
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0215 0.0536
Mycobacterium ulcerans lipase LipD 0.0074 0.0621 0.4997
Schistosoma mansoni hypothetical protein 0.0037 0.0151 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.03 0.2726
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0119 0.0048
Brugia malayi ecdysteroid receptor 0.0042 0.0215 0.0497
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0066 0.074
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.014 0.1272
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0215 0.0163
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.014 0.1272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0215 0.0497
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0196 0.1775
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0927 0.0862
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0131 0.1343 0.1452
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0217 0.0181
Loa Loa (eye worm) hypothetical protein 0.0052 0.0337 0.0809
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.5674 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0506 0.0492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0621 0.0622
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.03 0.2062
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.1102 1
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0196 0.0708
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.014 0.1096
Echinococcus granulosus expressed conserved protein 0.0092 0.0851 0.0897
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0314
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0217 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0334 0.3916 0.3872
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.5566 0.5535
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Loa Loa (eye worm) phosphofructokinase 0.0112 0.1102 0.2773
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0144 1
Leishmania major hypothetical protein, conserved 0.0074 0.0621 0.5633
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0066 0.074
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0621 0.2247
Brugia malayi AMP-binding enzyme family protein 0.0049 0.03 0.0715
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.0916 0.2296
Trichomonas vaginalis esterase, putative 0.0074 0.0621 0.2247
Echinococcus multilocularis geminin 0.0729 0.8914 0.8906
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.0916 0.2296
Loa Loa (eye worm) RNA binding protein 0.0065 0.0506 0.1244
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0074 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0621 0.0947
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0293 0.1061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Echinococcus multilocularis protein dispatched 1 0.0048 0.0292 0.0223
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.0916 0.8313
Schistosoma mansoni hypothetical protein 0.0033 0.0103 0.0036
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.0916 0.8313
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.0916 0.0851
Echinococcus granulosus geminin 0.0729 0.8914 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0506 0.1244
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0215 0.0179
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.3858 0.9853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0334 0.3916 0.4348
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.03 0.2726
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0103 0.0208
Schistosoma mansoni hypothetical protein 0.033 0.3858 0.4283
Plasmodium vivax SET domain protein, putative 0.0031 0.0071 0.082
Brugia malayi beta-lactamase family protein 0.0074 0.0621 0.1538
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.03 0.0373
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.03 0.2726
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0215 0.0497
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0131 0.1343 0.1281
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0066 0.3621
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0215 0.0163
Echinococcus granulosus tar DNA binding protein 0.0065 0.0506 0.0508
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1102 0.3988
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.03 0.0259
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0621 0.0637
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.03 0.1666
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0334 0.3916 0.3872
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.1993 0.5063
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0621 0.1538
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.014 0.5
Echinococcus granulosus GPCR family 2 0.0033 0.0103 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1102 0.3988
Entamoeba histolytica hypothetical protein 0.0037 0.0151 0.1366
Echinococcus multilocularis lysosomal alpha glucosidase 0.0182 0.1993 0.1936
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0196 0.0446
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0022 0.0198
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0621 0.0947
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0196 0.0708
Schistosoma mansoni hypothetical protein 0.0729 0.8914 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0074 0.0134
Loa Loa (eye worm) hypothetical protein 0.0074 0.0621 0.1538
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.1102 0.1808
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.03 0.1666
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0621 0.0622
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0215 0.0497
Mycobacterium ulcerans hypothetical protein 0.0049 0.03 0.1666
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0215 0.0145
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0066 0.0239
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.014 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0217 0.0784
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0215 0.0145
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0071 0.0016
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0196 0.0126
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0215 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0621 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.03 0.2062
Leishmania major hypothetical protein, conserved 0.0027 0.0022 0.0198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0103 0.0032
Echinococcus multilocularis snurportin 1 0.033 0.3858 0.3814
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.1102 0.3988
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0314
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0621 0.2247
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0927 0.8412
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0131 0.1343 0.3392
Onchocerca volvulus 0.0162 0.1733 0.6175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0314
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Mycobacterium tuberculosis Conserved protein 0.0074 0.0621 0.0947
Onchocerca volvulus 0.0049 0.03 0.0852
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.146 0.1399
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0215 0.0145
Brugia malayi TAR-binding protein 0.0065 0.0506 0.1244
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Loa Loa (eye worm) hypothetical protein 0.0042 0.0217 0.05
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0621 0.0947
Onchocerca volvulus 0.0074 0.0621 0.2042
Brugia malayi RNA, U transporter 1 0.0088 0.0795 0.1986
Brugia malayi Importin beta-1 subunit 0.0031 0.0074 0.0134
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.014 0.0094
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0927 0.0982
Schistosoma mansoni inositol monophosphatase 0.0036 0.014 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.0215 0.0497
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0066 0.06
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0215 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0215 0.0497
Brugia malayi hypothetical protein 0.0244 0.2769 0.7056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0215 0.0497
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.2769 0.3063
Brugia malayi 6-phosphofructokinase 0.0112 0.1102 0.2773
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0506 0.0492
Mycobacterium tuberculosis Conserved protein 0.0074 0.0621 0.0947
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0621 0.2247
Loa Loa (eye worm) hypothetical protein 0.0162 0.1733 0.4394
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0131 0.1343 0.1438
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0022 0.0198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.03 0.2726
Mycobacterium tuberculosis Conserved protein 0.0074 0.0621 0.0947
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0215 0.0497
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0071 0.082
Brugia malayi beta-lactamase 0.0074 0.0621 0.1538
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0506 0.1244
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0334 0.3916 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0916 0.3315
Brugia malayi beta-lactamase family protein 0.0074 0.0621 0.1538
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1011 0.2539

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs ChEMBL. 19447611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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