Detailed information for compound 113404

Basic information

Technical information
  • TDR Targets ID: 113404
  • Name: 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6H-py rido[4,3-b]carbazol-2-ium-9-ol
  • MW: 374.499 | Formula: C24H28N3O+
  • H donors: 2 H acceptors: 1 LogP: 4.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c1c(C)c3c[n+](CCN4CCCCC4)ccc3c(c1[nH]2)C
  • InChi: 1S/C24H27N3O/c1-16-21-15-27(13-12-26-9-4-3-5-10-26)11-8-19(21)17(2)24-23(16)20-14-18(28)6-7-22(20)25-24/h6-8,11,14-15,28H,3-5,9-10,12-13H2,1-2H3/p+1
  • InChiKey: FYCLDNIGWUYSFQ-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

  • 5,11-dimethyl-2-[2-(1-piperidyl)ethyl]-6H-pyrido[4,3-b]carbazol-2-ium-9-ol
  • 5,11-dimethyl-2-(2-piperidinoethyl)-6H-pyrido[4,3-b]carbazol-2-ium-9-ol
  • 5,11-dimethyl-2-(2-piperidin-1-ylethyl)-6H-pyrido[3,4-h]carbazol-2-ium-9-ol
  • 5,11-dimethyl-2-[2-(1-piperidyl)ethyl]-6H-pyrido[3,4-h]carbazol-2-ium-9-ol
  • 5,11-dimethyl-2-(2-piperidinoethyl)-6H-pyrido[3,4-h]carbazol-2-ium-9-ol
  • NCI60_002686
  • Neuro_000159

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.0164 0.0479 0.2676
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.0164 0.0479 1
Brugia malayi hypothetical protein 0.0336 0.1572 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.031 0.1407 0.8493
Brugia malayi hypoxia-induced factor 1 0.031 0.1407 0.8896
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0164 0.0479 0.5
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.1671 1 1
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.0164 0.0479 1
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.0164 0.0479 0.5
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0164 0.0479 0.5
Loa Loa (eye worm) hypothetical protein 0.0336 0.1572 1
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.0164 0.0479 0.0092
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0164 0.0479 0.5
Mycobacterium ulcerans proteasome PrcA 0.1671 1 1
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.0164 0.0479 0.5
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0088 0 0.5
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.0164 0.0479 0.5
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.0164 0.0479 0.0092
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.0164 0.0479 0.5
Schistosoma mansoni hypothetical protein 0.0149 0.0391 0.7782
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0164 0.0479 1
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.0164 0.0479 0.5

Activities

Activity type Activity value Assay description Source Reference
Ratio (functional) = 1.7 Ratio between brain tumor full panel [A] and sub panel [B] ChEMBL. 8035425
TGI (functional) = 20 uM Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in brain tumor sub panel ChEMBL. 8035425
TGI (functional) = 34 uM Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in full panel ChEMBL. 8035425
TGI concentration (functional) = 20 uM Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in brain tumor sub panel ChEMBL. 8035425
TGI concentration (functional) = 34 uM Concentration yielding an amount of cellular protein at the end of the incubation that is the same as at the beginning of the incubation in full panel ChEMBL. 8035425
TGI correlation coefficient (functional) = 0.71 TGI correlation coefficient value of the compound ChEMBL. 8035425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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