Detailed information for compound 113423

Basic information

Technical information
  • TDR Targets ID: 113423
  • Name: 2-(1H-indol-3-yl)-N-[2-(4-methoxyphenyl)ethyl ]-2-oxoacetamide
  • MW: 322.358 | Formula: C19H18N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.13 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CCNC(=O)C(=O)c1c[nH]c2c1cccc2
  • InChi: 1S/C19H18N2O3/c1-24-14-8-6-13(7-9-14)10-11-20-19(23)18(22)16-12-21-17-5-3-2-4-15(16)17/h2-9,12,21H,10-11H2,1H3,(H,20,23)
  • InChiKey: ILCDWBMMCNVAFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1H-indol-3-yl)-N-[2-(4-methoxyphenyl)ethyl]-2-oxo-acetamide
  • 2-(1H-indol-3-yl)-N-[2-(4-methoxyphenyl)ethyl]-2-oxo-ethanamide
  • 2-(1H-indol-3-yl)-2-keto-N-[2-(4-methoxyphenyl)ethyl]acetamide
  • Biomol-NT_000282
  • NCGC00163293-01
  • BPBio1_001058
  • ZINC03202988

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus GABA-A receptor; anion channel Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus GABA-A receptor; anion channel   555 aa 466 aa 31.3 %
Echinococcus granulosus Cys loop ligand gated ion channel subunit GABA-A receptor; anion channel   555 aa 578 aa 25.8 %
Echinococcus multilocularis Cys loop ligand gated ion channel subunit GABA-A receptor; anion channel   555 aa 583 aa 25.4 %
Onchocerca volvulus GABA-A receptor; anion channel   555 aa 516 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.2504 0.2446
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Brugia malayi TAR-binding protein 0.0061 0.3288 0.371
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.076 0.0788
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.2504 0.2446
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0427 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Loa Loa (eye worm) GABA receptor subunit 0.0012 0.0078 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Onchocerca volvulus 0.0023 0.076 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0632 0.0997
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Brugia malayi Cation transporter family protein 0.0023 0.076 0.0788
Brugia malayi Cation transporter family protein 0.0023 0.076 0.0788
Loa Loa (eye worm) TAR-binding protein 0.0061 0.3288 0.3766
Echinococcus granulosus tar DNA binding protein 0.0061 0.3288 0.3236
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0425 0.4484
Brugia malayi Cation transporter family protein 0.0023 0.076 0.0788
Echinococcus multilocularis nAChR subunit 0.0023 0.076 0.0687
Schistosoma mansoni hypothetical protein 0.0164 1 1
Onchocerca volvulus 0.0023 0.076 1
Echinococcus granulosus nAChR subunit 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.076 0.0687
Schistosoma mansoni hypothetical protein 0.0164 1 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0023 0.076 0.087
Brugia malayi excitatory GABA receptor EXP-1A 0.0023 0.076 0.0788
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Echinococcus multilocularis geminin 0.0164 1 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.3288 0.3766
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Onchocerca volvulus Putative nachr subunit 0.0023 0.076 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0023 0.076 0.0788
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Onchocerca volvulus 0.0023 0.076 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0425 0.035
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0023 0.076 0.0687
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0425 0.035
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Brugia malayi RNA binding protein 0.0061 0.3288 0.371
Echinococcus granulosus muscleblind protein 0.0144 0.873 0.872
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.076 0.0687
Trypanosoma brucei protein kinase, putative 0.0049 0.2504 1
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0852 0.0781
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0023 0.076 0.0687
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Echinococcus multilocularis tar DNA binding protein 0.0061 0.3288 0.3236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0852 0.0895
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0023 0.076 0.0687
Echinococcus granulosus glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Brugia malayi Muscleblind-like protein 0.0144 0.873 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0425 0.0402
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.076 0.087
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.2504 0.2446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.2504 0.2446
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.076 0.0687
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.076 0.0687
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Onchocerca volvulus 0.0023 0.076 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3288 0.3236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0425 0.0402
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0427 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.076 0.0788
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0023 0.076 0.087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0425 0.035
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3288 0.3236
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3288 0.3236
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0852 0.2055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.076 0.0687
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0425 0.0487
Brugia malayi MAP kinase sur-1 0.0049 0.2504 0.2805
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0023 0.076 0.0788
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0023 0.076 0.0687
Loa Loa (eye worm) RNA binding protein 0.0061 0.3288 0.3766
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0425 0.035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.2504 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.076 0.0687
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0425 0.035
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0023 0.076 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3288 0.3236
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0023 0.076 0.0687
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.2504 0.2446
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0852 0.0781
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.873 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0023 0.076 0.0788
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2504 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.2504 0.2869
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0425 0.035
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.076 0.0687
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0023 0.076 0.0687
Echinococcus multilocularis muscleblind protein 1 0.0144 0.873 0.872
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.2504 1
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0852 0.3404
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0023 0.076 0.0687
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0023 0.076 0.0788
Echinococcus granulosus glycine receptor subunit beta 0.0023 0.076 0.0687
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.2504 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0023 0.076 0.087
Onchocerca volvulus 0.0023 0.076 1
Schistosoma mansoni nAChR subunit 0.0023 0.076 0.0687
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2504 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.2504 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0023 0.076 0.0687
Onchocerca volvulus 0.0023 0.076 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0425 0.1697
Entamoeba histolytica hypothetical protein 0.0024 0.0852 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.076 0.0687
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.2504 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0023 0.076 0.0687
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.3288 0.371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0023 0.076 0.0788
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.076 0.0788
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0852 0.3404
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0023 0.076 0.0788
Echinococcus multilocularis glycine receptor subunit beta 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.2504 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2504 1
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0023 0.076 0.0687
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.2504 1
Loa Loa (eye worm) ACC-1 protein 0.0023 0.076 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Echinococcus multilocularis muscleblind protein 0.0144 0.873 0.872
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0425 0.4484
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0425 0.1697
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0425 0.0487
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0144 0.873 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Loa Loa (eye worm) hypothetical protein 0.0023 0.076 0.087
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) ACC-1 protein 0.0023 0.076 0.087
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0852 0.3404
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0852 0.0781
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.076 0.0788
Loa Loa (eye worm) LGC-31 protein 0.0023 0.076 0.087
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0023 0.076 0.087
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.076 0.0788
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0023 0.076 0.0687
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.2504 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0425 0.1697
Loa Loa (eye worm) hypothetical protein 0.0021 0.0632 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3288 0.3236

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Anticonvulsant activity in mice on ip dose before 80 mg/kg of PTZ (NE=no effect) ChEMBL. 1319492
Activity (functional) 0 Anticonvulsant activity in mice on ip dose before 80 mg/kg of PTZ (NE=no effect) ChEMBL. 1319492
ED50 (functional) mg kg-1 In vivo ip dose to antagonize diazepam (2.5 mg/kg) anticonvulsant effect in mice treated with 80 mg/kg PTZ (NE=no effect) ChEMBL. 1319492
ED50 (functional) mg kg-1 In vivo ip dose to induce convulsions in mice treated with subconvulsant PTZ (40 mg/kg) (NE=no effect) ChEMBL. 1319492
ED50 (functional) 0 mg kg-1 In vivo ip dose to induce convulsions in mice treated with subconvulsant PTZ (40 mg/kg) (NE=no effect) ChEMBL. 1319492
ED50 (functional) 0 mg kg-1 In vivo ip dose to antagonize diazepam (2.5 mg/kg) anticonvulsant effect in mice treated with 80 mg/kg PTZ (NE=no effect) ChEMBL. 1319492
Inhibition (functional) = 68.5 % Antileishmanial activity against Leishmania donovani assesed as inhibition of promastigotes at 10 ug/ml ChEMBL. 17548194
Inhibition (functional) = 68.5 % Antileishmanial activity against Leishmania donovani assesed as inhibition of promastigotes at 10 ug/ml ChEMBL. 17548194
Inhibition (binding) = 97 % In vitro inhibition of specific binding of [3H]-flunitrazepam to benzodiazepine receptor in bovine cerebral cortex membrane at a concentration of 10 uM. ChEMBL. 1319492
Inhibition (binding) = 97 % In vitro inhibition of specific binding of [3H]-flunitrazepam to benzodiazepine receptor in bovine cerebral cortex membrane at a concentration of 10 uM. ChEMBL. 1319492
Ki (binding) = 0.09 uM In vitro inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of bovine cerebral cortical membranes at 10 uM ChEMBL. 1319492
Ki (binding) = 0.09 uM In vitro inhibition of [3H]-flunitrazepam binding to GABA-A benzodiazepine receptor of bovine cerebral cortical membranes at 10 uM ChEMBL. 1319492
Ratio (binding) = 1.3 Relative binding to GABA-A receptor in the presence and absence of GABA (GABA shift), Ki(-GABA)/Ki(+GABA) ChEMBL. 1319492

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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