Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0039 | 0.185 | 0.183 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.1777 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.002 | 0.0647 | 0.1859 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.1083 | 0.281 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.185 | 0.511 |
Echinococcus granulosus | dna polymerase eta | 0.0065 | 0.3482 | 0.3031 |
Echinococcus granulosus | dna polymerase kappa | 0.0039 | 0.185 | 0.1286 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1744 | 0.4972 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0039 | 0.185 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0039 | 0.185 | 0.5313 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1744 | 0.9376 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0647 | 0.3642 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.1777 | 0.489 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.1744 | 0.1172 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0647 | 0.0624 |
Giardia lamblia | DINP protein human, muc B family | 0.0039 | 0.185 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.528 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0039 | 0.185 | 0.5313 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1744 | 0.9115 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0647 | 0.1505 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0012 | 0.0145 | 0.0348 |
Trypanosoma brucei | unspecified product | 0.0039 | 0.185 | 0.511 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.1496 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.1083 | 0.281 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.528 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0039 | 0.185 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.002 | 0.0647 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0065 | 0.3482 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0012 | 0.0145 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0025 | 0.0000000005248 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.185 | 0.1286 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.1744 | 0.1172 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.185 | 0.511 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0647 | 0.1505 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0039 | 0.185 | 1 |
Brugia malayi | Bloom's syndrome protein homolog | 0.002 | 0.0647 | 0.051 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.1744 | 0.9813 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0039 | 0.185 | 0.511 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0039 | 0.185 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.002 | 0.0647 | 0.2945 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0065 | 0.3482 | 0.3386 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.1744 | 0.9425 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1744 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.001 | 0.0025 | 0.17 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.1744 | 0.9115 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0012 | 0.0145 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 1 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.002 | 0.0647 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1744 | 0.4791 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 1 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.001 | 0.0025 | 0.0133 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.1777 | 0.5068 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.001 | 0.0025 | 0.0071 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0647 | 0.051 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0012 | 0.0145 | 0.0816 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0145 | 0.0348 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.002 | 0.0647 | 0.0624 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0145 | 0.0348 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1744 | 0.5008 |
Treponema pallidum | ATP-dependent DNA helicase | 0.001 | 0.0025 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.528 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 1 | 1 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.002 | 0.0647 | 0.1801 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.1083 | 0.281 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0039 | 0.185 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0039 | 0.185 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0039 | 0.185 | 0.1286 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.511 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1744 | 0.1723 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1744 | 0.4972 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0039 | 0.185 | 0.173 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.1744 | 0.5008 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0012 | 0.0145 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0647 | 0.3642 |
Loa Loa (eye worm) | RecQ helicase | 0.002 | 0.0647 | 0.0624 |
Trypanosoma brucei | unspecified product | 0.0027 | 0.1083 | 0.281 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0145 | 0.0121 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1744 | 0.9115 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1744 | 0.1622 |
Echinococcus multilocularis | dna polymerase kappa | 0.0039 | 0.185 | 0.1286 |
Leishmania major | DNA polymerase eta, putative | 0.0065 | 0.3482 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.002 | 0.0647 | 0.1859 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0039 | 0.185 | 0.528 |
Entamoeba histolytica | recQ family helicase, putative | 0.002 | 0.0647 | 0.3498 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.0025 | 0.0139 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.002 | 0.0647 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.3482 | 0.3466 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0065 | 0.3482 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0065 | 0.3482 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0065 | 0.3482 | 0.3031 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1744 | 0.4791 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0027 | 0.1083 | 0.281 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0012 | 0.0145 | 0.0348 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0039 | 0.185 | 0.511 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0039 | 0.185 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.