Detailed information for compound 1134446

Basic information

Technical information
  • TDR Targets ID: 1134446
  • Name: (2S)-2-[[(2S)-2-(hydroxy-propylphosphoryl)oxy -4-methylpentanoyl]amino]-3-(1H-indol-3-yl)pr opanoic acid
  • MW: 424.428 | Formula: C20H29N2O6P
  • H donors: 4 H acceptors: 5 LogP: 2.61 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCP(=O)(O[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)CC(C)C)O
  • InChi: 1S/C20H29N2O6P/c1-4-9-29(26,27)28-18(10-13(2)3)19(23)22-17(20(24)25)11-14-12-21-16-8-6-5-7-15(14)16/h5-8,12-13,17-18,21H,4,9-11H2,1-3H3,(H,22,23)(H,24,25)(H,26,27)/t17-,18-/m0/s1
  • InChiKey: DUHSOXZZDRRFST-ROUUACIJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(2S)-2-(hydroxy-propyl-phosphoryl)oxy-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
  • (2S)-2-[[(2S)-2-(hydroxy-propylphosphoryl)oxy-4-methyl-1-oxopentyl]amino]-3-(1H-indol-3-yl)propanoic acid
  • (2S)-2-[[(2S)-2-(hydroxy-propyl-phosphoryl)oxy-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0068 0.3945 0.8716
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0941 0.1324
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0288 0.0358
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.1729 0.4058
Echinococcus granulosus bloom syndrome protein 0.0023 0.1162 0.1027
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0216 0.0957
Brugia malayi nuclear receptor NHR-88 0.002 0.0941 0.1851
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0041 0.2259 0.2141
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0288 0.0277
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0498 0.1236
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0216 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0941 0.0804
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0941 0.0931
Schistosoma mansoni thyroid hormone receptor 0.002 0.0941 0.0931
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0065 0.3757 0.9496
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.4507 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.286 0.2751
Schistosoma mansoni coup transcription factor 0.002 0.0941 0.0931
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0941 0.4793
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0216 0.0067
Brugia malayi nuclear hormone receptor 0.002 0.0941 0.1851
Schistosoma mansoni DNA helicase recq1 0.001 0.0306 0.0295
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Giardia lamblia DINP protein human, muc B family 0.0041 0.2259 1
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0498 0.0755
Onchocerca volvulus 0.0029 0.1495 0.8452
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0216 0.0205
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0455
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0498 0.0755
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0216 0.0957
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0498 0.0755
Echinococcus granulosus dna polymerase kappa 0.0041 0.2259 0.2141
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0288 0.0141
Brugia malayi hypothetical protein 0.001 0.0358 0.0518
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0306 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0358 0.0347
Echinococcus multilocularis pyruvate kinase 0.0032 0.1729 0.1603
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0865 0.1214
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0259 0.0352
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0288 0.0141
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0865 0.0726
Brugia malayi nuclear receptor NHR-88 0.0009 0.0288 0.0358
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.1359 0.2664
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0216 0.052
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1467 0.3353
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0941 0.0804
Loa Loa (eye worm) DR-78 0.0009 0.0288 0.0394
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0498 0.1236
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0216 0.0957
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.286 0.6237
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0865 0.0726
Plasmodium vivax pyruvate kinase, putative 0.0032 0.1729 0.3837
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0216 0.0067
Schistosoma mansoni cpg binding protein 0.003 0.1597 0.1587
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0865 0.1511
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0288 0.0277
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0216 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0941 0.1851
Brugia malayi ImpB/MucB/SamB family protein 0.0041 0.2259 0.4863
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0941 0.0804
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.015 0.0138
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0216 0.0205
Brugia malayi steroid hormone receptor 0.002 0.0941 0.1851
Loa Loa (eye worm) RecQ helicase 0.0023 0.1162 0.1637
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0216 0.0067
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0865 0.1511
Schistosoma mansoni DNA helicase recq5 0.001 0.0306 0.0295
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0288 0.0358
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Echinococcus multilocularis dna polymerase eta 0.0068 0.3945 0.3853
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0216 0.048
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0865 0.3174
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0744 0.1629
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0941 0.0931
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0498 0.0755
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0941 0.1851
Schistosoma mansoni pyruvate kinase 0.0032 0.1729 0.172
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0306 0.021
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.4507 0.4423
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1467 0.3353
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0216 0.052
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0288 0.0394
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.3246 0.4603
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0358 0.0518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.286 0.2852
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0865 0.2169
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0288 0.0141
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.1729 0.7534
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.2259 0.5714
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0865 0.1511
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0855 0.0845
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0498 0.1082
Leishmania major DNA polymerase kappa, putative 0.0013 0.0498 0.0755
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.286 0.2751
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0941 0.0931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0941 0.1324
Brugia malayi nuclear hormone receptor 0.0009 0.0288 0.0358
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.1729 0.3652
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0216 0.0957
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0358 0.0212
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0216 0.0455
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0216 0.0491
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0306 0.042
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0941 0.0804
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.1162 0.2355
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0288 0.0358
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.1729 0.7534
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.1359 0.2664
Echinococcus multilocularis pyruvate kinase 0.0017 0.0744 0.0603
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Schistosoma mansoni zinc finger protein 0.0009 0.0288 0.0277
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Brugia malayi hypothetical protein 0.0008 0.0216 0.0194
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0.0216 0.0957
Entamoeba histolytica deoxycytidyl transferase, putative 0.0041 0.2259 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0216 0.052
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0216 0.052
Toxoplasma gondii exonuclease III APE 0.0019 0.0865 0.1898
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0216 0.0067
Schistosoma mansoni DNA polymerase eta 0.0068 0.3945 0.3938
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0358 0.0347
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0216 0.052
Brugia malayi nuclear receptor RXR 0.001 0.0358 0.0518
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0941 0.0804
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0865 0.3509
Toxoplasma gondii hypothetical protein 0.0027 0.1359 0.2998
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0288 0.0394
Echinococcus multilocularis pyruvate kinase 0.0032 0.1729 0.1603
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.2183 0.4832
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0216 0.052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0483 0.0716
Echinococcus granulosus oxidoreductase 0.0008 0.0216 0.0067
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.1117 0.4943
Brugia malayi polk-prov protein 0.0013 0.0498 0.0837
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.1729 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0865 0.1739
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0065 0.3757 0.3749
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.3757 0.3662
Echinococcus granulosus cpg binding protein 0.003 0.1597 0.1469
Loa Loa (eye worm) hypothetical protein 0.0013 0.0498 0.0692
Brugia malayi nuclear receptor NHR-67 0.0009 0.0288 0.0358
Brugia malayi conserved hypotetical protein 0.0009 0.0288 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Mycobacterium ulcerans hypothetical protein 0.0013 0.0498 0.0656
Brugia malayi CXXC zinc finger family protein 0.0029 0.1495 0.3116
Loa Loa (eye worm) pyruvate kinase 0.0032 0.1729 0.2445
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0358 0.0493
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0065 0.3757 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0941 0.0804
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0941 0.1324
Schistosoma mansoni nuclear hormone receptor 0.002 0.0941 0.0931
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0455
Brugia malayi hypothetical protein 0.0008 0.0216 0.0194
Schistosoma mansoni cpg binding protein 0.0029 0.1495 0.1485
Echinococcus granulosus FTZ F1 alpha 0.002 0.0941 0.0804
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.2259 0.225
Onchocerca volvulus 0.0009 0.0288 0.0476
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0358 0.0518
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0941 0.0804
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0216 0.0067
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0455
Echinococcus multilocularis pyruvate kinase 0.0017 0.0744 0.0603
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0941 0.0931
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0318 0.0425
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Entamoeba histolytica hypothetical protein 0.0008 0.0216 0.0957
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0306 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0111 0.000000001154
Trypanosoma brucei unspecified product 0.0028 0.1467 0.3353
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0216 0.0194
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0216 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0941 0.1324
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0216 0.052
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0941 0.1851
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0483 0.0716
Trypanosoma brucei unspecified product 0.0028 0.1467 0.3353
Echinococcus granulosus hypothetical protein 0.0008 0.0216 0.0067
Loa Loa (eye worm) pyruvate kinase 0.0032 0.1729 0.2445
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0288 0.0476
Echinococcus granulosus pyruvate kinase 0.0017 0.0744 0.0603
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.4507 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.2259 0.4762
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0216 0.0455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0216 0.0491
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0216 0.052
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0216 0.0957
Loa Loa (eye worm) hypothetical protein 0.0068 0.3945 0.5598
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0216 0.0205
Brugia malayi ecdysone receptor 0.0009 0.0288 0.0358
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0865 0.1739
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0288 0.0358
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.1162 0.4892
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0941 0.0804
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0216 0.052
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0941 0.0931
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0216 0.0957
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0216 0.0194
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0941 0.0804
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0498 0.0656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0288 0.0141
Brugia malayi tailless protein 0.0009 0.0288 0.0358
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.2852 0.7445
Onchocerca volvulus 0.0009 0.0288 0.0476
Giardia lamblia Pyruvate kinase 0.0017 0.0744 0.2584
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0216 0.052
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0216 0.052
Trypanosoma brucei unspecified product 0.0041 0.2259 0.5479
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.4507 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0288 0.0141
Loa Loa (eye worm) hypothetical protein 0.0118 0.7037 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.3757 0.8286
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0216 0.0067
Echinococcus granulosus peptidase Clp S14 family 0.005 0.2852 0.2744
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0483 0.1199
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0941 0.1324
Schistosoma mansoni carbonyl reductase 0.0008 0.0216 0.0205
Loa Loa (eye worm) hypothetical protein 0.0023 0.1117 0.1573
Schistosoma mansoni pyruvate kinase 0.0017 0.0744 0.0733
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0941 0.1324
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Schistosoma mansoni carbonyl reductase 0.0008 0.0216 0.0205
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0941 0.4793
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0288 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.286 0.2852
Echinococcus granulosus pyruvate kinase 0.0017 0.0744 0.0603
Echinococcus multilocularis pyruvate kinase 0.0026 0.1303 0.1171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.3757 0.8252
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.1729 0.4273
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0216 0.0067
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0216 0.0067
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0216 0.048
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0216 0.052
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0744 0.123
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0865 0.3509
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0358 0.0212
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0259 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.2259 0.5714
Echinococcus granulosus pyruvate kinase 0.0017 0.0744 0.0603
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0216 0.0067
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0744 0.1651
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0498 0.1082
Loa Loa (eye worm) pyruvate kinase 0.0007 0.0132 0.0171
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0288 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0941 0.1851
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.4507 0.4423
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Brugia malayi nuclear receptor RXR 0.0009 0.0288 0.0358
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.1117 0.1573
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.286 0.4054
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0941 0.0804
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.1729 0.3527
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0216 0.0067
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0216 0.0194
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.2259 0.4762
Schistosoma mansoni thyroid hormone receptor 0.002 0.0941 0.0931
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0865 0.1831
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.2259 0.5479
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0216 0.0491
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0288 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0306 0.0159
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0216 0.0194
Schistosoma mansoni pyruvate kinase 0.0032 0.1729 0.172
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.1162 0.4892
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0941 0.0931
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0216 0.0067
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0865 0.3827
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0288 0.0141
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.2259 0.5479
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0941 0.1851
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.3096 0.6862
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0941 0.0804
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0865 0.1675
Loa Loa (eye worm) hypothetical protein 0.001 0.0358 0.0493
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.1729 0.3821
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0216 0.0067
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0306 0.0656
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.3502 0.3494
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0288 0.0141
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni nuclear receptor 0.0009 0.0288 0.0277
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0216 0.0957
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0216 0.052
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0288 0.0141
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0216 0.0067
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0216 0.0291
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0216 0.0067
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0216 0.0067
Schistosoma mansoni hypothetical protein 0.0165 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0941 0.1851
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.2183 0.5522
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.286 0.2751
Schistosoma mansoni terminal deoxycytidyl transferase 0.0041 0.2259 0.225
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0288 0.0141
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0288 0.0141
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0288 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0216 0.0491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0111 0.000000001154
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0216 0.052
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Schistosoma mansoni nuclear receptor 0.0009 0.0288 0.0277
Loa Loa (eye worm) dehydrogenase 0.0008 0.0216 0.0291
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0865 0.2169
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0306 0.0656
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Trypanosoma cruzi DNA polymerase eta, putative 0.0068 0.3945 1
Trypanosoma brucei pyruvate kinase 1 0.0032 0.1729 0.4058
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0041 0.2259 0.2141
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Brugia malayi hypothetical protein 0.001 0.0358 0.0518
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.2259 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0259 0.0111
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0012 0.0052
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0216 0.052
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0941 0.1851
Loa Loa (eye worm) hypothetical protein 0.001 0.0306 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0941 0.0804
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0483 0.1734
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0941 0.1851
Leishmania major pyruvate kinase 0.0032 0.1729 0.4058
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.1729 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0941 0.1851
Plasmodium falciparum pyruvate kinase 0.0032 0.1729 0.3527
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0498 0.1236
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0216 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.2259 0.5714
Loa Loa (eye worm) hypothetical protein 0.001 0.0358 0.0493
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0216 0.0194
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Echinococcus multilocularis cpg binding protein 0.003 0.1597 0.1469
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.2852 0.7445
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0941 0.4793
Leishmania major DNA polymerase eta, putative 0.0068 0.3945 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0455
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0216 0.0455
Brugia malayi Probable ClpP-like protease 0.0077 0.4507 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0941 0.0931
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.2259 0.577
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Loa Loa (eye worm) hypothetical protein 0.0077 0.4507 0.6398
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.2852 0.2744
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.4507 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.2259 0.577
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Loa Loa (eye worm) pyruvate kinase 0.0032 0.1729 0.2445
Echinococcus multilocularis oxidoreductase 0.0008 0.0216 0.0067
Onchocerca volvulus 0.002 0.0941 0.4793
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0216 0.0455
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0941 0.1851
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0216 0.052
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0216 0.0491
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0498 0.0755
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.2259 0.5479
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.2259 0.5479
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.1495 0.2111
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0216 0.052
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0306 0.04
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0216 0.0067
Giardia lamblia Pyruvate kinase 0.0032 0.1729 0.7406
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0455
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Schistosoma mansoni hypothetical protein 0.0165 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0941 0.0931
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0216 0.0455
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Brugia malayi ecdysteroid receptor 0.002 0.0941 0.1851
Leishmania major DNA damage repair protein, putative 0.0013 0.0498 0.0755
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0216 0.0067
Trypanosoma brucei DNA polymerase eta, putative 0.0068 0.3945 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0678 0.1483
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0941 0.1324
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0216 0.0067
Mycobacterium ulcerans pyruvate kinase 0.0032 0.1729 0.3527
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0065 0.3757 0.8252
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0216 0.0067
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0941 0.0931
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.1729 0.4367
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.1467 0.3353
Loa Loa (eye worm) dehydrogenase 0.0008 0.0216 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0288 0.0476
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0065 0.3757 0.3662
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0216 0.0205
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.1729 0.4367
Echinococcus granulosus pyruvate kinase 0.0032 0.1729 0.1603
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0306 0.04
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0865 0.1919
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0306 0.0441
Loa Loa (eye worm) hypothetical protein 0.001 0.0358 0.0493
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0941 0.0804
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0306 0.0159
Echinococcus multilocularis pyruvate kinase 0.0017 0.0744 0.0603
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.1359 0.3016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0865 0.1898
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0216 0.0194
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0941 0.0804
Echinococcus multilocularis geminin 0.0165 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.1729 0.2445
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Schistosoma mansoni ap endonuclease 0.0019 0.0865 0.0854
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0498 0.1105
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.4507 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0941 0.1851
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0941 0.0804
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0483 0.214
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.2852 0.6144
Echinococcus multilocularis bloom syndrome protein 0.0023 0.1162 0.1027
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0216 0.0205
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0288 0.0277
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.1359 0.2998
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.4507 0.45
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Leishmania major pyruvate kinase 0.0032 0.1729 0.4058
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0941 0.1851
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Leishmania major DNA polymerase eta, putative 0.004 0.2183 0.5276
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0216 0.0205
Giardia lamblia DNA damage repair protein 0.0013 0.0498 0.1378
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0288 0.0394
Echinococcus granulosus dna polymerase eta 0.0068 0.3945 0.3853
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0941 0.1851
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0941 0.1851
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0216 0.0067
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0498 0.0755
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.1729 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.286 0.2751
Loa Loa (eye worm) hypothetical protein 0.0009 0.0288 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0111 0.000000001154
Loa Loa (eye worm) hypothetical protein 0.002 0.0941 0.1324
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0941 0.1851
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0216 0.052
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.2259 0.5714
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0216 0.0194
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0216 0.0957
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0941 0.0804
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0498 0.1236
Leishmania major DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.286 0.2852
Brugia malayi hypothetical protein 0.0009 0.0288 0.0358
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.2259 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.1729 0.3652
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0498 0.0755
Loa Loa (eye worm) hypothetical protein 0.0008 0.0216 0.0291
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0216 0.0067
Schistosoma mansoni ap endonuclease 0.0019 0.0865 0.0854
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Loa Loa (eye worm) hypothetical protein 0.001 0.0358 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0941 0.1851
Schistosoma mansoni cpg binding protein 0.003 0.1597 0.1587
Brugia malayi hypothetical protein 0.0009 0.0288 0.0358
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0288 0.0358
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0288 0.0358
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0216 0.0194
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.069 0.1531
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.2259 0.5479
Echinococcus granulosus hypothetical protein 0.0008 0.0216 0.0067
Loa Loa (eye worm) oxidoreductase 0.0008 0.0216 0.0291
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0498 0.0487
Brugia malayi oxidoreductase 0.0008 0.0216 0.0194
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0252 0.0275
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0041 0.2259 0.3199
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0216 0.0067
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0216 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0941 0.0804
Echinococcus granulosus pyruvate kinase 0.0032 0.1729 0.1603
Loa Loa (eye worm) hypothetical protein 0.001 0.0358 0.0493
Schistosoma mansoni carbonyl reductase 0.0008 0.0216 0.0205
Echinococcus multilocularis dna polymerase kappa 0.0041 0.2259 0.2141
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0985 0.1791
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0941 0.1324

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) >> 100 uM Inhibition of endothelin converting enzyme in an RIA assay using ET-1 as substrate (value corresponds to <25% inhibition when assayed at a 100 uM screening concentration) ChEMBL. 8421284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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