Detailed information for compound 1134825

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.441 | Formula: C17H14FN3OS2
  • H donors: 0 H acceptors: 1 LogP: 3.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1sc2c(c1)n(c1c2cnn(c1=O)Cc1ccccc1F)C
  • InChi: 1S/C17H14FN3OS2/c1-20-13-7-14(23-2)24-16(13)11-8-19-21(17(22)15(11)20)9-10-5-3-4-6-12(10)18/h3-8H,9H2,1-2H3
  • InChiKey: KNCIHDGEEMFGMQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL References
Homo sapiens pyruvate kinase, liver and RBC Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, liver and RBC 574 aa 524 aa 36.3 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Pyruvate kinase, M2 isozyme 0.0081 0.2549 0.2549
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0091 0.2951 1
Brugia malayi follicle stimulating hormone receptor 0.0225 0.8344 0.8344
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.8344 0.8344
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.4762 0.4762
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.2267 0.1968
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0091 0.2951 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0091 0.2951 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1718 0.375
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0091 0.2951 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.1655 0.3433
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0091 0.2951 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0091 0.2951 0.4172
Loa Loa (eye worm) cytochrome P450 0.0091 0.2951 0.2951
Leishmania major cytochrome p450-like protein 0.0091 0.2951 0.4172
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.2267 0.2267
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0091 0.2951 0.4172
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.2549 0.5
Loa Loa (eye worm) pyruvate kinase-PB 0.0056 0.1572 0.1572
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.2267 0.1968
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0091 0.2951 0.4172
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1718 0.375
Brugia malayi Pyruvate kinase, muscle isozyme 0.0081 0.2549 0.2549
Echinococcus multilocularis pyruvate kinase 0.0081 0.2549 0.7964
Leishmania major pyruvate kinase 0.0081 0.2549 0.2878
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0091 0.2951 0.4172
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0081 0.2549 0.6899
Trypanosoma brucei cytochrome P450, putative 0.0136 0.4762 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.2267 0.6531
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0091 0.2951 0.4172
Loa Loa (eye worm) pyruvate kinase 0.0081 0.2549 0.2549
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.1655 0.3433
Toxoplasma gondii exonuclease III APE 0.0058 0.1655 0.3433
Trypanosoma cruzi cytochrome P450, putative 0.0136 0.4762 1
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.2549 1
Schistosoma mansoni cytochrome P450 0.0091 0.2951 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1718 0.0483
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0091 0.2951 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.2267 0.1968
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0091 0.2951 0.4172
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0091 0.2951 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1718 0.375
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0091 0.2951 0.4172
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.2549 0.2878
Brugia malayi Cytochrome P450 family protein 0.0136 0.4762 0.4762
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0091 0.2951 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.2267 0.8201
Loa Loa (eye worm) hypothetical protein 0.0045 0.113 0.113
Leishmania major cytochrome p450-like protein 0.0091 0.2951 0.4172
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.2267 0.6531
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0091 0.2951 0.4172
Leishmania major pyruvate kinase 0.0081 0.2549 0.2878
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.2549 0.5
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.2549 0.5
Trypanosoma brucei pyruvate kinase 1, putative 0.0081 0.2549 0.2878
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.2267 0.6531
Loa Loa (eye worm) pyruvate kinase 0.0081 0.2549 0.2549
Schistosoma mansoni ap endonuclease 0.0058 0.1655 0.3433
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.1655 0.1655
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.2267 0.6531
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0091 0.2951 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0091 0.2951 0.4172
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1718 0.375
Schistosoma mansoni pyruvate kinase 0.0081 0.2549 0.7964
Echinococcus multilocularis 0.0091 0.2951 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.2267 0.6838
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.2267 0.6838
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.1655 0.1655
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.2267 0.6531
Echinococcus multilocularis pyruvate kinase 0.0064 0.1869 0.4516
Echinococcus granulosus pyruvate kinase 0.0081 0.2549 0.7964
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0091 0.2951 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1655 0.4311
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.2549 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0091 0.2951 0.4172
Loa Loa (eye worm) hypothetical protein 0.0074 0.2267 0.2267
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.2267 0.6531
Mycobacterium leprae putative cytochrome p450 0.0091 0.2951 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.1655 0.5
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0091 0.2951 0.4172
Loa Loa (eye worm) hypothetical protein 0.0081 0.2549 0.2549
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0091 0.2951 0.4172
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.2267 0.1968
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.4762 0.4762
Mycobacterium leprae Conserved hypothetical protein 0.0091 0.2951 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1718 0.375
Schistosoma mansoni ap endonuclease 0.0058 0.1655 0.3433
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0024 0.0297 0.0297
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0091 0.2951 0.4172
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.2267 0.6531
Mycobacterium ulcerans pyruvate kinase 0.0081 0.2549 0.2878
Echinococcus granulosus pyruvate kinase 0.0081 0.2549 0.7964
Chlamydia trachomatis pyruvate kinase 0.0081 0.2549 0.5
Brugia malayi Cytochrome P450 family protein 0.0091 0.2951 0.2951
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.2267 0.6531
Loa Loa (eye worm) cytochrome P450 family protein 0.0266 1 1
Echinococcus multilocularis pyruvate kinase 0.0081 0.2549 0.7964
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0136 0.4762 1
Schistosoma mansoni hypothetical protein 0.0091 0.2951 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.2549 0.2878
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.2267 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0091 0.2951 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0091 0.2951 0.4172
Toxoplasma gondii pyruvate kinase PyK1 0.0081 0.2549 0.7964
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1718 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0091 0.2951 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1718 0.0202
Plasmodium falciparum pyruvate kinase 0.0081 0.2549 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0091 0.2951 1
Brugia malayi Cytochrome P450 family protein 0.0136 0.4762 0.4762
Trypanosoma cruzi cytochrome P450, putative 0.0136 0.4762 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0091 0.2951 0.4172
Loa Loa (eye worm) pyruvate kinase 0.0081 0.2549 0.2549
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1718 0.0202
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.1655 0.4311
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0091 0.2951 0.4172
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0091 0.2951 1
Schistosoma mansoni pyruvate kinase 0.0081 0.2549 0.7964
Loa Loa (eye worm) CYP4Cod1 0.0136 0.4762 0.4762
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0091 0.2951 0.4172
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1718 0.0202
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0091 0.2951 1
Echinococcus granulosus cytochrome P450 2K1 0.0091 0.2951 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0091 0.2951 1
Giardia lamblia Pyruvate kinase 0.0081 0.2549 1
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.2267 0.6838
Loa Loa (eye worm) hypothetical protein 0.0056 0.1572 0.1572
Leishmania major cytochrome p450-like protein 0.0136 0.4762 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0091 0.2951 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0091 0.2951 1
Brugia malayi cytochrome P450 0.0091 0.2951 0.2951
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.1655 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0091 0.2951 1
Plasmodium vivax pyruvate kinase, putative 0.0081 0.2549 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0091 0.2951 0.4172
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1655 0.4311
Trypanosoma brucei pyruvate kinase 1 0.0081 0.2549 0.2878
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0091 0.2951 0.4172
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0091 0.2951 0.4172
Toxoplasma gondii cytochrome p450 superfamily protein 0.0091 0.2951 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.1655 0.1193
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0091 0.2951 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.024 uM Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assay ChEMBL. 20451379
Activity (binding) Activation of PKR assessed as ATP product formation by luminescent pyruvate kinase-luciferase coupled assay ChEMBL. 20451379
Activity (binding) Activation of PKL assessed as pyruvate formation by fluorescent pyruvate kinase-lactate dehydrogenase coupled assay ChEMBL. 20451379
Activity (binding) Activation of PKR assessed as pyruvate formation by fluorescent pyruvate kinase-lactate dehydrogenase coupled assay ChEMBL. 20451379
Activity (binding) Activation of PKL assessed as ATP product formation by luminescent pyruvate kinase-luciferase coupled assay ChEMBL. 20451379
Activity (binding) = 96 % Maximum activation of human PKM2 assessed as ATP product formation at 57 uM after 1 hr by luminescent pyruvate kinase-luciferase coupled assay relative to fructose-1,6-bis-phosphate ChEMBL. 20451379
Potency (functional) = 0.0004 um PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Liver Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 954 (Counter assay for activators of Human Pyruvate Kinase M2 isoform)] ChEMBL. No reference
Potency (functional) = 0.0032 um PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M1 isoform. (Class of assay: confirmatory) [Related pubchem assays: 954 (Counter assay for activators of Human Pyruvate Kinase M2 isoform)] ChEMBL. No reference
Potency (functional) = 0.0142 um PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 954, 1631 ] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Pyruvate Kinase M2 isoform. (Class of assay: confirmatory) [Related pubchem assays: 1634, 1631 ] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: Secondary assay for Activators of Human Reticulocyte Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 954 (Counter assay for activators of Human Pyruvate Kinase M2 isoform)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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