Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, shaker-related subfamily, member 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | voltage gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 5 | 613 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.1606 | 0.1559 |
Onchocerca volvulus | 0.0027 | 0.1606 | 0.5 | |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0104 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2607 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.0214 | 0.0214 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.2607 | 0.1193 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.1606 | 0.1422 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0099 | 0.9502 | 0.95 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1551 | 0.1551 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.1606 | 0.1559 |
Brugia malayi | hypothetical protein | 0.0036 | 0.2607 | 0.2445 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0055 | 0.0055 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.1606 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2607 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0104 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2607 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.1606 | 0.1559 |
Echinococcus granulosus | lamin | 0.0027 | 0.1606 | 0.1559 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.1606 | 0.1606 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.2607 | 0.2566 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.2607 | 0.2566 |
Echinococcus multilocularis | lamin | 0.0027 | 0.1606 | 0.1559 |
Echinococcus multilocularis | musashi | 0.0027 | 0.1606 | 0.1559 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1606 | 0.1606 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.1606 | 0.1422 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2607 | 0.1193 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0104 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.2607 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.1606 | 0.1606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.