Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.3311 | 0.4774 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0027 | 0.0514 | 0.0451 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.1876 | 0.1689 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0027 | 0.0525 | 0.0472 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0522 | 0.281 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.122 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0388 | 0.0257 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.3311 | 0.3157 |
Trichomonas vaginalis | helicase, putative | 0.002 | 0.0298 | 0.2378 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.0644 | 0.0591 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0795 | 0.6491 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0224 | 0.0169 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0388 | 0.0168 |
Echinococcus granulosus | cpg binding protein | 0.0094 | 0.2574 | 0.2532 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Brugia malayi | CXXC zinc finger family protein | 0.0089 | 0.2418 | 0.3393 |
Brugia malayi | MAP kinase sur-1 | 0.005 | 0.122 | 0.1542 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0056 | 0.0056 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0227 | 0.6692 | 0.6616 |
Echinococcus multilocularis | geminin | 0.0333 | 0.9967 | 0.9967 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.9967 | 0.9967 |
Echinococcus granulosus | geminin | 0.0333 | 0.9967 | 0.9967 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.3311 | 0.3157 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0644 | 0.4064 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0023 | 0.0388 | 0.3529 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0461 | 0.3726 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0224 | 0.0224 |
Trypanosoma brucei | protein kinase, putative | 0.005 | 0.122 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0522 | 0.281 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0795 | 0.1182 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0022 | 0.0358 | 0.0303 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.122 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0224 | 0.0003 |
Onchocerca volvulus | 0.017 | 0.4922 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.122 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.005 | 0.122 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0644 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.086 | 0.065 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0249 | 0.0249 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0795 | 0.5626 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0089 | 0.2418 | 0.2244 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.1876 | 0.1689 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0249 | 0.387 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.122 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.005 | 0.122 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0224 | 0.0224 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0795 | 0.5626 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1264 | 0.1264 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.005 | 0.122 | 0.2101 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.086 | 0.086 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0249 | 0.0041 |
Brugia malayi | hypothetical protein | 0.0135 | 0.3856 | 0.5617 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0522 | 0.8109 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.005 | 0.122 | 0.1171 |
Schistosoma mansoni | cpg binding protein | 0.0089 | 0.2418 | 0.2418 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1264 | 0.1215 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0224 | 0.0169 |
Brugia malayi | hypothetical protein | 0.017 | 0.4922 | 0.7264 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0795 | 0.5626 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0022 | 0.0358 | 0.0303 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.1876 | 0.2555 |
Schistosoma mansoni | ran | 0.0023 | 0.0388 | 0.0388 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.122 | 0.122 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.1264 | 0.1611 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1264 | 0.1264 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.1876 | 0.1689 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.1876 | 0.183 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.1264 | 0.1064 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0027 | 0.0525 | 0.0472 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.9967 | 0.9967 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.005 | 0.122 | 0.1019 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.1876 | 0.183 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0795 | 0.0584 |
Brugia malayi | RNA, U transporter 1 | 0.0089 | 0.2427 | 0.3407 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0795 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0022 | 0.0358 | 0.0303 |
Echinococcus multilocularis | snurportin 1 | 0.0334 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0188 | 0.5491 | 0.5491 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0522 | 0.0463 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0522 | 0.8109 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0168 | 0.487 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.4922 | 0.4806 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.3856 | 0.5744 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0022 | 0.0358 | 0.0303 |
Echinococcus granulosus | mitogen activated protein kinase | 0.005 | 0.122 | 0.1171 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0461 | 0.5793 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0022 | 0.0358 | 0.0358 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1876 | 0.1876 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.1407 | 0.1831 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0388 | 0.1434 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0334 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0.122 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0461 | 0.3726 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0224 | 0.0169 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0795 | 0.0744 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0249 | 0.1977 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3856 | 0.3715 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.005 | 0.122 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Onchocerca volvulus | Huntingtin homolog | 0.0135 | 0.3856 | 0.5744 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.122 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0795 | 0.5626 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0795 | 0.6491 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0522 | 0.0591 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0795 | 0.0795 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0522 | 0.281 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.0644 | 0.0644 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0678 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0249 | 0.0026 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0388 | 0.1434 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.0644 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.1264 | 0.1264 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0249 | 0.0194 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Brugia malayi | follicle stimulating hormone receptor | 0.0227 | 0.6692 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0522 | 0.6916 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0461 | 0.3726 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0224 | 0.0169 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0249 | 0.0249 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1876 | 0.1876 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0224 | 0.0224 |
Trichomonas vaginalis | ran, putative | 0.0023 | 0.0388 | 0.3128 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1264 | 0.1215 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.1407 | 0.121 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0032 | 0.0678 | 0.5 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0795 | 0.0886 |
Leishmania major | GTP-binding protein, putative | 0.0023 | 0.0388 | 0.1434 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0795 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0027 | 0.0525 | 0.0307 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1876 | 0.1876 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0644 | 0.0429 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0249 | 0.0194 |
Entamoeba histolytica | Ran family GTPase | 0.0023 | 0.0388 | 0.4882 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.005 | 0.122 | 0.1171 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0388 | 0.1434 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0795 | 0.6491 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0023 | 0.0388 | 0.1434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.002 | 0.0298 | 0.2378 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0522 | 0.0305 |
Schistosoma mansoni | ran | 0.0023 | 0.0388 | 0.0388 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3856 | 0.3715 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0224 | 0.0003 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0522 | 0.281 |
Schistosoma mansoni | cpg binding protein | 0.0094 | 0.2574 | 0.2574 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0795 | 0.0795 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1876 | 0.1876 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.1264 | 0.1215 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.005 | 0.122 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0094 | 0.2574 | 0.2532 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0023 | 0.0388 | 0.0301 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0461 | 0.218 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.0388 | 0.0334 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0013 | 0.007 | 0.007 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.1876 | 0.2555 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.1876 | 0.1876 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.0388 | 0.6033 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.1264 | 0.1215 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.002 | 0.0298 | 0.2378 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0644 | 0.0854 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0461 | 0.218 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.005 | 0.122 | 0.1171 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.1407 | 0.1831 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0224 | 0.0169 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0795 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0224 | 0.0224 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0249 | 0.1977 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0249 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0644 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0224 | 0.0169 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0.122 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0795 | 0.0744 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.1407 | 0.121 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.0644 | 0.0591 |
Brugia malayi | RNA binding protein | 0.0071 | 0.1876 | 0.2555 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.0644 | 0.4064 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0.122 | 1 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.0388 | 0.0334 |
Schistosoma mansoni | cpg binding protein | 0.0094 | 0.2574 | 0.2574 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0249 | 0.3132 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.086 | 0.0985 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 91 % | Antiproliferative activity against human PC3 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay | ChEMBL. | 20304644 |
Activity (functional) | = 96.2 % | Antiproliferative activity against human Capan2 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay | ChEMBL. | 20304644 |
Activity (functional) | = 137.7 % | Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay | ChEMBL. | 20304644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.