Detailed information for compound 113556

Basic information

Technical information
  • TDR Targets ID: 113556
  • Name: (2E,4E)-3-methyl-5-[2-methyl-2-(5,5,8,8-tetra methyl-6,7-dihydronaphthalen-2-yl)cyclopropyl ]penta-2,4-dienoic acid
  • MW: 352.51 | Formula: C24H32O2
  • H donors: 1 H acceptors: 2 LogP: 7.3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C(/C=C/C1CC1(C)c1ccc2c(c1)C(C)(C)CCC2(C)C)\C
  • InChi: 1S/C24H32O2/c1-16(13-21(25)26)7-8-18-15-24(18,6)17-9-10-19-20(14-17)23(4,5)12-11-22(19,2)3/h7-10,13-14,18H,11-12,15H2,1-6H3,(H,25,26)/b8-7+,16-13+
  • InChiKey: BOOOLEGQBVUTKC-YWRSBGDESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2E,4E)-3-methyl-5-[2-methyl-2-(1,1,4,4-tetramethyltetralin-6-yl)cyclopropyl]penta-2,4-dienoic acid
  • (2E,4E)-3-methyl-5-[2-methyl-2-(1,1,4,4-tetramethyl-6-tetralinyl)cyclopropyl]penta-2,4-dienoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens retinoic acid receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoid X receptor, gamma Starlite/ChEMBL References
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, alpha Starlite/ChEMBL References
Homo sapiens retinoic acid receptor, beta Starlite/ChEMBL No references
Homo sapiens retinoid X receptor, beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131607 All targets in OG5_131607
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Brugia malayi nuclear hormone receptor Get druggable targets OG5_131607 All targets in OG5_131607
Loa Loa (eye worm) nuclear receptor nhr-7B Get druggable targets OG5_131607 All targets in OG5_131607
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog Get druggable targets OG5_131607 All targets in OG5_131607
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor retinoid X receptor, gamma 340 aa 338 aa 24.6 %
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Onchocerca volvulus 0.0047 0.038 0.0144
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0563 0.0931
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.038 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Brugia malayi nuclear hormone receptor 0.0807 0.9497 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0079 0.0772 0.081
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi PHD-finger family protein 0.0028 0.0154 0.016
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.038 0.0398
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.038 0.0633
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0021 0.0018
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.038 0.0398
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.038 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0079 0.0772 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0739 0.123
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0278 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.0378
Schistosoma mansoni transient receptor potential channel 4 0.0111 0.1154 0.192
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Onchocerca volvulus 0.0047 0.038 0.0144
Onchocerca volvulus 0.0079 0.0772 0.0546
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0017 0.0014
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.0346 0.0367
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0686 0.0719
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.038 0.0404
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0772 0.1285
Echinococcus granulosus g-protein coupled receptor 0.0047 0.038 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1546 0.1653
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.038 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0269 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0269 0.0443
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0774 0.0811
Echinococcus multilocularis GPCR, family 2 0.0033 0.0221 0.0233
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0038 0.0271 0.0281
Echinococcus granulosus transient receptor potential gamma protein 0.0111 0.1154 0.1915
Loa Loa (eye worm) hypothetical protein 0.0035 0.0239 0.0248
Echinococcus granulosus neuropeptide receptor 0.0047 0.038 0.0628
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis g protein coupled receptor 0.0047 0.038 0.0404
Echinococcus multilocularis sex peptide receptor 0.0047 0.038 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0079 0.0772 0.081
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0269 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Brugia malayi nuclear receptor NHR-67 0.0037 0.0269 0.0281
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.9337 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.038 0.0628
Brugia malayi G-protein coupled receptor 0.0047 0.038 0.0398
Schistosoma mansoni nuclear receptor 0.0037 0.0269 0.0448
Schistosoma mansoni hypothetical protein 0.0033 0.0221 0.0368
Schistosoma mansoni neuropeptide receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) Smad1 0.0016 0.0017 0.0014
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0713 0.076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0079 0.0772 0.0823
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.038 0.0628
Echinococcus multilocularis FTZ F1 alpha 0.0079 0.0772 0.0823
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0079 0.0772 0.081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0772 0.081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0593
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0336 0.0356
Echinococcus granulosus somatostatin receptor 0.0047 0.038 0.0628
Echinococcus multilocularis muscleblind protein 0.0167 0.1823 0.195
Onchocerca volvulus 0.0037 0.0269 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0395 0.052
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0269 0.0448
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0079 0.0772 0.1285
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0043 0.0336 0.035
Onchocerca volvulus 0.0475 0.5523 0.5414
Brugia malayi Pre-SET motif family protein 0.0418 0.4831 0.5085
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.038 0.0397
Schistosoma mansoni retinoic acid receptor RXR 0.0516 0.6009 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0079 0.0772 0.128
Schistosoma mansoni steroid hormone receptor ad4bp 0.0079 0.0772 0.1285
Echinococcus multilocularis orexin receptor type 2 0.0047 0.038 0.0404
Brugia malayi photoreceptor-specific nuclear receptor 0.0079 0.0772 0.081
Brugia malayi ecdysone receptor 0.0037 0.0269 0.0281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi hypothetical protein 0.0037 0.0269 0.0281
Loa Loa (eye worm) hypothetical protein 0.005 0.0424 0.0443
Schistosoma mansoni thyroid hormone receptor 0.0079 0.0772 0.1285
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.038 0.0404
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.038 0.0404
Brugia malayi hypothetical protein 0.0033 0.021 0.0219
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0079 0.0772 0.1285
Brugia malayi AKH receptor 0.0047 0.038 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0079 0.0772 0.081
Brugia malayi G-protein coupled receptor 0.0047 0.038 0.0398
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0269 0.0281
Schistosoma mansoni histamine h1 receptor 0.0047 0.038 0.0633
Onchocerca volvulus 0.0047 0.038 0.0144
Loa Loa (eye worm) hypothetical protein 0.0077 0.0739 0.0775
Schistosoma mansoni biogenic amine receptor 0.0047 0.038 0.0633
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.038 0.0404
Echinococcus granulosus smad 0.0016 0.0017 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0348 0.5491
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0079 0.0772 0.081
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.038 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0079 0.0772 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0079 0.0772 0.081
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.038 0.0633
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0079 0.0772 0.0823
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0774 0.1219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Brugia malayi neuropeptide F receptor 0.0047 0.038 0.0398
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0424 0.7301
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0114 0.0184
Brugia malayi MH1 domain containing protein 0.0016 0.0017 0.0015
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.038 0.0628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0221 0.0362
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0079 0.0772 0.0823
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1546 0.2573
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.038 0.0397
Schistosoma mansoni hypothetical protein 0.002 0.0063 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0772 0.081
Brugia malayi steroid hormone receptor 0.0079 0.0772 0.081
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0323 0.0538
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.038 0.0628
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0269 0.0443
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.038 0.0633
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0772 0.081
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.4831 0.5085
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0323 0.0337
Loa Loa (eye worm) hypothetical protein 0.0068 0.0638 0.0668
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.038 0.0628
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.0346 0.0361
Schistosoma mansoni amine GPCR 0.0047 0.038 0.0633
Schistosoma mansoni neuropeptide receptor 0.0047 0.038 0.0633
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0079 0.0772 0.1285
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.038 0.0628
Schistosoma mansoni hypothetical protein 0.051 0.5941 0.9888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.0588
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.038 0.0404
Leishmania major hypothetical protein, conserved 0.005 0.0424 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0772 0.128
Brugia malayi Dopamine receptor 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0114 0.2692
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Brugia malayi RE15519p 0.0047 0.038 0.0398
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.038 0.0628
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.038 0.0633
Onchocerca volvulus 0.0047 0.038 0.0144
Brugia malayi nuclear receptor RXR 0.0037 0.0269 0.0281
Echinococcus multilocularis serotonin receptor 0.0047 0.038 0.0404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1087 0.1141
Echinococcus granulosus Smad4 0.0016 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus granulosus transient receptor potential ion channel A 0.0105 0.1078 0.179
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi putative neuropeptide receptor 0.0047 0.038 0.0398
Brugia malayi conserved hypotetical protein 0.0037 0.0269 0.0281
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0269 0.0448
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0271
Echinococcus granulosus serotonin receptor 0.0047 0.038 0.0628
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0424 1
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0772 0.081
Echinococcus multilocularis somatostatin receptor 0.0047 0.038 0.0404
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.038 0.0404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0323 0.0538
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0085 0.0136
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.038 0.0628
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0221 0.0233
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0079 0.0772 0.0823
Brugia malayi larval opioid receptor 0.0047 0.038 0.0398
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0079 0.0772 0.128
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0772 0.0823
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0269 0.0448
Schistosoma mansoni hypothetical protein 0.0047 0.038 0.0633
Brugia malayi hypothetical protein 0.0042 0.0323 0.0337
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.038 0.0144
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.038 0.0633
Schistosoma mansoni hypothetical protein 0.0023 0.0091 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0079 0.0772 0.081
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2704 0.2844
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0269 0.0281
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0363 0.0378
Brugia malayi nuclear receptor NHR-88 0.0079 0.0772 0.081
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.038 0.0397
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0424 0.7301
Echinococcus multilocularis ecdysone induced protein 78C 0.0079 0.0772 0.0823
Trichomonas vaginalis set domain proteins, putative 0.0475 0.5523 1
Schistosoma mansoni hypothetical protein 0.0033 0.0221 0.0368
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2704 0.2844
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi sulfakinin receptor protein 0.0047 0.038 0.0398
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0348 0.5491
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0348 0.0431
Plasmodium vivax SET domain protein, putative 0.006 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0114 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0091 0.0146
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0269 0.0285
Onchocerca volvulus 0.0047 0.038 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.0772 0.1285
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.038 0.0628
Schistosoma mansoni biogenic amine receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Schistosoma mansoni transient receptor potential channel 0.0074 0.0713 0.1187
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0348 0.5491
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0079 0.0772 0.1285
Echinococcus multilocularis neuropeptide receptor 0.0047 0.038 0.0404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Loa Loa (eye worm) steroid hormone receptor 0.0079 0.0772 0.081
Echinococcus multilocularis serotonin receptor 0.0047 0.038 0.0404
Brugia malayi Bromodomain containing protein 0.0077 0.0742 0.0779
Onchocerca volvulus Protein ultraspiracle homolog 0.0079 0.0772 0.0546
Echinococcus granulosus zinc finger protein 0.0023 0.0092 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.038 0.0628
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0017 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.038 0.0404
Brugia malayi ecdysteroid receptor 0.0079 0.0772 0.081
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0356 0.0372
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0079 0.0772 0.1285
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0337
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0348 0.0431
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.038 0.0404
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0091 0.0094
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.038 0.0633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0772 0.0823
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.038 0.0628
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.038 0.0633
Echinococcus multilocularis geminin 0.051 0.5941 0.6362
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0221 0.023
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0739 0.1225
Loa Loa (eye worm) hypothetical protein 0.0167 0.1823 0.1917
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.038 0.0628
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0772 0.128
Schistosoma mansoni amine GPCR 0.0047 0.038 0.0633
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0156
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0269 0.0285
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.038 0.0628
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0114 0.0117
Echinococcus multilocularis neuropeptide receptor 0.0047 0.038 0.0404
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.038 0.0633
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0017 0.0028
Schistosoma mansoni neuropeptide receptor 0.0047 0.038 0.0633
Schistosoma mansoni hypothetical protein 0.0047 0.038 0.0633
Echinococcus granulosus chromobox protein 1 0.0079 0.0774 0.1283
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0069 0.0069
Brugia malayi MH2 domain containing protein 0.024 0.2704 0.2845
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.038 0.0633
Schistosoma mansoni RAR-like nuclear receptor 0.0079 0.0772 0.1285
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.038 0.0398
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0269 0.028
Schistosoma mansoni adenoreceptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0337
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0397
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0355 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0593
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0807 0.9497 1
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0269 0.0443
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni coup transcription factor 0.0079 0.0772 0.1285
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0079 0.0772 0.081
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0323 0.0532
Onchocerca volvulus 0.0073 0.0695 0.0467
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0269 0.0443
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0323 0.0337
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0114 0.2692
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.038 0.0404
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.038 0.0404
Echinococcus granulosus muscleblind protein 0.0167 0.1823 0.303
Brugia malayi nuclear receptor NHR-88 0.0037 0.0269 0.0281
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0221 0.0229
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0114 0.019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0695 0.1157
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.038 0.0633
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0271 0.029
Schistosoma mansoni Smad4 0.0016 0.0017 0.0028
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.038 0.0628
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0336 0.0554
Echinococcus multilocularis muscleblind protein 1 0.0167 0.1823 0.195
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Echinococcus granulosus hypothetical protein 0.0047 0.038 0.0628
Brugia malayi G protein-coupled receptor 0.0047 0.038 0.0398
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.0346 0.057
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.038 0.0404
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0336 0.0351
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.038 0.0404
Loa Loa (eye worm) DR-78 0.0037 0.0269 0.028
Echinococcus multilocularis g protein coupled receptor 0.0047 0.038 0.0404
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0242 0.0256
Brugia malayi tailless protein 0.0037 0.0269 0.0281
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0079 0.0772 0.128
Schistosoma mansoni opsin-like receptor 0.0047 0.038 0.0633
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0269 0.0031
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.038 0.0633
Brugia malayi nuclear receptor RXR 0.0042 0.0323 0.0337
Echinococcus granulosus allatostatin A receptor 0.0047 0.038 0.0628
Echinococcus multilocularis fmrfamide receptor 0.0047 0.038 0.0404
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.038 0.0397
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0323 0.0337
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.0346 0.0361
Schistosoma mansoni opsin-like receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus multilocularis chromobox protein 1 0.0079 0.0774 0.0825
Echinococcus multilocularis short transient receptor potential channel 6 0.0074 0.0713 0.076
Schistosoma mansoni transient receptor potential channel 0.0074 0.0713 0.1187
Echinococcus multilocularis transient receptor potential gamma protein 0.0111 0.1154 0.1232
Loa Loa (eye worm) hypothetical protein 0.0106 0.1087 0.1141
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0079 0.0772 0.081
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0774 0.1219
Brugia malayi follicle stimulating hormone receptor 0.0047 0.038 0.0398
Onchocerca volvulus 0.0047 0.038 0.0144
Brugia malayi Serotonin receptor 0.0047 0.038 0.0398
Brugia malayi Serotonin receptor 0.0047 0.038 0.0398
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1471 0.2443
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.038 0.0633
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0739 0.0788
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0063 0.0062
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0713 0.1181
Echinococcus granulosus ecdysone induced protein 78C 0.0079 0.0772 0.128
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0079 0.0772 0.081
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0323 0.0342
Brugia malayi chromobox protein homolog 3 0.0045 0.0355 0.0371
Brugia malayi GnHR receptor homolog 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0424 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.0378
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.038 0.0404
Schistosoma mansoni neuropeptide receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0017 0.0014
Loa Loa (eye worm) acetyltransferase 0.0144 0.1546 0.1625
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis smad 0.0016 0.0017 0.0014
Brugia malayi Dopamine receptor protein 2 0.0047 0.038 0.0398
Echinococcus granulosus g protein coupled receptor 0.0047 0.038 0.0628
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0563 0.0599
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.038 0.0397
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.038 0.0628
Brugia malayi Pre-SET motif family protein 0.006 0.0539 0.0565
Echinococcus multilocularis transient receptor potential ion channel A 0.0105 0.1078 0.1152
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.038 0.0628
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.039 0.065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1087 0.1141
Schistosoma mansoni biogenic amine receptor 0.0047 0.038 0.0633
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0269 0.0281
Brugia malayi nuclear hormone receptor 0.0079 0.0772 0.081
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.038 0.0404
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0356 0.0372
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0269 0.0443
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.038 0.0628
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0539 1
Onchocerca volvulus 0.0037 0.0269 0.0031
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0278 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.038 0.0397
Echinococcus granulosus fmrfamide receptor 0.0047 0.038 0.0628
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0278 0.5285
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0337
Loa Loa (eye worm) hypothetical protein 0.0111 0.1154 0.1211
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.038 0.0628
Brugia malayi Dopamine receptor protein 1 0.0047 0.038 0.0398
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0079 0.0772 0.081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0337
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0269 0.0281
Schistosoma mansoni smad1 5 8 and 0.0016 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0769 0.9048 0.9527
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.038 0.0628
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.038 0.0404
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0269 0.0281
Brugia malayi Steroid receptor seven-up type 2 0.0079 0.0772 0.081
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.038 0.0633
Schistosoma mansoni hypothetical protein 0.051 0.5941 0.9888
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0269 0.028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Schistosoma mansoni amine GPCR 0.0047 0.038 0.0633
Brugia malayi MH1 domain containing protein 0.0016 0.0017 0.0015
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0021 0.0034
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.038 0.0144
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0513 0.0848
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni amine GPCR 0.0047 0.038 0.0633
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0085 0.0142
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus granulosus sex peptide receptor 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Schistosoma mansoni hypothetical protein 0.0033 0.0221 0.0368
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0271 0.029
Brugia malayi hypothetical protein 0.0037 0.0269 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0772 0.1285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0269 0.0285
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0114 0.2692
Schistosoma mansoni zinc finger protein 0.0037 0.0269 0.0448
Brugia malayi Muscleblind-like protein 0.0167 0.1823 0.1917
Echinococcus granulosus neuropeptide s receptor 0.0047 0.038 0.0628
Schistosoma mansoni hypothetical protein 0.0033 0.0221 0.0368
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Echinococcus multilocularis fmrfamide receptor 0.0047 0.038 0.0404
Schistosoma mansoni chromobox protein 0.0079 0.0774 0.1288
Schistosoma mansoni smad 0.0016 0.0017 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0739 0.123
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0395 0.052
Brugia malayi MH2 domain containing protein 0.0016 0.0017 0.0015
Echinococcus multilocularis Smad4 0.0016 0.0017 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0221 0.023
Brugia malayi MH2 domain containing protein 0.0016 0.0017 0.0015
Brugia malayi hypothetical protein 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Schistosoma mansoni opsin-like receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0072 0.0686 0.0719
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0348 0.0573
Loa Loa (eye worm) hypothetical protein 0.0069 0.065 0.0681
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0079 0.0772 0.081
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.038 0.0398
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0085 0.0087
Brugia malayi Melatonin receptor type 1A 0.0047 0.038 0.0398
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0221 0.0362
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0021 0.0028
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.038 0.0398
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0114 0.0119
Echinococcus granulosus chromobox protein 1 0.0079 0.0774 0.1283
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.038 0.0404
Echinococcus granulosus FTZ F1 alpha 0.0079 0.0772 0.128
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0395 0.016
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.038 0.0628
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0516 0.6009 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0269 0.0448
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0114 0.0117
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus granulosus neuropeptide receptor 0.0047 0.038 0.0628
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi Heterochromatin protein 1 0.0079 0.0774 0.0812
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0269 0.0285
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0017 0.0022
Echinococcus granulosus short transient receptor potential channel 6 0.0074 0.0713 0.1181
Brugia malayi neuropeptide F receptor 0.0047 0.038 0.0398
Brugia malayi hypothetical protein 0.0042 0.0323 0.0337
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus multilocularis g protein coupled receptor 0.0047 0.038 0.0404
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.038 0.0404
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0004 0.0006
Schistosoma mansoni transient receptor potential channel 0.0111 0.1154 0.192
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0355 0.0445
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.038 0.0397
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1546 0.1626
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0079 0.0772 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0156
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.038 0.0404
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0424 1
Schistosoma mansoni hypothetical protein 0.0047 0.038 0.0633
Echinococcus multilocularis chromobox protein 1 0.0079 0.0774 0.0825
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0221 0.0233
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0114 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0355 0.0445
Echinococcus granulosus GPCR family 2 0.0033 0.0221 0.0362
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0269 0.0448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0079 0.0772 0.081
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.038 0.0628
Echinococcus multilocularis zinc finger protein 0.0023 0.0092 0.0095
Schistosoma mansoni bromodomain containing protein 0.0065 0.0605 0.1006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0045 0.0355 0.037
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.039 0.065
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0017 0.0014
Echinococcus granulosus geminin 0.051 0.5941 0.9888
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.038 0.0398
Loa Loa (eye worm) hypothetical protein 0.0033 0.0221 0.0229
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0079 0.0772 0.081
Onchocerca volvulus 0.0047 0.038 0.0144
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0424 1
Brugia malayi hypothetical protein 0.005 0.0424 0.0444
Loa Loa (eye worm) hypothetical protein 0.0037 0.0269 0.028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.0294
Onchocerca volvulus 0.0047 0.038 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.038 0.0404
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0539 0.0897
Schistosoma mansoni chromobox protein 0.0079 0.0774 0.1288
Onchocerca volvulus Bile acid receptor homolog 0.0079 0.0772 0.0546
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.038 0.0404
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0079 0.0772 0.0823
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.038 0.0404
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.038 0.0397
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.038 0.0633
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0004 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.038 0.0633
Schistosoma mansoni zinc finger protein 0.0023 0.0092 0.0153
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0269 0.0443
Loa Loa (eye worm) hypothetical protein 0.0043 0.034 0.0355
Loa Loa (eye worm) hypothetical protein 0.0079 0.0772 0.081
Schistosoma mansoni hypothetical protein 0.0072 0.0686 0.1142
Schistosoma mansoni myosin xvIII 0.0047 0.038 0.0633
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0474 0.5506 0.5895
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0337
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1087 0.1141
Brugia malayi ORL1-like opioid receptor 0.0047 0.038 0.0398
Schistosoma mansoni amine GPCR 0.0047 0.038 0.0633
Brugia malayi Smad1 0.0016 0.0017 0.0015
Echinococcus granulosus g protein coupled receptor 0.0047 0.038 0.0628
Onchocerca volvulus 0.0047 0.038 0.0144
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.038 0.0397
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0269 0.0281
Loa Loa (eye worm) hypothetical protein 0.0167 0.1823 0.1917
Onchocerca volvulus 0.0047 0.038 0.0144
Echinococcus granulosus g protein coupled receptor 0.0047 0.038 0.0628
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0424 1
Echinococcus multilocularis allatostatin A receptor 0.0047 0.038 0.0404
Echinococcus granulosus orexin receptor type 2 0.0047 0.038 0.0628
Schistosoma mansoni hypothetical protein 0.0047 0.038 0.0633
Schistosoma mansoni nuclear receptor 0.0037 0.0269 0.0448
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0539 0.0574
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.038 0.0404
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0114 0.0117
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.038 0.0397
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.038 0.0633
Brugia malayi Bromodomain containing protein 0.0041 0.0312 0.0325
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.038 0.0404
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0079 0.0772 0.128
Loa Loa (eye worm) hypothetical protein 0.0047 0.038 0.0397
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0021 0.0034

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) = 1 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) = 1.5 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) = 1.5 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) = 2 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) = 2 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) = 200 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) = 200 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) = 340 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) = 340 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor gamma using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor beta using transactivation assay ChEMBL. No reference
EC50 (binding) > 1000 nM Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoic acid receptor gamma using transactivation assay ChEMBL. No reference
Kd (binding) = 1.5 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha ChEMBL. 11428923
Kd (binding) = 1.5 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 1.5 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-alpha ChEMBL. 11428923
Kd (binding) = 1.5 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 1.8 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma ChEMBL. 11428923
Kd (binding) = 1.8 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 1.8 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-gamma ChEMBL. 11428923
Kd (binding) = 1.8 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 2.5 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta ChEMBL. 11428923
Kd (binding) = 2.5 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 2.5 nM Inhibition of [3H]-9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta ChEMBL. 11428923
Kd (binding) = 2.5 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 556 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 556 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) > 1000 nM Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]-9-cis-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 9500 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha ChEMBL. 11428923
Kd (binding) = 9500 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha ChEMBL. 11428923
Kd (binding) = 9530 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 9530 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 15900 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma ChEMBL. 11428923
Kd (binding) = 15900 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-gamma ChEMBL. 11428923
Kd (binding) = 15942 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 15942 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 20472 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 20472 nM Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptor ChEMBL. No reference
Kd (binding) = 20500 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta ChEMBL. 11428923
Kd (binding) = 20500 nM Inhibition of [3H]-ATRA binding to baculovirus expressed retinoic acid receptor RAR-beta ChEMBL. 11428923

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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