Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3713 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.4331 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.1265 | 0.1265 |
Onchocerca volvulus | 0.0028 | 0.4331 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3713 | 0.8229 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0754 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0531 | 0.0531 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3713 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.4331 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.4619 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0006 | 0.042 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3713 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.4619 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3713 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3713 | 0.8239 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.1265 | 0.1796 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.042 | 0.5 |
Brugia malayi | hypothetical protein | 0.0016 | 0.214 | 0.376 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.4331 | 0.4331 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.8854 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0754 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.1265 | 0.1796 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4619 | 0.4619 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0006 | 0.042 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3713 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0006 | 0.042 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0006 | 0.042 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 uM | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | ChEMBL. | 21945250 |
IC50 (functional) | = 3.01 uM | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 21945250 |
IC50 (functional) | = 4.33 uM | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 21945250 |
IC50 (functional) | = 4.84 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 21945250 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21945250 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.