TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.426 | Formula: C24H20N2O5
H donors: 1 H acceptors: 3 LogP: 3.39 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1C(=O)c2c(C1=O)cc(cc2)OC(=O)CCc1ccc(cc1)N
InChi: 1S/C24H20N2O5/c1-30-18-9-7-17(8-10-18)26-23(28)20-12-11-19(14-21(20)24(26)29)31-22(27)13-4-15-2-5-16(25)6-3-15/h2-3,5-12,14H,4,13,25H2,1H3
InChiKey: SBHLOXKSQNXFIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	GPCR family 2	0.0034	0.0181	0.0181
Echinococcus granulosus	6 phosphofructokinase	0.0105	0.1014	0.1014
Schistosoma mansoni	hypothetical protein	0.0873	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0219	0.0781
Brugia malayi	hypothetical protein	0.0083	0.0752	0.2489
Loa Loa (eye worm)	RNA binding protein	0.0258	0.2801	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0028	0.0117	0.1549
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0825	0.0825
Plasmodium vivax	hypothetical protein, conserved	0.0071	0.0613	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0227	0.0812
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0324	0.0324
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.1014	0.362
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.1014	0.1014
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0098	0.0098
Brugia malayi	Heterochromatin protein 1	0.0067	0.0574	0.1836
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0073	0.072
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0191	0.0191
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.191	0.191
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Echinococcus granulosus	cpg binding protein	0.0094	0.0886	0.0886
Echinococcus multilocularis	expressed conserved protein	0.011	0.1067	0.1067
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0613	0.5986
Mycobacterium tuberculosis	Probable lipase LipE	0.0071	0.0613	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.2801	0.2801
Onchocerca volvulus		0.0071	0.0613	0.3417
Brugia malayi	RNA binding protein	0.0258	0.2801	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0245	0.0876
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0073	0.072
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0262
Brugia malayi	phosphofructokinase	0.0105	0.1014	0.3448
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.2801	0.2801
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.1014	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0181	0.0181
Loa Loa (eye worm)	6-phosphofructokinase	0.0105	0.1014	0.362
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0825	0.0825
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.064	0.2079
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0031	0.0145	0.1295
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0028	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0324	0.0324
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0022	0.0039	0.0039
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0324	0.0324
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0613	0.1207
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0574	0.5594
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0574	0.0574
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0452	0.5078	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0083	0.0752	1
Brugia malayi	chromobox protein homolog 3	0.0038	0.0227	0.0565
Plasmodium vivax	6-phosphofructokinase, putative	0.0028	0.0117	0.1549
Loa Loa (eye worm)	beta-lactamase	0.0071	0.0613	0.219
Leishmania major	hypothetical protein, conserved	0.0083	0.0752	0.7218
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0022	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0181	0.0646
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0613	0.0613
Mycobacterium ulcerans	lipase LipD	0.0071	0.0613	0.6048
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0181	0.0181
Mycobacterium tuberculosis	Probable hydrolase	0.0071	0.0613	0.1207
Echinococcus multilocularis	sterol regulatory element binding protein	0.005	0.0371	0.0371
Schistosoma mansoni	6-phosphofructokinase	0.0105	0.1014	0.1014
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.1014	0.8735
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0825	0.0825
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0021	0.0051
Brugia malayi	beta-lactamase	0.0071	0.0613	0.1979
Loa Loa (eye worm)	heterochromatin protein 1	0.0067	0.0574	0.205
Mycobacterium ulcerans	6-phosphofructokinase	0.0105	0.1014	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0181	0.0181
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0752	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0028	0.0117	0.0404
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.191	0.191
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0261	0.1187
Loa Loa (eye worm)	hypothetical protein	0.003	0.0132	0.0471
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0071	0.0613	0.0613
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0324	0.1587
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0324	0.0324
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0118	0.1171	0.1171
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0098	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0262
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0073	0.0144
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.0399	0.0399
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0073	0.072
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0105	0.1014	0.1996
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0574	0.0574
Mycobacterium leprae	Probable lipase LipE	0.0071	0.0613	0.5741
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0227	0.0974
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0261	0.2454
Brugia malayi	TAR-binding protein	0.0258	0.2801	1
Echinococcus multilocularis	protein dispatched 1	0.0057	0.0454	0.0454
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.1036	0.3531
Echinococcus multilocularis	dnaJ subfamily B	0.0827	0.9465	0.9465
Echinococcus granulosus	tar DNA binding protein	0.0258	0.2801	0.2801
Schistosoma mansoni	hypothetical protein	0.0034	0.0181	0.0181
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.1014	0.8735
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0071	0.0613	0.219
Schistosoma mansoni	cpg binding protein	0.0094	0.0886	0.0886
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0518	0.0518
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.1036	0.3531
Loa Loa (eye worm)	MBCTL1	0.0052	0.0399	0.1424
Echinococcus multilocularis	zinc finger protein	0.0024	0.0064	0.0064
Echinococcus multilocularis	tar DNA binding protein	0.0258	0.2801	0.2801
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0022	0.0039	0.0039
Toxoplasma gondii	LsmAD domain-containing protein	0.0083	0.0752	0.39
Schistosoma mansoni	cpg binding protein	0.0094	0.0886	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Trichomonas vaginalis	esterase, putative	0.0071	0.0613	0.5986
Brugia malayi	beta-lactamase family protein	0.0071	0.0613	0.1979
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0028	0.0117	0.1009
Onchocerca volvulus		0.0071	0.0613	0.3417
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.1014	1
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0037	0.0219	0.0219
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0031	0.0145	0.1295
Schistosoma mansoni	chromobox protein	0.0067	0.0574	0.0574
Mycobacterium ulcerans	beta-lactamase	0.0071	0.0613	0.6048
Onchocerca volvulus		0.0046	0.0324	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0073	0.0262
Echinococcus granulosus	expressed conserved protein	0.011	0.1067	0.1067
Schistosoma mansoni	hypothetical protein	0.0048	0.035	0.035
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0518	0.0518
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0071	0.0613	0.1207
Echinococcus granulosus	Niemann Pick C1 protein	0.0117	0.115	0.115
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Mycobacterium tuberculosis	Probable lipase LipD	0.0071	0.0613	0.1207
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0031	0.0145	0.1295
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.1014	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0613	0.5986
Brugia malayi	Bromodomain containing protein	0.0037	0.0218	0.053
Schistosoma mansoni	hypothetical protein	0.002	0.0018	0.0018
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.0399	0.0399
Echinococcus granulosus	chromobox protein 1	0.0067	0.0574	0.0574
Echinococcus multilocularis	6 phosphofructokinase	0.0105	0.1014	0.1014
Entamoeba histolytica	phosphofructokinase, putative	0.0105	0.1014	0.8735
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0073	0.072
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0785	0.8973	0.8973
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.2801	0.2801
Schistosoma mansoni	hypothetical protein	0.0037	0.0219	0.0219
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.0399	0.0399
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0073	0.072
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0752	0.2686
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0574	0.5594
Leishmania major	hypothetical protein, conserved	0.0071	0.0613	0.5741
Brugia malayi	RNA recognition motif domain containing protein	0.0258	0.2801	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0071	0.0613	0.6048
Schistosoma mansoni	hypothetical protein	0.0048	0.035	0.035
Schistosoma mansoni	hypothetical protein	0.0034	0.0181	0.0181
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0105	0.1014	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0037	0.0219	0.0219
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0105	0.1014	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0613	0.5986
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0098	0.0098
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.0399	0.0399
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.072
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0168	0.1746	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0191	0.0191
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.1014	1
Schistosoma mansoni	hypothetical protein	0.028	0.3063	0.3063
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.0825	0.2755
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0325	0.1161
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Brugia malayi	CXXC zinc finger family protein	0.0087	0.0806	0.2685
Schistosoma mansoni	bromodomain containing protein	0.0066	0.0559	0.0559
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0752	0.3469
Onchocerca volvulus		0.003	0.0132	0.0369
Echinococcus granulosus	dnaJ subfamily B	0.0827	0.9465	0.9465
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0181	0.0394
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0087	0.0806	0.2877
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0027	0.0101	0.0101
Brugia malayi	6-phosphofructokinase	0.0105	0.1014	0.3448
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.1036	0.37
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0073	0.0144
Schistosoma mansoni	hypothetical protein	0.0073	0.064	0.064
Loa Loa (eye worm)	histone methyltransferase	0.0027	0.0101	0.036
Brugia malayi	hypothetical protein	0.016	0.1654	0.5793
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0071	0.0613	0.0613
Trichomonas vaginalis	phosphofructokinase, putative	0.0105	0.1014	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0022	0.0038	0.0221
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0027	0.0101	0.0101
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.0399	0.0399
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0022	0.0039	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0371	0.3554
Brugia malayi	6-phosphofructokinase	0.0105	0.1014	0.3448
Brugia malayi	CHE-14 protein	0.005	0.0371	0.109
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.0825	0.2945
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0584	0.2087
Plasmodium falciparum	ataxin-2 like protein, putative	0.0083	0.0752	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0071	0.0613	0.6048
Schistosoma mansoni	chromobox protein	0.0067	0.0574	0.0574
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0261	0.2454
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0028	0.0117	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1036	0.37
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0613	0.1207
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0181	0.0181
Echinococcus multilocularis	Niemann Pick C1 protein	0.0117	0.115	0.115
Brugia malayi	Bromodomain containing protein	0.0077	0.0691	0.2264
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0324	0.0324
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0258	0.2801	1
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0227	0.2117
Leishmania major	ATP-dependent phosphofructokinase	0.0105	0.1014	1
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0324	0.0324
Onchocerca volvulus		0.0071	0.0613	0.3417
Schistosoma mansoni	hypothetical protein	0.0827	0.9465	0.9465
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.0825	0.0825
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0181	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0503	0.1794
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0185	0.195	0.195
Schistosoma mansoni	hypothetical protein	0.0034	0.0181	0.0181
Loa Loa (eye worm)	TAR-binding protein	0.0258	0.2801	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0167	0.1736	0.1736
Brugia malayi	mbt repeat family protein	0.0046	0.0324	0.0919
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.0825	0.0825
Brugia malayi	hypothetical protein	0.0053	0.0409	0.1232
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0098	0.0822
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0399	0.1424
Echinococcus granulosus	chromobox protein 1	0.0067	0.0574	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Trypanosoma cruzi	PAB1-binding protein , putative	0.0083	0.0752	0.3469
Loa Loa (eye worm)	hypothetical protein	0.0073	0.064	0.2287
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0022	0.0039	0.0039
Onchocerca volvulus		0.0087	0.0806	0.4635
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.072
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0105	0.1014	1
Schistosoma mansoni	cpg binding protein	0.0087	0.0806	0.0806
Toxoplasma gondii	ABC1 family protein	0.0071	0.0613	0.3048
Schistosoma mansoni	zinc finger protein	0.0024	0.0064	0.0064
Mycobacterium tuberculosis	Probable esterase LipL	0.0071	0.0613	0.1207
Mycobacterium tuberculosis	Conserved protein	0.0071	0.0613	0.1207
Loa Loa (eye worm)	hypothetical protein	0.016	0.1654	0.5903
Brugia malayi	PHD-finger family protein	0.0029	0.0125	0.0188
Trichomonas vaginalis	penicillin-binding protein, putative	0.0071	0.0613	0.5986
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0181	0.0181
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0071	0.0613	0.1207
Loa Loa (eye worm)	hypothetical protein	0.0117	0.115	0.4106
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0117	0.115	1
Echinococcus granulosus	zinc finger protein	0.0024	0.0064	0.0064
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0825	0.0825
Trypanosoma brucei	PAB1-binding protein , putative	0.0083	0.0752	0.3469
Echinococcus granulosus	sterol regulatory element binding protein	0.005	0.0371	0.0371
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0071	0.0613	0.1979
Schistosoma mansoni	hypothetical protein	0.0873	1	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.005	0.0371	0.1324
Echinococcus granulosus	Protein patched homolog 1	0.005	0.0371	0.0371
Echinococcus multilocularis	cpg binding protein	0.0094	0.0886	0.0886
Brugia malayi	mbt repeat family protein	0.0046	0.0324	0.0919
Echinococcus multilocularis	protein patched	0.005	0.0371	0.0371
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.0399	0.1193
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0018	0.0065
Schistosoma mansoni	hypothetical protein	0.0048	0.035	0.035
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Loa Loa (eye worm)	hypothetical protein	0.005	0.0371	0.1324
Brugia malayi	Niemann-Pick C1 protein precursor	0.0117	0.115	0.3947
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0073	0.072
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0181	0.0394
Echinococcus multilocularis	Niemann Pick C1 protein	0.0167	0.1736	0.1736
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0324	0.0324
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0098	0.0098
Schistosoma mansoni	hypothetical protein	0.0048	0.035	0.035
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0071	0.0613	0.1207
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.0825	0.0825
Loa Loa (eye worm)	phosphofructokinase	0.0105	0.1014	0.362
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0028	0.0117	0.1549
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0613	0.6048
Schistosoma mansoni	patched 1	0.005	0.0371	0.0371
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0181	0.0181
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0038	0.0221
Mycobacterium leprae	conserved hypothetical protein	0.0071	0.0613	0.5741
Onchocerca volvulus		0.016	0.1654	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0324	0.1157
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.2801	0.2801
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0227	0.2117
Echinococcus multilocularis	geminin	0.0873	1	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0028	0.0117	0.1549
Trichomonas vaginalis	D-aminoacylase, putative	0.0071	0.0613	0.5986
Brugia malayi	F/Y-rich N-terminus family protein	0.0028	0.0118	0.0165
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0028	0.0117	1
Schistosoma mansoni	tar DNA-binding protein	0.0258	0.2801	0.2801
Brugia malayi	beta-lactamase family protein	0.0071	0.0613	0.1979
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0324	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0613	0.219
Trichomonas vaginalis	phosphofructokinase, putative	0.0028	0.0117	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0018	0	0.0002
Echinococcus granulosus	beta LACTamase domain containing family member	0.0071	0.0613	0.0613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1170082

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1136235