Detailed information for compound 113650

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 271.186 | Formula: C12H10Cl2NS-
  • H donors: 0 H acceptors: 1 LogP: 4.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1SCc1ccccn1.[Cl-]
  • InChi: 1S/C12H10ClNS.ClH/c13-11-6-1-2-7-12(11)15-9-10-5-3-4-8-14-10;/h1-8H,9H2;1H/p-1
  • InChiKey: RARPRHKGBHONOH-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0362 0.0833 0.0833
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.0065 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0247 0.0243
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0306 0.0698 0.3861
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0028 0.0031 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0004
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0203 0.0203
Echinococcus multilocularis chromobox protein 1 0.0074 0.0142 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0109 0.0105
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Giardia lamblia Kinase, PLK 0.0095 0.0193 1
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.024 0.112
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0193 0.0189
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0052 0.0048
Toxoplasma gondii exonuclease III APE 0.0037 0.0053 0.0052
Brugia malayi CXXC zinc finger family protein 0.0118 0.0247 0.0247
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0025 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0193 0.0193
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0012 0.0001
Echinococcus granulosus jumonji domain containing protein 0.0084 0.0166 0.0162
Mycobacterium tuberculosis Conserved protein 0.0115 0.024 0.112
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0193 0.0182
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0053 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.024 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0011 0.001
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0306 0.0698 0.3861
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0362 0.0833 0.0829
Schistosoma mansoni ran 0.0023 0.0019 0.0019
Brugia malayi RNA binding protein 0.0189 0.0417 0.0417
Brugia malayi PHD-finger family protein 0.006 0.0109 0.0109
Schistosoma mansoni kinase 0.0048 0.0081 0.0081
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0275 0.0624 0.342
Schistosoma mansoni hypothetical protein 0.0115 0.024 0.024
Schistosoma mansoni fructose-16-bisphosphatase-related 0.4185 1 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0212 0.0208
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Leishmania major 0.4185 1 1
Plasmodium falciparum T-complex protein 1 subunit beta 0.0028 0.0031 0.0811
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.0065 0.0054
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0028 0.0402
Echinococcus multilocularis peregrin 0.006 0.0109 0.0105
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.0417 0.0417
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.024 0.112
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0011 0.001
Onchocerca volvulus 0.0118 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.0038 0.0038
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0042 0.0065 0.064
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0275 0.0624 0.8393
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0109 0.0105
Brugia malayi AF-10 protein 0.002 0.0012 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0058 0.1744
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0011 0.0007
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Schistosoma mansoni ap endonuclease 0.0037 0.0053 0.0053
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0193 0.0189
Brugia malayi Smad1 0.0016 0.0004 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Loa Loa (eye worm) hypothetical protein 0.0362 0.0833 0.0829
Entamoeba histolytica hypothetical protein 0.0036 0.0052 0.1868
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.4185 1 1
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0417 0.0417
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.001 0.0006
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.0065 0.0054
Echinococcus multilocularis cpg binding protein 0.0124 0.0263 0.0259
Echinococcus multilocularis bloom syndrome protein 0.0023 0.002 0.0015
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0053 0.1716
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.0065 0.0064
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0011 0.0007
Leishmania major GTP-binding protein, putative 0.0023 0.0019 0.0008
Schistosoma mansoni cpg binding protein 0.0124 0.0263 0.0263
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.024 0.112
Brugia malayi beta-lactamase 0.0115 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Leishmania major T-complex protein 1, beta subunit, putative 0.0028 0.0031 0.002
Brugia malayi Latrophilin receptor protein 2 0.0115 0.024 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.024 1
Entamoeba histolytica hypothetical protein 0.0036 0.0052 0.1868
Trichomonas vaginalis esterase, putative 0.0115 0.024 1
Schistosoma mansoni microtubule-associated protein tau 0.2778 0.6626 0.6626
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0064 0.2028
Brugia malayi chromobox protein homolog 3 0.0041 0.0064 0.0064
Brugia malayi RNA, U transporter 1 0.0088 0.0175 0.0175
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0011 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0019 0.0019
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.0065 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0052 0.0048
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0053 0.1531
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0065 0.0054
Brugia malayi Bromodomain containing protein 0.006 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0064 0.2028
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0193 0.0182
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0012 0.0011
Onchocerca volvulus 0.0115 0.024 0.9712
Echinococcus granulosus tar DNA binding protein 0.0189 0.0417 0.0413
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.0065 0.0065
Treponema pallidum NADH oxidase 0.0042 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0174 0.017
Schistosoma mansoni hypothetical protein 0.0329 0.0754 0.0754
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0193 0.0189
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.024 0.0235
Schistosoma mansoni Smad4 0.0016 0.0004 0.0004
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0109 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Leishmania major importin beta-1 subunit, putative 0.0025 0.0025 0.0013
Mycobacterium tuberculosis Conserved protein 0.0115 0.024 0.112
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0019 0.0322
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0039 0.0027
Mycobacterium ulcerans lipase LipD 0.0115 0.024 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.0065 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.0065 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Mycobacterium ulcerans beta-lactamase 0.0115 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.1556 0.3697 0.3689
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0197 0.0438 0.0434
Brugia malayi jmjC domain containing protein 0.008 0.0156 0.0156
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0031 0.0031
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0011 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Echinococcus multilocularis muscleblind protein 0.1273 0.3018 0.3015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0223 0.05 0.0498
Schistosoma mansoni hypothetical protein 0.006 0.0109 0.0109
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0011 0.0007
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0028 0.0023
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0065 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0019 0.0015
Brugia malayi beta-lactamase family protein 0.0115 0.024 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.0558 0.0554
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0025 0.0251
Trichomonas vaginalis helicase, putative 0.0027 0.0029 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0011 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.014 0.0136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.024 0.112
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0031 0.0031
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0019 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0053 0.0042
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0011 0.0007
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0193 0.0182
Entamoeba histolytica hypothetical protein 0.0036 0.0052 0.1868
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.024 0.112
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.024 0.0229
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0306 0.0698 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0039 0.1467
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1556 0.3697 0.3689
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0052 0.0048
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Echinococcus granulosus tumor protein p63 0.0678 0.159 0.1587
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.001 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0417 0.0417
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.0754 0.075
Loa Loa (eye worm) hypothetical protein 0.006 0.0109 0.0105
Plasmodium falciparum glutathione reductase 0.0042 0.0065 0.2209
Schistosoma mansoni ap endonuclease 0.0037 0.0053 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.0563 0.0563
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0275 0.0624 0.342
Echinococcus granulosus bloom syndrome protein 0.0023 0.002 0.0015
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0028 0.0031 0.0684
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0039 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0065 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.024 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Loa Loa (eye worm) thioredoxin reductase 0.0121 0.0254 0.025
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.001 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0039 0.0037
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0013 0.0057
Leishmania major trypanothione reductase 0.0121 0.0254 0.0243
Schistosoma mansoni hypothetical protein 0.0115 0.024 0.024
Leishmania major hypothetical protein, conserved 0.0115 0.024 0.0229
Trypanosoma cruzi trypanothione reductase, putative 0.0121 0.0254 0.0243
Brugia malayi Heterochromatin protein 1 0.0074 0.0142 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0053 0.0049
Schistosoma mansoni cpg binding protein 0.0124 0.0263 0.0263
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.001 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0053 0.0049
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.0065 0.2508
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0065 0.0054
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0011 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.024 0.0229
Plasmodium vivax JmjC domain containing protein 0.0019 0.0011 0.0383
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.002 0.001
Onchocerca volvulus 0.0115 0.024 0.9712
Plasmodium falciparum glutathione reductase 0.0121 0.0254 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0053 0.1531
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.0065 0.2073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0042 0.0065 0.064
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0053 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0072 0.2369
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.0541 0.0537
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.0038 0.0038
Echinococcus multilocularis thioredoxin glutathione reductase 0.0122 0.0258 0.0254
Onchocerca volvulus 0.0115 0.024 0.9712
Echinococcus multilocularis tumor protein p63 0.0678 0.159 0.1587
Toxoplasma gondii ABC1 family protein 0.0115 0.024 0.0239
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0011 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0275 0.0624 0.342
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0156 0.0156
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.024 0.0235
Loa Loa (eye worm) hypothetical protein 0.0087 0.0174 0.017
Schistosoma mansoni cpg binding protein 0.0118 0.0247 0.0247
Brugia malayi jmjC domain containing protein 0.0019 0.0011 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0053 0.0042
Echinococcus granulosus snurportin 1 0.0329 0.0754 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0035 0.0716
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0035 0.0031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.0065 0.0061
Schistosoma mansoni importin beta-1 0.0031 0.0039 0.0039
Giardia lamblia TCP-1 chaperonin subunit beta 0.0028 0.0031 0.0684
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0011 0.0007
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0028 0.0031 0.1163
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0052 0.0048
Schistosoma mansoni jumonji domain containing protein 0.0157 0.034 0.034
Schistosoma mansoni hypothetical protein 0.0715 0.1679 0.1679
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.171 0.4065 0.4063
Schistosoma mansoni hypothetical protein 0.0247 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0036 0.0052 0.0052
Plasmodium falciparum thioredoxin reductase 0.0042 0.0065 0.2209
Loa Loa (eye worm) hypothetical protein 0.1273 0.3018 0.3015
Echinococcus granulosus thioredoxin glutathione reductase 0.0122 0.0258 0.0254
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.024 0.0236
Brugia malayi CHD4 protein 0.0019 0.001 0.001
Brugia malayi T-complex protein 1, beta subunit 0.0028 0.0031 0.0031
Echinococcus granulosus geminin 0.0715 0.1679 0.1676
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0142 0.0138
Mycobacterium tuberculosis Conserved protein 0.0115 0.024 0.112
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.4185 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0109 0.0108
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0028 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0058 0.1744
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0193 1
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.024 0.0229
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.024 0.0235
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0042 0.0065 0.2209
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0052 0.0048
Brugia malayi PHD-finger family protein 0.0026 0.0028 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.0417 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0417 0.0417
Brugia malayi Thioredoxin reductase 0.0121 0.0254 0.0254
Brugia malayi glutathione reductase 0.0121 0.0254 0.0254
Loa Loa (eye worm) T-complex protein 1 0.0028 0.0031 0.0027
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.002 0.002
Toxoplasma gondii fructose-bisphospatase II 0.4185 1 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0011 0.0011
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0028 0.0031 0.0538
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.024 0.0236
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Onchocerca volvulus 0.0032 0.0043 0.1724
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0027 0.0029 0.0734
Brugia malayi TAR-binding protein 0.0189 0.0417 0.0417
Echinococcus granulosus phd:f box containing protein 0.0019 0.0011 0.0007
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0065 0.0054
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0011 0.0007
Echinococcus granulosus fructose 16 bisphosphatase 1 0.4185 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Loa Loa (eye worm) hypothetical protein 0.0099 0.0203 0.0199
Schistosoma mansoni hypothetical protein 0.0115 0.024 0.024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.024 0.112
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0012 0.0001
Plasmodium falciparum importin beta, putative 0.0031 0.0039 0.1127
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.1556 0.3697 0.3696
Brugia malayi hypothetical protein 0.0087 0.0174 0.0174
Plasmodium vivax thioredoxin reductase, putative 0.0121 0.0254 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.0156 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0065 0.0054
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0072 0.2896
Echinococcus granulosus chromobox protein 1 0.0074 0.0142 0.0138
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.4185 1 1
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0197 0.0438 0.0434
Mycobacterium tuberculosis Probable reductase 0.0275 0.0624 0.342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.024 0.024
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0035 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0142 0.5549
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0029 0.1089
Echinococcus multilocularis tar DNA binding protein 0.0189 0.0417 0.0413
Plasmodium vivax hypothetical protein, conserved 0.0115 0.024 0.945
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0275 0.0624 0.342
Echinococcus granulosus lysine specific demethylase 5A 0.008 0.0156 0.0152
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0028 0.0031 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.024 1
Brugia malayi jmjC domain containing protein 0.0019 0.0011 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.1273 0.3018 0.3015
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0035 0.0716
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.0065 0.0064
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.0065 0.0054
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0065 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0023 0.019
Plasmodium falciparum thioredoxin reductase 0.0121 0.0254 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0025 0.0251
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.0156 0.0152
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0053 0.2033
Echinococcus multilocularis geminin 0.0715 0.1679 0.1676
Mycobacterium tuberculosis Probable oxidoreductase 0.0306 0.0698 0.3861
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0042 0.0065 0.2209
Loa Loa (eye worm) glutathione reductase 0.0121 0.0254 0.025
Echinococcus granulosus muscleblind protein 0.1273 0.3018 0.3015
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0193 0.7803
Echinococcus granulosus cpg binding protein 0.0124 0.0263 0.0259
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0082 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.024 0.024
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0019 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Toxoplasma gondii t-complex protein beta subunit 0.0028 0.0031 0.003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0275 0.0624 0.342
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0035 0.0031
Brugia malayi MH2 domain containing protein 0.024 0.0541 0.0541
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Schistosoma mansoni chromobox protein 0.0074 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0115 0.024 0.024
Schistosoma mansoni smad 0.0016 0.0004 0.0004
Loa Loa (eye worm) RecQ helicase 0.0023 0.002 0.0015
Schistosoma mansoni hypothetical protein 0.1276 0.3023 0.3023
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0733 0.1722 1
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.4185 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.0065 0.0061
Brugia malayi hypothetical protein 0.0036 0.0052 0.0052
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0028 0.0031 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.024 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.024 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0019 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0019 0.0693
Echinococcus multilocularis snurportin 1 0.0329 0.0754 0.075
Loa Loa (eye worm) RNA binding protein 0.0189 0.0417 0.0413
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0064 0.2591
Echinococcus granulosus dnaJ subfamily B 0.1276 0.3023 0.302
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.024 0.0236
Giardia lamblia NADH oxidase lateral transfer candidate 0.0042 0.0065 0.2636
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0417 0.0417
Trypanosoma brucei trypanothione reductase 0.0121 0.0254 0.0243
Mycobacterium ulcerans hypothetical protein 0.0115 0.024 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Echinococcus granulosus microtubule associated protein 2 0.2778 0.6626 0.6624
Toxoplasma gondii fructose-bisphospatase I 0.1556 0.3697 0.3696
Brugia malayi latrophilin 2 splice variant baaae 0.0247 0.0558 0.0558
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0025 0.0013
Loa Loa (eye worm) hypothetical protein 0.0041 0.0064 0.006
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0109 0.0109
Trypanosoma brucei fructose-1,6-bisphosphatase 0.4185 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0035 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0078 0.2648
Brugia malayi Calcitonin receptor-like protein seb-1 0.0362 0.0833 0.0833
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.0541 0.0537
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.0166 0.0162
Brugia malayi beta-lactamase family protein 0.0115 0.024 0.024
Onchocerca volvulus 0.0099 0.0203 0.8207
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0098 0.0098
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0031 0.0031
Trypanosoma brucei polo-like protein kinase 0.0095 0.0193 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0078 0.2648
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0417 0.0417
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Loa Loa (eye worm) hypothetical protein 0.0032 0.0043 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0058 0.1744
Brugia malayi Muscleblind-like protein 0.1273 0.3018 0.3018
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0263 0.0259
Echinococcus multilocularis chromobox protein 1 0.0074 0.0142 0.0138
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0028 0.0031 0.0031
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.0065 0.2073
Entamoeba histolytica hypothetical protein 0.0025 0.0025 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0035
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0011 0.0011
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0028 0.0031 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0072 0.2369
Plasmodium vivax hypothetical protein, conserved 0.006 0.0109 0.4262
Brugia malayi jmjC domain containing protein 0.0197 0.0438 0.0438
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0028 0.0402
Brugia malayi jmjC domain containing protein 0.0019 0.0011 0.0011
Plasmodium falciparum phd finger protein, putative 0.006 0.0109 0.4034
Trichomonas vaginalis chaperonin, putative 0.0028 0.0031 0.0538
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0019 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.024 0.112
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0052 0.0052
Echinococcus multilocularis dnaJ subfamily B 0.1276 0.3023 0.302
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0065 0.0054
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0039 0.0027
Giardia lamblia PHD finger protein 15 0.006 0.0109 0.5185
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.024 0.0235
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0042 0.0065 0.064
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0019 0.0015
Plasmodium vivax glutathione reductase, putative 0.0121 0.0254 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0012 0.0011
Loa Loa (eye worm) TAR-binding protein 0.0189 0.0417 0.0413
Echinococcus multilocularis muscleblind protein 1 0.1273 0.3018 0.3015
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.0065 0.2508
Brugia malayi Importin beta-1 subunit 0.0031 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0715 0.1679 0.1679
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0053 0.1947
Schistosoma mansoni chromobox protein 0.0074 0.0142 0.0142
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.1556 0.3697 0.3689
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0053 0.1947
Brugia malayi jmjC domain containing protein 0.0019 0.0011 0.0011
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0142 0.5549
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.024 0.0235
Loa Loa (eye worm) beta-lactamase 0.0115 0.024 0.0236
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0121 0.0254 0.1203
Echinococcus granulosus GPCR family 2 0.0115 0.024 0.0235
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0053 0.0053
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0115 0.024 0.0236
Echinococcus multilocularis GPCR, family 2 0.0115 0.024 0.0235
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0193 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Echinococcus granulosus peregrin 0.006 0.0109 0.0105
Schistosoma mansoni ran 0.0023 0.0019 0.0019
Schistosoma mansoni eyes absent homolog 0.0087 0.0174 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.024 0.024
Echinococcus multilocularis microtubule associated protein 2 0.2778 0.6626 0.6624
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0019 0.0018
Echinococcus granulosus chromobox protein 1 0.0074 0.0142 0.0138
Entamoeba histolytica hypothetical protein 0.0036 0.0052 0.1868
Toxoplasma gondii thioredoxin reductase 0.0121 0.0254 0.0252
Onchocerca volvulus Alhambra homolog 0.006 0.0109 0.4421
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.002 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0193 0.7862
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0053 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0029 0.0433
Echinococcus granulosus importin subunit beta 1 0.0031 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.024 0.024
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0109 0.0108

Activities

Activity type Activity value Assay description Source Reference
ED40 (functional) = 300 uM kg-1 Inhibiton of dermal RPAR in rats following p.o. administration. ChEMBL. 6827539

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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