Detailed information for compound 1136625

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 492.689 | Formula: C32H44O4
  • H donors: 1 H acceptors: 3 LogP: 7.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOC(=O)[C@]1(C)CC[C@]2([C@@H](C1)[C@]1(C)CC[C@@]3(C(=CC=C4C3=CC(=O)C(=C4C)O)[C@]1(CC2)C)C)C
  • InChi: 1S/C32H44O4/c1-8-17-36-27(35)29(4)12-11-28(3)13-15-31(6)24-10-9-21-20(2)26(34)23(33)18-22(21)30(24,5)14-16-32(31,7)25(28)19-29/h9-10,18,25,34H,8,11-17,19H2,1-7H3/t25-,28-,29-,30+,31-,32+/m1/s1
  • InChiKey: OKOGABAEYJRJOB-JSJVQHDDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Smad4 0.0017 0.0039 0.0037
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.1408 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0244 0.0498
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.1408 0.2907
Entamoeba histolytica hypothetical protein 0.0149 0.1085 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0031 0.0028
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0236 0.0233
Trypanosoma brucei glucosidase, putative 0.0042 0.0236 0.166
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0191 0.045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0207 0.0204
Onchocerca volvulus 0.0014 0.0016 0.009
Plasmodium vivax hypothetical protein, conserved 0.019 0.1408 1
Schistosoma mansoni hypothetical protein 0.0622 0.4837 0.4835
Echinococcus multilocularis Smad4 0.0017 0.0039 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0307 0.073
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0312 0.2202
Echinococcus multilocularis geminin 0.0693 0.54 0.5399
Schistosoma mansoni smad1 5 8 and 0.0017 0.0039 0.0037
Brugia malayi RNA, U transporter 1 0.0166 0.1218 0.2914
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0243 0.024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0131 0.083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0016 0.003
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0016 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0285 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0278 0.1964
Loa Loa (eye worm) hypothetical protein 0.0035 0.018 0.0366
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0337 0.0334
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0027 0.0225
Entamoeba histolytica hypothetical protein 0.0149 0.1085 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.1714
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0243 0.0497
Entamoeba histolytica hypothetical protein 0.0149 0.1085 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0098 0.0681
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0366 0.2585
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0026
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0207 0.3501
Onchocerca volvulus 0.0118 0.0843 0.5978
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0039 0.0037
Mycobacterium tuberculosis Conserved protein 0.019 0.1408 0.148
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0189 0.3168
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0095
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0016 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.1408 0.337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0173 0.0182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0285 0.1981
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0095
Brugia malayi beta-lactamase family protein 0.019 0.1408 0.337
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.1408 0.1406
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0028
Loa Loa (eye worm) Smad1 0.0017 0.0039 0.0076
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0037
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0042 0.0044
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0095
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0058
Leishmania major GTP-binding protein, putative 0.0043 0.0244 0.1687
Brugia malayi beta-lactamase 0.019 0.1408 0.337
Echinococcus multilocularis dnaJ subfamily B 0.1273 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0243 0.1714
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.14 0.1397
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0337 0.0354
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0243 0.1714
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0278 0.1964
Mycobacterium ulcerans beta-lactamase 0.019 0.1408 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0031 0.0068
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0016
Echinococcus granulosus ferritin 0.0017 0.0042 0.0039
Echinococcus multilocularis tar DNA binding protein 0.0538 0.4172 0.4171
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0236 0.0233
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0042 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0028
Schistosoma mansoni smad1 5 8 and 0.0017 0.0039 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0538 0.4172 0.4171
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0027 0.0178
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0236 0.166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0038 0.0035
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0031 0.0059
Brugia malayi MH1 domain containing protein 0.0017 0.0039 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0236 0.166
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0207 0.0217
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0384
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0312 0.2202
Onchocerca volvulus 0.0014 0.0016 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Schistosoma mansoni ran 0.0043 0.0244 0.0241
Echinococcus granulosus cpg binding protein 0.0125 0.0897 0.0894
Loa Loa (eye worm) hypothetical protein 0.0083 0.0564 0.1161
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0131 0.2124
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.003
Brugia malayi TAR-binding protein 0.0538 0.4172 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0366 0.0751
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0016 0.0021
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0243 0.1714
Loa Loa (eye worm) TAR-binding protein 0.0538 0.4172 0.8626
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0087 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.1408 0.148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0251 0.1896 0.1894
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0013 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0137 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.14 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Mycobacterium ulcerans lipase LipD 0.019 0.1408 1
Schistosoma mansoni smad 0.0017 0.0039 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0137 0.0134
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0236 0.0558
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0149 0.1085 0.1083
Schistosoma mansoni apoferritin-2 0.0017 0.0042 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0002 0.00000000023534
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0039 0.0037
Toxoplasma gondii hypothetical protein 0.0029 0.0131 0.0693
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0236 0.215
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0027 0.0178
Brugia malayi MH1 domain containing protein 0.0017 0.0039 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0116 0.0812
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0307 0.063
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0564 0.3289
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0244 0.0241
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0007 0.0037
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0027 0.0178
Plasmodium falciparum importin beta, putative 0.0058 0.0366 0.6391
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0236 0.166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0026
Plasmodium vivax importin-beta 2, putative 0.0058 0.0366 0.2514
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1408 0.1406
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0244 0.1718
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0285 0.0299
Toxoplasma gondii histone lysine methyltransferase SET1 0.0224 0.1683 1
Leishmania major hypothetical protein, conserved 0.0051 0.0312 0.2173
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0098 0.0095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0236 0.215
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0194 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0236 0.166
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Brugia malayi CXXC zinc finger family protein 0.0118 0.0843 0.2015
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0027 0.0178
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0016 0.0016
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0039 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 1
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.1898 0.3921
Schistosoma mansoni ferritin 0.0017 0.0042 0.0039
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0042 0.019
Schistosoma mansoni alpha glucosidase 0.0042 0.0236 0.0233
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0016 0.0095
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0243 0.9855
Schistosoma mansoni tar DNA-binding protein 0.0538 0.4172 0.4171
Schistosoma mansoni Smad4 0.0017 0.0039 0.0037
Schistosoma mansoni hypothetical protein 0.0023 0.0087 0.0084
Echinococcus multilocularis cpg binding protein 0.0125 0.0897 0.0894
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0236 0.166
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Schistosoma mansoni ferritin 0.0017 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.0051 0.0312 0.0639
Mycobacterium leprae Probable lipase LipE 0.019 0.1408 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0244 0.1718
Schistosoma mansoni apoferritin-2 0.0017 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Schistosoma mansoni ap endonuclease 0.0038 0.0207 0.0204
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0031 0.0068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0207 0.1455
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0035 0.014
Toxoplasma gondii exonuclease III APE 0.0038 0.0207 0.1147
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0207 0.3157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0285 0.1934
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0007 0.0042
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0278 0.1964
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0042 0.0044
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0244 0.1718
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0291 0.2214 0.5303
Entamoeba histolytica Ran family GTPase 0.0043 0.0244 0.2225
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0312 0.5411
Echinococcus granulosus snurportin 1 0.0622 0.4837 0.4835
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0243 0.222
Mycobacterium ulcerans hypothetical protein 0.019 0.1408 1
Schistosoma mansoni hypothetical protein 0.0693 0.54 0.5399
Schistosoma mansoni tar DNA-binding protein 0.0538 0.4172 0.4171
Loa Loa (eye worm) oxidoreductase 0.0014 0.0016 0.0026
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0243 0.024
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0027 0.0178
Schistosoma mansoni ferritin 0.0017 0.0042 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0207 0.1885
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1408 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0564 0.0561
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0337 0.0334
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0016 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1408 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0027 0.0178
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0384
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0584
Echinococcus granulosus tar DNA binding protein 0.0538 0.4172 0.4171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0384
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0039 0.0037
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0016 0.0016
Trichomonas vaginalis esterase, putative 0.019 0.1408 1
Entamoeba histolytica hypothetical protein 0.0149 0.1085 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.1408 0.148
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0137 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0236 0.166
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0307 0.073
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.1408 0.148
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0207 0.1455
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.1408 0.148
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0027 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.1408 0.1406
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0207 0.0489
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0149 0.1085 0.1083
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0016 0.0117
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0016 0.0016
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.14 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0027 0.0178
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0236 0.1319
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.6487 0.6486
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0244 0.1638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.2214 0.2212
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0564 0.3289
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0028
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0087 0.0084
Schistosoma mansoni ferritin 0.0017 0.0042 0.0039
Echinococcus granulosus bloom syndrome protein 0.0025 0.0098 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1408 1
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0035 0.018 0.0177
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0016 0.0016
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0207 0.1455
Schistosoma mansoni myst-related protein 0.0014 0.0014 0.0012
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0285 0.2606
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1408 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0033 0.0107
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0337 0.2305
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0207 0.1455
Mycobacterium ulcerans hypothetical protein 0.0048 0.0285 0.1934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0285 0.1981
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0003 0.0004
Trypanosoma brucei hypothetical protein, conserved 0.019 0.1408 1
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0098 0.0681
Trichomonas vaginalis ferritin, putative 0.0017 0.0042 0.0283
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.1408 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0207 0.1455
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0337 0.0354
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0244 0.0241
Onchocerca volvulus 0.0014 0.0016 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.1898 0.3921
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0137 0.0134
Schistosoma mansoni alpha-glucosidase 0.0162 0.1191 0.1189
Brugia malayi hypothetical protein 0.0149 0.1085 0.2596
Mycobacterium tuberculosis Conserved protein 0.019 0.1408 0.148
Echinococcus multilocularis ferritin 0.0017 0.0042 0.0039
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0016 0.0016
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0312 0.1777
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0207 0.0204
Trichomonas vaginalis ran, putative 0.0043 0.0244 0.1718
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0016 0.003
Toxoplasma gondii ABC1 family protein 0.019 0.1408 0.835
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0194 0.0396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0028
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0016 0.0013
Schistosoma mansoni hypothetical protein 0.0693 0.54 0.5399
Schistosoma mansoni tar DNA-binding protein 0.0538 0.4172 0.4171
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0243 0.024
Brugia malayi MH2 domain containing protein 0.0017 0.0039 0.0088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0173 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0285 0.1981
Loa Loa (eye worm) hypothetical protein 0.0051 0.0307 0.063
Loa Loa (eye worm) beta-lactamase 0.019 0.1408 0.2907
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0236 0.166
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0027 0.0178
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0312 0.2202
Brugia malayi Importin beta-1 subunit 0.0058 0.0366 0.087
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0538 0.4172 0.8626
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0013 0.0003 0.0004
Schistosoma mansoni hypothetical protein 0.0149 0.1085 0.1083
Onchocerca volvulus 0.0048 0.0285 0.2007
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0243 0.024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0285 0.1934
Echinococcus granulosus GPCR family 2 0.0016 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0036 0.0189 0.0384
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0016 0.0013
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0016 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.14 0.335
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0285 0.1934
Echinococcus multilocularis expressed protein 0.0017 0.0042 0.0039
Schistosoma mansoni ferritin light chain 0.0017 0.0042 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.2214 0.2212
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0189 0.1242
Brugia malayi Smad1 0.0017 0.0039 0.0088
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0244 0.1368
Mycobacterium leprae conserved hypothetical protein 0.019 0.1408 1
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0013 0.0003 0.0004
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0243 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.1408 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0564 0.0561
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0207 0.1424
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0039 0.0037
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0236 0.166
Schistosoma mansoni ferritin light chain 0.0017 0.0042 0.0039
Loa Loa (eye worm) hypothetical protein 0.019 0.1408 0.2907
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0312 0.5411
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0027 0.0178
Trichomonas vaginalis hypothetical protein 0.0014 0.0018 0.0111
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0243 0.024
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.1408 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0622 0.4837 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.1408 0.148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0285 0.1934
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0207 0.1374
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0244 0.4171
Trichomonas vaginalis helicase, putative 0.0027 0.0116 0.0812
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.2214 0.2212
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0285 0.1934
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0207 0.0422
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0027 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0285 0.2606
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0013 0.0003 0.0004
Onchocerca volvulus 0.0109 0.0769 0.5451
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0285 0.1934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0291 0.2214 0.2212
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0018 0.0111
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0207 0.1374
Schistosoma mansoni cpg binding protein 0.0118 0.0843 0.084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0116 0.0812
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0584
Schistosoma mansoni myst-related protein 0.0014 0.0014 0.0012
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0016
Echinococcus granulosus importin subunit beta 1 0.0058 0.0366 0.0363
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.1408 0.148
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0039 0.0076
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.1408 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0131 0.1707
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0291 0.2214 0.4574
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0366 0.0363
Schistosoma mansoni cpg binding protein 0.0125 0.0897 0.0894
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 1
Loa Loa (eye worm) RNA binding protein 0.0538 0.4172 0.8626
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.1714
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0131 0.083
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0016 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0027 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.003
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0243 0.024
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0236 0.1629
Schistosoma mansoni smad1 5 8 and 0.0017 0.0039 0.0037
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.018 0.0424
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0366 0.2585
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0003 0.0004
Brugia malayi hypothetical protein 0.0033 0.0167 0.0394
Leishmania major importin beta-1 subunit, putative 0.0047 0.0278 0.1934
Schistosoma mansoni cpg binding protein 0.0125 0.0897 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0016 0.0058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0236 0.166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0137 0.0134
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0366 0.21
Echinococcus granulosus smad 0.0017 0.0039 0.0037
Entamoeba histolytica hypothetical protein 0.0014 0.0014 0.0107
Schistosoma mansoni hypothetical protein 0.1273 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0244 0.0578
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0564 0.3939
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0207 0.3157
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0236 0.166
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0074 0.1091
Loa Loa (eye worm) RecQ helicase 0.0025 0.0098 0.0197
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0236 0.166
Brugia malayi RNA recognition motif domain containing protein 0.0538 0.4172 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0059
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0016 0.0095
Brugia malayi RNA binding protein 0.0538 0.4172 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0243 0.024
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0312 0.2128
Echinococcus multilocularis snurportin 1 0.0622 0.4837 0.4835
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0016 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.2214 0.2212
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0244 1
Mycobacterium tuberculosis Probable hydrolase 0.019 0.1408 0.148
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0285 0.1934
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0027 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Entamoeba histolytica hypothetical protein 0.0047 0.0278 0.2545
Schistosoma mansoni tar DNA-binding protein 0.0538 0.4172 0.4171
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0116 0.0812
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0243 0.0576
Brugia malayi beta-lactamase family protein 0.019 0.1408 0.337
Schistosoma mansoni importin beta-1 0.0058 0.0366 0.0363
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0243 0.1714
Echinococcus granulosus geminin 0.0693 0.54 0.5399
Schistosoma mansoni ran 0.0043 0.0244 0.0241
Leishmania major hypothetical protein, conserved 0.019 0.1408 1
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0098 0.0228
Loa Loa (eye worm) CXXC zinc finger family protein 0.0118 0.0843 0.1738
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.14 0.289
Schistosoma mansoni transcription factor LCR-F1 0.0149 0.1085 0.1083
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0016 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0173 0.0182
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0013 0.0003 0.0004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0018 0.0111
Schistosoma mansoni ap endonuclease 0.0038 0.0207 0.0204
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0016 0.0095
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0285 0.1934
Brugia malayi hypothetical protein 0.0051 0.0312 0.0741
Onchocerca volvulus 0.0014 0.0016 0.009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0236 0.0481
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0243 0.1683
Loa Loa (eye worm) hypothetical protein 0.0123 0.0882 0.1819
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0291 0.2214 0.2212
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 0.3939
Brugia malayi MH2 domain containing protein 0.0251 0.1898 0.4546
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0042 0.019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0189 0.0198
Brugia malayi MH2 domain containing protein 0.0017 0.0039 0.0088
Onchocerca volvulus 0.019 0.1408 1
Onchocerca volvulus 0.019 0.1408 1
Mycobacterium tuberculosis Conserved protein 0.019 0.1408 0.148
Onchocerca volvulus 0.019 0.1408 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0194 0.0191
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0189 0.1242
Brugia malayi Probable ClpP-like protease 0.0083 0.0564 0.1346
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0564 0.3939
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0564 0.3939
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0116 0.0812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0291 0.2214 0.2212
Echinococcus multilocularis smad 0.0017 0.0039 0.0037
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0278 0.1964
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0285 0.0299
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0027 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0285 0.0677
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0285 0.1934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0173 0.0182
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0016 0.0095
Schistosoma mansoni alpha-glucosidase 0.0162 0.1191 0.1189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0007 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1212 0.9516 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0564 0.0561
Loa Loa (eye worm) hypothetical protein 0.0048 0.0285 0.0584
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0057 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0285 0.0677
Echinococcus granulosus expressed protein 0.0017 0.0042 0.0039
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.1408 0.1406
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0285 0.2606

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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