Detailed information for compound 113675

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.654 | Formula: C26H29N3O7S2
  • H donors: 4 H acceptors: 6 LogP: 2.39 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H](c1ccc(c(c1)NS(=O)(=O)C)O)CNC1CCN(CC1)S(=O)(=O)c1ccc2c(c1)c1ccccc1o2
  • InChi: 1S/C26H29N3O7S2/c1-37(32,33)28-22-14-17(6-8-23(22)30)24(31)16-27-18-10-12-29(13-11-18)38(34,35)19-7-9-26-21(15-19)20-4-2-3-5-25(20)36-26/h2-9,14-15,18,24,27-28,30-31H,10-13,16H2,1H3/t24-/m0/s1
  • InChiKey: SHUMLMXHWRHUSZ-DEOSSOPVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis MAM 0.0094 0.0073 0.0091
Plasmodium falciparum cysteine repeat modular protein 1 0.0049 0.0028 0.0656
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.044 0.042 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0023 0.0494
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0062 0.004 0.09
Echinococcus multilocularis tissue type plasminogen activator 0.0049 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.0392 0.0372 0.0372
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0076 0.0055 0.1234
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Toxoplasma gondii bicoid-interacting protein BIN3 0.0052 0.0031 0.0741
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0024 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.04 0.038 0.0475
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0017 0.0017
Plasmodium falciparum subtilisin-like protease 1 0.044 0.042 1
Loa Loa (eye worm) transcriptional regulator 0.0723 0.0703 0.0703
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0703 0.0703
Plasmodium falciparum plasmepsin I 0.0038 0.0017 0.0394
Onchocerca volvulus 0.0023 0.0002 0.0027
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0009 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.044 0.042 0.0687
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6109 0.6106 0.6106
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.003 0.003
Brugia malayi Probable ATP-dependent helicase DHX35 0.0068 0.0047 0.0047
Plasmodium vivax aspartyl protease, putative 0.0038 0.0017 0.0394
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0052 0.0031 0.0053
Onchocerca volvulus 0.003 0.0009 0.0127
Brugia malayi hypothetical protein 0.0134 0.0112 0.0112
Giardia lamblia hypothetical protein 0.0059 0.0038 0.0099
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Toxoplasma gondii kringle domain-containing protein 0.0049 0.0028 0.0656
Brugia malayi astacin protease protein 30 0.003 0.0009 0.0009
Echinococcus multilocularis epidermal growth factor receptor 0.0653 0.0633 0.0791
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0052 0.0031 0.0039
Brugia malayi celfurPC protein 0.8001 0.8004 0.8004
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0112 0.0091 0.0091
Onchocerca volvulus 0.0094 0.0073 0.105
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.044 0.042 0.042
Toxoplasma gondii serpin (serine proteinase inhibitor) superfamily protein 0.0023 0.0002 0.0045
Brugia malayi ADAMTS-like protease 0.0026 0.0005 0.0005
Echinococcus granulosus MAM 0.0094 0.0073 0.0073
Echinococcus granulosus integrin alpha ps 0.0032 0.001 0.001
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0018 0.0018
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0017 0.0017
Toxoplasma gondii subtilisin SUB10 0.044 0.042 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0107 0.0085 0.0085
Echinococcus granulosus C type lectin domian containing protein 0.0037 0.0016 0.0016
Toxoplasma gondii aspartyl protease ASP5 0.0388 0.0368 0.877
Schistosoma mansoni serpin 0.0023 0.0002 0.0002
Schistosoma mansoni tyrosine kinase 0.0653 0.0633 0.0633
Onchocerca volvulus 0.0023 0.0002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0145 0.0124 0.0124
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Brugia malayi Pepsin A precursor 0.0038 0.0017 0.0017
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.044 0.042 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0107 0.0085 0.0107
Schistosoma mansoni integrin alpha 0.0148 0.0127 0.0127
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0134 0.0112 0.2621
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.003 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0112 0.268
Trichomonas vaginalis conserved hypothetical protein 0.044 0.042 0.0687
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0055 0.1245
Onchocerca volvulus 0.0144 0.0123 0.1778
Loa Loa (eye worm) hypothetical protein 0.0094 0.0073 0.0073
Brugia malayi serpin (BmSERPIN) 0.0023 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Echinococcus granulosus epidermal growth factor receptor 0.0653 0.0633 0.0633
Brugia malayi serpin 0.0023 0.0002 0.0002
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.003 0.0009 0.0009
Leishmania major subtilisin-like serine peptidase 0.044 0.042 0.5801
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.047 0.045 0.625
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 0.0212 0.0212
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0052 0.0031 0.0031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Echinococcus multilocularis integrin alpha 3 0.0114 0.0092 0.0115
Toxoplasma gondii histone deacetylase SIR2-like 0.0107 0.0085 0.2037
Loa Loa (eye worm) fatty acid synthase 0.0078 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0657 0.0638 0.0638
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6109 0.6106 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.006 0.1363
Leishmania major sir2-family protein-like protein 0.0107 0.0085 0.0858
Brugia malayi Furin-like cysteine rich region family protein 0.0653 0.0633 0.0633
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0657 0.0638 0.0638
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Schistosoma mansoni hypothetical protein 0.0144 0.0123 0.0123
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.003 0.003
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.0072 0.0072
Trypanosoma brucei subtilisin peptidase 0.044 0.042 0.5779
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Echinococcus multilocularis 0.0134 0.0112 0.0141
Echinococcus multilocularis discoidin domain receptor 0.0051 0.003 0.0037
Echinococcus multilocularis protein jagged 2 0.0059 0.0038 0.0048
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.044 0.042 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0134 0.0112 0.268
Echinococcus multilocularis integrin alpha ps 0.0066 0.0045 0.0056
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.044 0.042 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Brugia malayi Serpin protein 6 0.0023 0.0002 0.0002
Treponema pallidum hypothetical protein 0.0021 0 0.5
Treponema pallidum 76K protein 0.0021 0 0.5
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0723 0.0703 0.0879
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0052 0.0052
Echinococcus multilocularis integrin alpha ps 0.0032 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Schistosoma mansoni discoidin domain receptor 0.0051 0.003 0.003
Onchocerca volvulus 0.0028 0.0007 0.0097
Brugia malayi hypothetical protein 0.0038 0.0017 0.0017
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0052 0.0031 0.0741
Onchocerca volvulus 0.0713 0.0693 1
Echinococcus granulosus plasminogen activator inhibitor 2 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Onchocerca volvulus 0.0037 0.0016 0.0224
Mycobacterium ulcerans Sir2-like regulatory protein 0.0107 0.0085 0.1983
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0107 0.0085 0.1215
Trypanosoma cruzi subtilisin peptidase 0.044 0.042 0.5801
Onchocerca volvulus 0.0037 0.0016 0.0224
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0032 0.001 0.0184
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0038
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0051 0.003 0.0645
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Entamoeba histolytica serine protease inhibitor, putative 0.0023 0.0002 0.0027
Schistosoma mansoni discoidin domain receptor 0.0051 0.003 0.003
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0049 0.0028 0.0028
Schistosoma mansoni amine oxidase 0.0134 0.0112 0.0112
Onchocerca volvulus Putative cubilin 0.0039 0.0018 0.026
Brugia malayi CUB domain containing protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.3883 0.3873 0.3873
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0055 0.1245
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0081 0.006 0.1352
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0047 0.0025 0.0025
Brugia malayi Carm1-pending protein 0.0052 0.0031 0.0031
Echinococcus multilocularis protein kinase c epsilon type 0.0096 0.0075 0.0093
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0017 0.0017
Mycobacterium ulcerans thioesterase 0.0066 0.0044 0.0996
Giardia lamblia Hypothetical protein 0.0723 0.0703 0.1914
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0076 0.0055 0.1253
Toxoplasma gondii subtilisin SUB11 0.044 0.042 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0085 0.0085
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0052 0.0031 0.0442
Leishmania major silent information regulator 2, putative 0.0723 0.0703 1
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.243 0.2416 0.2416
Toxoplasma gondii histone deacetylase SIR2 0.0107 0.0085 0.2037
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Loa Loa (eye worm) CUB domain-containing protein 0.003 0.0009 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0212 0.0212
Loa Loa (eye worm) proprotein convertase 2 0.243 0.2416 0.2416
Onchocerca volvulus 0.003 0.0009 0.0127
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0031 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Onchocerca volvulus 0.0023 0.0002 0.0027
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.003 0.0708
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0059 0.0038 0.0062
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0723 0.0703 0.1152
Echinococcus granulosus membrane bound transcription factor site 1 0.044 0.042 0.042
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0072 0.0118
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0055 0.1245
Entamoeba histolytica SWIRM domain protein 0.0056 0.0034 0.0487
Echinococcus multilocularis c4b binding protein beta chain 0.0037 0.0016 0.0019
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0002
Loa Loa (eye worm) acyl carrier protein 0.0036 0.0015 0.0015
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Echinococcus multilocularis 0.8001 0.8004 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0134 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.9992 1 1
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0052 0.0031 0.0031
Plasmodium vivax LCCL domain-containing protein 0.0051 0.003 0.0708
Brugia malayi CUB domain containing protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0068 0.0047 0.0047
Echinococcus multilocularis fibrillin 1 0.0062 0.0041 0.0051
Schistosoma mansoni integrin alpha-ps 0.0035 0.0013 0.0013
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0723 0.0703 0.1152
Giardia lamblia Neurogenic locus Notch protein precursor 0.0059 0.0038 0.0099
Onchocerca volvulus 0.0037 0.0016 0.0224
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Echinococcus granulosus tissue type plasminogen activator 0.0049 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Brugia malayi Subtilase family protein 0.044 0.042 0.042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Toxoplasma gondii subtilisin SUB8 0.044 0.042 1
Trichomonas vaginalis hypothetical protein 0.1991 0.1975 0.3235
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0034 0.0056
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0072 0.0118
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Chlamydia trachomatis protoporphyrinogen oxidase 0.0134 0.0112 0.5
Toxoplasma gondii rhoptry neck protein RON9 0.0037 0.0016 0.0371
Onchocerca volvulus 0.0051 0.003 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0061 0.0039 0.0875
Schistosoma mansoni integrin alpha-ps 0.0066 0.0045 0.0045
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Plasmodium vivax NAD-dependent deacetylase, putative 0.0107 0.0085 0.2037
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0044 0.0996
Loa Loa (eye worm) serpin protein 6 0.0023 0.0002 0.0002
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0076 0.0055 0.1253
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0002
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.003 0.0009 0.0011
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0081 0.006 0.1363
Loa Loa (eye worm) reprolysin 0.0045 0.0024 0.0024
Echinococcus granulosus neuropilin nrp and tolloid tll 0.003 0.0009 0.0009
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0017 0.0394
Plasmodium falciparum plasmepsin VII 0.0038 0.0017 0.0394
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0023 0.0002 0.0027
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0049 0.0028 0.0592
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0017 0.0017
Leishmania major UDP-galactopyranose mutase 0.0134 0.0112 0.1257
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0024 0.0024
Onchocerca volvulus 0.0049 0.0028 0.0397
Brugia malayi NAD-dependent deacetylase SIRT1 0.0107 0.0085 0.0085
Brugia malayi Sex muscle abnormal protein 5 0.0135 0.0114 0.0114
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0017 0.0017
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0017 0.0017
Plasmodium vivax subtilisin-like protease 2, putative 0.044 0.042 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Toxoplasma gondii type I fatty acid synthase, putative 0.0081 0.006 0.142
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0076 0.0055 0.1234
Schistosoma mansoni hypothetical protein 0.0094 0.0073 0.0073
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Onchocerca volvulus 0.0037 0.0016 0.0224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Entamoeba histolytica hypothetical protein, conserved 0.0107 0.0085 0.1215
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Schistosoma mansoni site-1 peptidase (S08 family) 0.044 0.042 0.042
Loa Loa (eye worm) integrin beta-2 0.2555 0.2542 0.2542
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0091 0.0091
Giardia lamblia Furin precursor putative serine protease 0.1991 0.1975 0.5382
Echinococcus granulosus protein arginine N methyltransferase 7 0.0052 0.0031 0.0031
Schistosoma mansoni furin-1 (S08 family) 0.4323 0.4314 0.4314
Mycobacterium ulcerans polyketide synthase Pks9 0.0049 0.0028 0.0604
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0038
Echinococcus multilocularis cpg binding protein 0.003 0.0008 0.001
Echinococcus granulosus cubilin 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0189 0.0168 0.0168
Echinococcus multilocularis protoporphyrinogen oxidase 0.0134 0.0112 0.0141
Mycobacterium ulcerans polyketide synthase 0.0076 0.0055 0.1245
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6109 0.6106 1
Mycobacterium ulcerans oxidoreductase 0.0134 0.0112 0.2631
Loa Loa (eye worm) hypothetical protein 0.0056 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0045 0.0024 0.0024
Brugia malayi transcriptional regulator, Sir2 family protein 0.0107 0.0085 0.0085
Brugia malayi Lectin C-type domain containing protein 0.003 0.0009 0.0009
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0091 0.0091
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0075 0.0053 0.0053
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1341 0.1324 0.1324
Onchocerca volvulus 0.003 0.0009 0.0127
Loa Loa (eye worm) endoprotease bli-4 0.9992 1 1
Onchocerca volvulus 0.0037 0.0016 0.0224
Brugia malayi Angiotensin-converting enzyme family protein 0.0664 0.0645 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0034 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Plasmodium falciparum plasmepsin VI 0.0038 0.0017 0.0394
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Mycobacterium tuberculosis Conserved hypothetical protein 0.0134 0.0112 0.2631
Mycobacterium ulcerans monoamine oxidase 0.0134 0.0112 0.2631
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0107 0.0085 0.2037
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0146 0.0125 0.0125
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.003 0.003
Toxoplasma gondii subtilisin SUB7 0.044 0.042 1
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1991 0.1975 0.3235
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.044 0.042 0.042
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0044 0.0996
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.0072 0.0072
Brugia malayi Protein arginine N-methyltransferase 0.0052 0.0031 0.0031
Toxoplasma gondii subtilisin SUB5 0.044 0.042 1
Brugia malayi CUB domain containing protein 0.003 0.0009 0.0009
Giardia lamblia High cysteine membrane protein Group 2 0.3678 0.3668 1
Echinococcus granulosus neuroendocrine convertase 2 0.6313 0.6311 0.6311
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.047 0.045 0.625
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0657 0.0638 0.0797
Plasmodium vivax aspartyl protease, putative 0.0038 0.0017 0.0394
Brugia malayi hypothetical protein 0.0392 0.0372 0.0372
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1991 0.1975 0.3235
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0664 0.0645 0.0645
Brugia malayi protein kinase C II. 0.0096 0.0075 0.0075
Plasmodium falciparum subtilisin-like protease 2 0.044 0.042 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0723 0.0703 0.0879
Mycobacterium ulcerans polyketide synthase Pks13 0.0115 0.0094 0.2181
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.003 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0134 0.0112 0.268
Echinococcus granulosus dnaJ subfamily B 0.04 0.038 0.038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0128 0.0107 0.0134
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0076 0.0055 0.0055
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.044 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0046 0.0025 0.0025
Brugia malayi amine oxidase, flavin-containing family protein 0.0189 0.0168 0.0168
Brugia malayi proprotein convertase 2 0.6313 0.6311 0.6311
Toxoplasma gondii histone lysine-specific demethylase 0.0134 0.0112 0.268
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0085 0.2037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Plasmodium falciparum plasmepsin X 0.0038 0.0017 0.0394
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Schistosoma mansoni cpg binding protein 0.003 0.0008 0.0008
Onchocerca volvulus 0.0031 0.0009 0.0133
Brugia malayi Protein kinase domain containing protein 0.0094 0.0073 0.0073
Brugia malayi Kringle domain containing protein 0.0049 0.0028 0.0028
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0052 0.0031 0.0053
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Brugia malayi hypothetical protein 0.0038 0.0017 0.0017
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0134 0.0112 0.268
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0107 0.0085 0.0228
Brugia malayi serpin precursor 0.0023 0.0002 0.0002
Schistosoma mansoni protein kinase 0.0128 0.0107 0.0107
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0051 0.003 0.0049
Echinococcus multilocularis protein will die slowly 0.0144 0.0123 0.0154
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0107 0.0085 0.0107
Mycobacterium leprae Polyketide synthase Pks13 0.0115 0.0094 0.2172
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0051 0.003 0.003
Echinococcus multilocularis Furin 1 0.243 0.2416 0.3019
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0044 0.0984
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.044 0.042 0.042
Echinococcus multilocularis integrin alpha ps 0.0066 0.0045 0.0056
Brugia malayi serpin 0.0023 0.0002 0.0002
Mycobacterium ulcerans dehydrogenase 0.0134 0.0112 0.2631
Onchocerca volvulus 0.0094 0.0073 0.105
Brugia malayi serpin 0.0023 0.0002 0.0002
Giardia lamblia High cysteine protein 0.0059 0.0038 0.0099
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0017 0.0394
Echinococcus granulosus furin 0.9992 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0657 0.0638 0.0638
Brugia malayi hypothetical protein 0.0145 0.0124 0.0124
Onchocerca volvulus 0.003 0.0009 0.0127
Brugia malayi EGF-like domain containing protein 0.0059 0.0038 0.0038
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0076 0.0055 0.1245
Echinococcus multilocularis integrin beta 2 0.1887 0.1871 0.2338
Plasmodium falciparum plasmepsin IV 0.0038 0.0017 0.0394
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Trichomonas vaginalis WD repeat domain, putative 0.0144 0.0123 0.0202
Toxoplasma gondii subtilisin SUB4 0.044 0.042 1
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Brugia malayi Nematode astacin protease protein 30 0.003 0.0009 0.0009
Echinococcus multilocularis fibrillin 2 0.0059 0.0038 0.0048
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.0072 0.0072
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Entamoeba histolytica SWIRM domain protein 0.0056 0.0034 0.0487
Onchocerca volvulus 0.0037 0.0016 0.0224
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.044 0.042 0.042
Onchocerca volvulus 0.0038 0.0017 0.0238
Giardia lamblia Transcriptional regulator, Sir2 family 0.0107 0.0085 0.0228
Schistosoma mansoni hypothetical protein 0.0052 0.0031 0.0031
Echinococcus granulosus c4b binding protein beta chain 0.0037 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.04 0.038 0.038
Echinococcus granulosus Furin 1 0.243 0.2416 0.2416
Echinococcus multilocularis cubilin 0.003 0.0009 0.0011
Brugia malayi EGF-like domain containing protein 0.0059 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.001
Onchocerca volvulus 0.0023 0.0002 0.0027
Brugia malayi EGF-like domain containing protein 0.0059 0.0038 0.0038
Schistosoma mansoni septate junction protein 0.006 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0094 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0076 0.0055 0.1245
Loa Loa (eye worm) CUB domain-containing protein 0.003 0.0009 0.0009
Brugia malayi serpin 0.0023 0.0002 0.0002
Brugia malayi SWIRM domain containing protein 0.0056 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.0013
Toxoplasma gondii subtilisin SUB6 0.044 0.042 1
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0093 0.0072 0.1712
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0056 0.0034 0.0043
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0134 0.0112 0.268
Schistosoma mansoni protein kinase 0.0128 0.0107 0.0107
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0017 0.0017
Brugia malayi CUB domain containing protein 0.003 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.1991 0.1975 0.1975
Giardia lamblia hypothetical protein 0.0056 0.0034 0.0088
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.003 0.0049
Brugia malayi ADAM-TS Spacer 1 family protein 0.0026 0.0005 0.0005
Schistosoma mansoni serpin 0.0023 0.0002 0.0002
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0422 0.0402 0.0402
Echinococcus multilocularis Estrogen regulated protein EP45 0.0023 0.0002 0.0002
Plasmodium falciparum plasmepsin V 0.0426 0.0406 0.9676
Echinococcus granulosus protein will die slowly 0.0144 0.0123 0.0123
Leishmania major arginine N-methyltransferase-like protein 0.0093 0.0072 0.0656
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Echinococcus granulosus fibrillin 2 0.0059 0.0038 0.0038
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.044 0.042 0.042
Trypanosoma brucei SIR2-like protein 4, putative 0.0107 0.0085 0.0809
Loa Loa (eye worm) hypothetical protein 0.0082 0.006 0.006
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.0208 0.0208
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0017 0.0021
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0107 0.0085 0.0107
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0035 0.0778
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0093 0.0072 0.009
Onchocerca volvulus Fatty acid synthase homolog 0.0142 0.0121 0.1742
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0128 0.0107 0.0107
Plasmodium vivax plasmepsin V, putative 0.0426 0.0406 0.9676
Brugia malayi BmSERPIN, truncated 0.0023 0.0002 0.0002
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0035 0.0827
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0145 0.0124 0.1388
Loa Loa (eye worm) hypothetical protein 0.0051 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0116 0.0095 0.0095
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0081 0.006 0.1352
Leishmania major arginine N-methyltransferase, type I 0.0052 0.0031 0.0053
Schistosoma mansoni SWI/SNF complex-related 0.0056 0.0034 0.0034
Plasmodium falciparum apical sushi protein 0.0037 0.0016 0.0371
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.003 0.0037
Giardia lamblia Tenascin precursor 0.0059 0.0038 0.0099
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0051 0.003 0.0634
Brugia malayi serpin (BmSERPIN) 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0074 0.0052 0.0754
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0017 0.0017
Loa Loa (eye worm) lectin C-type domain-containing protein 0.003 0.0009 0.0009
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0107 0.0085 0.1215
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0024 0.0003 0.0002
Giardia lamblia Tenascin-like 0.0059 0.0038 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0107 0.0085 0.1983
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.047 0.045 0.623
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Loa Loa (eye worm) hypothetical protein 0.0134 0.0112 0.0112
Loa Loa (eye worm) sirtuin 4 0.0107 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0118 0.0097 0.0097
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0017 0.0017
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.003 0.0037
Brugia malayi hypothetical protein 0.0094 0.0073 0.0073
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0703 0.0703
Echinococcus granulosus lysine specific histone demethylase 1A 0.0657 0.0638 0.0638
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Brugia malayi hypothetical protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0051 0.003 0.003
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0107 0.0085 0.0858
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0723 0.0703 1
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Toxoplasma gondii hypothetical protein 0.0059 0.0038 0.0908
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Plasmodium vivax subtilisin-like protease 1 0.044 0.042 1
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0134 0.0112 0.2631
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Trypanosoma cruzi UDP-galactopyranose mutase 0.0134 0.0112 0.1257
Echinococcus granulosus CUB 0.003 0.0009 0.0009
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0076 0.0055 0.1245
Brugia malayi transcriptional regulator, Sir2 family protein 0.0723 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.001
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0107 0.0085 0.0858
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Mycobacterium ulcerans fatty acid synthase Fas 0.0025 0.0003 0.0013
Echinococcus multilocularis membrane bound transcription factor site 1 0.044 0.042 0.0524
Schistosoma mansoni c4b-binding protein beta chain 0.0037 0.0016 0.0016
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0052 0.0031 0.0053
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0052 0.0031 0.0741
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Loa Loa (eye worm) TK/ALK protein kinase 0.0094 0.0073 0.0073
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0024 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Onchocerca volvulus 0.044 0.042 0.6052
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0723 0.0703 1
Echinococcus multilocularis CUB 0.003 0.0009 0.0011
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0052 0.0031 0.0039
Giardia lamblia Tenascin-37 0.0059 0.0038 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0003 0.0003
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0085 0.0085
Echinococcus multilocularis adam 0.0119 0.0098 0.0122
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0002 0.0002
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0031 0.0051
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0723 0.0703 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Loa Loa (eye worm) Carm1-pending protein 0.0052 0.0031 0.0031
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0017 0.0394
Brugia malayi zinc metalloproteinase toh-2 precursor 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0653 0.0633 0.0633
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0115 0.0094 0.2181
Plasmodium falciparum subtilisin-like protease 3 0.044 0.042 1
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.003 0.0708
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.044 0.042 0.0524
Echinococcus multilocularis serine protease inhibitor 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0178 0.0157 0.2259
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0112 0.0091 0.0091
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0081 0.006 0.1363
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.003 0.0009 0.0009
Echinococcus granulosus protein kinase c epsilon type 0.0096 0.0075 0.0075
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0061 0.0039 0.0875
Mycobacterium leprae Probable polyketide synthase Pks1 0.0081 0.006 0.1352
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Brugia malayi angiogenesis inhibito 0.0026 0.0005 0.0005
Brugia malayi Sushi domain 0.0037 0.0016 0.0016
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0017 0.0394
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0096 0.0075 0.0075
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0115 0.0094 0.2181
Echinococcus granulosus cubilin 0.003 0.0009 0.0009
Brugia malayi Integrin beta pat-3 precursor 0.2555 0.2542 0.2542
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Brugia malayi Protein kinase domain containing protein 0.0049 0.0028 0.0028
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.0017 0.0027
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.044 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Schistosoma mansoni growth factor receptor-bound protein 0.0135 0.0114 0.0114
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.003 0.0037
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0135 0.0114 0.2721
Trichomonas vaginalis conserved hypothetical protein 0.044 0.042 0.0687
Brugia malayi pregnancy-associated plasma protein-A 0.0037 0.0016 0.0016
Toxoplasma gondii aspartyl protease 0.0038 0.0017 0.0394
Schistosoma mansoni protein arginine n-methyltransferase 0.0052 0.0031 0.0031
Mycobacterium leprae Possible secreted protease 0.044 0.042 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0107 0.0085 0.2037
Brugia malayi CUB domain containing protein 0.003 0.0009 0.0009
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Giardia lamblia Tenascin-X 0.0059 0.0038 0.0099
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0017 0.0394
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0031 0.0051
Echinococcus multilocularis neuroendocrine convertase 2 0.6313 0.6311 0.7885
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0081 0.006 0.1363
Echinococcus multilocularis protein arginine methyltransferase 0.0093 0.0072 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Mycobacterium ulcerans NAD-dependent deacetylase 0.0107 0.0085 0.1983
Brugia malayi CXXC zinc finger family protein 0.0028 0.0007 0.0007
Mycobacterium tuberculosis Possible oxidoreductase 0.0134 0.0112 0.2631
Entamoeba histolytica PH domain containing protein kinase, putative 0.0078 0.0057 0.0812
Echinococcus granulosus integrin alpha ps 0.0066 0.0045 0.0045
Toxoplasma gondii SWIRM domain-containing protein 0.0056 0.0034 0.0817
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0049 0.0028 0.0656
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0135 0.0114 0.0114
Toxoplasma gondii subtilisin SUB9 0.044 0.042 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0007 0.0007
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.003 0.0037
Echinococcus granulosus fibrillin 1 0.0062 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.0072 0.0118
Onchocerca volvulus 0.0059 0.0038 0.055
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.003 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.003 0.0708
Echinococcus granulosus serine protease inhibitor 0.0023 0.0002 0.0002
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.044 0.042 0.5801
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.003 0.0049
Schistosoma mansoni serine protease inhibitors serpins 0.0023 0.0002 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6109 0.6106 0.7629
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0056 0.0034 0.0034
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0093 0.0072 0.1712
Echinococcus granulosus chromatin regulatory protein sir2 0.0723 0.0703 0.0703
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0134 0.0112 0.2631
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0107 0.0085 0.0085
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0107 0.0085 0.0858
Schistosoma mansoni integrin beta subunit 0.1495 0.1478 0.1478
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0085 0.014
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0723 0.0703 1
Giardia lamblia Sirtuin type 2 0.0107 0.0085 0.0228
Brugia malayi serpin 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0037 0.0016 0.0224
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1991 0.1975 0.3235
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9992 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0135 0.0114 0.0114
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0017 0.0394
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.003 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.003 0.0708
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0017
Toxoplasma gondii subtilisin SUB1 0.044 0.042 1
Entamoeba histolytica hypothetical protein 0.0056 0.0034 0.0487
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0018 0.0439
Brugia malayi hypothetical protein 0.0059 0.0038 0.0038
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.044 0.042 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0057 0.0057
Schistosoma mansoni amine oxidase 0.0134 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0094 0.0073 0.0073
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0032 0.076
Brugia malayi GCC2 and GCC3 family protein 0.0046 0.0025 0.0025
Schistosoma mansoni site-1 peptidase (S08 family) 0.044 0.042 0.042
Schistosoma mansoni cpg binding protein 0.0028 0.0007 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Loa Loa (eye worm) bone morphogenetic protein 1b 0.003 0.0009 0.0009
Brugia malayi Kelch motif family protein 0.0422 0.0402 0.0402
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0025 0.0003 0.0013
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0723 0.0703 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0074 0.0052 0.1187
Brugia malayi BmSERPIN 0.0023 0.0002 0.0002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0145 0.0124 0.1434
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0723 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0703 0.0703
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0005
Plasmodium vivax apical sushi protein, putative 0.0037 0.0016 0.0371
Loa Loa (eye worm) subtilase 0.044 0.042 0.042
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Plasmodium vivax LCCL domain-containing protein 0.0051 0.003 0.0708
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0075 0.0075
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Onchocerca volvulus 0.0037 0.0016 0.0224
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0017 0.0394
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.044 0.042 1
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0017 0.0394
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0134 0.0112 0.268
Brugia malayi EGF-like domain containing protein 0.0059 0.0038 0.0038
Mycobacterium ulcerans polyketide synthase 0.0081 0.006 0.1363
Brugia malayi neuroendocrine convertase 1 precursor 0.6313 0.6311 0.6311
Brugia malayi Nematode astacin protease protein 30 0.003 0.0009 0.0009
Echinococcus granulosus protein arginine methyltransferase 0.0093 0.0072 0.0072
Onchocerca volvulus 0.0038 0.0017 0.0238
Loa Loa (eye worm) transcriptional regulator 0.0107 0.0085 0.0085
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 0.0212 0.0212
Brugia malayi Reprolysin 0.0027 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Toxoplasma gondii rhoptry neck protein RON1 0.0037 0.0016 0.0371
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.002
Brugia malayi SWIRM domain containing protein 0.0713 0.0693 0.0693
Loa Loa (eye worm) transcriptional regulator 0.0107 0.0085 0.0085
Trichomonas vaginalis hypothetical protein 0.0051 0.003 0.0049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016
Loa Loa (eye worm) DPY-31 protein 0.003 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0009
Echinococcus multilocularis growth factor receptor bound protein 2 0.0135 0.0114 0.0142
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0145 0.0124 0.1434
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0127 0.0127
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0145 0.0124 0.1769
Onchocerca volvulus 0.0037 0.0016 0.0224
Schistosoma mansoni cpg binding protein 0.003 0.0008 0.0008
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0093 0.0072 0.1712
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.003 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0074 0.0052 0.0052
Loa Loa (eye worm) DEAH box polypeptide 35 0.0068 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0059 0.0038 0.0038
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0052 0.0031 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Onchocerca volvulus 0.0137 0.0116 0.1672
Toxoplasma gondii subtilisin SUB2 0.044 0.042 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 0.0212 0.0264
Plasmodium falciparum plasmepsin IX 0.0038 0.0017 0.0394
Echinococcus granulosus cpg binding protein 0.003 0.0008 0.0008
Echinococcus multilocularis cubilin 0.003 0.0009 0.0011
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0061 0.0039 0.0863
Giardia lamblia High cysteine protein 0.0059 0.0038 0.0099
Echinococcus granulosus Tolloid protein 1 0.003 0.0009 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Loa Loa (eye worm) hypothetical protein 0.0713 0.0693 0.0693
Schistosoma mansoni dock 0.0051 0.003 0.003
Schistosoma mansoni protein kinase 0.0128 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0134 0.0112 0.0112
Echinococcus granulosus protein arginine N methyltransferase 8 0.0093 0.0072 0.0072
Onchocerca volvulus 0.0037 0.0016 0.0224
Brugia malayi Suppressor of lurcher protein 1 precursor 0.003 0.0009 0.0009
Echinococcus granulosus adam 0.0119 0.0098 0.0098
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0134 0.0112 0.2631
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.044 0.042 1
Brugia malayi serpin 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.243 0.2416 0.3957
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0244 0.0223 0.0223
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0076 0.0055 0.1245
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Entamoeba histolytica hypothetical protein 0.0145 0.0124 0.1769
Echinococcus granulosus methyltransferase protein 5 0.0052 0.0031 0.0031
Loa Loa (eye worm) TK/ROR protein kinase 0.0049 0.0028 0.0028
Plasmodium falciparum plasmepsin II 0.0038 0.0017 0.0394
Brugia malayi Stress-activated protein kinase jnk-1 0.0232 0.0212 0.0212
Echinococcus granulosus Estrogen regulated protein EP45 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0038 0.0038
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Plasmodium falciparum protoporphyrinogen oxidase 0.0134 0.0112 0.268
Onchocerca volvulus 0.0051 0.003 0.0428
Brugia malayi Protein kinase domain containing protein 0.0051 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.003 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.1991 0.1975 0.3235
Onchocerca volvulus 0.0023 0.0002 0.0027
Echinococcus multilocularis serine:threonine protein kinase N2 0.0088 0.0067 0.0083
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.044 0.042 1
Schistosoma mansoni hypothetical protein 0.003 0.0009 0.0009
Plasmodium falciparum plasmepsin III 0.0038 0.0017 0.0394
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0052 0.0031 0.0053
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.003 0.0009 0.0009
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0107 0.0085 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.044 0.042 0.0687
Brugia malayi transcriptional regulator, Sir2 family protein 0.0107 0.0085 0.0085
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.003 0.003
Brugia malayi hypothetical protein 0.0037 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0081 0.006 0.1363
Echinococcus granulosus discoidin domain receptor 0.0051 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0009
Loa Loa (eye worm) WD40 repeat protein 0.0144 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0094 0.0073 0.0073
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0031 0.0009 0.0009
Plasmodium vivax subtilisin-like serine protease, putative 0.044 0.042 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0085 0.0085
Toxoplasma gondii protease inhibitor PI1 0.0023 0.0002 0.0045
Toxoplasma gondii subtilisin SUB12 0.044 0.042 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0049 0.0028 0.0604
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0107 0.0085 0.0809
Loa Loa (eye worm) hypothetical protein 0.0129 0.0108 0.0108
Echinococcus multilocularis Tolloid protein 1 0.003 0.0009 0.0011
Loa Loa (eye worm) serpin 0.0023 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0051 0.003 0.0708
Echinococcus granulosus integrin alpha 3 0.0114 0.0092 0.0092
Echinococcus multilocularis C type lectin domian containing protein 0.0037 0.0016 0.0019
Schistosoma mansoni growth factor receptor-bound protein 0.0135 0.0114 0.0114
Echinococcus granulosus integrin beta 2 0.1887 0.1871 0.1871
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.044 0.042 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0134 0.0112 0.1257
Plasmodium vivax aspartyl protease, putative 0.0038 0.0017 0.0394
Brugia malayi Will die slowly protein 0.0144 0.0123 0.0123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Giardia lamblia Neurogenic locus notch-like protein 0.0059 0.0038 0.0099
Loa Loa (eye worm) hypothetical protein 0.0039 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.042 0.0687
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0037 0.0016 0.0016
Trichomonas vaginalis hypothetical protein 0.0059 0.0038 0.0062
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0134 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0016

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) uM Agonistic activity against cloned human beta1-AR (beta1-adrenergic receptor) in CHO cells; not tested ChEMBL. 12798332
EC50 (functional) uM Agonistic activity against cloned human beta1-AR (beta2-adrenergic receptor) in CHO cells; not tested ChEMBL. 12798332
EC50 (functional) 0 uM Agonistic activity against cloned human beta1-AR (beta1-adrenergic receptor) in CHO cells; not tested ChEMBL. 12798332
EC50 (functional) 0 uM Agonistic activity against cloned human beta1-AR (beta2-adrenergic receptor) in CHO cells; not tested ChEMBL. 12798332
EC50 (functional) = 0.12 uM Agonistic activity against cloned human beta3-AR (beta3-adrenergic receptor) in CHO cells ChEMBL. 12798332
EC50 (functional) = 0.12 uM Agonistic activity against cloned human beta3-AR (beta3-adrenergic receptor) in CHO cells ChEMBL. 12798332
Intrinsic activity (binding) Intrinsic activity against cloned human beta1-AR was measured as fractions of the maximal response; not tested ChEMBL. 12798332
Intrinsic activity (binding) Intrinsic activity against cloned human beta2-AR was measured as fractions of the maximal response; not tested ChEMBL. 12798332
Intrinsic activity (binding) = 0.88 Intrinsic activity against cloned human beta3-AR was measured as fractions of the maximal response ChEMBL. 12798332
Intrinsic activity (binding) 0 Intrinsic activity against cloned human beta1-AR was measured as fractions of the maximal response; not tested ChEMBL. 12798332
Intrinsic activity (binding) 0 Intrinsic activity against cloned human beta2-AR was measured as fractions of the maximal response; not tested ChEMBL. 12798332
Intrinsic activity (binding) = 0.88 Intrinsic activity against cloned human beta3-AR was measured as fractions of the maximal response ChEMBL. 12798332

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.