Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Rattus norvegicus | Aminopeptidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0158 | 0.9978 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.4797 | 0.4808 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0131 | 0.5203 | 0.5214 |
Echinococcus granulosus | aminopeptidase N | 0.0158 | 1 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0158 | 0.9978 | 0.5 |
Onchocerca volvulus | 0.0158 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.00091 uM | Inhibitory activity against aminopeptidase B | ChEMBL. | 3184126 |
Ki (binding) | = 0.00091 uM | Inhibitory activity against aminopeptidase B | ChEMBL. | 3184126 |
Ki (binding) | = 0.11 uM | Inhibitory activity against Aminopeptidase M | ChEMBL. | 3184126 |
Ki (binding) | = 0.11 uM | Inhibitory activity against Aminopeptidase M | ChEMBL. | 3184126 |
Ki (binding) | > 1000 uM | Inhibitory activity against Leucine aminopeptidase | ChEMBL. | 3184126 |
Ki (binding) | > 1000 uM | Inhibitory activity against Leucine aminopeptidase | ChEMBL. | 3184126 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.