Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0382 | 0.5 |
Brugia malayi | intermediate filament protein | 0.003 | 0.3537 | 0.3537 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0382 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.3537 | 0.5541 |
Onchocerca volvulus | 0.003 | 0.3537 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.3537 | 0.3537 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Schistosoma mansoni | lamin | 0.003 | 0.3537 | 0.5541 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.6081 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0382 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6081 | 0.5 |
Echinococcus granulosus | lamin | 0.003 | 0.3537 | 0.5541 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0382 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.6081 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0382 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.3537 | 0.5541 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0382 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 1 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0382 | 0.5 |
Onchocerca volvulus | 0.003 | 0.3537 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.5545 | 0.5545 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.3537 | 0.3537 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0382 | 0.0013 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0375 | 0.0375 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0375 | 0.0375 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0382 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.6081 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.6081 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6081 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.5545 | 0.5545 |
Echinococcus multilocularis | lamin | 0.003 | 0.3537 | 0.5541 |
Brugia malayi | hypothetical protein | 0.004 | 0.6081 | 0.6081 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0382 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.3537 | 0.3537 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6081 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.3537 | 0.5541 |
Schistosoma mansoni | lamin | 0.003 | 0.3537 | 0.5541 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0375 | 0.0375 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.3537 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.3397 | 0.3397 |
Echinococcus multilocularis | musashi | 0.003 | 0.3537 | 0.5541 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0382 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.5545 | 0.906 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.3537 | 0.5541 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.6081 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0382 | 0.0013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.89 uM | Cytotoxicity against human HeLa cells after 72 hrs by MTT assay | ChEMBL. | 20409617 |
EC50 (functional) | = 31.69 uM | Cytotoxicity against human A549 cells after 72 hrs by MTT assay | ChEMBL. | 20409617 |
EC50 (functional) | = 64.98 uM | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | ChEMBL. | 20409617 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 20409617 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.