Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Schistosoma mansoni | biogenic amine (5HT) receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Echinococcus granulosus | biogenic amine 5HT receptor | Get druggable targets OG5_133074 | All targets in OG5_133074 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Serotonin 2 (5-HT2) receptor | 460 aa | 417 aa | 21.3 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Serotonin 2 (5-HT2) receptor | 460 aa | 405 aa | 31.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 2 (5-HT2) receptor | 460 aa | 427 aa | 28.3 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2 (5-HT2) receptor | 460 aa | 409 aa | 21.5 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2 (5-HT2) receptor | 460 aa | 409 aa | 21.8 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2 (5-HT2) receptor | 460 aa | 412 aa | 19.7 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2 (5-HT2) receptor | 460 aa | 412 aa | 19.9 % |
Echinococcus multilocularis | neuropeptides capa receptor | Serotonin 2 (5-HT2) receptor | 460 aa | 408 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.672 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Echinococcus granulosus | carboxylesterase 5A | 0.672 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.1135 | 0.1074 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.1135 | 0.1074 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.1135 | 0.1074 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.1135 | 0.1074 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.1135 | 0.1074 | 0.1074 |
Echinococcus multilocularis | neuroligin | 0.1135 | 0.1074 | 0.1074 |
Loa Loa (eye worm) | carboxylesterase | 0.672 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.1135 | 0.1074 | 0.1074 |
Echinococcus granulosus | BC026374 protein S09 family | 0.1135 | 0.1074 | 0.1074 |
Onchocerca volvulus | 0.1135 | 0.1074 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.672 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.672 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.672 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1135 | 0.1074 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.672 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.1135 | 0.1074 | 0.5 |
Schistosoma mansoni | gliotactin | 0.1135 | 0.1074 | 0.1074 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Echinococcus multilocularis | acetylcholinesterase | 0.672 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.1135 | 0.1074 | 0.1074 |
Echinococcus granulosus | neuroligin | 0.1135 | 0.1074 | 0.1074 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Onchocerca volvulus | 0.1135 | 0.1074 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.672 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Onchocerca volvulus | 0.1135 | 0.1074 | 0.5 | |
Onchocerca volvulus | 0.1135 | 0.1074 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.672 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Echinococcus granulosus | acetylcholinesterase | 0.672 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.672 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.1135 | 0.1074 | 0.1074 |
Schistosoma mansoni | acetylcholinesterase | 0.1135 | 0.1074 | 0.1074 |
Onchocerca volvulus | 0.1135 | 0.1074 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -7.62 | Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]-5-CT as radioligand | ChEMBL. | 12014957 |
Ki (binding) | = -7.34 | In vitro binding affinity to 5-hydroxytryptamine 2 receptor of rat cerebral cortex membranes using [3H]-ketanserin as the radioligand | ChEMBL. | 12014957 |
Log Ki (binding) | = 7.34 | In vitro binding affinity to 5-hydroxytryptamine 2 receptor of rat cerebral cortex membranes using [3H]-ketanserin as the radioligand | ChEMBL. | 12014957 |
Log Ki (binding) | = 7.62 | Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]-5-CT as radioligand | ChEMBL. | 12014957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.