Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Echinococcus granulosus | uridine phosphorylase 1 | 0.0119 | 0.11 | 0.1342 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.0488 | 0.0922 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0119 | 0.11 | 0.1146 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0488 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0851 | 0.1608 |
Treponema pallidum | pfs protein (pfs) | 0.0119 | 0.11 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0851 | 0.1608 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1787 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0008 | 0.0015 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.1389 | 0.2625 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0684 | 0.8144 | 0.8143 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0105 | 0.0144 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1093 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.11 | 0.1491 |
Echinococcus multilocularis | uridine phosphorylase 1 | 0.0119 | 0.11 | 0.1093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1389 | 0.1698 |
Treponema pallidum | uridine phosphorylase (udp) | 0.0119 | 0.11 | 0.5 |
Trypanosoma brucei | uridine phosphorylase | 0.0119 | 0.11 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.3793 | 0.3788 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.0488 | 0.0709 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0488 | 0.048 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0105 | 0.0156 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.0461 | 0.0669 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0574 | 0.6775 | 1 |
Brugia malayi | hypothetical protein | 0.0155 | 0.1552 | 0.2282 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0574 | 0.6775 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0142 | 0.0056 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1787 | 0.2187 |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.3793 | 0.4652 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0365 | 0.0439 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0008 | 0.0015 |
Brugia malayi | MTAP | 0.0119 | 0.11 | 0.1613 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0574 | 0.6775 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0365 | 0.0439 |
Echinococcus multilocularis | geminin | 0.0174 | 0.1787 | 0.1781 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0119 | 0.11 | 0.1146 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0851 | 0.1246 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.1389 | 0.1698 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.1389 | 0.1698 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0574 | 0.6775 | 1 |
Toxoplasma gondii | phosphorylase family protein | 0.0119 | 0.11 | 1 |
Brugia malayi | uridine phosphorylase family protein | 0.0119 | 0.11 | 0.1613 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1389 | 0.1698 |
Chlamydia trachomatis | AMP nucleosidase | 0.0119 | 0.11 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0488 | 0.059 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0142 | 0.0056 |
Treponema pallidum | purine nucleoside phosphorylase (deoD) | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0684 | 0.8144 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.0488 | 0.0573 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1146 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0488 | 0.059 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.5293 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0119 | 0.11 | 0.1146 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0365 | 0.0358 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0229 | 0.0271 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1552 | 0.2933 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0119 | 0.11 | 0.1491 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.0488 | 0.059 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Loa Loa (eye worm) | uridine phosphorylase | 0.0119 | 0.11 | 0.2078 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 1 |
Schistosoma mansoni | uridine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Toxoplasma gondii | phosphorylase family protein | 0.0119 | 0.11 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0851 | 0.1246 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0574 | 0.6775 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0142 | 0.021 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0574 | 0.6775 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.0488 | 0.048 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.0488 | 0.059 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0119 | 0.11 | 1 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.1389 | 0.1383 |
Schistosoma mansoni | uridine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0119 | 0.11 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0105 | 0.0199 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.1389 | 0.2042 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0455 | 0.5293 | 0.5289 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Trypanosoma cruzi | nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0119 | 0.11 | 0.5 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0119 | 0.11 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.1389 | 0.1698 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0119 | 0.11 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0461 | 0.0871 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0119 | 0.11 | 0.1146 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0455 | 0.5293 | 0.5289 |
Echinococcus granulosus | geminin | 0.0174 | 0.1787 | 0.2187 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0119 | 0.11 | 0.2078 |
Leishmania major | nucleoside phosphorylase-like protein | 0.0119 | 0.11 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0684 | 0.8144 | 1 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0455 | 0.5293 | 0.6495 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0461 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0229 | 0.0432 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.6772 |
Onchocerca volvulus | 0.0049 | 0.0229 | 0.0338 | |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.1491 |
Onchocerca volvulus | 0.0155 | 0.1552 | 0.2291 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.1389 | 0.1383 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0365 | 0.0439 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0119 | 0.11 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0574 | 0.6775 | 0.8317 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.