Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Leishmania major | trypanothione reductase | 0.0088 | 0.0965 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0222 | 0.3231 | 0.3231 |
Mycobacterium tuberculosis | Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) | 0.0624 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0068 | 0.0641 | 0.1521 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0088 | 0.0965 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0208 | 0.0447 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0043 | 0.0208 | 0.0208 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.017 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0043 | 0.0208 | 0.0208 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0208 | 1 |
Brugia malayi | Cell death protein 3 precursor | 0.0068 | 0.0641 | 0.6221 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0485 | 0.3663 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.5476 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.02 | 0.2856 | 0.2856 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.042 | 0.6561 | 0.6561 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0088 | 0.0965 | 0.923 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0295 | 0.07 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Treponema pallidum | NADH oxidase | 0.003 | 0 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0222 | 0.3231 | 0.3087 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0057 | 0.0443 | 0.3176 |
Plasmodium vivax | glutathione reductase, putative | 0.0088 | 0.0965 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.02 | 0.2856 | 0.2704 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.042 | 0.6561 | 0.6561 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0043 | 0.0208 | 0.0208 |
Brugia malayi | Thioredoxin reductase | 0.0088 | 0.0965 | 0.9357 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.0359 | 0.3481 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0208 | 0.2021 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.0359 | 0.3481 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0068 | 0.0641 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.02 | 0.2856 | 0.2856 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0222 | 0.3231 | 0.3231 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0092 | 0.1031 | 1 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.042 | 0.6561 | 0.6488 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0092 | 0.1031 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.017 | 0.1648 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0295 | 0.1453 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Echinococcus multilocularis | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Brugia malayi | glutathione reductase | 0.0088 | 0.0965 | 0.9357 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0273 | 0.4088 | 0.4088 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus granulosus | caspase 2 | 0.0068 | 0.0641 | 0.6221 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.02 | 0.2856 | 0.2856 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0043 | 0.0208 | 0.0208 |
Plasmodium falciparum | glutathione reductase | 0.0088 | 0.0965 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0208 | 1 |
Mycobacterium leprae | Isocitrate lyase | 0.0197 | 0.2804 | 0.265 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0048 | 0.0292 | 0.0292 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0043 | 0.0208 | 0.0208 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.02 | 0.2856 | 0.2856 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0092 | 0.1031 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.0359 | 0.2195 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.003 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.02 | 0.2856 | 0.2856 |
Brugia malayi | Cytochrome P450 family protein | 0.0057 | 0.0443 | 0.43 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0208 | 0.216 |
Mycobacterium tuberculosis | Conserved protein | 0.0043 | 0.0208 | 0.0208 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.042 | 0.6561 | 0.6561 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0088 | 0.0965 | 1 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0295 | 0.2861 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0092 | 0.1031 | 0.2445 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0485 | 0.4707 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | glutathione reductase | 0.0088 | 0.0965 | 0.923 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0043 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.003 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0208 | 0.0494 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.042 | 0.6561 | 0.6561 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0485 | 0.3663 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | naphthoate synthase | 0.0624 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0208 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0485 | 0.4707 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.0359 | 0.0851 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0208 | 0.2021 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0208 | 0.2021 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0048 | 0.0295 | 0.2861 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.02 | 0.2856 | 0.2856 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0208 | 0.2021 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0569 | 0.135 |
Plasmodium falciparum | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Onchocerca volvulus | 0.0048 | 0.0295 | 0.2 | |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0208 | 0.216 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0089 | 0.0984 | 0.9548 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0222 | 0.3231 | 0.3231 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0088 | 0.0965 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0208 | 0.0447 |
Toxoplasma gondii | thioredoxin reductase | 0.0088 | 0.0965 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0569 | 0.5521 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.0359 | 0.3481 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0208 | 0.0447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.