Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0907 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0907 | 0.0907 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | LGC-31 protein | 0.0018 | 0.0687 | 0.0687 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0907 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.2468 | 0.2468 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0907 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 1 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.2468 | 0.2468 |
Brugia malayi | Cation transporter family protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.2468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0907 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0907 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0907 | 0.3676 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0018 | 0.0687 | 0.0687 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 | |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0907 | 0.0907 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.2468 | 0.2468 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0018 | 0.0687 | 0.0687 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0907 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0907 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.2468 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0018 | 0.0687 | 0.0687 |
Onchocerca volvulus | Putative nachr subunit | 0.0018 | 0.0687 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.2468 | 0.2468 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0018 | 0.0687 | 0.0687 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0907 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0907 | 0.0907 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Echinococcus granulosus | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.2468 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.2468 | 0.2468 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0018 | 0.0687 | 0.0687 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0907 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0907 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0907 | 0.0907 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0018 | 0.0687 | 0.0687 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0907 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | ACC-1 protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.2468 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0907 | 0.0907 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Cation transporter family protein | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Cation transporter family protein | 0.0018 | 0.0687 | 0.0687 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0907 | 0.0907 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0018 | 0.0687 | 0.0687 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0018 | 0.0687 | 0.0687 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0018 | 0.0687 | 0.0687 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0018 | 0.0687 | 0.0687 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0018 | 0.0687 | 0.0687 |
Onchocerca volvulus | 0.0018 | 0.0687 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k cat (binding) | = 63 s-1 | Kcat of the compound was determined against P99 beta-lactamase | ChEMBL. | No reference |
Km (binding) | = 26.9 mM | Km of the compound was determined against P99 beta-lactamase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.