Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.6471 | 1 |
Onchocerca volvulus | 0.0332 | 1 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.6547 | 0.5 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0332 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.6471 | 0.6471 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0332 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.6547 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.8717 | 0.8717 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.6471 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0332 | 1 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0332 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.6547 | 0.5 |
Onchocerca volvulus | 0.0332 | 1 | 1 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0332 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.6471 | 0.6471 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 0.6547 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.6547 | 0.5 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0332 | 1 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0332 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.6547 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.6471 | 0.6471 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0332 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0332 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.6471 | 0.6471 |
Trichomonas vaginalis | cdc25b, putative | 0.0332 | 1 | 0.5 |
Onchocerca volvulus | 0.0332 | 1 | 1 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.6471 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.6471 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.6471 | 0.6471 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.6471 | 0.6471 |
Trichomonas vaginalis | cdc25c, putative | 0.0332 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0306 | 0.8717 | 0.8717 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0332 | 1 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0332 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0332 | 1 | 0.5 |
Trichomonas vaginalis | cdc25b, putative | 0.0332 | 1 | 0.5 |
Onchocerca volvulus | 0.0332 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 61 nM | Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay | ChEMBL. | 20452776 |
IC50 (binding) | = 356.6 nM | Inhibition of human DHFR by spectrophotometric assay | ChEMBL. | 20452776 |
Ki (binding) | = 3.6 nM | Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assay | ChEMBL. | 20452776 |
Ki (binding) | = 49.8 nM | Inhibition of human DHFR by spectrophotometric assay | ChEMBL. | 20452776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.