Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1761 | 0.1761 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.1761 | 0.6003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1761 | 0.1761 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1761 | 0.1761 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1111 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.1761 | 0.1761 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2934 | 0.2934 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2934 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2934 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2934 | 0.2934 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2934 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.1761 | 0.1761 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2934 | 0.2934 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1111 | 0.3787 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2934 | 0.2934 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.1111 | 0.1111 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.1111 | 0.1111 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1761 | 0.1761 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.1761 | 0.1761 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.1761 | 0.6003 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.1111 | 0.1111 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2934 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1111 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2934 | 0.2934 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2934 | 0.2934 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1111 | 0.1111 |
Echinococcus multilocularis | geminin | 0.0197 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1111 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2934 | 0.2934 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2934 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1111 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2934 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 | Compound was tested in vitro for antiaggregation induced by 0.5 uM ADP in guinea pig PRP | ChEMBL. | 3783580 |
Activity (functional) | = 0 | Compound was tested in vitro for antiaggregation induced by thrombin at 0.625 IU/mL in guinea pig PRP after 2 min | ChEMBL. | 3783580 |
Activity (functional) | = 0 | Compound was tested in vitro for antiaggregation induced by thrombin at 0.625 IU/mL in guinea pig PRP after 4 min | ChEMBL. | 3783580 |
Activity (functional) | = 44 | Compound was tested in vitro for the antithrombotic activity in mouse | ChEMBL. | 3783580 |
Activity (functional) | = 75 | Compound was tested in vitro for antiaggregation induced by collagen (0.8 ug/mL) in guinea pig PRP | ChEMBL. | 3783580 |
Activity (functional) | = 100 | In vitro inhibition of platelet aggregation induced by 0.5 uM ADP (irreversible activity) was determined in guinea pig PRP | ChEMBL. | 3783580 |
ED50 (functional) | = 145 mg kg-1 | Compound was evaluated for its antiinflammatory activity in rat by Carrageenan paw edema test | ChEMBL. | 3783580 |
LD50 (ADMET) | = 1100 mg kg-1 | Compound was tested for its lethality in vitro in mouse | ChEMBL. | 3783580 |
LD50 (ADMET) | = 1100 mg kg-1 | Compound was tested for its lethality in vitro in mouse | ChEMBL. | 3783580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.