TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.582 | Formula: C28H26N2O4S
H donors: 1 H acceptors: 4 LogP: 6.86 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(c1ccccc1)Sc1nc(OCCc2ccccc2)cc(n1)OCCc1ccccc1
InChi: 1S/C28H26N2O4S/c31-27(32)26(23-14-8-3-9-15-23)35-28-29-24(33-18-16-21-10-4-1-5-11-21)20-25(30-28)34-19-17-22-12-6-2-7-13-22/h1-15,20,26H,16-19H2,(H,31,32)
InChiKey: VHUIDJVKELHGQO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prostaglandin E synthase	Starlite/ChEMBL	References
Homo sapiens	arachidonate 5-lipoxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	ko:K00799 glutathione S-transferase [EC2.5.1.18], putative	Get druggable targets OG5_131112	All targets in OG5_131112
Schistosoma japonicum	ko:K00799 glutathione S-transferase [EC2.5.1.18], putative	Get druggable targets OG5_131112	All targets in OG5_131112
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	Get druggable targets OG5_131112	All targets in OG5_131112

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.002	0.0178	0.0617
Onchocerca volvulus		0.0026	0.0293	0.1016
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0167	0.0349
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.2253	0.3741
Schistosoma mansoni	myosin xvIII	0.0026	0.0293	0.0293
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0167	0.0277
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0167	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0178	0.0296
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0026	0.0293	0.1016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0178	0.0296
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	hypothetical protein	0.0024	0.0251	0.0417
Brugia malayi	steroid hormone receptor	0.002	0.0178	0.0296
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0025	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Onchocerca volvulus		0.0026	0.0293	0.1016
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0178	0.0296
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.001	0.0019	0.0019
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0308	0.0261
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0269	0.4481	0.744
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0019	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0293	0.0367
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0178	0.0296
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0178	0.0223
Echinococcus granulosus	cpg binding protein	0.0031	0.0378	0.0474
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0178	0.0178
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0308	0.4549
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0026	0.0293	0.0293
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0025	0.0268	1
Brugia malayi	neuropeptide F receptor	0.0026	0.0293	0.0487
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.3274	0.3274
Schistosoma mansoni	polycystin 1-related	0.0024	0.0251	0.0251
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0293	0.0487
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0268	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0293	0.0367
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0178	0.0223
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0178	0.0223
Schistosoma mansoni	hypothetical protein	0.0026	0.0293	0.0293
Schistosoma mansoni	cpg binding protein	0.0031	0.0378	0.0378
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.055	0.069
Brugia malayi	Serotonin receptor	0.0026	0.0293	0.0487
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.3274	0.3274
Schistosoma mansoni	hypothetical protein	0.0026	0.0293	0.0293
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0383	0.0635
Brugia malayi	hypothetical protein	0.0027	0.0308	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1358	0.2254
Schistosoma mansoni	amine GPCR	0.0026	0.0293	0.0293
Brugia malayi	larval opioid receptor	0.0026	0.0293	0.0487
Echinococcus multilocularis	dro:myosuppressin receptor	0.0026	0.0293	0.0367
Brugia malayi	RNA binding protein	0.0199	0.3274	0.5435
Schistosoma mansoni	cpg binding protein	0.003	0.0349	0.0349
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.3274	0.3274
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	hypothetical protein	0.0031	0.0383	0.0383
Echinococcus granulosus	sex peptide receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	microsomal glutathione s-transferase	0.0135	0.2169	0.2169
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0308	0.0407
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0178	0.0296
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0178	0.0223
Echinococcus granulosus	G protein coupled receptor 139	0.0026	0.0293	0.0367
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	neuropeptide receptor A26	0.0472	0.7977	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0293	0.0293
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0167	0.1043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0167	0.0209
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0026	0.0293	0.0293
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.305	0.6691
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0178	0.0296
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0199	0.3274	0.5435
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.0268	0.0559
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0178	0.0223
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0178	0.0178
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0026	0.0293	0.0367
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	serotonin receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0178	0.0223
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0178	0.0296
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0178	0.0223
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.0251	0.2858
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0167	0.002
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	0.9598
Brugia malayi	G protein-coupled receptor	0.0026	0.0293	0.0487
Loa Loa (eye worm)	RNA binding protein	0.0199	0.3274	0.5435
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.3069	0.3069
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	neuropeptide receptor	0.0026	0.0293	0.0367
Brugia malayi	Dopamine receptor protein 2	0.0026	0.0293	0.0487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0178	0.0296
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0167	0.0209
Schistosoma mansoni	coup transcription factor	0.002	0.0178	0.0178
Trypanosoma brucei	unspecified product	0.0019	0.0167	0.017
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.001	0.0019	0.0024
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0167	0.0209
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0032
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0293	0.0367
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0025	0.0268	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0026	0.0293	0.0367
Onchocerca volvulus		0.0026	0.0293	0.1016
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0293	0.0487
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0293	0.0293
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0026	0.0293	0.0367
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0293	0.0367
Echinococcus multilocularis	somatostatin receptor	0.0026	0.0293	0.0367
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0167	0.002
Leishmania major	DNA polymerase eta, putative	0.0019	0.0167	0.002
Echinococcus multilocularis	geminin	0.0373	0.6272	0.7863
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.2295	0.2877
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0251	0.0315
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0268	0.2846
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0178	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	0.9598
Brugia malayi	RE15519p	0.0026	0.0293	0.0487
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0178	0.0296
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0308	0.0261
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0308	0.3869
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0293	0.0293
Echinococcus granulosus	fmrfamide receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0167	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0383	0.048
Brugia malayi	Doublecortin family protein	0.0024	0.0251	0.0417
Echinococcus granulosus	GPCR family 2	0.0031	0.0383	0.048
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0026	0.0293	0.0487
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.3069	0.3848
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0167	0.0277
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0026	0.0293	0.0367
Brugia malayi	nuclear receptor RXR	0.001	0.0019	0.0032
Echinococcus granulosus	dro:myosuppressin receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	hypothetical protein	0.0037	0.0478	0.0478
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0155	0.015
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0293	0.0367
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0178	0.0296
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0026	0.0293	0.0367
Brugia malayi	follicle stimulating hormone receptor	0.0252	0.4177	0.6935
Loa Loa (eye worm)	TAR-binding protein	0.0199	0.3274	0.5435
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0178	0.0178
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Leishmania major	hypothetical protein, conserved	0.0027	0.0308	0.0261
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0293	0.0367
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Brugia malayi	hypothetical protein	0.0018	0.0143	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	opsin-like receptor	0.0026	0.0293	0.0293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.3069	0.3848
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0026	0.0293	0.0367
Echinococcus granulosus	dnaJ subfamily B	0.042	0.708	0.8876
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0167	0.1043
Brugia malayi	putative neuropeptide receptor	0.0026	0.0293	0.0487
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0167	0.0277
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0155	0.0194
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0019	0.0019
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0187	0.3069	0.3848
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1553	0.2578
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0478	0.0599
Schistosoma mansoni	opsin-like receptor	0.0026	0.0293	0.0293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.3069	0.3069
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	loxhd1	0.0024	0.0251	0.0251
Onchocerca volvulus		0.0026	0.0293	0.1016
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0293	0.0293
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0178	0.0178
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0026	0.0293	0.0487
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0167	0.0209
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	hypothetical protein	0.0373	0.6272	0.6272
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.055	0.1963
Brugia malayi	Dopamine receptor	0.0026	0.0293	0.0487
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0293	0.0367
Echinococcus multilocularis	sex peptide receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	histamine h1 receptor	0.0026	0.0293	0.0293
Echinococcus granulosus	RUN	0.0024	0.0251	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	orexin receptor type 2	0.0026	0.0293	0.0367
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0478	0.0478
Brugia malayi	Serotonin receptor	0.0026	0.0293	0.0487
Schistosoma mansoni	amine GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0032
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.0251	0.0417
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0167	0.0167
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0178	0.0223
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0167	0.0209
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.0251	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Trichomonas vaginalis	glucosylceramidase, putative	0.0177	0.2886	0.6312
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0178	0.0296
Echinococcus granulosus	7TM GPCR rhodopsin	0.0026	0.0293	0.0367
Schistosoma mansoni	amine GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0251	0.0417
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0178	0.0223
Echinococcus multilocularis	orexin receptor type 2	0.0026	0.0293	0.0367
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	hypothetical protein	0.0012	0.0051	0.0051
Echinococcus multilocularis	allatostatin A receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0178	0.0296
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0026	0.0293	0.0487
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0026	0.0293	0.0293
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0293	0.0293
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0178	0.0178
Echinococcus granulosus	tar DNA binding protein	0.0199	0.3274	0.4104
Brugia malayi	putative neuropeptide receptor NPR1	0.0026	0.0293	0.0487
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0308	0.0759
Schistosoma mansoni	rab6-interacting	0.0024	0.0251	0.0251
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0359	0.6023	1
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.001	0.0019	0.0032
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0178	0.0223
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0178	0.0223
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0383	0.048
Onchocerca volvulus		0.0026	0.0293	0.1016
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0178	0.0178
Echinococcus multilocularis	tar DNA binding protein	0.0199	0.3274	0.4104
Schistosoma mansoni	hypothetical protein	0.0031	0.0383	0.0383
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0167	0.0027
Echinococcus granulosus	allatostatin A receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.3274	0.3274
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Brugia malayi	G-protein coupled receptor	0.0026	0.0293	0.0487
Schistosoma mansoni	thyroid hormone receptor	0.002	0.0178	0.0178
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0178	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	lipoxygenase	0.01	0.1556	0.1556
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0025	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0308	0.0511
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0178	0.0296
Schistosoma mansoni	cpg binding protein	0.0031	0.0378	0.0378
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	G protein-coupled receptor F59B2.13	0.0026	0.0293	0.0487
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0383	0.048
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0383	0.0635
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0178	0.0223
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0178	0.0178
Brugia malayi	TAR-binding protein	0.0199	0.3274	0.5435
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	amine GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0383	0.0635
Echinococcus granulosus	hypothetical protein	0.0026	0.0293	0.0367
Echinococcus multilocularis	neuropeptide receptor A26	0.0472	0.7977	1
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0293	0.0367
Brugia malayi	AKH receptor	0.0026	0.0293	0.0487
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0155	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0251	0.0417
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0026	0.0293	0.1016
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0026	0.0293	0.0367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0293	0.0293
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0293	0.0293
Onchocerca volvulus		0.0026	0.0293	0.1016
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0099	0.1553	0.2578
Schistosoma mansoni	hypothetical protein	0.042	0.708	0.708
Loa Loa (eye worm)	hypothetical protein	0.0183	0.3001	0.4982
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0359	0.6023	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0099	0.1553	0.2578
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0026	0.0293	0.0367
Echinococcus granulosus	geminin	0.0373	0.6272	0.7863
Brugia malayi	ecdysteroid receptor	0.002	0.0178	0.0296
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0178	0.0223
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0026	0.0293	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0178	0.0296
Brugia malayi	hypothetical protein	0.0037	0.0478	0.0793
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0349	0.058
Echinococcus granulosus	L aminoadipate semialdehyde	0.0088	0.1358	0.1702
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0088	0.1358	0.2254
Schistosoma mansoni	lipoxygenase	0.0142	0.2295	0.2295
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0155	0.0194
Schistosoma mansoni	hypothetical protein	0.0024	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0178	0.0296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0178	0.0223
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0026	0.0293	0.0367
Echinococcus multilocularis	neuropeptide s receptor	0.0472	0.7977	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0178	0.0296
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.0268	0.0559
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0491	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0167	0.0277
Schistosoma mansoni	growth hormone secretagogue receptor	0.0026	0.0293	0.0293
Onchocerca volvulus		0.0026	0.0293	0.1016
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0025	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0026	0.0293	0.0293
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.055	0.1963
Loa Loa (eye worm)	TYRA-2 protein	0.0026	0.0293	0.0487
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.0251	0.0315
Echinococcus multilocularis	RUN	0.0024	0.0251	0.0315
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0293	0.0367
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0491	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.2253	0.2825
Schistosoma mansoni	adenoreceptor	0.0026	0.0293	0.0293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0187	0.3069	0.3069
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.1011	0.1679
Echinococcus multilocularis	G protein coupled receptor 139	0.0026	0.0293	0.0367
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0167	0.017
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0178	0.0296
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0251	0.0315
Brugia malayi	GnHR receptor homolog	0.0026	0.0293	0.0487
Brugia malayi	Melatonin receptor type 1A	0.0026	0.0293	0.0487
Echinococcus granulosus	7tm_1 domain containing protein	0.0026	0.0293	0.0367
Onchocerca volvulus		0.003	0.0349	0.1211
Loa Loa (eye worm)	acetyltransferase	0.014	0.2253	0.3741
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0026	0.0293	0.0487
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0167	0.002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0026	0.0293	0.0487
Onchocerca volvulus		0.0088	0.1358	0.4706
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0293	0.0367
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1011	0.1679
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0178	0.0223
Schistosoma mansoni	neuropeptide f receptor 76f	0.0026	0.0293	0.0293
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0491	1
Brugia malayi	hypothetical protein	0.0024	0.0251	0.0417
Echinococcus multilocularis	serotonin receptor	0.0026	0.0293	0.0367
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0167	0.002
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0293	0.0367
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.305	0.6691
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0293	0.0293
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0178	0.0296
Echinococcus multilocularis	dnaJ subfamily B	0.042	0.708	0.8876
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0178	0.0223
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0293	0.0367
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.0251	0.2431
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.055	0.0914
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0293	0.0487
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0359	0.6023	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	0.9598
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0308	0.4549
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0178	0.0296
Echinococcus granulosus	serotonin receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0187	0.3069	0.3848
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0383	0.048
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0178	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0293	0.0487
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0252	0.4177	0.6935
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Echinococcus granulosus	somatostatin receptor	0.0026	0.0293	0.0367
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0155	0.0258
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0167	0.0167
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0099	0.1553	0.2578
Schistosoma mansoni	amine GPCR	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0032
Schistosoma mansoni	hypothetical protein	0.0068	0.1011	0.1011
Brugia malayi	sulfakinin receptor protein	0.0026	0.0293	0.0487
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0293	0.0293
Brugia malayi	G-protein coupled receptor	0.0026	0.0293	0.0487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0178	0.0296
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0167	0.0349
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0026	0.0293	0.0487
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.055	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0167	0.1043
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0135	0.2169	0.2719
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0019	0.0032
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0293	0.0367
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.2295	0.2877
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0167	0.017
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0293	0.0367
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0293	0.0367
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0178	0.0178
Onchocerca volvulus		0.0026	0.0293	0.1016
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0026	0.0293	0.0367
Schistosoma mansoni	hypothetical protein	0.0031	0.0383	0.0383
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0167	0.002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.002	0.0178	0.0296
Schistosoma mansoni	hypothetical protein	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	tar DNA-binding protein	0.0199	0.3274	0.3274
Echinococcus granulosus	neuropeptide receptor	0.0026	0.0293	0.0367
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0178	0.0178
Brugia malayi	RNA recognition motif domain containing protein	0.0199	0.3274	0.5435
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0026	0.0293	0.0293
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0293	0.0293
Brugia malayi	ORL1-like opioid receptor	0.0026	0.0293	0.0487
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0051	0.0063
Echinococcus multilocularis	cpg binding protein	0.0031	0.0378	0.0474
Loa Loa (eye worm)	melatonin receptor type 1A	0.0026	0.0293	0.0487
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0025	0.0268	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0919	0.0919
Brugia malayi	Dopamine receptor protein 1	0.0026	0.0293	0.0487
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0293	0.0293
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Schistosoma mansoni	hypothetical protein	0.0026	0.0293	0.0293
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.001	0.0019	0.0024
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0051	0.0063
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0293	0.0367
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0293	0.0367
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0178	0.0617
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Brugia malayi	neuropeptide F receptor	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0178	0.0296
Leishmania major	C-8 sterol isomerase-like protein	0.0359	0.6023	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0167	0.0027
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0135	0.2169	0.2719
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0167	0.002
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0251	0.0315
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	0.9598
Echinococcus multilocularis	g-protein coupled receptor	0.0026	0.0293	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0359	0.6023	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0032
Entamoeba histolytica	hypothetical protein	0.0025	0.0268	0.3346
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0187	0.3069	0.5096
Schistosoma mansoni	hypothetical protein	0.0373	0.6272	0.6272
Schistosoma mansoni	ap endonuclease	0.0018	0.0155	0.0155
Schistosoma mansoni	rab6-interacting	0.0024	0.0251	0.0251
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0032
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0293	0.0367
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.2186	0.274
Onchocerca volvulus		0.0026	0.0293	0.1016
Brugia malayi	hypothetical protein	0.0026	0.0293	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0178	0.0296
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0293	0.0293
Onchocerca volvulus		0.0026	0.0293	0.1016
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0178	0.0617
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0178	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0863	0.3515
Schistosoma mansoni	hypothetical protein	0.0031	0.0383	0.0383
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0026	0.0293	0.0487
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0383	0.048
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0478	0.0599
Brugia malayi	hypothetical protein	0.001	0.0019	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Onchocerca volvulus	Glucosylceramidase homolog	0.0177	0.2886	1
Onchocerca volvulus		0.0026	0.0293	0.1016
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Brugia malayi	CXXC zinc finger family protein	0.003	0.0349	0.058
Brugia malayi	nuclear receptor NHR-88	0.002	0.0178	0.0296
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0088	0.1358	0.1702
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0167	0.017
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0178	0.0296
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0293	0.0367
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.055	0.0914
Echinococcus granulosus	neuropeptide s receptor	0.0472	0.7977	1
Brugia malayi	nuclear hormone receptor	0.002	0.0178	0.0296
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0251	0.0315
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0167	0.017
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0178	0.0178
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0167	0.1043
Leishmania major	phosphopantetheinyl transferase-like protein	0.0025	0.0268	0.0192
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0088	0.1358	0.1358
Schistosoma mansoni	opsin-like receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0269	0.4481	0.744
Echinococcus granulosus	g-protein coupled receptor	0.0026	0.0293	0.0367
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.2253	0.2253
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0293	0.0293
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0187	0.3069	0.5096
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0026	0.0293	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.0487
Onchocerca volvulus		0.0024	0.0251	0.0871
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0025	0.0268	0.3346
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0293	0.0293
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0167	0.017
Brugia malayi	hypothetical protein	0.001	0.0019	0.0032
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0268	0.0339
Schistosoma mansoni	ap endonuclease	0.0018	0.0155	0.0155
Onchocerca volvulus		0.0024	0.0251	0.0871
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0293	0.0293
Toxoplasma gondii	MAPEG family protein	0.0135	0.2169	1
Onchocerca volvulus		0.0026	0.0293	0.1016
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0383	0.0635
Trichomonas vaginalis	glucosylceramidase, putative	0.0269	0.4481	1
Echinococcus granulosus	dna polymerase eta	0.0019	0.0167	0.0209

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Agonist activity at human PPARgamma-LBD expressed in COS7 cells co-transfected with Gal4 at 20 uM by luciferase based transactivation assay	ChEMBL.	20503989
Activity (functional)		Agonist activity at human PPARdelta-LBD expressed in COS7 cells co-transfected with Gal4 at 10 uM by luciferase based transactivation assay	ChEMBL.	20503989
Activity (functional)		Agonist activity at human PPARalpha-LBD expressed in COS7 cells co-transfected with Gal4 at 10 uM by luciferase based transactivation assay	ChEMBL.	20503989
Activity (binding)	= 72.2 %	Inhibition of ovine COX1 assessed as residual activity at 10 uM after 5 mins	ChEMBL.	20503989
Activity (binding)	= 86 %	Inhibition of human recombinant COX2 assessed as residual activity at 10 uM after 5 mins	ChEMBL.	20503989
IC50 (binding)	= 0.8 uM	Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challenge	ChEMBL.	21591611
IC50 (binding)	= 1.2 uM	Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC analysis	ChEMBL.	21591611
IC50 (binding)	= 4.9 uM	Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysis	ChEMBL.	21591611

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1171851

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 1138107