Detailed information for compound 1138136

Basic information

Technical information
  • TDR Targets ID: 1138136
  • Name: 5-chloro-4-nitrothiophene-2-sulfonamide
  • MW: 242.661 | Formula: C4H3ClN2O4S2
  • H donors: 1 H acceptors: 4 LogP: 1.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(sc1Cl)S(=O)(=O)N
  • InChi: 1S/C4H3ClN2O4S2/c5-4-2(7(8)9)1-3(12-4)13(6,10)11/h1H,(H2,6,10,11)
  • InChiKey: CKMLFNQCVNTKHN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-4-nitro-thiophene-2-sulfonamide
  • 5-chloro-4-nitro-2-thiophenesulfonamide
  • ZINC04253283

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum MO15-related protein kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii cell-cycle-associated protein kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium falciparum MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
Cryptosporidium hominis cyclin-dependent kinase-related kinase Get druggable targets OG5_141009 All targets in OG5_141009
Cryptosporidium parvum cyclin-dependent kinase-related kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Babesia bovis cyclin-dependent kinase-related kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium knowlesi MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium berghei MO15-related protein kinase Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium yoelii MO15-related protein kinase Pfmrk Get druggable targets OG5_141009 All targets in OG5_141009
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative Get druggable targets OG5_141009 All targets in OG5_141009
Theileria parva cyclin-dependent kinase, putative Get druggable targets OG5_141009 All targets in OG5_141009
Neospora caninum CAM kinase, CDPK family, putative Get druggable targets OG5_141009 All targets in OG5_141009
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 MO15-related protein kinase 324 aa 313 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus chromobox protein 2 0.0013 0.0045 0.0045
Toxoplasma gondii ABC1 family protein 0.0039 0.0582 0.2114
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Brugia malayi F/Y-rich N-terminus family protein 0.0015 0.0088 0.008
Schistosoma mansoni tar DNA-binding protein 0.013 0.2479 0.2462
Brugia malayi CXXC zinc finger family protein 0.0034 0.0496 0.0837
Echinococcus multilocularis cpg binding protein 0.0041 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Echinococcus multilocularis dnaJ subfamily B 0.049 1 1
Onchocerca volvulus 0.0052 0.0866 1
Mycobacterium ulcerans glutaminase 0.0271 0.5428 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0079 0.1428 0.1409
Loa Loa (eye worm) hypothetical protein 0.0099 0.1846 0.3401
Schistosoma mansoni tar DNA-binding protein 0.013 0.2479 0.2462
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0082 0.1486 0.1486
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Mycobacterium ulcerans beta-lactamase 0.0039 0.0582 0.0841
Schistosoma mansoni apoferritin-2 0.0054 0.0909 0.0888
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0582 0.0998
Schistosoma mansoni tar DNA-binding protein 0.013 0.2479 0.2462
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0054 0.0909 0.1648
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0259 0.023
Schistosoma mansoni ferritin light chain 0.0054 0.0909 0.0888
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0582 0.0968
Schistosoma mansoni chromobox protein 0.0078 0.141 0.139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0477
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0019 0.0177 0.0177
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0582 0.0998
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0259 0.1548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.012 0.014
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.023
Brugia malayi RNA binding protein 0.013 0.2479 0.4521
Trichomonas vaginalis glutaminase, putative 0.0271 0.5428 1
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.511 0.511
Schistosoma mansoni cpg binding protein 0.0041 0.0627 0.0607
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.004 0.0604 0.0604
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0137 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0041
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0054 0.0909 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0866 0.1524
Echinococcus granulosus cpg binding protein 0.0041 0.0627 0.0627
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1849 0.1849
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0398
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0208 0.0302
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0014 0.0061 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0582 0.0968
Loa Loa (eye worm) bromodomain containing protein 0.004 0.0618 0.1138
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0589 0.0568
Plasmodium falciparum MO15-related protein kinase 0.0144 0.2785 1
Brugia malayi hypothetical protein 0.0256 0.511 0.9409
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0144 0.2785 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1428 1
Schistosoma mansoni hypothetical protein 0.0052 0.0866 0.0845
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0019 0.0177 0.0155
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.247 0.455
Loa Loa (eye worm) CHromoDomain protein family member 0.0019 0.0177 0.0326
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0582 0.0968
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0259 0.0294
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Loa Loa (eye worm) glutaminase 0.0271 0.5428 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0079 0.1428 0.263
Schistosoma mansoni tar DNA-binding protein 0.013 0.2479 0.2462
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0259 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0693 0.1203
Mycobacterium tuberculosis Conserved protein 0.0039 0.0582 0.0968
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0259 0.0294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1849 0.1831
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0582 0.0582
Brugia malayi TAR-binding protein 0.013 0.2479 0.4521
Echinococcus multilocularis chromobox protein 1 0.0078 0.141 0.141
Onchocerca volvulus 0.0039 0.0582 0.6549
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.1849 0.3352
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0582 0.0836
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0582 0.0968
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0259 0.1548
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.247 0.455
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0693 0.7892
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1428 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0079 0.1428 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0891 0.0891
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0208 0.0302
Schistosoma mansoni ferritin 0.0054 0.0909 0.0888
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0259 0.1548
Echinococcus multilocularis chromobox protein 1 0.0078 0.141 0.141
Onchocerca volvulus 0.0014 0.0061 0.0191
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0733 0.0733
Schistosoma mansoni survival motor neuron protein 0.0052 0.0866 0.0845
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Loa Loa (eye worm) beta-lactamase 0.0039 0.0582 0.1073
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0762 0.1332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1849 0.1831
Loa Loa (eye worm) hypothetical protein 0.004 0.0604 0.1113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0137 0.0337
Leishmania major hypothetical protein, conserved 0.0039 0.0582 0.2766
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0253
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.511 0.511
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.13 0.1281
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0582 0.0841
Mycobacterium ulcerans hypothetical protein 0.0039 0.0582 0.0841
Echinococcus multilocularis ferritin 0.0054 0.0909 0.0909
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0398
Schistosoma mansoni cpg binding protein 0.0034 0.0496 0.0475
Schistosoma mansoni chromobox protein 0.0013 0.0045 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0582 0.0841
Onchocerca volvulus 0.0034 0.0496 0.5493
Schistosoma mansoni ferritin 0.0054 0.0909 0.0888
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Brugia malayi beta-lactamase family protein 0.0039 0.0582 0.0998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0604 0.0583
Loa Loa (eye worm) hypothetical protein 0.0093 0.1715 0.3159
Brugia malayi SET domain containing protein 0.0014 0.0061 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0132 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0425 0.0707
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0582 0.0998
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0762 0.8738
Echinococcus multilocularis chromobox protein 2 0.0013 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0253
Echinococcus granulosus tar DNA binding protein 0.013 0.2479 0.2479
Loa Loa (eye worm) hypothetical protein 0.0256 0.511 0.9414
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Mycobacterium ulcerans bacterioferritin BfrA 0.0054 0.0909 0.1458
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0253
Schistosoma mansoni apoferritin-2 0.0054 0.0909 0.0888
Schistosoma mansoni ferritin 0.0054 0.0909 0.0888
Schistosoma mansoni zinc finger protein 0.0047 0.075 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0693 0.1203
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0259 0.023
Echinococcus granulosus methyl CpG binding domain protein 2 0.0039 0.0589 0.0589
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.4917 1
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0733 0.0733
Mycobacterium ulcerans hypothetical protein 0.0023 0.0259 0.023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0137 0.0337
Schistosoma mansoni hypothetical protein 0.0013 0.0045 0.0023
Trichomonas vaginalis chromobox protein, putative 0.0078 0.141 0.2535
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0891 0.0891
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0082 0.1486 0.1486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Onchocerca volvulus 0.0039 0.0582 0.6549
Schistosoma mansoni chromobox protein 0.0013 0.0045 0.0023
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Trichomonas vaginalis esterase, putative 0.0039 0.0582 0.0998
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0582 0.1073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0582 0.1073
Onchocerca volvulus 0.0039 0.0582 0.6549
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Echinococcus granulosus chromobox protein 1 0.0078 0.141 0.141
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0582 0.0968
Mycobacterium ulcerans bacterioferritin BfrB 0.0054 0.0909 0.1458
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0582 0.4976
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0138 0.2657 0.2657
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.125 0.4742
Echinococcus granulosus zinc finger protein 0.0047 0.075 0.075
Loa Loa (eye worm) glutaminase 2 0.0271 0.5428 1
Brugia malayi Heterochromatin protein 1 0.0078 0.141 0.2535
Loa Loa (eye worm) hypothetical protein 0.0161 0.314 0.5785
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0582 0.0998
Schistosoma mansoni tar DNA-binding protein 0.013 0.2479 0.2462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0138 0.2657 0.2657
Brugia malayi Bromodomain containing protein 0.0087 0.1599 0.2886
Echinococcus granulosus histone lysine methyltransferase setb 0.004 0.0604 0.0604
Trichomonas vaginalis chromobox protein, putative 0.0078 0.141 0.2535
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.1849 0.3407
Schistosoma mansoni bromodomain containing protein 0.0146 0.2827 0.2811
Loa Loa (eye worm) hypothetical protein 0.0087 0.1602 0.2951
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.1849 0.1831
Brugia malayi chromobox protein homolog 3 0.0044 0.0693 0.1203
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0582 0.0998
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0045 0.0045
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0079 0.1428 0.1428
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0495 0.0912
Brugia malayi beta-lactamase family protein 0.0039 0.0582 0.0998
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0045 0.0045
Mycobacterium tuberculosis Conserved protein 0.0039 0.0582 0.0968
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0477
Echinococcus granulosus chromobox protein 1 0.0078 0.141 0.141
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0891 0.087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0477
Onchocerca volvulus 0.0023 0.0259 0.2609
Schistosoma mansoni chromobox protein 0.0078 0.141 0.139
Echinococcus granulosus expressed protein 0.0054 0.0909 0.0909
Echinococcus granulosus Chromo domain 0.0013 0.0045 0.0045
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0762 0.1332
Loa Loa (eye worm) TAR-binding protein 0.013 0.2479 0.4566
Schistosoma mansoni methyl-cpg binding protein mbd 0.0039 0.0589 0.0568
Onchocerca volvulus 0.0034 0.0495 0.5484
Schistosoma mansoni zinc finger protein 0.0035 0.0505 0.0484
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0079 0.1428 0.2568
Loa Loa (eye worm) PHD-finger family protein 0.0047 0.0759 0.1398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0582 0.0561
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.1849 0.1849
Leishmania major hypothetical protein, conserved 0.0035 0.0505 0.2106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0582 0.0561
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.141 0.2597
Brugia malayi RNA recognition motif domain containing protein 0.013 0.2479 0.4521
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0582 0.0582
Schistosoma mansoni glutaminase 0.0271 0.5428 0.5418
Brugia malayi beta-lactamase 0.0039 0.0582 0.0998
Schistosoma mansoni ferritin 0.0054 0.0909 0.0888
Echinococcus multilocularis Chromo domain 0.0013 0.0045 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0582 0.0998
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Mycobacterium leprae Probable lipase LipE 0.0039 0.0582 0.4976
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0132 0.0162
Schistosoma mansoni cpg binding protein 0.0041 0.0627 0.0607
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0582 0.0836
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0054 0.0909 0.5
Echinococcus multilocularis expressed protein 0.0054 0.0909 0.0909
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.023
Brugia malayi Bromodomain containing protein 0.0173 0.3384 0.6203
Schistosoma mansoni ferritin light chain 0.0054 0.0909 0.0888
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0079 0.1428 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0079 0.1428 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0398
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0582 0.0968
Echinococcus multilocularis zinc finger protein 0.0047 0.075 0.075
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0135 0.2587 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0039 0.0589 0.0589
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.2479 0.4566
Echinococcus granulosus ferritin 0.0054 0.0909 0.0909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0208 0.0302
Trichomonas vaginalis ferritin, putative 0.0054 0.0909 0.1604
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0079 0.1428 0.1428
Loa Loa (eye worm) helicase 0.0013 0.0045 0.0083
Mycobacterium ulcerans lipase LipD 0.0039 0.0582 0.0841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1849 0.1849
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0496 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0425 0.0707
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0045 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.023
Loa Loa (eye worm) RNA binding protein 0.013 0.2479 0.4566
Brugia malayi glutaminase DH11.1 0.0271 0.5428 1
Treponema pallidum bacterioferrin (TpF1) 0.0054 0.0909 0.5
Brugia malayi CHD4 protein 0.0019 0.0177 0.0245
Echinococcus granulosus Chromobox protein 3 0.0013 0.0045 0.0045
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0083
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0259 0.023
Schistosoma mansoni hypothetical protein 0.0035 0.0505 0.0484
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0137 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0582 0.0968
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0137 0.0253
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0054 0.0909 0.1648
Echinococcus multilocularis tar DNA binding protein 0.013 0.2479 0.2479
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.004 0.0604 0.0583
Mycobacterium tuberculosis Conserved protein 0.0039 0.0582 0.0968
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0045 0.0023
Loa Loa (eye worm) hypothetical protein 0.0044 0.0693 0.1276
Brugia malayi PHD-finger family protein 0.0059 0.1003 0.178
Schistosoma mansoni hypothetical protein 0.049 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.1849 0.1849
Schistosoma mansoni hypothetical protein 0.0047 0.0759 0.0738
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0582 0.0836
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0582 0.1961
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0019 0.0177 0.0177
Brugia malayi MH2 domain containing protein 0.0129 0.247 0.4505

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17.4 uM Inhibition of His6x-tagged Plasmodium falciparum Pfmrk expressed in Escherichia coli by microtiter plate scintillation counting ChEMBL. 20627564

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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