Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0535 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.1474 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1474 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.1474 | 0.1474 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.0535 | 0.0535 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0535 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.6434 | 0.6232 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1474 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.6434 | 0.6232 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.6434 | 1 |
Schistosoma mansoni | eyes absent homolog | 0.0085 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.1474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.6434 | 0.6434 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0535 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.6434 | 0.6232 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.1474 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0535 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.6434 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.6434 | 0.6232 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.6434 | 0.6232 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.6434 | 0.6434 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.6434 | 0.6232 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0535 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0535 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.6434 | 0.6232 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1474 | 0.0993 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.1474 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.1474 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0.0535 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.1474 | 1 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.6434 | 0.6434 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0535 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.6434 | 0.6232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.