Detailed information for compound 113852

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 597.15 | Formula: C26H39ClN7O5S-
  • H donors: 5 H acceptors: 5 LogP: 2.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC1CNc2c(C1)cccc2S(=O)(=O)N[C@@H]1CCC[C@H]2N(C1=O)[C@@H](CC2)C(=O)N[C@@H]1CCCN(C1O)C(=N)N.[Cl-]
  • InChi: 1S/C26H39N7O5S.ClH/c1-15-13-16-5-2-9-21(22(16)29-14-15)39(37,38)31-19-7-3-6-17-10-11-20(33(17)25(19)36)23(34)30-18-8-4-12-32(24(18)35)26(27)28;/h2,5,9,15,17-20,24,29,31,35H,3-4,6-8,10-14H2,1H3,(H3,27,28)(H,30,34);1H/p-1/t15?,17-,18-,19-,20-,24?;/m0./s1
  • InChiKey: RITRGMCNUPSEBT-DCZAXYNPSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.012 0.2564 0.4533
Brugia malayi ImpB/MucB/SamB family protein 0.008 0.1583 0.2865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.043 0.043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0773 0.0773
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.1583 0.4087
Schistosoma mansoni hypothetical protein 0.0048 0.0814 0.0814
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0064 0.0064
Echinococcus multilocularis dna polymerase kappa 0.008 0.1583 0.1583
Leishmania major hypothetical protein, conserved 0.0048 0.0814 0.095
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0135 0.0245
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0967 0.1163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0733 0.0835
Schistosoma mansoni ap endonuclease 0.002 0.0135 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0986 0.119
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.043 0.043
Brugia malayi hypothetical protein 0.004 0.0615 0.1113
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0257 0.017
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.1532 0.1953
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.7287 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0543 0.6008
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0543 0.0602
Giardia lamblia DNA damage repair protein 0.0025 0.0257 0.018
Echinococcus granulosus GPCR family 2 0.0017 0.0064 0.0064
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.7287 1
Echinococcus granulosus dna polymerase eta 0.0133 0.2858 0.2858
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0986 0.119
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.1583 0.2024
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Schistosoma mansoni DNA polymerase eta 0.0133 0.2858 0.2858
Echinococcus granulosus dna polymerase kappa 0.008 0.1583 0.1583
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0064
Onchocerca volvulus 0.0017 0.0075 0.0132
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.3201 0.8657
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.008 0.1583 0.2137
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.6909 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0048 0.0814 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0937 0.1696
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0257 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0733 0.0835
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0543 0.6008
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Onchocerca volvulus 0.0017 0.0075 0.0132
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0135 0.0367
Onchocerca volvulus 0.0017 0.0075 0.0132
Onchocerca volvulus 0.0249 0.5658 1
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0075 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.008 0.1583 0.2024
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.2675 0.4841
Trichomonas vaginalis DNA polymerase eta, putative 0.008 0.1583 0.2137
Onchocerca volvulus 0.003 0.0386 0.0683
Entamoeba histolytica hypothetical protein 0.004 0.0615 0.0708
Trypanosoma brucei chrX additional, unordered contigs 0.0025 0.0257 0.017
Schistosoma mansoni hypothetical protein 0.0429 1 1
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Mycobacterium ulcerans DNA polymerase IV 0.008 0.1583 0.4304
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.1583 0.2024
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0257 0.017
Brugia malayi Protein kinase domain containing protein 0.0048 0.0814 0.1474
Onchocerca volvulus 0.0017 0.0075 0.0132
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.3201 0.8706
Brugia malayi MH2 domain containing protein 0.0125 0.2675 0.4841
Onchocerca volvulus 0.0017 0.0075 0.0132
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0048 0.0814 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0857 0.0857
Onchocerca volvulus 0.0017 0.0075 0.0132
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0543 0.057
Trypanosoma cruzi DNA polymerase eta, putative 0.0133 0.2858 0.3807
Plasmodium vivax SET domain protein, putative 0.0032 0.043 0.4341
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0733 0.0835
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0773 0.0773
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0257 0.017
Trypanosoma brucei unspecified product 0.008 0.1583 0.2024
Onchocerca volvulus 0.0017 0.0075 0.0132
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0025 0.0257 0.125
Echinococcus granulosus tissue type plasminogen activator 0.0048 0.0814 0.0814
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0615 0.0615
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.1583 0.2024
Trypanosoma brucei unspecified product 0.0055 0.0986 0.119
Onchocerca volvulus 0.0017 0.0075 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.0937 0.1696
Onchocerca volvulus 0.0106 0.2225 0.3932
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0543 0.057
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0075 0.0135
Entamoeba histolytica deoxycytidyl transferase, putative 0.008 0.1583 0.2137
Echinococcus multilocularis dna polymerase eta 0.0133 0.2858 0.2858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Onchocerca volvulus 0.0032 0.043 0.076
Mycobacterium ulcerans DNA polymerase IV 0.008 0.1583 0.4304
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0773 0.0773
Schistosoma mansoni hypothetical protein 0.004 0.0615 0.0615
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Echinococcus granulosus geminin 0.0361 0.8359 0.8359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Loa Loa (eye worm) hypothetical protein 0.0133 0.2858 0.5172
Leishmania major DNA polymerase kappa, putative 0.0025 0.0257 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0543 0.0602
Schistosoma mansoni DNA polymerase IV / kappa 0.0025 0.0257 0.0257
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0135 0.0245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0257 0.0465
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0257 0.017
Mycobacterium ulcerans hypothetical protein 0.0167 0.3677 1
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0075 0.0135
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0533 0.0965
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0075 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0543 0.057
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0064 0.0064
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0135 0.5
Loa Loa (eye worm) hypothetical protein 0.012 0.2564 0.4641
Loa Loa (eye worm) hypothetical protein 0.0243 0.5525 1
Brugia malayi polk-prov protein 0.0025 0.0257 0.0465
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0937 0.1696
Brugia malayi beta-NAC-like protein 0.0037 0.0543 0.0983
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.008 0.1583 0.4087
Trypanosoma brucei unspecified product 0.0055 0.0986 0.119
Leishmania major DNA damage repair protein, putative 0.0025 0.0257 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0133 0.2858 0.5172
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0615 0.0615
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0078 0.1532 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.327 0.4383
Echinococcus multilocularis GPCR, family 2 0.0017 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0037 0.0543 0.0602
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0064 0.0064
Giardia lamblia DINP protein human, muc B family 0.008 0.1583 0.2137
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.043 0.043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.043 0.043
Entamoeba histolytica hypothetical protein 0.004 0.0615 0.0708
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.1583 0.2024
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Toxoplasma gondii kringle domain-containing protein 0.0048 0.0814 0.5074
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4931 0.8925
Brugia malayi Trypsin family protein 0.012 0.2564 0.4641
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0135 0.0135
Echinococcus multilocularis geminin 0.0361 0.8359 0.8359
Onchocerca volvulus 0.0017 0.0075 0.0132
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.1583 0.2024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0064 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1228 0.1228
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Trypanosoma brucei DNA polymerase eta, putative 0.0133 0.2858 0.3807
Schistosoma mansoni terminal deoxycytidyl transferase 0.008 0.1583 0.1583
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.1583 0.2024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0257 0.125
Brugia malayi Pre-SET motif family protein 0.0032 0.043 0.0778
Leishmania major DNA polymerase kappa, putative 0.008 0.1583 0.2024
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.7287 1
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Loa Loa (eye worm) PAN domain-containing protein 0.0017 0.0075 0.0135
Echinococcus multilocularis transcription factor btf3 0.0037 0.0543 0.0543
Schistosoma mansoni ap endonuclease 0.002 0.0135 0.0135
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.2564 0.2564
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Brugia malayi Kringle domain containing protein 0.0048 0.0814 0.1474
Leishmania major DNA polymerase eta, putative 0.0133 0.2858 0.3807
Plasmodium falciparum DNA repair protein REV1, putative 0.0025 0.0257 0.1794
Schistosoma mansoni hypothetical protein 0.0036 0.0533 0.0533
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.5525 0.5525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0533 0.0965
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0257 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0615 0.0615
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0064 0.0116
Echinococcus granulosus cpg binding protein 0.0032 0.0428 0.0428
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.0986 0.119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0733 0.0835
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0257 0.017
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.2675 0.4841
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0543 0.0602
Schistosoma mansoni transcription factor btf3 0.0037 0.0543 0.0543
Loa Loa (eye worm) hypothetical protein 0.012 0.2564 0.4641
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.6909 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.7287 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Trypanosoma brucei DNA damage repair protein, putative 0.0025 0.0257 0.017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Echinococcus multilocularis dnaJ subfamily B 0.0429 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0814 0.1474
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.6909 1
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0937 0.1696
Brugia malayi CXXC zinc finger family protein 0.003 0.0386 0.0699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0773 0.0773
Entamoeba histolytica hypothetical protein 0.004 0.0615 0.0708
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0135 0.0135
Onchocerca volvulus 0.0048 0.0814 0.1439
Toxoplasma gondii hypothetical protein 0.0051 0.089 0.5596
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0773 0.1398
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.3677 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.6909 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0257 0.017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0773 0.1398
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.008 0.1583 0.2865
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.008 0.1583 0.1583
Onchocerca volvulus 0.005 0.0857 0.1514
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Loa Loa (eye worm) hypothetical protein 0.0032 0.043 0.0778
Echinococcus multilocularis tissue type plasminogen activator 0.0048 0.0814 0.0814
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.327 0.4383
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.043 0.043
Brugia malayi PAN domain containing protein 0.0017 0.0075 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.043 0.043
Brugia malayi hypothetical protein 0.0243 0.5525 1
Schistosoma mansoni cpg binding protein 0.003 0.0386 0.0386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0064 0.0064
Leishmania major DNA polymerase eta, putative 0.0078 0.1532 0.1953
Schistosoma mansoni cpg binding protein 0.0032 0.0428 0.0428
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.008 0.1583 0.1583
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.043 0.043
Schistosoma mansoni hypothetical protein 0.0361 0.8359 0.8359
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0773 0.0773
Echinococcus multilocularis cpg binding protein 0.0032 0.0428 0.0428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0386 0.0386
Echinococcus granulosus transcription factor btf3 0.0037 0.0543 0.0543
Schistosoma mansoni cpg binding protein 0.0032 0.0428 0.0428
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.043 0.2437
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0773 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Brugia malayi Pre-SET motif family protein 0.0219 0.4931 0.8925
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0773 0.0773
Loa Loa (eye worm) hypothetical protein 0.0048 0.0814 0.1474
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.3201 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.327 0.4383
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0814 0.095
Schistosoma mansoni hypothetical protein 0.005 0.0857 0.0857
Toxoplasma gondii exonuclease III APE 0.002 0.0135 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0064 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0543 0.0602
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0543 0.0983
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0116
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1063 0.6784
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.1583 0.2024
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0857 0.155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0386 0.0699
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.008 0.1583 0.1583
Onchocerca volvulus 0.0017 0.0075 0.0132
Schistosoma mansoni hypothetical protein 0.0361 0.8359 0.8359
Trypanosoma cruzi DNA damage repair protein, putative 0.0025 0.0257 0.017
Entamoeba histolytica hypothetical protein 0.004 0.0615 0.0708
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.012 0.2564 0.2564
Mycobacterium ulcerans hypothetical protein 0.0025 0.0257 0.0699
Leishmania major basic transcription factor 3a, putative 0.0037 0.0543 0.057
Onchocerca volvulus 0.0017 0.0075 0.0132
Trichomonas vaginalis set domain proteins, putative 0.0249 0.5658 0.8152
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0543 0.3214
Plasmodium vivax DNA repair protein REV1, putative 0.0025 0.0257 0.1794
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.1583 0.2024
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.5525 0.5525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.6909 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.018 uM Compound was evaluated in vitro for its ability to inhibit the activity of human alpha Thrombin ChEMBL. No reference
IC50 (binding) = 0.1 uM Compound was evaluated in vitro for its ability to inhibit the activity of Trypsin ChEMBL. No reference
IC50 (binding) = 1.04 uM Compound was evaluated in vitro for its ability to inhibit the activity of Plasmin ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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