TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 588.702 | Formula: C34H36N8O2
H donors: 2 H acceptors: 4 LogP: 4.48 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Nc1ccccc1)Nc1ccc(cc1)c1nc(N2CCOCC2)c2c(n1)n(nc2)C1CCN(CC1)Cc1ccccc1
InChi: 1S/C34H36N8O2/c43-34(36-27-9-5-2-6-10-27)37-28-13-11-26(12-14-28)31-38-32(41-19-21-44-22-20-41)30-23-35-42(33(30)39-31)29-15-17-40(18-16-29)24-25-7-3-1-4-8-25/h1-14,23,29H,15-22,24H2,(H2,36,37,43)
InChiKey: PLQOKDSGXCSTPR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References
Homo sapiens	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	phosphatidylinositol kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania infantum	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	Get druggable targets OG5_127444	All targets in OG5_127444
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	Get druggable targets OG5_127444	All targets in OG5_127444
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative	Get druggable targets OG5_127444	All targets in OG5_127444
Leishmania mexicana	phosphatidylinositol 3-kinase, putative	Get druggable targets OG5_127444	All targets in OG5_127444
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	Get druggable targets OG5_127444	All targets in OG5_127444
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1068 aa	927 aa	29.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.0696	0.2713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0476	0.0827
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0058	0.1011	0.0949
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0019	0.0178	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1525	0.1525
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0085	0.1588	0.3081
Schistosoma mansoni	lamin	0.0082	0.1524	0.3204
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0266	0.0565
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.2945	0.2945
Toxoplasma gondii	exonuclease III APE	0.0039	0.0598	0.2327
Loa Loa (eye worm)	MH2 domain-containing protein	0.0123	0.24	0.24
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0475	0.0825
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0079	0.1458	0.1458
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0014	0.0068	0.0068
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0019	0.0178	0.0111
Onchocerca volvulus		0.0097	0.1859	0.3366
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0824	0.0824
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0026	0.0331	0.1577
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0056	0.0971	0.3905
Schistosoma mansoni	cpg binding protein	0.0032	0.0465	0.0872
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0061	0.1071	0.4865
Trypanosoma brucei	polo-like protein kinase	0.0092	0.1736	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0773	0.1429
Onchocerca volvulus		0.0031	0.0445	0.0377
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0266	0.0565
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0019	0.0178	0.0476
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.012	0.2344	0.2344
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0093	0.0051
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0019	0.0178	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1501	0.1501
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.2945	0.6333
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0598	0.0598
Onchocerca volvulus		0.0244	0.4999	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0543	0.0962
Schistosoma mansoni	lamin	0.0082	0.1524	0.3204
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0238	0.0735
Onchocerca volvulus		0.0082	0.1524	0.2658
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0445	0.1653
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0122	0.2381	0.2328
Schistosoma mansoni	survival motor neuron protein	0.0097	0.1859	0.3943
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0445	0.0445
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.1736	0.1736
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0773	0.1429
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.1736	0.367
Brugia malayi	Pre-SET motif family protein	0.0215	0.4367	0.4328
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0098	0.1864	0.7763
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.0598	0.2144
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.1011	0.1911
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.1736	0.1736
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0019	0.0178	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0476	0.0827
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0445	0.0445
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0142	0.0142
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0122	0.2381	0.469
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.1525	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0598	0.2291
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0598	0.2291
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.2344	0.501
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0106	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0445	0.0828
Echinococcus granulosus	geminin	0.0174	0.3502	0.3502
Schistosoma mansoni	hypothetical protein	0.0016	0.0106	0.0083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.016	0.0187
Echinococcus granulosus	peptidase Clp S14 family	0.0054	0.0921	0.0921
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	0.628
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0406	0.0406
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0054	0.0921	0.3599
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0598	0.1074
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0047	0.0774	0.4231
Echinococcus granulosus	lamin dm0	0.0082	0.1524	0.1524
Echinococcus multilocularis	tar DNA binding protein	0.0203	0.4117	0.4117
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0079	0.1458	0.1458
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0058	0.1011	0.4074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0543	0.0962
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.012	0.2344	0.2344
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0058	0.1011	0.5651
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0058	0.1011	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0266	0.0266
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0019	0.0178	0.066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0628	0.1135
Schistosoma mansoni	tar DNA-binding protein	0.0203	0.4117	0.8912
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0226	0.4611	0.4611
Brugia malayi	Pre-SET motif family protein	0.0031	0.0445	0.0379
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.012	0.2344	1
Schistosoma mansoni	tar DNA-binding protein	0.0203	0.4117	0.8912
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0238	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0492	0.0492
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0019	0.0178	0.0476
Loa Loa (eye worm)	phosphatidylinositol 3	0.0036	0.0546	0.0546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0475	0.0825
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0043	0.0696	0.2713
Echinococcus multilocularis	survival motor neuron protein 1	0.0478	1	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.1525	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0079	0.1458	0.306
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0266	0.0404
Schistosoma mansoni	hypothetical protein	0.0034	0.0492	0.0932
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.1525	0.1525
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0238	0.0374
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0745	0.1372
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.008	0.1489	0.143
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0266	0.0565
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0266	0.0565
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0019	0.0178	0.0178
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0036	0.0548	0.0548
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0598	0.1074
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0266	0.0404
Schistosoma mansoni	tar DNA-binding protein	0.0203	0.4117	0.8912
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0044	0.0711	0.0711
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.1501	0.6194
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	1
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.1489	0.1489
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.2945	0.2945
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0266	0.0404
Schistosoma mansoni	hypothetical protein	0.0097	0.1859	0.3943
Echinococcus multilocularis	serine protein kinase ATM	0.0014	0.0068	0.0068
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.1736	0.1679
Entamoeba histolytica	hypothetical protein	0.0079	0.1458	0.6011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.0841	0.1566
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0266	0.0855
Echinococcus multilocularis	lamin dm0	0.0082	0.1524	0.1524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0476	0.0827
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.2945	0.6333
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0824	0.0761
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0773	0.1429
Trichomonas vaginalis	CAMK family protein kinase	0.0045	0.0745	0.1372
Schistosoma mansoni	hypothetical protein	0.0174	0.3502	0.7558
Echinococcus granulosus	cpg binding protein	0.0032	0.0465	0.0465
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0238	0.0171
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0598	0.33
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0427	0.0361
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0047	0.0774	0.2749
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0068	0.0068
Brugia malayi	hypothetical protein	0.0052	0.0889	0.0826
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0019	0.0178	0.0484
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0824	0.0824
Echinococcus granulosus	survival motor neuron protein 1	0.0478	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.1489	0.1489
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.1525	0.3206
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0266	0.0266
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0054	0.0921	0.0921
Schistosoma mansoni	kinase	0.0047	0.0771	0.1546
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0773	0.1429
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0142	0.0142
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0266	0.0565
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.2945	0.6333
Loa Loa (eye worm)	hypothetical protein	0.008	0.1492	0.1492
Plasmodium vivax	ataxin-2 like protein, putative	0.0081	0.1501	0.9826
Toxoplasma gondii	LsmAD domain-containing protein	0.0081	0.1501	0.6293
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0377	0.1702
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0445	0.0828
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0097	0.1859	0.1803
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0019	0.0178	0.0178
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0029	0.0398	0.1978
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0142	0.0142
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.2945	0.2945
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.1501	0.6194
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0148	0.2945	0.2897
Schistosoma mansoni	ap endonuclease	0.0039	0.0598	0.1166
Brugia malayi	Probable ClpP-like protease	0.0082	0.1525	0.1466
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0036	0.0548	0.0548
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.1011	0.1911
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0058	0.1011	0.3842
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0427	0.0427
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0266	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1524	0.1524
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	0.628
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.1525	0.1525
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0019	0.0178	0.0223
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0226	0.4611	0.4611
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0598	0.0598
Giardia lamblia	Kinase, PLK	0.0092	0.1736	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Entamoeba histolytica	hypothetical protein	0.0079	0.1458	0.6011
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.012	0.2344	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0043	0.0696	0.1272
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0238	0.0238
Brugia malayi	TAR-binding protein	0.0203	0.4117	0.4076
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0044	0.0713	0.2832
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0238	0.0238
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0058	0.1011	0.2074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.1736	0.7189
Schistosoma mansoni	hypothetical protein	0.0174	0.3502	0.7558
Loa Loa (eye worm)	RNA binding protein	0.0203	0.4117	0.4117
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0058	0.1011	0.4074
Schistosoma mansoni	tar DNA-binding protein	0.0203	0.4117	0.8912
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0618	0.0618
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2344	1
Toxoplasma gondii	aldehyde dehydrogenase	0.012	0.2344	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0824	0.0761
Leishmania major	hypothetical protein, conserved	0.0081	0.1501	0.6105
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1736	0.721
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0266	0.0266
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0028	0.0377	0.0881
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0106	0.0106
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.1525	0.6399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0476	0.0827
Schistosoma mansoni	transcription factor LCR-F1	0.0079	0.1458	0.306
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0019	0.0178	0.0476
Brugia malayi	intermediate filament protein	0.0082	0.1524	0.1466
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0598	0.1926
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.1501	0.9826
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0603	0.1084
Echinococcus granulosus	lamin	0.0082	0.1524	0.1524
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1184	0.2457
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0266	0.0565
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0773	0.1429
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0238	0.0735
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0266	0.065
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0043	0.0696	0.2713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0238	0.0345
Loa Loa (eye worm)	intermediate filament protein	0.0082	0.1524	0.1524
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0226	0.4611	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0142	0.0142
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0058	0.1011	0.4074
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0058	0.1011	0.1011
Echinococcus multilocularis	Zinc finger, PHD finger	0.0019	0.0178	0.0178
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0215	0.4367	0.4367
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.2381	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0445	0.0445
Plasmodium vivax	SET domain protein, putative	0.0031	0.0445	0.2191
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0492	0.0426
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0598	0.0598
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0082	0.1524	0.1524
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.0598	0.1937
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0122	0.2381	0.469
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0015	0.0093	0.011
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0093	0.0093
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0266	0.0855
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0266	0.0199
Loa Loa (eye worm)	transcription factor SMAD2	0.0123	0.24	0.24
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.1736	0.1736
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0019	0.0178	0.0267
Echinococcus granulosus	tar DNA binding protein	0.0203	0.4117	0.4117
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0043	0.0696	0.1272
Entamoeba histolytica	hypothetical protein	0.0079	0.1458	0.6011
Schistosoma mansoni	tar DNA-binding protein	0.0203	0.4117	0.8912
Brugia malayi	hypothetical protein	0.0081	0.1501	0.1442
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0266	0.065
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0598	0.3177
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0238	0.0276
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0445	0.0828
Loa Loa (eye worm)	phosphatidylinositol 3	0.0058	0.1011	0.1011
Echinococcus multilocularis	cpg binding protein	0.0032	0.0465	0.0465
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0019	0.0178	0.0267
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0598	0.0533
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0586	0.0586
Loa Loa (eye worm)	phosphatidylinositol 3	0.0202	0.4094	0.4094
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0019	0.0178	0.0223
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0238	0.0276
Schistosoma mansoni	hypothetical protein	0.0016	0.0106	0.0083
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.1736	0.3381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0536	0.0948
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0203	0.4117	0.4117
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0014	0.0068	0.000000060555
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0122	0.2381	0.469
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.1736	0.3105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0043	0.0696	0.3763
Brugia malayi	hypothetical protein	0.0079	0.1458	0.14
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0666	0.0666
Onchocerca volvulus		0.0082	0.1524	0.2658
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0115	0.2231	0.9352
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0039	0.0618	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0478	1	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0014	0.0068	0.0068
Echinococcus granulosus	serine protein kinase ATM	0.0014	0.0068	0.0068
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0039	0.0618	0.0618
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0106	0.0038
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0106	0.0106
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0148	0.2945	0.2945
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.1501	0.9826
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0238	0.1019
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0019	0.0178	0.0223
Schistosoma mansoni	intermediate filament proteins	0.0082	0.1524	0.3204
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2344	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0598	0.1215
Brugia malayi	Intermediate filament tail domain containing protein	0.0082	0.1524	0.1466
Onchocerca volvulus		0.0031	0.0427	0.0341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0238	0.0345
Schistosoma mansoni	ap endonuclease	0.0039	0.0598	0.1166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0238	0.0345
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.1011	0.1911
Trypanosoma cruzi	target of rapamycin kinase 3	0.0047	0.0774	0.305
Brugia malayi	MH2 domain containing protein	0.0123	0.24	0.2348
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0598	0.33
Entamoeba histolytica	hypothetical protein	0.0098	0.1864	0.7763
Entamoeba histolytica	hypothetical protein	0.0079	0.1458	0.6011
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.008	0.1489	0.1489
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0036	0.0546	0.2064
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.1525	0.6399
Giardia lamblia	GTOR	0.0058	0.1011	0.4401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0238	0.0345
Echinococcus granulosus	GPCR family 2	0.0016	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0586	0.0586
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0266	0.0199
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0019	0.0178	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0106	0.0106
Echinococcus granulosus	intermediate filament protein	0.0082	0.1524	0.1524
Schistosoma mansoni	hypothetical protein	0.0036	0.0548	0.1056
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0266	0.0199
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0019	0.0178	0.0178
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0238	0.0238
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.1736	0.721
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.1525	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0058	0.1011	0.4074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0543	0.0962
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0266	0.0855
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.1736	0.721
Echinococcus multilocularis	lamin	0.0082	0.1524	0.1524
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.2344	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0106	0.0106
Toxoplasma gondii	hypothetical protein	0.0028	0.0377	0.1356
Brugia malayi	RNA binding protein	0.0203	0.4117	0.4076
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0377	0.1702
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0054	0.0921	0.3599
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0122	0.2381	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1036	0.4253
Trypanosoma brucei	PAB1-binding protein , putative	0.0081	0.1501	0.8592
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0104	0.2004	0.1949
Schistosoma mansoni	cpg binding protein	0.0031	0.0427	0.079
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0266	0.0565
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0142	0.009
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0598	0.2291
Trichomonas vaginalis	set domain proteins, putative	0.0244	0.4999	1
Brugia malayi	RNA recognition motif domain containing protein	0.0203	0.4117	0.4076
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0122	0.2381	1
Loa Loa (eye worm)	TAR-binding protein	0.0203	0.4117	0.4117
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0058	0.1011	0.5651
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0043	0.0696	0.1381
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0043	0.0696	0.0632
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.2945	0.2945
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0106	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0713	0.1307
Brugia malayi	cytoplasmic intermediate filament protein	0.0044	0.0711	0.0647
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0054	0.0921	0.5207
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0445	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0445	0.0445
Schistosoma mansoni	cpg binding protein	0.0032	0.0465	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.0016	0.0106	0.0083
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0085	0.1588	0.3081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0475	0.0825
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.0598	0.2072
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.2344	0.501
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0058	0.1011	0.3842
Schistosoma mansoni	hypothetical protein	0.0016	0.0106	0.0083
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0238	0.1019
Echinococcus multilocularis	musashi	0.0082	0.1524	0.1524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0536	0.0948
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0019	0.0178	0.0178
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0106	0.0106
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0043	0.0696	0.1272
Echinococcus multilocularis	geminin	0.0174	0.3502	0.3502

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 nM	Inhibition of human mTOR (1360-2549 amino acids) expressed in HEK293 cells	ChEMBL.	19894727
IC50 (binding)	= 16.5 nM	Inhibition of PI3Kalpha by DELFIA assay	ChEMBL.	19894727
IC50 (functional)	= 200 nM	Antiproliferative activity against human LNCAP cells after 3 days by MTS assay	ChEMBL.	19894727

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19894727

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1097900

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1138609