Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cathepsin B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | cathepsin B | 339 aa | 368 aa | 26.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.1787 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.956 | 0.9424 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2357 | 0.2465 |
Toxoplasma gondii | cathepsin B | 0.0055 | 0.1787 | 1 |
Echinococcus granulosus | cathepsin b | 0.0166 | 0.956 | 0.9424 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2357 | 0.2465 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0166 | 0.956 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.038 | 0.0398 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.1787 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0055 | 0.1787 | 0.1869 |
Loa Loa (eye worm) | cathepsin B | 0.0055 | 0.1787 | 0.1869 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1501 | 0.157 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1501 | 0.157 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.956 | 0.9424 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.956 | 0.9543 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.038 | 0.0398 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2357 | 0.2465 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0166 | 0.956 | 0.9543 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.956 | 0.9543 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0055 | 0.1787 | 0.1462 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0166 | 0.956 | 0.9543 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2357 | 0.2054 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2357 | 0.2465 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0166 | 0.956 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0055 | 0.1787 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2357 | 0.2465 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0055 | 0.1787 | 0.5 |
Echinococcus multilocularis | geminin | 0.0172 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1501 | 0.157 |
Echinococcus multilocularis | cathepsin b | 0.0166 | 0.956 | 0.9424 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0055 | 0.1787 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2357 | 0.2054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2357 | 0.2054 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0055 | 0.1787 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.956 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1501 | 0.157 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2357 | 0.2054 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2357 | 0.2465 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2357 | 0.2054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 485.8 uM | Inhibition of human DNA topoisomerase IIalpha using plasmid pNO1 as a substrate after 30 mins | ChEMBL. | 26183545 |
Inhibition (binding) | Inhibition of human recombinant cathepsin L expressed in Escherichia coli assessed as formation of fluorescent degradation product AMC using Z-Phe-Arg-AMC as substrate at 50 uM by fluorescence microplate assay | ChEMBL. | 21849222 | |
Inhibition (binding) | Inhibition of human liver cathepsin H expressed in Escherichia coli assessed as formation of fluorescent degradation product AMC using Arg-AMC as substrate at 50 uM by fluorescence microplate assay | ChEMBL. | 21849222 | |
Ki (binding) | = 9.7 uM | Partial mixed-type inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as substrate by Michaelis-Menten method | ChEMBL. | 21849222 |
Ki (binding) | = 23 uM | Reversible inhibition of human recombinant cathepsin B assessed as formation of fluorescent degradation product AMC using Z-Arg-Arg-AMC as substrate by Michaelis-Menten method | ChEMBL. | 21849222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.